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WO2018145446A1 - Dispositif de remplissage aseptique de masque facial et procédé de préparation de masque associé - Google Patents

Dispositif de remplissage aseptique de masque facial et procédé de préparation de masque associé Download PDF

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Publication number
WO2018145446A1
WO2018145446A1 PCT/CN2017/099148 CN2017099148W WO2018145446A1 WO 2018145446 A1 WO2018145446 A1 WO 2018145446A1 CN 2017099148 W CN2017099148 W CN 2017099148W WO 2018145446 A1 WO2018145446 A1 WO 2018145446A1
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WO
WIPO (PCT)
Prior art keywords
filling
mask
high temperature
sterilization
steam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/099148
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English (en)
Chinese (zh)
Inventor
喻君
孙杨
李俊成
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Additive Free Cosmetic Co Ltd
Original Assignee
Guangzhou Additive Free Cosmetic Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Additive Free Cosmetic Co Ltd filed Critical Guangzhou Additive Free Cosmetic Co Ltd
Priority to SG11201801259PA priority Critical patent/SG11201801259PA/en
Priority to ZA2018/00673A priority patent/ZA201800673B/en
Publication of WO2018145446A1 publication Critical patent/WO2018145446A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
    • B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/12—Sterilising contents prior to, or during, packaging
    • B65B55/14—Sterilising contents prior to, or during, packaging by heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/12—Sterilising contents prior to, or during, packaging
    • B65B55/16—Sterilising contents prior to, or during, packaging by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the invention belongs to the technical field of cosmetics, and particularly relates to an equipment device for aseptic filling facial mask and a preparation method thereof.
  • the existing mask is usually provided with a preservative, and the preservative is applied to the anti-corrosion performance of the mask to protect the product from microbial contamination and deterioration, and prolong the shelf life of the product.
  • the preservative is applied to the anti-corrosion performance of the mask to protect the product from microbial contamination and deterioration, and prolong the shelf life of the product.
  • it is useless for skin care itself, and may even increase skin irritation and allergies; to ensure the safety of the product, to prevent possible infections caused by the use of microbial-contaminated products, if preservatives If the amount added is not enough, the microorganism may adapt to the surrounding growth environment and produce drug resistance, resulting in corrosion failure.
  • the ideal preservative should be spectrally active, allowing rapid microbial inactivation, stable formulation, long-term safe use, no irritation and sensitization.
  • most preservatives or antibacterials are effective or effective against fungi and cannot be effective for both; currently there are more preservatives on the market.
  • Preservatives are useless to skin care itself, and may even increase skin irritation and sensitization, such as the burning sensation produced by phenoxyethanol, which may be produced by methyl isothiazolone (MIT). Allergies and so on. Therefore, the existing cosmetic related regulations also clearly stipulate the requirements for the addition of restricted substances (preservatives). At present, in the production of mask products, the traditional hot-press sterilization process is adopted.
  • the disadvantage of this method is that the mask-type mask causes deformation, expansion and rupture of the mask bag.
  • “zero addition”, “zero burden” and “no preservative added” are more and more valued and respected, especially with the popularity of masks in recent years.
  • the development and application of sterilization technology is playing an increasingly important role in the field of cosmetic safety and natural research and development.
  • the applicant has obtained a new equipment device after many years, including: high temperature drying oven, high temperature and high pressure sterilization tank, high temperature steam sterilization conveying pipeline, high temperature steam sterilization filling machine And the 100-level filling workshop; the device can be well sterilized on the mask, and no preservative is added to the mask to ensure the sterility of the mask.
  • the present invention has been achieved by the following technical solutions.
  • a device for sterilizing filling mask comprising a high temperature drying box, a high temperature and high pressure sterilization tank, a high temperature steam sterilization conveying pipeline, a high temperature steam sterilization filling machine and a hundred level filling workshop.
  • the device for aseptic filling facial mask comprises a high temperature drying box, a high temperature and high pressure sterilization tank, a high temperature steam sterilization conveying pipeline, a high temperature steam sterilization filling machine and a hundred level filling workshop,
  • the high temperature sterilization tank is sterilized by high temperature steam
  • the device is composed of a closed tank with a jacket and a stirring paddle, an air filter, a feeding port, a peristaltic pump, a temperature sensor and a control system;
  • the inner material conveying pipe a feed valve connected to the sterilization tank, a stainless steel delivery pipe, a steam inlet valve, a dead angle exhaust valve, a sewage valve, a sewage pipe, and a discharge valve connected to the filling machine;
  • the sterilizable filling machine It consists of a transparent protective cover with a hole at the top, a high temperature resistant conveying hose, a high temperature resistant gear pump, a stainless steel filling head, an ultraviolet lamp system, an anti-ultra lamp cover, and a
  • the mask packaging material is treated at 90 ° C for 2 hours in a high temperature drying oven, and can be used after the aseptic inspection.
