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WO2018181880A1 - Composé permettant d'améliorer la sensibilité de la perception olfactive d'un nématode - Google Patents

Composé permettant d'améliorer la sensibilité de la perception olfactive d'un nématode Download PDF

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Publication number
WO2018181880A1
WO2018181880A1 PCT/JP2018/013568 JP2018013568W WO2018181880A1 WO 2018181880 A1 WO2018181880 A1 WO 2018181880A1 JP 2018013568 W JP2018013568 W JP 2018013568W WO 2018181880 A1 WO2018181880 A1 WO 2018181880A1
Authority
WO
WIPO (PCT)
Prior art keywords
behavior
cineole
nematode
nematodes
chemotaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/013568
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English (en)
Japanese (ja)
Inventor
崇亮 広津
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hirotsu Bio Science Inc
Original Assignee
Hirotsu Bio Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hirotsu Bio Science Inc filed Critical Hirotsu Bio Science Inc
Priority to JP2019510234A priority Critical patent/JP6788921B2/ja
Publication of WO2018181880A1 publication Critical patent/WO2018181880A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/30—Rearing or breeding invertebrates
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Definitions

  • running behavior means attracting behavior or avoidance behavior. Attracting behavior means behavior that shortens the physical distance from a certain substance, and repelling behavior means behavior that widens the physical distance from a certain substance. Substances that induce attraction behavior are called attractants, and substances that induce repellent behavior are called repellent substances. Nematodes have the property of attracting attractants by olfaction and repelling repellents. The act of attracting an attracting substance is called an attracting action (sometimes referred to as “positive” in the present specification), and an action repelling from a repellent substance is referred to as a repelling action (sometimes referred to as “negative” in this specification). . In addition, attracting behavior and repelling behavior are collectively referred to as chemotaxis behavior.
  • Cineol (eg, 1,8-cineole and / or 1,4-cineole) need not be in direct contact with the nematode.
  • Cineol eg, 1,8-cineole and / or 1,4-cineole
  • cineole is applied somewhere on the inner wall of the culture vessel where the nematode is bred to increase the olfactory sensitivity of the nematode. be able to.
  • it can be attached to an inner wall such as a lid of a culture vessel.
  • Cineol (for example, 1,8-cineole and / or 1,4-cineole) may be added to the medium.
  • bornyl acetate, D-camphor, camphene, linalool, linalyl acetate, graniol, phenylethyl alcohol, citronellol, pinene, limonene, benzyl acetate, vanillin, eugenol, and myrcene are similarly given to the behavior of nematodes. Although the effects were examined, no significant effects were observed for these.
  • Example 2 Analysis using odr-3 mutant
  • the responsiveness to the odorant observed in the above example is based on olfaction
  • there is an abnormality in the AWC nerve which is the olfactory nerve involved in the attraction behavior
  • cineol was confirmed.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un composé permettant d'améliorer la sensibilité de la perception olfactive d'un nématode.
PCT/JP2018/013568 2017-03-31 2018-03-30 Composé permettant d'améliorer la sensibilité de la perception olfactive d'un nématode Ceased WO2018181880A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019510234A JP6788921B2 (ja) 2017-03-31 2018-03-30 線虫の嗅覚の感度を向上させる化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017-069473 2017-03-31
JP2017069473 2017-03-31

Publications (1)

Publication Number Publication Date
WO2018181880A1 true WO2018181880A1 (fr) 2018-10-04

Family

ID=63676155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/013568 Ceased WO2018181880A1 (fr) 2017-03-31 2018-03-30 Composé permettant d'améliorer la sensibilité de la perception olfactive d'un nématode

Country Status (2)

Country Link
JP (1) JP6788921B2 (fr)
WO (1) WO2018181880A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106401A (ja) * 1982-12-11 1984-06-20 Kinogen:Kk マツノザイセンチユウの殺線虫剤
JP2003171217A (ja) * 2001-09-28 2003-06-17 Jukankyo Kojo Jumoku Seibun Riyo Gijutsu Kenkyu Kumiai 線虫防除剤及び土壌活性化剤
US20140023770A1 (en) * 2012-07-17 2014-01-23 Symrise Ag Use Of Defined Cyclohexenones As Agents For The Superadditive Enhancement Of An Olfactory Impression And Fragrance And/Or Flavor Material Composition
WO2015088039A1 (fr) * 2013-12-10 2015-06-18 国立大学法人九州大学 Méthode de détection d'un cancer utilisant le sens de l'odorat des nématodes
US20160220640A1 (en) * 2013-06-11 2016-08-04 The Brigham And Women's Hospital, Inc. Methods and compositions for increasing neurogenesis and angiogenesis
WO2016138186A1 (fr) * 2015-02-24 2016-09-01 Takasago International Corporation Compositions de parfum améliorées

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106401A (ja) * 1982-12-11 1984-06-20 Kinogen:Kk マツノザイセンチユウの殺線虫剤
JP2003171217A (ja) * 2001-09-28 2003-06-17 Jukankyo Kojo Jumoku Seibun Riyo Gijutsu Kenkyu Kumiai 線虫防除剤及び土壌活性化剤
US20140023770A1 (en) * 2012-07-17 2014-01-23 Symrise Ag Use Of Defined Cyclohexenones As Agents For The Superadditive Enhancement Of An Olfactory Impression And Fragrance And/Or Flavor Material Composition
US20160220640A1 (en) * 2013-06-11 2016-08-04 The Brigham And Women's Hospital, Inc. Methods and compositions for increasing neurogenesis and angiogenesis
WO2015088039A1 (fr) * 2013-12-10 2015-06-18 国立大学法人九州大学 Méthode de détection d'un cancer utilisant le sens de l'odorat des nématodes
WO2016138186A1 (fr) * 2015-02-24 2016-09-01 Takasago International Corporation Compositions de parfum améliorées

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UOZUMI, TAKAYUKI ET AL., AROMA RESEARCH, vol. 13, no. 3, 2012, pages 244 *

Also Published As

Publication number Publication date
JPWO2018181880A1 (ja) 2019-11-07
JP6788921B2 (ja) 2020-11-25

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