[go: up one dir, main page]

WO2018194496A3 - Моноклональное антитело к pd-l1 - Google Patents

Моноклональное антитело к pd-l1 Download PDF

Info

Publication number
WO2018194496A3
WO2018194496A3 PCT/RU2018/050039 RU2018050039W WO2018194496A3 WO 2018194496 A3 WO2018194496 A3 WO 2018194496A3 RU 2018050039 W RU2018050039 W RU 2018050039W WO 2018194496 A3 WO2018194496 A3 WO 2018194496A3
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibody
antibodies
methods
relates
biotechnology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2018/050039
Other languages
English (en)
French (fr)
Other versions
WO2018194496A2 (ru
Inventor
Андрей Борисович УЛИТИН
Виктория Михайловна ЕКИМОВА
Екатерина Владимировна СОФРОНОВА
Юлия Сергеевна ЧЕРНЫХ
Сергей Андреевич АГЕЕВ
Анна Константиновна ВЛАДИМИРОВА
Алексей Александрович АЛЕКСАНДРОВ
Павел Алексеевич ГРЕБНЕВ
Валерий Владимирович СОЛОВЬЕВ
Яков Юрьевич УСТЮГОВ
Павел Андреевич ЯКОВЛЕВ
Тимофей Александрович НЕМАНКИН
Дмитрий Валентинович МОРОЗОВ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocad JSC
Original Assignee
Biocad JSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PE2019002020A priority Critical patent/PE20191786A1/es
Priority to CN201880040390.1A priority patent/CN111247166B/zh
Priority to US16/605,865 priority patent/US11236167B2/en
Priority to BR112019021781A priority patent/BR112019021781A2/pt
Priority to NZ758093A priority patent/NZ758093A/en
Priority to EA201992206A priority patent/EA201992206A1/ru
Priority to KR1020197033829A priority patent/KR102679554B1/ko
Priority to MA47221A priority patent/MA47221A1/fr
Priority to AU2018255132A priority patent/AU2018255132C1/en
Priority to JP2020506702A priority patent/JP2020516323A/ja
Priority to EP18786945.8A priority patent/EP3613770A4/en
Priority to CA3060395A priority patent/CA3060395A1/en
Application filed by Biocad JSC filed Critical Biocad JSC
Publication of WO2018194496A2 publication Critical patent/WO2018194496A2/ru
Publication of WO2018194496A3 publication Critical patent/WO2018194496A3/ru
Priority to PH12019502298A priority patent/PH12019502298A1/en
Priority to CONC2019/0011458A priority patent/CO2019011458A2/es
Anticipated expiration legal-status Critical
Priority to ZA2019/07065A priority patent/ZA201907065B/en
Priority to JP2023031932A priority patent/JP7600285B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Реферат Настоящее изобретение относится к области биотехнологии и предлагает антитела, которые специфично связываются с PD-L1. Изобретение также относится к ДНК, кодирующей указанные антитела, соответствующим экспрессионным векторам и способам продукции, а также к способам лечения с использованием указанных антител.
PCT/RU2018/050039 2017-04-17 2018-04-11 Моноклональное антитело к pd-l1 Ceased WO2018194496A2 (ru)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP18786945.8A EP3613770A4 (en) 2017-04-17 2018-04-11 MONOCLONAL ANTIBODY AGAINST PD-L1
US16/605,865 US11236167B2 (en) 2017-04-17 2018-04-11 Monoclonal antibody to PD-L1
BR112019021781A BR112019021781A2 (pt) 2017-04-17 2018-04-11 anticorpo monoclonal, célula hospedeira, método para produzir anticorpo, composição farmacêutica, combinação farmacêutica, método para inibir a atividade biológica e método de utilização do anticorpo
NZ758093A NZ758093A (en) 2017-04-17 2018-04-11 Monoclonal antibody to pd-l1
EA201992206A EA201992206A1 (ru) 2017-04-17 2018-04-11 Моноклональное антитело к pd-l1
KR1020197033829A KR102679554B1 (ko) 2017-04-17 2018-04-11 Pd-l1에 대한 단일클론 항체
MA47221A MA47221A1 (fr) 2017-04-17 2018-04-11 Anticorps monoclonal à pd-l1
AU2018255132A AU2018255132C1 (en) 2017-04-17 2018-04-11 Monoclonal antibody to PD-L1
JP2020506702A JP2020516323A (ja) 2017-04-17 2018-04-11 抗ｐｄ−ｌ１モノクローナル抗体
PE2019002020A PE20191786A1 (es) 2017-04-17 2018-04-11 Anticuerpo monoclonal para pd-l1
CN201880040390.1A CN111247166B (zh) 2017-04-17 2018-04-11 针对pd-l1的单克隆抗体
CA3060395A CA3060395A1 (en) 2017-04-17 2018-04-11 Monoclonal antibody to pd-l1
PH12019502298A PH12019502298A1 (en) 2017-04-17 2019-10-07 Monoclonal antibody to pd-l1
CONC2019/0011458A CO2019011458A2 (es) 2017-04-17 2019-10-16 Anticuerpo monoclonal para pd-l1
ZA2019/07065A ZA201907065B (en) 2017-04-17 2019-10-25 Monoclonal antibody to pd-l1
JP2023031932A JP7600285B2 (ja) 2017-04-17 2023-03-02 抗ｐｄ－ｌ１モノクローナル抗体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2017113141A RU2665790C1 (ru) 2017-04-17 2017-04-17 Моноклональное антитело к pd-l1
RU2017113141 2017-04-17

