WO2018157749A8 - 一种利福霉素-喹嗪酮双靶标分子的新用途 - Google Patents
一种利福霉素-喹嗪酮双靶标分子的新用途 Download PDFInfo
- Publication number
- WO2018157749A8 WO2018157749A8 PCT/CN2018/076968 CN2018076968W WO2018157749A8 WO 2018157749 A8 WO2018157749 A8 WO 2018157749A8 CN 2018076968 W CN2018076968 W CN 2018076968W WO 2018157749 A8 WO2018157749 A8 WO 2018157749A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- quinolizidone
- rifamycin
- dual
- target molecules
- new uses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
一种式Ⅰ所示的利福霉素-喹嗪酮双靶标分子在抑制胃肠道产氨菌群中的应用。式Ⅰ的利福霉素-喹嗪酮双靶标分子与利福昔明的抗菌谱类似，对胃肠道常见产氨菌群具有抗菌活性，同时耐药频率低，在肝性脑病的预防与治疗方面具有应用前景。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/488,937 US20200061047A1 (en) | 2017-02-28 | 2018-02-22 | New use of rifamycin-quinolizidone dual-action molecule |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710109969.6A CN106822125A (zh) | 2017-02-28 | 2017-02-28 | 一种利福霉素‑喹嗪酮双靶标分子的新用途 |
| CN201710109969.6 | 2017-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2018157749A1 WO2018157749A1 (zh) | 2018-09-07 |
| WO2018157749A8 true WO2018157749A8 (zh) | 2023-03-30 |
Family
ID=59134617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2018/076968 Ceased WO2018157749A1 (zh) | 2017-02-28 | 2018-02-22 | 一种利福霉素-喹嗪酮双靶标分子的新用途 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20200061047A1 (zh) |
| CN (1) | CN106822125A (zh) |
| WO (1) | WO2018157749A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822125A (zh) * | 2017-02-28 | 2017-06-13 | 丹诺医药(苏州）有限公司 | 一种利福霉素‑喹嗪酮双靶标分子的新用途 |
| CN109453166B (zh) * | 2018-10-16 | 2021-03-12 | 丹诺医药(苏州）有限公司 | 一种利福霉素-喹嗪酮偶联分子的固体分散体及其应用 |
| CN109464673A (zh) * | 2019-01-08 | 2019-03-15 | 丹诺医药(苏州）有限公司 | 利福霉素-喹嗪酮偶联分子及其盐的应用和制剂 |
| WO2025157240A1 (zh) * | 2024-01-26 | 2025-07-31 | 丹诺医药（苏州）股份有限公司 | 化合物用于制备治疗细菌代谢相关疾病的药物的用途 |
| WO2025167866A1 (zh) * | 2024-02-07 | 2025-08-14 | 丹诺医药（苏州）股份有限公司 | 化合物的固体分散体及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1781670A1 (en) * | 2004-07-22 | 2007-05-09 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives for treating microbial infections |
| MX364102B (es) * | 2008-10-02 | 2019-04-12 | Salix Pharmaceuticals Ltd | Medicamentos para usarse en el tratamiento de la encefalopatía hepática. |
| CN105879009A (zh) * | 2016-04-18 | 2016-08-24 | 丹诺医药(苏州）有限公司 | 一种用于治疗革兰氏阴性菌感染的抗菌药物组合物 |
| CN106822125A (zh) * | 2017-02-28 | 2017-06-13 | 丹诺医药(苏州）有限公司 | 一种利福霉素‑喹嗪酮双靶标分子的新用途 |
-
2017
- 2017-02-28 CN CN201710109969.6A patent/CN106822125A/zh active Pending
-
2018
- 2018-02-22 WO PCT/CN2018/076968 patent/WO2018157749A1/zh not_active Ceased
- 2018-02-22 US US16/488,937 patent/US20200061047A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN106822125A (zh) | 2017-06-13 |
| US20200061047A1 (en) | 2020-02-27 |
| WO2018157749A1 (zh) | 2018-09-07 |
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