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WO2018174448A1 - Composition pour le traitement et la prévention du syndrome climactérique contenant un extrait médicinal végétal combiné d'atractylis, de mori fructus, de lyciet commun, de longane, d'achyranthes, d'écorce d'eucommia et d'asperge de cochinchine merr. comme ingrédient actif, et son utilisation - Google Patents

Composition pour le traitement et la prévention du syndrome climactérique contenant un extrait médicinal végétal combiné d'atractylis, de mori fructus, de lyciet commun, de longane, d'achyranthes, d'écorce d'eucommia et d'asperge de cochinchine merr. comme ingrédient actif, et son utilisation Download PDF

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Publication number
WO2018174448A1
WO2018174448A1 PCT/KR2018/002803 KR2018002803W WO2018174448A1 WO 2018174448 A1 WO2018174448 A1 WO 2018174448A1 KR 2018002803 W KR2018002803 W KR 2018002803W WO 2018174448 A1 WO2018174448 A1 WO 2018174448A1
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WIPO (PCT)
Prior art keywords
vitamin
baekchul
combination
wolfberry
astronomical dong
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Ceased
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PCT/KR2018/002803
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English (en)
Korean (ko)
Inventor
김순일
류종훈
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Olmanfood Co Ltd
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Olmanfood Co Ltd
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Publication of WO2018174448A1 publication Critical patent/WO2018174448A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • the present invention relates to a composition for the prevention and treatment of menopausal syndrome and its use containing the extract of the combination herbal extract of baekchul, heartache, goji berry, longan meat, dew, tofu and astronomical dong as an active ingredient.
  • Menopause is an inevitable phenomenon in all women, but the resulting deficiency of female hormones is an important factor that causes physical and mental illness over a long period of time.
  • the so-called "menopausal syndrome” includes a variety of symptoms and diseases, which can be divided into early acute symptoms, mid-term symptoms and long-term sequelae, depending on the time of onset. Symptoms of early menopausal period include vasomotor symptoms such as febrile flushing and night sweats, as well as mental and psychological symptoms. Mid-term symptoms include symptoms of urogenital atrophy and symptoms caused by decreased collagen from connective tissue in each part of the body. This mid-term symptom, unlike the acute early symptom, which is of limited nature, takes a worse course as the menopause progresses.
  • the long-term sequelae of late stages of menopause include osteoporosis, cardiovascular and cerebrovascular diseases, and senile dementia belongs to this category.
  • the rate of menopausal symptoms among menopausal women in Korea ranged from 57% to 90% .
  • the range of symptoms experienced was neurological sensitivity, musculoskeletal symptoms, fatigue and systemic weakness, and headache. The frequency and intensity were high.
  • vasomotor symptoms such as hot flashes and sweating were reported to increase in the late 1990s than the 1980s.
  • 89% of women who experienced natural menopause experienced at least one of the symptoms of menopause, with 61% reported that hot flashes were the most common.
  • Hormone therapy is typically used to treat such female hormone regulation-related diseases or symptoms. However, hormone therapy has been shown to cause side effects such as breast cancer, stroke, heart attack, venous thrombosis, and cardiovascular disease. (Korean Patent No. 10-1400913)
  • Baekchul refers to the root of the perennial herb, Atractylodes macrocephala KOIDZ, and the related plant of the same genus, which contains essential oils, attractyllone, and attractyllol. , Arthritis, keratosis, urinary inflammation, etc. It is known to have been used (information interception, Dohae Hyangjeomsa, Yeonglimsa, pp1026, 1998).
  • the lettuce is a seed of the broad-leaved mulberry (Morus alba L.) belonging to the Moraceae family, and is related to sugar, tannic acid, linoloic acid, stearinic acid, etc. It contains a substance and is known to have been used for the treatment of thirst and joint bleeding (information disclosure, Dohae Hyangdae, Yeonglimsa, pp545-548, 1998).
  • Goji refers to the mature fruit of the vine shrub Lycium chinensis, Lycium barbarum L. belonging to the Solanaceae, and contains substances such as carotene, nicotinc acid, etc. It is known to have a blood sugar and cholesterol lowering effect, lowering blood pressure, etc. (Interpretation of Information, Dohae Hyangdae, Yeonglimsa, pp826-828, 1998).
