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WO2018150348A1 - Système non invasif pour mesurer la fonction d'entrée artérielle pour imagerie tep - Google Patents

Système non invasif pour mesurer la fonction d'entrée artérielle pour imagerie tep Download PDF

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Publication number
WO2018150348A1
WO2018150348A1 PCT/IB2018/050930 IB2018050930W WO2018150348A1 WO 2018150348 A1 WO2018150348 A1 WO 2018150348A1 IB 2018050930 W IB2018050930 W IB 2018050930W WO 2018150348 A1 WO2018150348 A1 WO 2018150348A1
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WO
WIPO (PCT)
Prior art keywords
scintillator material
pet
measuring
transducers
transducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/050930
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English (en)
Inventor
Francisco José SANTIAGO FERNANDES AMADO CARAMELO
Francisco Paulo MARQUES DE OLIVEIRA
Carlos Manuel DE ALMEIDA PEREIRA
Nuno David DE SOUSA CHICHORRO DA FONSECA FERREIRA
Miguel José PATRÍCIO DIAS
Ângela Cristina SIMÕES CRUZ
Antero José PENA AFONSO DE ABRUNHOSA
Ana Paula MOURÃO MOREIRA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Coimbra
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Universidade de Coimbra
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Filing date
Publication date
Application filed by Universidade de Coimbra filed Critical Universidade de Coimbra
Publication of WO2018150348A1 publication Critical patent/WO2018150348A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting

