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WO2018153508A3 - Inhibiteurs de la sulfoximine glycosidase - Google Patents

Inhibiteurs de la sulfoximine glycosidase Download PDF

Info

Publication number
WO2018153508A3
WO2018153508A3 PCT/EP2017/071385 EP2017071385W WO2018153508A3 WO 2018153508 A3 WO2018153508 A3 WO 2018153508A3 EP 2017071385 W EP2017071385 W EP 2017071385W WO 2018153508 A3 WO2018153508 A3 WO 2018153508A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulfoximine
glycosidase inhibitors
glycosidase
inhibitors
tauopathies
Prior art date
Application number
PCT/EP2017/071385
Other languages
English (en)
Other versions
WO2018153508A2 (fr
Inventor
Anna Quattropani
Santosh S. Kulkarni
Awadut Gajendra Giri
Original Assignee
Asceneuron S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2017/054280 external-priority patent/WO2017144639A1/fr
Priority claimed from PCT/EP2017/054268 external-priority patent/WO2017144633A1/fr
Priority to MX2019010085A priority Critical patent/MX2019010085A/es
Priority to JP2019545961A priority patent/JP7082446B2/ja
Priority to US16/488,139 priority patent/US11261183B2/en
Priority to EA201991697A priority patent/EA201991697A1/ru
Priority to BR112019017514-8A priority patent/BR112019017514B1/pt
Priority to AU2017400271A priority patent/AU2017400271B2/en
Priority to EP17758140.2A priority patent/EP3585783A2/fr
Priority to KR1020237005097A priority patent/KR102620279B1/ko
Priority to CN201780089984.7A priority patent/CN110770226B/zh
Priority to CA3053200A priority patent/CA3053200C/fr
Priority to SG11201907774VA priority patent/SG11201907774VA/en
Application filed by Asceneuron S.A. filed Critical Asceneuron S.A.
Priority to KR1020197027278A priority patent/KR20190118184A/ko
Priority to PCT/EP2017/071385 priority patent/WO2018153508A2/fr
Publication of WO2018153508A2 publication Critical patent/WO2018153508A2/fr
Publication of WO2018153508A3 publication Critical patent/WO2018153508A3/fr
Priority to IL268501A priority patent/IL268501A/en
Priority to ZA2019/05405A priority patent/ZA201905405B/en
Anticipated expiration legal-status Critical
Priority to US17/552,100 priority patent/US12157734B2/en
Priority to US18/913,906 priority patent/US20250115604A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I) dans laquelle A, R, W, Q, n et m ont la signification indiquée dans les revendications, ces composés pouvant être utilisés, entre autres, pour le traitement de tauopathies et de la maladie d'Alzheimer.
PCT/EP2017/071385 2016-02-25 2017-08-24 Inhibiteurs de la sulfoximine glycosidase Ceased WO2018153508A2 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CA3053200A CA3053200C (fr) 2016-02-25 2017-08-24 Inhibiteurs de la sulfoximine glycosidase
PCT/EP2017/071385 WO2018153508A2 (fr) 2017-02-24 2017-08-24 Inhibiteurs de la sulfoximine glycosidase
SG11201907774VA SG11201907774VA (en) 2017-02-24 2017-08-24 Sulfoximine glycosidase inhibitors
US16/488,139 US11261183B2 (en) 2016-02-25 2017-08-24 Sulfoximine glycosidase inhibitors
EA201991697A EA201991697A1 (ru) 2016-02-25 2017-08-24 Сульфоксиминовые ингибиторы гликозидазы
BR112019017514-8A BR112019017514B1 (pt) 2017-02-24 2017-08-24 Composto sulfoximina, mistura, método para inibir uma glicosidase, e, composição farmacêutica
AU2017400271A AU2017400271B2 (en) 2017-02-24 2017-08-24 Sulfoximine glycosidase inhibitors
EP17758140.2A EP3585783A2 (fr) 2016-02-25 2017-08-24 Inhibiteurs de la sulfoximine glycosidase
KR1020237005097A KR102620279B1 (ko) 2016-02-25 2017-08-24 술폭시민 글리코시다제 억제제
CN201780089984.7A CN110770226B (zh) 2016-02-25 2017-08-24 亚砜亚胺糖苷酶抑制剂
KR1020197027278A KR20190118184A (ko) 2016-02-25 2017-08-24 술폭시민 글리코시다제 억제제
MX2019010085A MX2019010085A (es) 2017-02-24 2017-08-24 Inhibidores de la glicosidasa de sulfoximina.
JP2019545961A JP7082446B2 (ja) 2016-02-25 2017-08-24 スルホキシイミングリコシダーゼ阻害剤
IL268501A IL268501A (en) 2016-02-25 2019-08-05 Sulfoxyamine glycosidase inhibitors
ZA2019/05405A ZA201905405B (en) 2016-02-25 2019-08-15 Sulfoximine glycosidase inhibitors
US17/552,100 US12157734B2 (en) 2016-02-25 2021-12-15 Sulfoximine glycosidase inhibitors
US18/913,906 US20250115604A1 (en) 2016-02-25 2024-10-11 Sulfoximine glycosidase inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/EP2017/054280 WO2017144639A1 (fr) 2016-02-25 2017-02-24 Inhibiteurs de glycosidases
EPPCT/EP2017/054280 2017-02-24
EPPCT/EP2017/054268 2017-02-24
PCT/EP2017/054268 WO2017144633A1 (fr) 2016-02-25 2017-02-24 Inhibiteurs de glycosidases
PCT/EP2017/071385 WO2018153508A2 (fr) 2017-02-24 2017-08-24 Inhibiteurs de la sulfoximine glycosidase