  • Longan meat refers to the aphid of Euphoria lingan STEUD, an evergreen tree belonging to Sapinaceae. It contains substances such as glucose, sucrose and tartaric acid, and has been used to treat insomnia and forgetfulness. It is known to have been reported (Information Disclosure, Dohae Hyangjeomsa Dictionary, Younglim History, pp371-373, 1998).
  • the larvae refers to the bark of the Eucommia ulmoides OLIV, a broad-leaved arborescent, belonging to the Eucommiaceae family.
  • Astronomical dong is the tuber of Asparagus cochinchinensis MERR, a perennial herbaceous herb belonging to the Liliaceae family.
  • Antimicrobial activity, insecticidal action, anti-ulcer action are known (information disclosure, Dohaehyangsaemsa, Yeonglimsa, pp164-165, 1998).
  • Ginger refers to the root of Zingiber officinale ROSC, a perennial herb belonging to the family Zingiberaceae, and is known as zingiberol, zingiberone, phellandrene, gingerol, show It contains substances such as shogaol, and antibacterial and antiparasitic action is known (information disclosure, Dohae Hyangdae, Yeonglimsa, pp260-262, 1998).
  • Jujube refers to the fruit of Zizyphus jujubaMILL, a broad-leaved arborescent tree belonging to Rhamnaceae, and contains substances such as protein, organic acids, etc., and is known for strengthening muscles, protecting liver, and gaining weight. Sup-eup, Dohae Hyangjeomsa Dictionary, Younglim History, pp296-297, 1998).
  • the present inventors studied to find natural products that are excellent for improving menopausal syndrome, and the combination extract of the present invention measured the global skin ability evaluation test using tail mice in vivo, and the tail skin temperature.
  • the present invention was completed by confirming that the exercise time was increased, the increase in the tail skin temperature was suppressed, and the liver showed excellent menopausal symptoms improvement effect in clinical cases.
  • the present invention provides a pharmaceutical composition for treating and preventing menopausal syndrome, which contains a combination herbal extract consisting of baekchul, heartache, goji berry, longan meat, dew, tofu and astronomical dong as an active ingredient.
  • the present invention provides a health functional food for preventing and improving menopausal syndrome, which contains a combination herbal extract consisting of Baekchul, heartache, goji berry, longan meat, wort, tofu and astronomical dong as an active ingredient.
  • Combination herbal extracts as defined herein include water, including purified water, lower alcohols of C1 to C4 or mixed solvents thereof, preferably extracts available in water or mixed solvents of water and alcohol.
  • Combination herbal extracts as defined herein additionally include one or more herbal extracts consisting of ginger and jujube; At least one vitamin selected from the group consisting of vitamin A, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, biotin, nicotinamide, folic acid, and calcium pantothenate; And / or at least one mineral selected from the group consisting of ferrous sulfate, zinc oxide, magnesium carbonate, potassium monophosphate, dibasic calcium phosphate, potassium citrate, calcium carbonate, and magnesium chloride.
  • Preferred blending weight parts of the combination herbal extract as defined herein include (a) Baekchul 1, 10, beetle 1-10, Gojija 1 to 1 in the case of the combination of Baekchul, Wokjak, Gojija, Longan meat, dew, tofu and astronomical dong.
  • menopausal syndrome is preferably fatigue, febrile flushing, vasomotor symptoms, depression, anxiety, dizziness, headache, associated with changes in menopausal syndrome, more preferably sex hormones, before or after menopause or by disease. , Joint pain, muscle pain, osteoporosis, insomnia, vaginal dryness, and the symptoms or symptoms, including all or part of the syndrome.
  • the combination herbal extract of the present invention can be obtained as follows.
  • the herbal extract of the present invention is mixed with herbal medicines such as baekchul, sirloin, goji berry, longan meat, hyssop, tofu and astronomical dong, if necessary, ginger and jujube in a certain compounding ratio, and wash each combination sample with water. After drying, they are all ground and ground to a volume of water ranging from about 1 to 20 times, preferably about 2 to 10 times the weight of the herbal ingredient, C1 to C4 lower alcohol, or a mixed solvent thereof, preferably water.