Publications (2)

Publication Number Publication Date
WO2018194496A2 WO2018194496A2 (ru) 2018-10-25
WO2018194496A3 true WO2018194496A3 (ru) 2019-01-10

Family

ID=63459922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2018/050039 Ceased WO2018194496A2 (ru) 2017-04-17 2018-04-11 Моноклональное антитело к pd-l1

Country Status (21)

Country Link
US (1) US11236167B2 (ru)
EP (1) EP3613770A4 (ru)
JP (2) JP2020516323A (ru)
KR (1) KR102679554B1 (ru)
CN (1) CN111247166B (ru)
AR (1) AR113223A1 (ru)
AU (1) AU2018255132C1 (ru)
BR (1) BR112019021781A2 (ru)
CA (1) CA3060395A1 (ru)
CL (1) CL2019002894A1 (ru)
CO (1) CO2019011458A2 (ru)
EA (1) EA201992206A1 (ru)
JO (1) JOP20190246A1 (ru)
MA (1) MA47221A1 (ru)
NZ (1) NZ758093A (ru)
PE (1) PE20191786A1 (ru)
PH (1) PH12019502298A1 (ru)
RU (1) RU2665790C1 (ru)
UY (1) UY37683A (ru)
WO (1) WO2018194496A2 (ru)
ZA (1) ZA201907065B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017011644A (es) 2015-03-13 2017-12-04 Cytomx Therapeutics Inc Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos.
EP3630838A1 (en) 2017-06-01 2020-04-08 CytomX Therapeutics, Inc. Activatable anti-pdl1 antibodies, and methods of use thereof
EA039662B1 (ru) * 2017-10-03 2022-02-24 Закрытое Акционерное Общество "Биокад" Антитела, специфичные к cd47 и pd-l1
CN109929037B (zh) 2019-04-01 2023-03-17 华博生物医药技术（上海）有限公司 针对程序性死亡配体的结合物及其应用
RU2753282C2 (ru) 2019-09-19 2021-08-12 Закрытое Акционерное Общество "Биокад" ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ
WO2022121846A1 (zh) * 2020-12-08 2022-06-16 博际生物医药科技(杭州)有限公司 Pd-l1抗体及其应用
TW202306998A (zh) * 2021-06-21 2023-02-16 俄羅斯聯邦商拜奧卡德聯合股份公司 特異性結合ｃｄ４７和ｐｄ－ｌ１的分離的雙特異性抗體
US20250223361A1 (en) * 2022-04-01 2025-07-10 Mabtree Biologics Ag Human antibody or antigen binding fragment thereof specific against pd-l1 to enhance t-cell function
EP4658310A1 (en) 2023-01-30 2025-12-10 Kymab Limited Antibodies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2011128399A (ru) * 2008-12-09 2013-01-20 Дженентек, Инк. Антитела к pd-l1 и их применение для усиления функции т-клеток
US20140356353A1 (en) * 2009-11-24 2014-12-04 Medimmune Limited Targeted binding agents against b7-h1
WO2016061142A1 (en) * 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof
CN105777906A (zh) * 2014-12-19 2016-07-20 苏州丁孚靶点生物技术有限公司 抗pd-l1全人抗体及其应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
