WO2018150395A3 - 4-n-butylresorcinol preparations - Google Patents

Abstract

A medical or cosmetic formulation such as pastes, gels, lotions, serums, creams, peels and sprays comprising 4-n-butylresorcinol in a concentration greater than substantially 18% preferably between substantially 20% and substantially 60% diluted with a hydrophilic agent, or any diluent known in the art, can be used for treating various skin conditions, e.g. complexion, hyperpigmentation, melasma, pore size, skin density, hydration, superficial scars, post-operative scars, hypertrophic and atrophic scars, post-inflammatory hyperpigmentation, solar lentigines, acne vulgaris and as an anti-aging treatment. The formulae include peels and skincare using various delivery systems, such as liposomal delivery systems and all agents to aide penetration of the epidermis, known in the art. Compositions may include preservatives, such as levulinic acid. Formulation embodiments of the invention can have any one or more of the following features: • Said formulation is between substantially 18% and substantially 60% • Said concentration to produce a skincare treatment • Said concentration to produce a mild peel • Said concentration to produce a medium peel • Said concentration to produce a deep peel • For use in the treatment of any or more of the group comprising: complexion, anti-aging, hyperpigmentation skin disorders, atrophic and hypertrophic superficial and post-operative scars, hydration, skin density, pore size, acne vulgaris • Comprising any one or more of the ingredients mentioned herein for the treatment of melasma • Comprising any one or more of the ingredients mentioned herein for the treatment of hyperpigmentory skin disorders • Another aspect of the invention consists in a method of treating the skin, in which there is used a formulation embodying the invention • A formulation consisting any one of the following: DMSO, levulinic acid, fatty acids such as oleic acid, coconut oil, sources of vitamin C, e.g. rosehip seed, camu camu, infection control such as natural antibiotics e.g. colloidal silver, hydration agents such as glycerin and hyaluronic acid, walnuts, opti zinc, inhibition of collagen synthesis, healing agents such as croton lechleri, tyrosine kinase inhibitors, calcium antagonists such as magnesium, antioxidants such as r lipoic acid, astaxanthin and ubiquinol coqlO, telomeres lengthening agents such as resveratrol and cycloastrogenol, TGF-b inhibitors, protein kinase C (PKC) inhibitors, scar reduction agents such as niacinamide, anti¬ inflammatories such as white willow bark, bamboo, cannabinoids, watermelon skin, agents for collagen stimulation, anti-glycation, immune pathways, red spinach, cherry blossom, tormentil, chitin, rambutan, amino acids, (GL1), (GL3), (TTG1), soursop, oleuropein, cassia, apple skin, osmanthus and all anti-aging agents known in the art. These additional components, may be combined with 4-n-butylresorcinol or may be used separately.