  • herbal medicines such as baekchul, sirloin, goji berry, longan meat, hyssop, tofu and astronomical dong, if necessary, ginger and jujube in a certain compounding ratio
  • Extraction such as hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction or supercritical extraction, for about 1 hour to 1 day, preferably 2 hours to 8 hours at a temperature of from 120 to 120 ° C., preferably from 20 to 100 ° C.
  • a hot water extraction method After extracting by a method, preferably a hot water extraction method, the extract is cooled and then filtered, and the filtrate is lyophilized to obtain the combination herbal extract of the present invention.
  • the present invention provides a health functional food for improving and preventing menopausal syndrome, which contains a combination herbal extract consisting of baekchul, sirloin, goji berry, yongan meat, dew, worm and cheonmundong as an active ingredient.
  • a combination herbal extract consisting of baekchul, sirloin, goji berry, yongan meat, dew, worm and cheonmundong as an active ingredient.
  • the extract as defined herein is a polar solvent selected from water, alcohol, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably water or water and alcohol mixed solvents, more preferably water or 20 to 90% water And extracts soluble in alcohol mixed solvents.
  • the present invention provides a pharmaceutical composition and health functional food for the treatment and prevention of menopausal syndrome containing the preparation method and the combination herbal extract prepared by the manufacturing method as an active ingredient.
  • the global movement ability and tail skin temperature were measured using the menopausal induced mice in vivo, and the experimental group to which the extracts of Examples 1 to 3 were administered was compared to the negative control group.
  • the experimental group to which the extracts of Examples 1 to 3 were administered was compared to the negative control group.
  • the present invention provides a menopausal syndrome improvement agent containing a combination herbal extract consisting of Baekchul, heartache, goji berry, longan meat, wedge, head worm and astronomical dong as an active ingredient.
  • composition of the present invention comprises 0.01 to 99% by weight of the herbal extract based on the total weight of the composition.
  • composition as described above is not necessarily limited thereto, and may vary according to the condition of the patient and the type and extent of the disease.
  • composition comprising the extract of the present invention may further comprise suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.
  • compositions comprising extracts according to the invention are formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterile injectable solutions, respectively, according to conventional methods.
  • the carriers, excipients and diluents that may be included in the formulation may include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium Silicates, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate and mineral oil.
  • diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one or more excipients in the compound, at least cotton, starch, calcium carbonate, sucrose. Or lactose, gelatin, or the like is mixed. In addition to simple excipients, lubricants such as magnesium styrate talc are also used. Oral liquid preparations include suspending agents, liquid solutions, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. .
  • Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • non-aqueous solvent and suspending agent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerol gelatin and the like can be used.
  • Preferred dosages of the extracts of the present invention vary depending on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art.
  • the extract is preferably administered at 0.01 mg / kg to 10 g / kg, preferably 1 mg / kg to 1 g / kg per day. Administration may be administered once a day or may be divided several times. Therefore, the above dosage does not limit the scope of the present invention in any aspect.
  • composition of the present invention can be administered to mammals such as rats, mice, livestock, humans, etc. by various routes. All modes of administration can be expected, for example by oral and rectal or intravenous methods.
  • the present invention provides a therapeutic method for treating a climacteric syndrome patient, comprising administering a combination herbal extract consisting of baekchul, heartache, goji berry, longan meat, wedge, head worm and astronomical dong to patients with menopausal syndrome.
  • the present invention provides the use of a combination herbal extract consisting of baekchul, heartache, gojija, longan meat, dew, head worm and astronomical dong for the manufacture of a medicament for treating menopausal syndrome.
  • the present invention provides a health functional food for the improvement and prevention of climacteric syndrome, which contains a combination herbal extract consisting of baekchul, sirloin, goji berry, longan meat, dew, tofu and cheonmundong as an active ingredient.
  • a combination herbal extract consisting of baekchul, sirloin, goji berry, longan meat, dew, tofu and cheonmundong as an active ingredient.
  • health functional food refers to physical or mental functionality by adding the extract of the present invention to a conventional specimen for preventing or ameliorating a target disease in a human body or a mammal according to Korean Health Functional Food Act No. 6723. It includes a functional food to improve the functionality such as.