  • the mask packaging material is sealed with a sterile sealing pocket.
  • the mask material is sterilized, and the air filter is used to deliver the sterile air to maintain the positive pressure of the sterilization tank.
  • the conveying management sterilization and the filling machine sterilization are carried out simultaneously, and the steam inlet valve is connected to the high temperature steam, and the steam is filled through the conveying pipeline, the discharging valve, the high temperature resistant conveying hose, the high temperature resistant gear pump, and the stainless steel.
  • the head and sewage line are discharged; when the delivery line is sterilized, the dead angle exhaust valve should be opened to ensure complete sterilization.
  • the aseptic air outlet of the filling machine is directly above the filling machine, and the sterile air directly enters the inside of the filling machine through the top perforated protective cover to maintain the positive pressure inside the filling machine.
  • the internal UV lamp system of the filling machine is opened, and the filling process is carried out under the protection of the ultraviolet lamp.
  • the sterilization process includes the following steps:
  • Step (1) adding the prepared mask material into the sterilization tank, sealing the sterilization tank, opening the stirring paddle, and uniformly stirring the components;
  • Step (2) using a steam generator to provide high temperature and high pressure steam to the sterilization tank to heat up, when the tank temperature rises to 105 ° C, stop heating, keep the mask material temperature 105 ° C for 15 to 30 minutes, then start to cool down, cool down to 20-40 ° C ;
  • Step (3) sterilizing the mask material while sterilizing the air filter with high temperature steam, and keeping the air filter sealed after sterilization;
  • Step (4) providing compressed air by using an air compressor, and passing through the air filter into the sterilization tank to maintain a positive pressure inside the tank;
  • Step (5) introducing steam into the feed pipe via the steam inlet valve, sterilizing the feed pipe and the filling machine, maintaining steam for 20 minutes to 40 minutes, and then sealing all the piping systems;
  • Step (6) sterilize the space of the filling chamber with an ultraviolet lamp for more than 20 minutes, turn off the ultraviolet lamp, and pass the sterile air to maintain a positive pressure between the filling chambers;
  • Step (7) Open the UV lamp system of the filling machine, open the feed line feed valve, the discharge valve, and the feed liquid enters the filling machine via the feed line to start filling.
  • the mask material is composed of the following parts by weight: coenzyme Q10 0.01-0.1, olive oil 5-10, lipoic acid 0.1-0.5, nicotinamide 0.1-0.5, ⁇ -glucan 0.1-0.5, vitamin B 6 0.1-0.5, vitamin C 1.0-3.0, vitamin B 2 0.1-0.5, dipotassium glycyrrhizinate 0.1-0.5, citric acid 0.1-0.5, vitamin E 0.5-2.0, 1,2-propanediol 5.0-10.0, 1,3-butanediol 1.0 -5.0, polyglutamic acid 3.0-5.0, hydroxyethyl cellulose 0.1-0.3, glycerol polymethacrylate/1,2-propanediol/PVM/MA copolymer 4.0-8.0, triethanolamine 0.1-0.5, sodium lactate 1.0 -3.5, ethylhexyl glycerol 0.1-0.3, deionized water to 100.
  • the preparation method of the mask raw material is: taking coenzyme Q10, adding it into olive oil, shaking at 35 ° C for 30 minutes, so that coenzyme Q10 is fully dissolved in olive oil for use; deionized water, 1,3-butanediol, poly Mix glutamic acid, hydroxyethyl cellulose and water, heat to 85 ° C, dissolve completely, add coenzyme Q10, olive oil, add triethanolamine, glycerol polymethacrylate / 1,2-propanediol at 50 ° C / PVM/MA copolymer, sodium lactate, nicotinamide, ⁇ -glucan, lipoic acid, dipotassium glycyrrhizinate, stirred until completely dissolved; added vitamin C, vitamin B6, tannic acid, phenoxyethanol, ethyl at 45 ° C or less Other raw materials such as hexyl glycerol are used to obtain a prepared mask material.
  • the invention has the following advantages and outstanding effects: the state of the mask material is completely changed, and the preservative or antiseptic material needs to be added.