EP0216846B2 (en) 1985-04-01 1995-04-26 Celltech Limited Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
ATE144793T1 (de) 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
JPH06500011A (ja) 1990-06-29 1994-01-06 ラージ　スケール　バイオロジー　コーポレイション 形質転換された微生物によるメラニンの製造
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
ATE419355T1 (de) 1992-02-06 2009-01-15 Novartis Vaccines & Diagnostic Marker für krebs und biosynthetisches bindeprotein dafür
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
US5565323A (en) 1994-03-30 1996-10-15 Mitokor Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease
US5537905A (en) 1994-09-08 1996-07-23 Zimmer Industries, Inc. Nicked cutting rule
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
US6517529B1 (en) 1999-11-24 2003-02-11 Radius International Limited Partnership Hemodialysis catheter
WO2002086083A2 (en) 2001-04-20 2002-10-31 Mayo Foundation For Medical Education And Research Methods of enhancing cell responsiveness
KR101411165B1 (ko) * 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
ES2592216T3 (es) 2008-09-26 2016-11-28 Dana-Farber Cancer Institute, Inc. Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
US20110280877A1 (en) * 2010-05-11 2011-11-17 Koji Tamada Inhibition of B7-H1/CD80 interaction and uses thereof
EP2785375B1 (en) * 2011-11-28 2020-07-22 Merck Patent GmbH Anti-pd-l1 antibodies and uses thereof
CN104736168B (zh) 2012-05-31 2018-09-21 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白
JP6461800B2 (ja) 2012-10-04 2019-01-30 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒトモノクローナル抗ｐｄ−ｌ１抗体および使用方法
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
SG10201901057UA (en) 2014-08-05 2019-03-28 Cb Therapeutics Inc Anti-pd-l1 antibodies
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
MX2017011644A (es) * 2015-03-13 2017-12-04 Cytomx Therapeutics Inc Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos.
WO2017020291A1 (en) * 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2011128399A (ru) * 2008-12-09 2013-01-20 Дженентек, Инк. Антитела к pd-l1 и их применение для усиления функции т-клеток
US20140356353A1 (en) * 2009-11-24 2014-12-04 Medimmune Limited Targeted binding agents against b7-h1
WO2016061142A1 (en) * 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof
CN105777906A (zh) * 2014-12-19 2016-07-20 苏州丁孚靶点生物技术有限公司 抗pd-l1全人抗体及其应用