  • the present invention provides a menopausal nutritional supplement containing a combination herbal extract consisting of Baekchul, heartache, goji berry, longan meat, dew, tofu and astronomical dong as an active ingredient.
  • a combination herbal extract consisting of Baekchul, heartache, goji berry, longan meat, dew, tofu and astronomical dong as an active ingredient.
  • Health functional foods containing the extract of the present invention can be used in a variety of drugs, foods and beverages for the improvement and prevention of menopausal syndrome.
  • Foods to which the extract of the present invention may be added include, for example, various foods, beverages, gums, teas, vitamin complexes, leach teas, health supplements, and the like, and are in the form of powders, granules, tablets, capsules, or beverages. Can be used.
  • the total weight of the composition comprises 0.01 to 95%, preferably 1 to 80% by weight percentage.
  • composition of the present invention can be used as a major component or additive and adjuvant in the manufacture of various dietary supplements and dietary supplements for the purpose of preventing or treating menopausal syndrome.
  • menopausal syndrome for the purpose of preventing and improving menopausal syndrome, it is prepared as a pharmaceutical dosage form such as powders, granules, tablets, capsules, pills, suspensions, emulsions, syrups, or health functional foods in the form of tea bags, leach teas, and health drinks. And processing is possible.
  • a pharmaceutical dosage form such as powders, granules, tablets, capsules, pills, suspensions, emulsions, syrups, or health functional foods in the form of tea bags, leach teas, and health drinks. And processing is possible.
  • the present invention also provides a food additive for improving and preventing fatigue syndrome, menopausal syndrome, containing a combination herbal extracts of Baekchul, heartache, goji berry, longan meat, dew, tofu and cheonmundong as an active ingredient.
  • Food forms to which the extract of the present invention can be added include various foods, beverages, gums, teas, vitamin complexes, or health supplements of candy.
  • the health beverage composition of the present invention contains a mixture of the extract as an essential ingredient in the indicated proportions, and there is no particular limitation on the liquid component, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks.
  • natural carbohydrates are conventional monosaccharides such as disaccharides such as glucose and fructose, such as maltose, sucrose and the like, and polysaccharides such as dextrin, cyclodextrin and the like.
  • Sugars and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • natural flavoring agents such as, tauumatin, stevia extract (e.g., Rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used.
  • the proportion of such natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.
  • the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like.
  • the compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected from the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.
  • the extract of the present invention may be added to food or beverages for the purpose of preventing menopausal syndrome.
  • the amount of the extract in the food or beverage can be added in 0.01 to 15% by weight of the total food weight
  • the health beverage composition is added in a ratio of 0.02 to 5 g, preferably 0.3 to 1 g based on 100 ml Can be.
  • a combination extract can be used as a raw material for manufacturing health functional foods or supplements such as drugs for treating menopausal symptoms or menopausal nutritional supplements.
  • health functional foods or supplements such as drugs for treating menopausal symptoms or menopausal nutritional supplements.
  • F. It can be applied as a pharmaceutical composition, health functional food and health supplement food useful for suppressing, treating, preventing and improving menopausal syndrome.
  • the experiment was performed as follows in the menopausal animal model subjected to ovarian resection described in the literature.
  • mice Seven-week-old ICR mice (28-30 g) were supplied from Orient Bio Co., Ltd. (Seoul, Korea) and used in animal laboratories for about 5 days. The water and feed were freely consumed, and the temperature (23 ⁇ 2 °C), Humidity (50 ⁇ 10%) and contrast period (12 hours) were allowed to adjust automatically.
  • the samples of the present invention were administered orally in one dose group.
  • the control group (Sham) and negative control group (OVX + saline) were orally administered with saline.
  • After 2 weeks of administration weigh the mouse and measure the tail skin temperature before starting exercise. Place the mouse in the restrainer, stabilize for 5 minutes, and remove 1 cm from the base of the tail every 3 minutes.
  • the tail temperature was measured using a thermal imaging camera (FLIR T600, USA) (Basal temperature, T B ), followed by 10 minutes at 15 m / min on a treadmill (Exer-3 / 6, Columbus instruments, USA).