  • the system and the process of the invention can produce the mask material without the preservative antiseptic material completely.
  • the invention is sterilized by pure physical means to achieve prevention For the purpose of rot, there will be no chemical or radiation residues in the product, and the sealed product after filling is theoretically completely sterilized, which greatly prolongs the shelf life of the product, and the shelf life can be as long as several years after the sealed packaging material is not damaged.
  • the conditions required for the systems and processes of the present invention are readily attainable in normal cosmetic manufacturing enterprises and are suitable for large scale production applications.
  • Figure 1 is a schematic view showing the structure of an aseptic filling system provided by the present invention
  • FIG. 2 is a schematic flow chart of an aseptic filling process provided by the present invention.
  • Mask prescription Coenzyme Q10 0.01kg, olive oil 5kg, lipoic acid 0.1kg, nicotinamide 0.1kg, ⁇ -glucan 0.1kg, vitamin B6 0.1kg, vitamin C 1.0kg, vitamin B2 0.1kg, dipotassium glycyrrhizinate 0.1kg, 0.1kg of citric acid, 0.5kg of vitamin E, 5.0kg of 1,2-propanediol, 1.0kg of 1,3-butanediol, 3.0kg of polyglutamic acid, 0.1kg of hydroxyethylcellulose, polyglycerol Base acrylate/1,2-propanediol/PVM/MA copolymer 4.0 kg, triethanolamine 0.1 kg, sodium lactate 1.0 kg, ethylhexyl glycerol 0.1 kg, deionized water to 100 kg.
  • the preparation method of the mask raw material is as follows: taking coenzyme Q10, adding it into olive oil, shaking at 35 ° C for 30 minutes, so that coenzyme Q10 is fully dissolved in olive oil for use; deionized water, 1,3-butanediol, poly Valley Mix with hydroxyethyl cellulose, heat to 85 ° C, dissolve completely, add coenzyme Q10, olive oil, add triethanolamine, glycerol polymethacrylate / 1,2-propanediol / PVM / MA at 50 ° C Copolymer, sodium lactate, nicotinamide, ⁇ -glucan, lipoic acid, dipotassium glycyrrhizinate, stir to completely dissolve; add vitamin C, vitamin B 6 , tannic acid, ethylhexylglycerol and other raw materials below 45 ° C, A prepared mask material is obtained.
  • Mask prescription Coenzyme Q10 0.05kg, olive oil 7.5kg, lipoic acid 0.25kg, nicotinamide 0.25kg, ⁇ -glucan 0.25kg, vitamin B 6 0.25kg, vitamin C 2kg, vitamin B 2 0.25kg, glycyrrhizic acid Dipotassium 0.25kg, citric acid 0.25kg, vitamin E 1.5kg, 1,2-propanediol 7.5kg, 1,3-butanediol 2.5kg, polyglutamic acid 4kg, hydroxyethyl cellulose 0.2kg, glycerol poly 6 parts of methacrylate/1,2-propanediol/PVM/MA copolymer, 0.25 kg of triethanolamine, 2.5 kg of sodium lactate, 0.2 kg of ethylhexylglycerol, and deionized water to 100 kg.
  • the preparation method of the mask raw material is as follows: taking coenzyme Q10, adding it into olive oil, shaking at 35 ° C for 30 minutes, so that coenzyme Q10 is fully dissolved in olive oil for use; deionized water, 1,3-butanediol, poly Valley Mix with hydroxyethyl cellulose, heat to 85 ° C, dissolve completely, add coenzyme Q10, olive oil, add triethanolamine, glycerol polymethacrylate / 1,2-propanediol / PVM / MA at 50 ° C Copolymer, sodium lactate, nicotinamide, ⁇ -glucan, lipoic acid, dipotassium glycyrrhizinate, stir to completely dissolve; add vitamin C, vitamin B 6 , tannic acid, ethylhexylglycerol and other raw materials below 45 ° C, A prepared mask material is obtained.
  • Coenzyme Q10 0.1kg, olive oil 10kg, lipoic acid 0.5kg, nicotinamide 0.5kg, ⁇ -glucan 0.5kg, vitamin B 6 0.5kg, vitamin C 3kg, vitamin B 2 0.5kg, dipotassium glycyrrhizinate 0.5kg, 0.5kg of citric acid, 2kg of vitamin E, 10kg of 1,2-propanediol, 5kg of 1,3-butanediol, 5kg of polyglutamic acid, 0.3kg of hydroxyethylcellulose, glycerol polymethacrylate/1,2 - propylene glycol / PVM / MA copolymer 8 kg, triethanolamine 0.5 kg, sodium lactate 3.5 kg, ethylhexyl glycerol 0.3 kg, plus deionized water to 100 kg.
