[go: up one dir, main page]

WO2018151076A1 - Composition de dentifrice de type gel et inhibiteur de l'adhésivité pour celle-ci - Google Patents

Composition de dentifrice de type gel et inhibiteur de l'adhésivité pour celle-ci Download PDF

Info

Publication number
WO2018151076A1
WO2018151076A1 PCT/JP2018/004819 JP2018004819W WO2018151076A1 WO 2018151076 A1 WO2018151076 A1 WO 2018151076A1 JP 2018004819 W JP2018004819 W JP 2018004819W WO 2018151076 A1 WO2018151076 A1 WO 2018151076A1
Authority
WO
WIPO (PCT)
Prior art keywords
stickiness
gel
mass
dentifrice composition
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/004819
Other languages
English (en)
Japanese (ja)
Inventor
直輝 三田
平山　隆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to JP2018568520A priority Critical patent/JPWO2018151076A1/ja
Publication of WO2018151076A1 publication Critical patent/WO2018151076A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a gel-like dentifrice composition containing no abrasive and excellent in feeling of use, and a stickiness inhibitor used therefor.
  • a dentifrice composition usually contains an abrasive for the purpose of removing plaque and the like, but some users prefer a dentifrice that does not contain an abrasive.
  • dentifrice containing no abrasive is recommended to prevent adverse effects such as irritation caused by abrasive. Sometimes it is done. For this reason, there is a growing demand for dentifrice compositions such as gels that do not contain abrasives and that are less invasive to the oral mucosa even for high-risk individuals with periodontal disease and that can gently and carefully toothpaste. Yes.
  • dentifrice compositions basically contain wetting agents, binders, surfactants, and the like.
  • Polyhydric alcohol is blended.
  • Dentifrice compositions that do not contain abrasives, especially gel-like dentifrice compositions generally contain a relatively large amount of wetting agent in order to maintain general properties such as shape retention and suppression of liquid separation. Done.
  • stickiness is generated due to an increase in the amount of the wetting agent, and the feeling of use tends to deteriorate, and the flavor expression of the fragrance may be lowered, and improvement of the feeling of use has been an issue.
  • Patent Documents 1 to 3 Japanese Patent Laid-Open Nos. 2016-102076, 2007-176856, and 2016-40306 contain menthol and other specific fragrances to rinse, refresh, and taste.
  • the composition for oral cavity which the etc. improved is proposed.
  • the composition for oral cavity of patent document 1 is prepared in the dentifrice gel agent which does not contain an abrasive
  • the present invention has been made in view of the above circumstances, and an object thereof is to provide a gel-like dentifrice composition containing no abrasive and having excellent usability, and a tackiness inhibitor used therefor.
  • the present inventors have determined that menthol and N-ethyl-p have been added to an abrasive-free gel dentifrice composition containing 40% by mass or more of sorbitol as a wetting agent. It has been found that when blended with a specific ratio of -menthane-3-carboxamide, stickiness due to the wetting agent can be suppressed and an excellent feeling of use can be imparted.
  • a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40,
  • B) a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40,
  • A) The stickiness due to the component is suppressed, the sticky feeling is hardly felt after use, and the refreshing feeling is improved while suppressing the irritation, and the original expression of the flavor of
  • the expression of flavor can be further improved by further adding (D) eugenol to the gel dentifrice composition, whereby the flavor can be sufficiently expressed and stickiness can be suppressed. I found it.
  • the combination of the fragrances (B) and (C) has a mass ratio of (B) / (C) within a specific range, and is surprisingly unique to the component (A) as a stickiness inhibitor. It was able to give an exceptional effect.
  • stickiness may be strongly felt when the amount of wetting agent is increased.
  • the sugar alcohol sorbitol which is generally used as a wetting agent, is preferable in that it is less irritating, but it tends to give stickiness depending on the blending amount, and the stickiness may increase as the amount increases.
  • the present invention provides the following gel dentifrice composition and its stickiness inhibitor.
  • A 40-60 mass% sorbitol, (B) 0.1 to 1% by mass of menthol and (C) 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide
  • a gel dentifrice composition containing (B) / (C) in a mass ratio of 0.5 to 40 and containing no abrasive.