  • T B mean of three measurements of tail skin temperature before exercise
  • T E1 Tail skin temperature measurement 1 minute after exercise
  • T E2 Tail skin temperature measurement 2 minutes after exercise
  • the ovaries of the mice were excised and orally administered with the extracts of Examples 1 to 3 for 2 weeks, and the tail skin temperature was measured using a thermal imaging camera. .
  • Menopausal-induced mice were evaluated for the effects of menopausal fatigue by the extract administration of Examples 1 to 3 in the treadmill exercise experiment. Modify the method of Minghua et al. (Mechanisms of Ageing and Development, 2003, 124: 771) to raise the angle of the treadmill by 10 degrees, then start driving at 15 m / min, in steps of 5 m / min every three minutes. The speed was raised to a maximum of 30 m / min, and the time until the mouse became inoperable (maximum travel time) was measured.
  • Samples of the present invention exhibited excellent hot flush reduction effect in caudal skin test of climacteric-induced mice and showed excellent maximum running time even in climacteric antifatigue experiments. It is believed to improve or treat menopausal hot flush and menopausal fatigue.
  • Kupperman Index Symptom none slightly usually Severe One Flushing, hot, burning 0 4 8 12 2 Sweating 0 2 4 6 3 insomnia 0 2 4 6 4 nervousness 0 One 2 3 5 depression 0 One 2 3 6 whirl 0 One 2 3 7 Fatigue 0 One 2 3 8 Arthralgia, myalgia 0 One 2 3 9 headache 0 One 2 3 10 Heartbeat 0 One 2 3 11 Dryness 0 One 2 3
  • the above ingredients are mixed and filled in an airtight cloth to prepare a powder.
  • tablets are prepared by tableting according to a conventional method for preparing tablets.
  • the above ingredients are mixed and filled into gelatin capsules to prepare capsules.
  • the amount of the above ingredient is prepared per ampoule (2 ml).
  • composition ratio of the said vitamin and mineral mixture was mixed and comprised in the preferable embodiment the component suitable for a healthy food, you may change arbitrarily the compounding ratio considered that it does not deviate from the mind and range of this invention.
  • the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilization and refrigerated Used to prepare the healthy beverage composition of the invention.
  • the combination extract can be used as a raw material for manufacturing health functional foods or supplements such as drugs for treating menopausal symptoms or menopausal nutritional supplements. It was found for the first time that it can be applied as pharmaceutical composition, health functional food and health supplement food which is useful for suppression, treatment, prevention and improvement of menopausal syndrome.

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition pour le traitement et la prévention du syndrome climactérique, la composition contenant un extrait médicinal végétal combiné d'atractylis, de mori fructus, de lyciet commun, de longane, d'achyranthes, d'écorce d'eucommia et d'asperge de cochinchine Merr. en tant qu'ingrédient actif. Les résultats d'un test d'évaluation de capacité d'exercice d'endurance utilisant une souris et la mesure d'un effet d'atténuation de bouffées de chaleur à l'aide de la température de la peau de queue d'une souris induite par climacterium ont révélé qu'un groupe expérimental auquel l'extrait a été administré est capable d'effectuer un exercice d'endurance pendant une période de temps plus longue qu'un groupe témoin et que l'augmentation de la température de la peau de queue est supprimée dans le groupe expérimental. Ainsi, il a été confirmé que l'extrait a les effets de soulager et de traiter des symptômes climatériques, et l'extrait peut être utilisé en tant que matière première pour produire un médicament, un aliment fonctionnel de santé et un aliment complémentaire de santé.
PCT/KR2018/002803 2017-03-23 2018-03-09 Composition pour le traitement et la prévention du syndrome climactérique contenant un extrait médicinal végétal combiné d'atractylis, de mori fructus, de lyciet commun, de longane, d'achyranthes, d'écorce d'eucommia et d'asperge de cochinchine merr. comme ingrédient actif, et son utilisation Ceased WO2018174448A1 (fr)

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KR1020170036775A KR101793531B1 (ko) 2017-03-23 2017-03-23 백출, 상심자, 구기자, 용안육, 우슬, 두충 및 천문동의 조합생약 추출물을 유효성분으로 함유하는 갱년기증후군의 치료 및 예방을 위한 조성물

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