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WO2018164507A3 - Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법 - Google Patents

Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법 Download PDF

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Publication number
WO2018164507A3
WO2018164507A3 PCT/KR2018/002763 KR2018002763W WO2018164507A3 WO 2018164507 A3 WO2018164507 A3 WO 2018164507A3 KR 2018002763 W KR2018002763 W KR 2018002763W WO 2018164507 A3 WO2018164507 A3 WO 2018164507A3
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WO
WIPO (PCT)
Prior art keywords
composition
extracellular matrix
preparation
method therefor
mast4
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/002763
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English (en)
French (fr)
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WO2018164507A2 (ko
Inventor
김성진
정한성
다카하시사토루
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Gilo Inc
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Gilo Inc
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Publication date
Priority claimed from KR1020180027111A external-priority patent/KR102588627B1/ko
Priority to EP18764604.7A priority Critical patent/EP3594324A4/en
Priority to AU2018231559A priority patent/AU2018231559A1/en
Priority to JP2019571194A priority patent/JP7154238B2/ja
Priority to CN201880030519.0A priority patent/CN110612348B/zh
Priority to US16/492,477 priority patent/US11180573B2/en
Priority to CA3055729A priority patent/CA3055729A1/en
Application filed by Gilo Inc filed Critical Gilo Inc
Publication of WO2018164507A2 publication Critical patent/WO2018164507A2/ko
Publication of WO2018164507A3 publication Critical patent/WO2018164507A3/ko
Anticipated expiration legal-status Critical
Priority to US17/494,765 priority patent/US20220220221A1/en
Priority to JP2022159928A priority patent/JP7498239B2/ja
Priority to AU2023222944A priority patent/AU2023222944A1/en
Priority to JP2024087859A priority patent/JP2024116197A/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 MAST4(Microtubule Associated Serine/Threonine Kinase Family Member 4) 단백질 또는 이의 단편에 특이적으로 결합할 수 있는 폴리펩티드 또는 화합물, 또는 상기 MAST4 단백질 또는 이의 단편을 코딩하는 핵산에 특이적으로 결합할 수 있는 폴리뉴클레오티드, 폴리펩티드 또는 화합물을 포함하는, 진핵세포로부터 세포외 기질(extracellular matrix)을 생산하기 위한 조성물 및 상기 조성물을 포함하는 연골재생 촉진용 조성물에 관한 것이다.
PCT/KR2018/002763 2017-03-08 2018-03-08 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법 Ceased WO2018164507A2 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP18764604.7A EP3594324A4 (en) 2017-03-08 2018-03-08 EXTRACELLULAR MATRIX-PRODUCING COMPOSITION WITH MAST4-GEN AND MANUFACTURING METHOD FOR IT
AU2018231559A AU2018231559A1 (en) 2017-03-08 2018-03-08 Extracellular matrix-producing composition using MAST4 gene and preparation method therefor
JP2019571194A JP7154238B2 (ja) 2017-03-08 2018-03-08 Ｍａｓｔ４遺伝子を利用した細胞外基質生産用組成物及びその製造方法
CN201880030519.0A CN110612348B (zh) 2017-03-08 2018-03-08 用于使用mast4基因产生细胞外基质的组合物及其制备方法
US16/492,477 US11180573B2 (en) 2017-03-08 2018-03-08 Extracellular matrix-producing composition using MAST4 gene and preparation method therefor
CA3055729A CA3055729A1 (en) 2017-03-08 2018-03-08 Extracellular matrix-producing composition using mast4 gene and preparation method therefor
US17/494,765 US20220220221A1 (en) 2017-03-08 2021-10-05 Extracellular matrix-producing composition using mast4 gene and preparation method therefor
JP2022159928A JP7498239B2 (ja) 2017-03-08 2022-10-04 Ｍａｓｔ４遺伝子を利用した細胞外基質生産用組成物及びその製造方法
AU2023222944A AU2023222944A1 (en) 2017-03-08 2023-08-31 Extracellular matrix-producing composition using MAST4 gene and preparation method therefor
JP2024087859A JP2024116197A (ja) 2017-03-08 2024-05-30 Ｍａｓｔ４遺伝子を利用した細胞外基質生産用組成物及びその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170029607 2017-03-08
KR10-2017-0029607 2017-03-08
KR1020180027111A KR102588627B1 (ko) 2017-03-08 2018-03-07 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
KR10-2018-0027111 2018-03-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/492,477 A-371-Of-International US11180573B2 (en) 2017-03-08 2018-03-08 Extracellular matrix-producing composition using MAST4 gene and preparation method therefor
US17/494,765 Continuation US20220220221A1 (en) 2017-03-08 2021-10-05 Extracellular matrix-producing composition using mast4 gene and preparation method therefor

Publications (2)

Publication Number Publication Date
WO2018164507A2 WO2018164507A2 (ko) 2018-09-13
WO2018164507A3 true WO2018164507A3 (ko) 2019-04-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/002763 Ceased WO2018164507A2 (ko) 2017-03-08 2018-03-08 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법

Country Status (1)

Country Link
WO (1) WO2018164507A2 (ko)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140033284A (ko) * 2012-09-07 2014-03-18 주식회사 마크로젠 Ａｘｌ을 포함하는 융합 단백질 및 이를 포함하는 암 진단용 조성물
US20140341887A1 (en) * 2009-09-03 2014-11-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
US20160220699A1 (en) * 2013-09-09 2016-08-04 Figene, Llc Gene therapy for the regeneration of chondrocytes or cartilage type cells
WO2016201370A1 (en) * 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140341887A1 (en) * 2009-09-03 2014-11-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
KR20140033284A (ko) * 2012-09-07 2014-03-18 주식회사 마크로젠 Ａｘｌ을 포함하는 융합 단백질 및 이를 포함하는 암 진단용 조성물
US20160220699A1 (en) * 2013-09-09 2016-08-04 Figene, Llc Gene therapy for the regeneration of chondrocytes or cartilage type cells
WO2016201370A1 (en) * 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE protein 6 September 2016 (2016-09-06), XP055590115, Database accession no. AOK98352.1 *

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