  • the gel dentifrice composition according to [1] further comprising (D) eugenol in an amount of 0.01 to 0.1% by mass.
  • a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive A stickiness inhibitor comprising (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, wherein (B) / (C) has a mass ratio of 0.5 to 40.
  • a gel-like dentifrice composition containing no abrasive and excellent in feeling of use and a stickiness inhibitor used therefor.
  • This gel dentifrice composition is low in invasiveness to the oral mucosa because it does not contain abrasives, has good general properties such as shape retention, and can be used widely for high-risk people who have developed periodontal disease. It is.
  • the gel dentifrice composition of the present invention contains no abrasive, contains (A) 40% by mass or more of sorbitol, and (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide.
  • the mass ratio of (B) / (C) is contained within a specific range.
  • the gel-like dentifrice composition of the present invention is a dentifrice composition that does not contain an abrasive but has a shape-retaining property that does not drip from the toothbrush when placed on the toothbrush.
  • (A) Sorbitol is a wetting agent, and for example, commercially available products such as those manufactured by Mitsubishi Shoji Foodtech Co., Ltd. can be used.
  • the blending amount of (A) sorbitol is 40 to 60% (mass%, the same applies hereinafter) of the whole composition, preferably 40 to 50%, particularly from the viewpoint of the shape retention of the preparation and the like. % Is more preferable.
  • it is 40% or more, basic physical properties such as shape retention can be sufficiently secured with a composition not containing an abrasive. If it exceeds 60%, the stickiness becomes too strong to be suppressed, and the refreshing feeling is lowered and the flavor expression is also lowered.
  • the compounding quantity of (A) component is 42% or more, and also 45% or more, stickiness is fully suppressed and the non-stickiness after use is excellent.
  • sugar alcohols and polyhydric alcohols can be blended within a range that does not interfere with the effects of the present invention.
  • the blending amount of sugar alcohols other than sorbitol may be 20% or less, particularly 15% or less of the whole composition, or may be unblended (0%).
  • Polyhydric alcohol is also used as a solvent, and examples thereof include propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications), ethylene glycol, and the like.
  • the blending amount of these polyhydric alcohols is preferably 0 to 10%, particularly 4 to 10% of the whole composition.
  • (B) L-menthol is used as the menthol.
  • commercially available products such as L-menthol manufactured by Takasago International Corporation can be used.
  • menthol-containing essential oils such as peppermint oil and peppermint oil can be used.
  • the blending amount of (B) menthol is 0.1 to 1%, preferably 0.2 to 1%, more preferably 0.2 to 0.5% of the whole composition as a pure component. If it is less than 0.1%, stickiness is not sufficiently suppressed, and the feeling of refreshing after use is also inferior. If it exceeds 1%, its own irritation may become too strong to perform sufficient oral cleaning.
  • (C) N-ethyl-p-menthane-3-carboxamide a synthetic product can be used, and for example, a commercially available product such as manufactured by Dibodan Japan Co., Ltd. can be used.
  • the blending amount of (C) N-ethyl-p-menthane-3-carboxamide is 0.02 to 0.2%, preferably 0.05 to 0.1% of the whole composition. If it is less than 0.02%, the stickiness derived from the component (A) is not sufficiently suppressed, and the refreshing feeling after use may be inferior. If it exceeds 0.2%, flavor expression may be suppressed.
  • (B) / (C) indicating the blending ratio of the component (B) to the component (C) is 0.5 to 40, preferably 2 to 10, more preferably 3 to 10 as a mass ratio.
  • the stimulation becomes stronger or the flavor expression is suppressed than when the (B) component alone or the (C) component alone is added. Problems such as disappearance or stickiness may not be suppressed, but if it is within the above range, the stickiness derived from the component (A) is sufficiently eliminated, and the stimulus derived from the component (B) is suppressed.
  • (D) eugenol when (D) eugenol is further blended with the (C) component, the flavor expression is prevented from being lowered by the (C) component, and the flavor expression is further improved, while sufficiently expressing the flavor, Stickiness can be suppressed.
  • eugenol for example, a commercial product such as manufactured by Toyoda Fragrance Co., Ltd. can be used.