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2017/054268 Continuation-In-Part WO2017144633A1 (fr) 2016-02-25 2017-02-24 Inhibiteurs de glycosidases
PCT/EP2017/054280 Continuation-In-Part WO2017144639A1 (fr) 2016-02-25 2017-02-24 Inhibiteurs de glycosidases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/488,139 A-371-Of-International US11261183B2 (en) 2016-02-25 2017-08-24 Sulfoximine glycosidase inhibitors
US17/552,100 Division US12157734B2 (en) 2016-02-25 2021-12-15 Sulfoximine glycosidase inhibitors

Publications (2)

Publication Number Publication Date
WO2018153508A2 WO2018153508A2 (fr) 2018-08-30
WO2018153508A3 true WO2018153508A3 (fr) 2019-02-21

Family

ID=59686981

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2017/071384 Ceased WO2018153507A1 (fr) 2016-02-25 2017-08-24 Inhibiteurs de dihydrobenzofurane glycosidase substitués
PCT/EP2017/071385 Ceased WO2018153508A2 (fr) 2016-02-25 2017-08-24 Inhibiteurs de la sulfoximine glycosidase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/071384 Ceased WO2018153507A1 (fr) 2016-02-25 2017-08-24 Inhibiteurs de dihydrobenzofurane glycosidase substitués

Country Status (5)

Country Link
EP (2) EP3585783A2 (fr)
AU (1) AU2017400271B2 (fr)
MX (1) MX2019010085A (fr)
SG (1) SG11201907774VA (fr)
WO (2) WO2018153507A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201701315VA (en) 2014-08-28 2017-03-30 Asceneuron Sa Glycosidase inhibitors
CN108884078A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
US11612599B2 (en) 2016-02-25 2023-03-28 Asceneuron Sa Glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
SG11201807012QA (en) 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
MA53429A (fr) * 2018-08-22 2022-03-30 Asceneuron Sa Sels d'addition d'acide succinate et fumarate de dérivés de pipérazine utiles en tant qu'inhibiteurs de glycosidase
WO2020039028A1 (fr) 2018-08-22 2020-02-27 Asceneuron S. A. Inhibiteurs de tétrahydro-benzoazépine glycosidase
WO2020039029A1 (fr) 2018-08-22 2020-02-27 Asceneuron S. A. Composés spiro utilisés en tant qu'inhibiteurs de glycosidases
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
WO2025131275A1 (fr) 2023-12-20 2025-06-26 Asceneuron Sa (2-(4-(1-(benzo[d]thiazol-5-yl)éthyl)pipérazin-1-yl) pyrimidin-5-yl)(imino)(méthyl)-lamda6-sulfanone destiné à être utilisé dans le traitement de la colite, de la maladie de parkinson, de la tauopathie, de la sla et de la maladie d'alzheimer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094799A2 (fr) * 2001-05-22 2002-11-28 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: analogues de 1-benzyl-4-aryl piperazine substituee
WO2014159234A1 (fr) * 2013-03-14 2014-10-02 Merck Patent Gmbh Inhibiteurs de glycosidases
WO2016030443A1 (fr) * 2014-08-28 2016-03-03 Asceneuron Sa Inhibiteurs de glycosidases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127996C (fr) 1963-11-19
DE1595923A1 (de) * 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung
ES2241172T3 (es) 1997-10-24 2005-10-16 Neurogen Corporation 1-(2-naftil) y 1-(2-azanaftil)-4-(1-fenilmetil)piperazinas que son ligandos del subtipo de receptor de dopamina d4.
WO2005110982A2 (fr) * 2004-04-07 2005-11-24 Neurogen Corporation Analogues substitues 1-benzyl-4-substitues piperazine
JP5380293B2 (ja) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
WO2009053373A1 (fr) 2007-10-26 2009-04-30 Janssen Pharmaceutica Nv Dérivés de quinolinone en tant qu'inhibiteurs de parp
WO2014032187A1 (fr) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Inhibiteurs de glycosidases et leurs utilisations
CN108884078A (zh) * 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
SG11201807012QA (en) * 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
US11612599B2 (en) * 2016-02-25 2023-03-28 Asceneuron Sa Glycosidase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094799A2 (fr) * 2001-05-22 2002-11-28 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: analogues de 1-benzyl-4-aryl piperazine substituee
WO2014159234A1 (fr) * 2013-03-14 2014-10-02 Merck Patent Gmbh Inhibiteurs de glycosidases
WO2016030443A1 (fr) * 2014-08-28 2016-03-03 Asceneuron Sa Inhibiteurs de glycosidases

Also Published As

Publication number Publication date
EP3585783A2 (fr) 2020-01-01
EP3585779A1 (fr) 2020-01-01
AU2017400271B2 (en) 2020-09-24
SG11201907774VA (en) 2019-09-27
WO2018153508A2 (fr) 2018-08-30
MX2019010085A (es) 2019-11-21
WO2018153507A1 (fr) 2018-08-30
AU2017400271A1 (en) 2019-08-22

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