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WO2018171371A3 - 一种双二羧酸二氨络铂(ii)衍生物的制备方法 - Google Patents

一种双二羧酸二氨络铂(ii)衍生物的制备方法 Download PDF

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Publication number
WO2018171371A3
WO2018171371A3 PCT/CN2018/076946 CN2018076946W WO2018171371A3 WO 2018171371 A3 WO2018171371 A3 WO 2018171371A3 CN 2018076946 W CN2018076946 W CN 2018076946W WO 2018171371 A3 WO2018171371 A3 WO 2018171371A3
Authority
WO
WIPO (PCT)
Prior art keywords
dicarboxylic acid
bis
derivative
preparation
diammine platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2018/076946
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English (en)
French (fr)
Other versions
WO2018171371A2 (zh
Inventor
杨旭清
普绍平
丛艳伟
刘其星
王应飞
彭娟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KUNMING GUIYAN PHARMACEUTICAL CO Ltd
Original Assignee
KUNMING GUIYAN PHARMACEUTICAL CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KUNMING GUIYAN PHARMACEUTICAL CO Ltd filed Critical KUNMING GUIYAN PHARMACEUTICAL CO Ltd
Priority to PCT/CN2018/076946 priority Critical patent/WO2018171371A2/zh
Priority to CN201880000700.7A priority patent/CN108884119A/zh
Publication of WO2018171371A2 publication Critical patent/WO2018171371A2/zh
Publication of WO2018171371A3 publication Critical patent/WO2018171371A3/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本发明提供了一种改进的双二羧酸二氨络铂(II)衍生物的制备方法。相对于现有技术，根据本发明的方法在卡铂或卡铂类似物与二羧酸反应后，无需进行蒸馏浓缩的过程，可直接获得双二羧酸二氨络铂(II)衍生物的产品，所得产品纯度高，无需进行进一步的纯化处理，产品质量稳定，生产周期短，适合工业化放大生产。本发明的方法可以仅用水作为溶剂，对环境友好，废弃物处理简单。
PCT/CN2018/076946 2018-02-22 2018-02-22 一种双二羧酸二氨络铂(ii)衍生物的制备方法 Ceased WO2018171371A2 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2018/076946 WO2018171371A2 (zh) 2018-02-22 2018-02-22 一种双二羧酸二氨络铂(ii)衍生物的制备方法
CN201880000700.7A CN108884119A (zh) 2018-02-22 2018-02-22 一种双二羧酸二氨络铂(ii)衍生物的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/076946 WO2018171371A2 (zh) 2018-02-22 2018-02-22 一种双二羧酸二氨络铂(ii)衍生物的制备方法

Publications (2)

Publication Number Publication Date
WO2018171371A2 WO2018171371A2 (zh) 2018-09-27
WO2018171371A3 true WO2018171371A3 (zh) 2018-11-08

Family

ID=63584984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/076946 Ceased WO2018171371A2 (zh) 2018-02-22 2018-02-22 一种双二羧酸二氨络铂(ii)衍生物的制备方法

Country Status (2)

Country Link
CN (1) CN108884119A (zh)
WO (1) WO2018171371A2 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112262123B (zh) * 2018-09-18 2023-12-15 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的纯化方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311183A (zh) * 2000-03-03 2001-09-05 杨旭清 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
CN104693245A (zh) * 2015-03-13 2015-06-10 卓越同达医药科技开发（苏州）有限公司 超分子抗癌药物双环铂的制备方法
CN106132408A (zh) * 2015-04-10 2016-11-16 新纳特产品公司 一种双环铂的制备方法
CN106188150A (zh) * 2016-04-13 2016-12-07 范如霖 一类碳铂复合物抗癌药及其制备方法和用途
WO2016205782A1 (en) * 2015-06-19 2016-12-22 Syn-Nat Products Enterprise LLC Composition containing carboplatin and use
CN106995467A (zh) * 2017-05-03 2017-08-01 江苏大红鹰恒顺药业有限公司 一种微波催化合成双环铂的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111638234B (zh) * 2014-08-13 2024-09-03 北京默加农生物技术发展有限公司 一种以双环铂为有效成分的药物的检测方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311183A (zh) * 2000-03-03 2001-09-05 杨旭清 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
CN104693245A (zh) * 2015-03-13 2015-06-10 卓越同达医药科技开发（苏州）有限公司 超分子抗癌药物双环铂的制备方法
CN106132408A (zh) * 2015-04-10 2016-11-16 新纳特产品公司 一种双环铂的制备方法
WO2016205782A1 (en) * 2015-06-19 2016-12-22 Syn-Nat Products Enterprise LLC Composition containing carboplatin and use
CN106188150A (zh) * 2016-04-13 2016-12-07 范如霖 一类碳铂复合物抗癌药及其制备方法和用途
CN106995467A (zh) * 2017-05-03 2017-08-01 江苏大红鹰恒顺药业有限公司 一种微波催化合成双环铂的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
APPS, M.G. ET AL.: "The state-of-play and future of platinum drugs", ENDOCRINE-RELATED CANCE, vol. 22, 25 June 2015 (2015-06-25), pages R219 - R233, XP055546108 *

Also Published As

Publication number Publication date
CN108884119A (zh) 2018-11-23
WO2018171371A2 (zh) 2018-09-27

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