  • essential oils containing eugenol such as clove oil, cassia oil, pimento oil, bay oil, basil oil, laurel oil, and the like can also be used.
  • the blending amount of eugenol is preferably 0.01 to 0.1% of the total composition as a pure component. If it is 0.01% or more, the flavor expression is sufficiently improved. When it is 0.1% or less, irritation and taste (bitterness) by itself can be sufficiently suppressed.
  • (D) / (C) indicating the blending ratio of component (D) to component (C) is preferably 0.05 to 5, more preferably 0.1 to 2, as a mass ratio. Within this range, flavor development is further enhanced.
  • a fragrance other than these can be added to the composition of the present invention.
  • one or more known fragrance materials such as a natural fragrance added as a general oral fragrance, a fragrance obtained by processing a natural fragrance, a simple fragrance, and a blended fragrance can be used.
  • the blending amount of such a fragrance is preferably 0.000001 to 2%, particularly 0.00001 to 1% of the whole composition.
  • Specific examples of the above-mentioned general flavors for oral use include spearmint oil, anise oil, eucalyptus oil, winter green oil, thyme oil, sage oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, and lime oil. , Lavender oil, rosemary oil, camomil oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute rose, orange flower, etc.
  • Fragrances obtained by processing these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), carvone, anethole, cineol, methyl salicylate, 3-l-ment Xipropane-1,2-diol, thymol, linalool, linalyl ace , Limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, Single item flavors such as vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl
  • the amount of these components is included in the blending amount of the component (B), (C) or (D) described above. , And can be used within the range of the amount of each component.
  • the gel dentifrice composition of the present invention no abrasive is blended, but in addition to the above-described components, other known components can be blended as necessary in a range not impeding the effects of the present invention.
  • a binder, a surfactant, a sweetener, an antiseptic, a colorant, various active ingredients, a pH adjuster, and the like can be blended, and these ingredients can be mixed with water to produce by a known method.
  • organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, guar gum, gelatin, crystalline cellulose, polyvinyl alcohol, polyvinylpyrrolidone, etc.
  • Inorganic binders such as gelling silica, gelling aluminum silica, montmorillonite, kaolin and bentonite can be used, and one or more of these can be used.
  • the compounding amount of the binder is usually 0.1 to 13%, particularly 1.1 to 10% of the whole composition.
  • the compounding amount of the organic binder is preferably 0.1 to 5% of the whole composition
  • the compounding amount of the inorganic binder is preferably 1 to 8%, particularly 1 to 5% of the whole composition.
  • the surfactant examples include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.
  • Anionic surfactants alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl sulfoacetate, sodium ⁇ -olefin sulfonate nonionic surfactants; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, Polyoxyethylene higher alcohol ether such as polyoxyethylene lauryl ether, sugar fatty acid ester such as sucrose fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant; distearyl chloride Methylammonium, stearyldimethylbenzylammonium chloride amphoteric
  • sweetening agent examples include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, and perilartin.
  • preservative examples include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
  • colorant Blue No. 1, Yellow No. 4, Green No. 3, and the like can be blended in a normal amount.
  • active ingredients include known ingredients that are usually blended in dentifrice compositions, such as fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anticalculus agents, anti-plaque agents, and the like of the present invention.
  • An effective amount can be blended within a range that does not interfere with the effect.
  • fluorides such as sodium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, sodium salt of orthophosphoric acid, tranexamic acid, epsilon aminocaproic acid, tocopherol acetate, ⁇ -bisabolol , Dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetic acid, glycyrrhizic acid or salts thereof, copper compounds such as copper chlorophyllin sodium, chlorophyll, copper gluconate, chelating phosphate compounds such as glycerophosphate, hydroxamic acid or derivatives thereof , Sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, isopropylmethylphenol, benzethonium chloride, cetylpyridinium chloride, allantochlorohydroxyal Chloride, ascorbic acid or
  • Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid or salts thereof, phosphoric acid or salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide and potassium hydroxide.
  • the water content of the gel dentifrice composition of the present invention is preferably 20 to 60%, more preferably 30 to 50% of the entire composition.
  • the stickiness inhibitor of the present invention is (A) a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% sorbitol and not containing an abrasive, comprising (B) menthol and (C ) N-ethyl-p-menthane-3-carboxamide, more preferably (D) eugenol, wherein (B) / (C) has a mass ratio of 0.5 to 40.
  • the components (B) and (C), more preferably the component (D) are effective components for suppressing stickiness, and the components (B) and (C) are used in combination at a specific blending ratio (mass ratio).
  • these components can be used as stickiness inhibitor composed of only the above-mentioned active ingredient, which is blended into the gel dentifrice composition. Further, these components can be used as stickiness suppressing agents for gel dentifrice compositions by adding these components as active ingredients for stickiness suppression and further adding other components.
  • the details of the components (A), (B) and (C), further the component (D), the blending amount and blending ratio thereof, and other components are all the same as the gel dentifrice composition. It is the same.
  • Gel dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method.
  • sorbitol manufactured by Mitsubishi Corporation Foodtech Co., Ltd.
  • menthol manufactured by Takasago International Corporation, L-menthol
  • N-ethyl-p-menthane-3-carboxamide Gibodan Japan Co., Ltd., trade name: WS-3
  • Eugenol Toyotama Fragrance Co., Ltd.
  • the other ingredients were used as standard products for the outer general standards (quasi-drug raw material standards), and the purified water was used as the standard for the cosmetic base (cosmetic raw material standards).
  • the perfume A used is a general oral perfume and does not contain menthol, N-ethyl-p-menthane-3-carboxamide and eugenol.
  • the composition of perfume A is shown below. Composition of perfume A; Cineol 20 parts by weight Limonene 10 Mentone 20 Carvone 10 Anethol 20 Ethanol 20 Total 100 parts by mass
  • Flavor expression 4 points: very good flavor expression 3 points: good flavor expression 2 points: slightly good flavor expression 1 point: poor flavor expression (evaluation criteria) Average score for flavor development ⁇ : 3.5 to 4.0 points ⁇ : 3.0 to less than 3.5 points ⁇ : 2.0 to less than 3.0 points ⁇ : 1.0 to 2 Less than 0 points
  • the gel dentifrice compositions (Examples) of the present invention were excellent in non-stickiness, inferior in irritation, refreshing and flavor development.
  • the components (B) and / or (C) were absent, the non-stickiness was inferior, and the refreshing feeling and flavor expression were also inferior (Comparative Examples 1 to 3).
  • (B) / (C) was too large, even if it contained (B) and (C) component, the non-stickiness was inferior and irritation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice de type gel qui contient 40 à 60 % en masse de (A) sorbitol, 0,1 à 1 % en masse de (B) menthol, et 0,02 à 0,2 % en masse de (C) N-éthyl-p-menthane-3-carboxamide de sorte que le rapport en masse (B)/(C) soit de 0,5 à 40, tout en ne contenant pas d'agent de polissage. Cette composition de dentifrice de type gel contient en outre 0,01 à 0,1 % en masse de (D) eugénol. L'invention concerne un inhibiteur d'adhésivité pour compositions de dentifrice de type gel, qui contient le composant décrit ci-dessus (A) mais ne contient pas d'agent de polissage, et qui contient également les composants (B) et (C), et de préférence en plus le composant (D), tout en ayant le rapport de masse (B)/(C) de 0,5 à 40. Par conséquent, la présente invention peut fournir : une composition de dentifrice de type gel dont l'adhésivité est supprimée et qui a une excellente sensation d'utilisation, tout en ne contenant pas d'agent de polissage; et un inhibiteur d'adhésivité qui est utilisé pour cette composition de dentifrice de type gel.
PCT/JP2018/004819 2017-02-20 2018-02-13 Composition de dentifrice de type gel et inhibiteur de l'adhésivité pour celle-ci Ceased WO2018151076A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018568520A JPWO2018151076A1 (ja) 2017-02-20 2018-02-13 ジェル状歯磨剤組成物及びそのべたつき抑制剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017029110 2017-02-20
JP2017-029110 2017-02-20