Definitions

  • This application relates to a non-invasive system for measuring the arterial input function for PET imaging.
  • PET Positron Emission Tomography
  • This capacity generally associated to static acquisition, has medical meaning and is relevant both in the clinical and in the research setting.
  • PET data holds a much more valuable power, which is the capacity of providing quantitative information about biochemical, physiological and pharmacokinetics processes which are targeted by different radiotracers.
  • In order to quantify the parameters related to the biological behaviour for each radiotracer dynamic acquisitions are required as well as performing a mathematical treatment of the collected data. Only then PET data is translated into quantities amenable to statistical analysis.
  • There is a plethora of methods for calculating parametric images that are generally classified either as data-driven or model-driven methods. Data-driven methods make no assumptions about the data structure whereas model- driven methods start from a model that constraint data.
  • tissue time activity curve is modelled as a convolution of the plasma input with exponential terms.
  • the system is described by its impulse response function expressed as a positive sum of exponentials.
  • the technique provides information on the number of compartments underlying the kinetics of the system.
  • Model-driven methods assume PET data as a mixture of several components originated by different pools of tracer, labelled as compartments.
  • compartment analysis In order to isolate the part of signal of interest a mathematical framework was developed and is known as compartment analysis.
  • a typical four compartments model has one compartment of arterial blood (Cp) , one of free radiotracer (Ct) , one compartment of specific binding (Cb) and one of non-specific binding (Cn) .
  • Cp arterial blood
  • Ct free radiotracer
  • Cb specific binding
  • Cn non-specific binding
  • All the above methods require the knowledge of the plasma time activity curve.
  • arterial blood sampling is very invasive and technically demanding. Therefore, there have been several attempts to obtain the necessary information by other forms, namely the image-derived input function (IDIF) .
  • IDIF image-derived input function
  • IDIF may be an elegant technique some nuisances persist, namely: the requirement for blood sampling is not complete overcome, the validation for a specific tracer and machine may not be correct for a different experimental setting and the accuracy of the image input might dependent on the radiometabolite fraction .
  • TRM tissue reference methods
  • a region without specific binding of the radioligand to its target is used as a reference to describe the time-activity curve of a region of interest.
  • the inaccuracies arise in these methods especially because of failures on the assumption of absence of binding in the reference region.
  • the identification of a region of reference that lies in the field-of-view could be problematic.
  • the present application describes a non-invasive system for measuring the arterial input function for PET imaging comprising :
  • each transducer is encapsulated in a box and is comprised by:
  • At least one light sensor At least one light sensor
  • control and communication module comprising processing and wireless communication means; a power module; and
  • an external processing device comprising processing means configured to process data sent by the at least two transducers, and communication means configured to remotely program the control and communication module with a set of measuring parameters.
  • the measuring parameters are an integration period of the signal generated by each transducer (A) and a lower and upper bounds of a gamma photons radiation energy range.
  • the scintillator material is configured to collect and transform gamma photons emitted by a radiotracer used in PET scan into ultraviolet or visible light photons.
  • the scintillator material is of a regular prism with rectangular or square base .
  • the scintillator material is a scintillator crystal.
  • the radioactive shielding is lead.
  • the shielding material involves all the faces of the scintillator material that are not facing towards the patient's body.
  • the light sensor is a photodiode.
  • the processing means of the control and communication module (E) are configured to determine, during the integration period, the number of effective events representing gamma photons whose radiation energy sensed by the scintillator material (B) is within a specific range of energy, defined by the lower and upper bounds .
  • the box is made of a metal such as copper or iron.
  • the present application is related to a radioactive sensor system capable of continuously measuring the concentration of a radiotracer within the blood flow of a patient who undergoes a Positron Emission Tomography (PET) scan (A) .
  • PET Positron Emission Tomography
  • a non-invasive system for measuring the arterial input function comprising at least two transducers, distributed along the body of a patient, being each transducer comprised by:
  • Each transducer is encapsulated in a metal box, that shield all the transducer components against exterior electronic noise providing also mechanical robustness.
  • An advantage of the present non-invasive solution is the small dimension of each transducer used, which allows its temporarily attachment to the patient's body who can move freely without hindering the AIF determination.
  • the AIF is measured attaching at least two transducers (A) , before the administration of the radiotracer, to the patient's body in different locations and having them remain attached during the PET scan.
  • the process of measuring the AIF is adapted according to the patient's characteristics, choice of radiotracer and PET acquisition protocol, with the information on these three conditions being remotely indicated via wireless communication to the control and communication module before beginning the process of measuring.
  • Said control and communication module (E) is configured to adjust the measured data by selecting only the events that are most likely to be real gamma photon interactions, before sending it via wireless communication to external processing devices .
  • Figure 1 illustrate a particular embodiment of the system wherein four transducers are temporarily attached to a patient's body, in which the reference signs represent:
  • Figure 2 is a 2D depiction of a single transducer and its components, in which the reference signs represent:
  • Figure 3 is a 3D depiction of a single transducer and its components, in which the reference signs represent:
  • Figure 4 is a 3D depiction of a single transducer and its components, in which the reference signs represent:
  • the present application relates to non-invasive system for the determination of the arterial input function (AIF) for Positron Emission Tomography image quantification (PET) .
  • AIF arterial input function
  • PET Positron Emission Tomography image quantification
  • each transducer (A) is comprised by one or more scintillator materials (B) encapsulated in a radioactive shielding (G) , one or more light sensors (C) , an amplification module (D) , a control and communication module (E) and a power module (F) . All this components are contained in the transducer box (H) .
  • the said scintillator material (B) such as a scintillator crystal, is of a regular prism with a rectangular or square base. It transforms the gamma photons emitted by the radiotracer used in the PET scan into ultraviolet or visible light photons.
  • the scintillator material (B) is encapsulated in a radioactive shielding material (G) , such as lead, that shields the crystal limiting the directions of the photons reaching the said scintillator material (B) .
  • the said radioactive shielding material (G) surrounds only the faces of the said scintillator material (B) that do not contribute for measuring the AIF, in order to reduce the noisy radiation from other parts of the patient's body.
  • the shielding material involves the scintillator materials (B) in all the faces of the scintillator material (B) except the one that faces towards the patient's body when a transducer (A) is attached to the body.
  • the light originated in the said scintillator material (B) is collected by one or more light sensors (C) , such as photodiodes, that transforms it into an electric signal.
  • the amplification module (D) is responsible for the integration and amplification of the signal coming from the light sensor, which is then processed and transmitted to external devices
  • Module (E) is provided with processing means configured to process the integrated signal coming from the module (D) in order to determine, in a predefined time period, the number of effective events representing gamma photons whose radiation energy sensed by the scintillator material (B) is within a specific range of values.
  • Said control and communication module (E) is also provided with wireless communication capabilities, which allows for remote programming. Based on that, it is possible to configure the processing stage at module (E) to measure the AIF for each radiotracer, each patient and each protocol acquisition, according to a set of measuring parameters .
  • Such measuring parameters are the integration period of the signal generated by each transducer
  • a power module (F) such as a battery
  • the transducer box (H) encapsulating all the transducer components is made of a metal such as copper, iron or any other metal that has the capacity of reducing electrical noise.
  • the transducers (A) are placed at different locations on the body, receiving the signal corresponding to the AIF at slightly different instants.
  • the preferential locations to place the said transducers (A) are near blood arteries, such as the aorta, the carotid, the radial, the brachial or the femoral artery.
  • Each transducer (A) collects different signal components that are related not only to the arterial blood's radiopharmaceutical element, which is responsible for the AIF calculation, but also to the signals from the surrounding tissues' radiopharmaceutical elements. Therefore, each transducer (A) is responsible for the integration of these distinct signal components and its respective processing stage according to the set of parameters programmed at module (E) , prior to sending the information to an external processing device.
  • This remote processing device is provided with processing means adapted to combine the distinct components carried by the signals sent by the set of transducers (A) , in order to determine the AIF that is used to PET quantification.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine (AREA)