Also Published As

Publication number Publication date
RU2665790C1 (ru) 2018-09-04
UY37683A (es) 2018-11-30
WO2018194496A2 (ru) 2018-10-25
KR20190140979A (ko) 2019-12-20
AU2018255132A2 (en) 2019-11-07
BR112019021781A2 (pt) 2020-05-05
JP2023081942A (ja) 2023-06-13
PH12019502298A1 (en) 2020-07-06
KR102679554B1 (ko) 2024-07-01
JP2020516323A (ja) 2020-06-11
CN111247166A (zh) 2020-06-05
EA201992206A1 (ru) 2020-02-21
CN111247166B (zh) 2024-03-26
AU2018255132B2 (en) 2025-04-17
US11236167B2 (en) 2022-02-01
MA47221A1 (fr) 2020-04-30
AU2018255132A1 (en) 2019-10-31
PE20191786A1 (es) 2019-12-24
EP3613770A2 (en) 2020-02-26
CL2019002894A1 (es) 2020-03-13
JOP20190246A1 (ar) 2019-10-16
AR113223A1 (es) 2020-02-19
NZ758093A (en) 2022-09-30
EP3613770A4 (en) 2021-01-27
CA3060395A1 (en) 2019-11-18
US20200369771A1 (en) 2020-11-26
ZA201907065B (en) 2020-09-30
CO2019011458A2 (es) 2020-01-17
JP7600285B2 (ja) 2024-12-16
AU2018255132C1 (en) 2025-08-07

Similar Documents

Publication Publication Date Title
WO2018194496A3 (ru) Моноклональное антитело к pd-l1
MA49038B1 (fr) Anticorps bispécifiques se liant particulièrement à pd1 et lag3
MA49034B1 (fr) Anticorps anti-lag3
MA46619B1 (fr) Anticorps anti-il-33 et leurs utilisations
MA49599B1 (fr) Anticorps spécifiques à cd47 et pd-l1
EA202190609A1 (ru) Антитела против hla-g, композиции, содержащие антитела против hla-g, и способы применения антител против hla-g
MA43186B1 (fr) Anticorps se liant spécifiquement à pd-1 et leurs utilisations
MA43028B1 (fr) Anticorps bispécifiques pour pd1 et tim3
MX2018008934A (es) Anticuerpos anti-ror1, anticuerpos biespecíficos ror1 x cd3 y métodos para su uso.
MA40576A (fr) Anticorps et immunoconjugués anti-her2
MA42622B1 (fr) Agents de liaison à tigit et leurs utilisations
JOP20220119A1 (ar) أجسام مضادة trem2 واستخداماتها
SA523450918B1 (ar) أجسام مضادة للنكتين-4 واستخداماتها
MA38161A1 (fr) Anticorps anti-bmp-6
EA201791691A1 (ru) ОДНОДОМЕННЫЕ АНТИТЕЛА, НАПРАВЛЕННЫЕ НА CD1d
MA45999A (fr) Anticorps anti-pd-1, ou leurs fragments, pour le traitement de l'hépatite b
MA49607A1 (fr) Anticorps monoclonal pour il-5ra
MA43600B2 (fr) Anticorps trispecifique anti il-17a,il-17f et une autre molécule anti-inflammatoire
EA202090944A1 (ru) Анти-cd3-антитело и фармацевтическая композиция для лечения онкологических заболеваний, содержащая его
WO2018227063A8 (en) Anti-robo2 antibodies, compositions, methods and uses thereof
MA45831B1 (fr) Anticorps monoclonaux anti-punaises de lit et leurs procédés de production et d'utilisation
MA53186B2 (fr) Anticorps monoclonal qui se lie spécifiquement à cd20
GEP20247700B (en) Antibody variants
MA39300A1 (fr) Anticorps bispécifiques anti-il-13/il-17 et leurs utilisations
EA202191243A1 (ru) Активируемые антитела к cd166 и способы их применения

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18786945

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2020506702

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: NC2019/0011458

Country of ref document: CO

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: DZP2019000508

Country of ref document: DZ

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112019021781

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 2018255132

Country of ref document: AU

Date of ref document: 20180411

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20197033829

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2018786945

Country of ref document: EP

Effective date: 20191118

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18786945

Country of ref document: EP

Kind code of ref document: A2

WWP Wipo information: published in national office

Ref document number: NC2019/0011458

Country of ref document: CO

ENP Entry into the national phase

Ref document number: 112019021781

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20191017

WWG Wipo information: grant in national office

Ref document number: NC2019/0011458

Country of ref document: CO