Publications (1)

Publication Number Publication Date
WO2018151076A1 true WO2018151076A1 (fr) 2018-08-23

Family

ID=63169478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/004819 Ceased WO2018151076A1 (fr) 2017-02-20 2018-02-13 Composition de dentifrice de type gel et inhibiteur de l'adhésivité pour celle-ci

Country Status (2)

Country Link
JP (1) JPWO2018151076A1 (fr)
WO (1) WO2018151076A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022533218A (ja) * 2019-05-22 2022-07-21 コスメティック ウォリアーズ エルティーディー ソルビトール又はキシリトール、及びゲル化剤を含む組成物
JP2023005021A (ja) * 2021-06-28 2023-01-18 ライオン株式会社 味覚改善剤

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003026557A (ja) * 2001-07-13 2003-01-29 Takayuki Kodama 口腔用組成物
JP2009120552A (ja) * 2007-11-16 2009-06-04 Lion Corp 練歯磨剤組成物の製造方法
JP2009221208A (ja) * 2004-08-12 2009-10-01 Procter & Gamble Co 口腔用組成物及びそのシステム
JP2010523551A (ja) * 2007-04-16 2010-07-15 ザ プロクター アンド ギャンブル カンパニー 精油又は精油成分の抗菌性混合物を含むパーソナルケア組成物
JP2011530608A (ja) * 2008-08-15 2011-12-22 ザ プロクター アンド ギャンブル カンパニー 消費者製品における感覚剤として有用なシクロヘキサン誘導体の合成
JP2014125440A (ja) * 2012-12-26 2014-07-07 Lion Corp 口腔用組成物
WO2016006647A1 (fr) * 2014-07-11 2016-01-14 ライオン株式会社 Composition pour son utilisation dans la cavité buccale
JP2016040306A (ja) * 2015-10-23 2016-03-24 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 矯味されたオーラルケア組成物
JP2016121089A (ja) * 2014-12-25 2016-07-07 ライオン株式会社 口腔用組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3334425B2 (ja) * 1995-04-10 2002-10-15 ライオン株式会社 液体口腔用組成物
JP2016517445A (ja) * 2013-03-15 2016-06-16 エイピーアイ・ジェネシス，エルエルシー ポリフェノール／フラボノイド組成物および口腔衛生製品を調合する方法
JP6673348B2 (ja) * 2015-05-29 2020-03-25 ライオン株式会社 口腔用組成物

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003026557A (ja) * 2001-07-13 2003-01-29 Takayuki Kodama 口腔用組成物
JP2009221208A (ja) * 2004-08-12 2009-10-01 Procter & Gamble Co 口腔用組成物及びそのシステム
JP2010523551A (ja) * 2007-04-16 2010-07-15 ザ プロクター アンド ギャンブル カンパニー 精油又は精油成分の抗菌性混合物を含むパーソナルケア組成物
JP2009120552A (ja) * 2007-11-16 2009-06-04 Lion Corp 練歯磨剤組成物の製造方法
JP2011530608A (ja) * 2008-08-15 2011-12-22 ザ プロクター アンド ギャンブル カンパニー 消費者製品における感覚剤として有用なシクロヘキサン誘導体の合成
JP2014125440A (ja) * 2012-12-26 2014-07-07 Lion Corp 口腔用組成物
WO2016006647A1 (fr) * 2014-07-11 2016-01-14 ライオン株式会社 Composition pour son utilisation dans la cavité buccale
JP2016121089A (ja) * 2014-12-25 2016-07-07 ライオン株式会社 口腔用組成物
JP2016040306A (ja) * 2015-10-23 2016-03-24 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 矯味されたオーラルケア組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022533218A (ja) * 2019-05-22 2022-07-21 コスメティック ウォリアーズ エルティーディー ソルビトール又はキシリトール、及びゲル化剤を含む組成物
JP2023005021A (ja) * 2021-06-28 2023-01-18 ライオン株式会社 味覚改善剤

Also Published As

Publication number Publication date
JPWO2018151076A1 (ja) 2019-12-12

Similar Documents

Publication Publication Date Title
JP5251350B2 (ja) 歯磨組成物
JP5597970B2 (ja) 歯磨剤組成物
JP5573111B2 (ja) イソプロピルメチルフェノール含有液体口腔用組成物
JP6610561B2 (ja) 口腔用組成物
JP6201851B2 (ja) 歯磨組成物
JP7236623B2 (ja) 口腔用組成物
WO2011055707A1 (fr) Composition de dentifrice
JP2020011951A (ja) 口腔用組成物
JP5842565B2 (ja) 洗口剤組成物及び洗口剤組成物における変色抑制方法
WO2018066341A1 (fr) Composition pour cavité buccale, et procédé d'inhibition de variation de couleur de préparation et de séparation de liquide associés
WO2018151076A1 (fr) Composition de dentifrice de type gel et inhibiteur de l'adhésivité pour celle-ci
JP4158036B2 (ja) 歯磨剤組成物及びその製造方法
JP2009137897A (ja) 歯磨組成物
JP7655225B2 (ja) 液体口腔用組成物
JP6409618B2 (ja) 歯磨組成物
JP2019167297A (ja) 歯磨剤組成物
CN111050747B (zh) 洁齿剂组合物
JP6753142B2 (ja) 口腔用組成物
JP6693504B2 (ja) 歯磨剤組成物
WO2019107340A1 (fr) Composition pour utilisation par voie orale
JP5625704B2 (ja) 歯磨剤組成物
JP7388126B2 (ja) 口腔用組成物
JP7371351B2 (ja) 口腔用組成物
JP2020015704A (ja) 口腔用組成物
JP6617535B2 (ja) 歯磨剤組成物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18754395

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2018568520

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18754395

Country of ref document: EP

Kind code of ref document: A1