Abstract

La présente invention concerne un système non invasif pour la détermination de la fonction d'entrée artérielle (AIF) pour la quantification d'image par tomographie par émission de positons (TEP). Le système est basé sur un ensemble distribué de transducteurs (A) fixés au corps d'un patient qui mesurent de façon non invasive, dans des artères sanguines distinctes, la concentration du radiotraceur utilisé dans des scans TEP. Les données mesurées sont ensuite combinées pour calculer l'AIF. Les transducteurs (A) composant le système comportent un matériau scintillateur (B) qui interagit avec les photons gamma émis par le radiotraceur et convertit ceux-ci en lumière ultraviolette ou visible. Cette lumière est ensuite collectée par un capteur de lumière (C) créant un signal électrique qui est amplifié (D) et prétraité (E). Le système est commandé à distance par un dispositif de traitement externe permettant son adaptation à chaque situation.
PCT/IB2018/050930 2017-02-15 2018-02-15 Système non invasif pour mesurer la fonction d'entrée artérielle pour imagerie tep Ceased WO2018150348A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT109914 2017-02-15
PT10991417 2017-02-15

Publications (1)

Publication Number Publication Date
WO2018150348A1 true WO2018150348A1 (fr) 2018-08-23

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Family Applications (1)

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PCT/IB2018/050930 Ceased WO2018150348A1 (fr) 2017-02-15 2018-02-15 Système non invasif pour mesurer la fonction d'entrée artérielle pour imagerie tep

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PT (1) PT2018150348B (fr)
WO (1) WO2018150348A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020188197A1 (en) * 2000-12-01 2002-12-12 Harry Bishop Cardiovascular imaging and functional analysis system
WO2011037462A1 (fr) * 2009-09-25 2011-03-31 Stichting Het Nederlands Kanker Instituut Procédé d'évaluation quantitative non invasive de taux de traceur radioactif dans la circulation sanguine
US20150276937A1 (en) * 2012-05-30 2015-10-01 Lucerno Dynamics, Llc System and method for the detectio of gamma radiation from a radioactive analyte

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020188197A1 (en) * 2000-12-01 2002-12-12 Harry Bishop Cardiovascular imaging and functional analysis system
WO2011037462A1 (fr) * 2009-09-25 2011-03-31 Stichting Het Nederlands Kanker Instituut Procédé d'évaluation quantitative non invasive de taux de traceur radioactif dans la circulation sanguine
US20150276937A1 (en) * 2012-05-30 2015-10-01 Lucerno Dynamics, Llc System and method for the detectio of gamma radiation from a radioactive analyte

Also Published As

Publication number Publication date
PT2018150348B (pt) 2021-03-12

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