  • the preparation method of the mask raw material is as follows: taking coenzyme Q10, adding it into olive oil, shaking at 35 ° C for 30 minutes, so that coenzyme Q10 is fully dissolved in olive oil for use; deionized water, 1,3-butanediol, poly Valley Mix with hydroxyethyl cellulose, heat to 85 ° C, dissolve completely, add coenzyme Q10, olive oil, add triethanolamine, glycerol polymethacrylate / 1,2-propanediol / PVM / MA at 50 ° C Copolymer, sodium lactate, nicotinamide, ⁇ -glucan, lipoic acid, dipotassium glycyrrhizinate, stir to completely dissolve; add vitamin C, vitamin B 6 , tannic acid, ethylhexylglycerol and other raw materials below 45 ° C, A prepared mask material is obtained.
  • FIG. 1 is a schematic view showing the structure principle of an aseptic filling system according to the present invention, which comprises a packaging material sterilization system, a mask material preparation and sterilization system, a mask material conveying and an aseptic filling system, that is, mainly by high The temperature drying box, the high temperature and high pressure sterilization tank 1, the high temperature steam sterilization conveying pipeline 2, the high temperature steam sterilization filling machine 3 and the hundred level filling workshop, the high temperature sterilization tank is sterilized by high temperature steam
  • the device is composed of a closed tank with a jacket 4 and a stirring paddle 5, an air filter 6, a feeding port 7, a peristaltic pump 8, and a temperature sensor 9;
  • the mask raw material conveying line 2 is sterilized by a tank-connected feed valve 10, a steam intake valve 11, a dead-end exhaust valve 12, a drain valve 13, a drain pipe 14, and a discharge valve 15 connected to the filling machine;
  • the sterilizable filling machine is provided by the top The hole transparent protective cover 16, the high temperature resistant conveying
  • the mask material is sterilized by a high-temperature drying oven, and the mask material is sterilized by a sterilization tank, and transported to a filling machine through a conveying pipeline, and sealed and sealed using a sterilized mask raw material in a hundred-level environment.
  • FIG. 2 is a schematic diagram of an aseptic filling process provided by the present invention, which mainly includes packaging material sterilization, mask material preparation, mask material sterilization, feeding, conveying pipeline sterilization, and filling machine sterilization.
  • the process of sterilizing and filling in the filling room includes the following steps:
  • the mask raw material packaging material is treated at 90 ° C for 2 hours in a high temperature drying oven, and the sterilized test can be used, and the mask raw material packaging material is sealed by a sterile sealing pocket;
  • the mask material of the embodiment 1 or the embodiment 2 or the embodiment 3 is added to the sterilization tank 1, the sterilization tank is sealed, the stirring paddle 5 is opened, and the components are uniformly stirred;
  • Use steam generator to provide high temperature and high pressure steam to raise the temperature of the sterilization tank When the temperature of the tank rises to 105 °C, stop the temperature rise, keep the temperature of the mask material at 105 °C for 15 to 30 minutes, then start to cool down, cool down to below 40 °C, sample test, test Qualified before proceeding to the next process;
  • the sterilized feeding bottle 24 is connected to the sterilization tank 1 through the feeding port 7, and the feeding pump is pumped into the sterilization tank by the peristaltic pump 8, and stirred for 20 minutes to 40 minutes to be mixed with the tank mask raw material liquid.
  • the compressed air is supplied by an air compressor, and is introduced into the sterilization tank through the air filter 6, and the pressure in the tank is maintained at 0.05 MPa to 0.1 MPa (gauge pressure);
  • the pressure difference between the filling and the buffer corridor is above 8Pa;
  • the ultraviolet lamp system 20 of the filling machine is opened, the feed line feed valve 10 is opened, the discharge valve 11 is fed, and the feed liquid enters the filling machine 3 via the feed line 2 to start filling to obtain a mask.
  • the preparation method of the mask raw material is as follows: taking coenzyme Q10, adding it into olive oil, shaking at 35 ° C for 30 minutes, so that coenzyme Q10 is fully dissolved in olive oil for use; deionized water, 1,3-butanediol, poly Valley Mix the amino acid and hydroxyethyl cellulose, heat to 85 ° C, add the coenzyme Q10 olive oil after dissolution, and add triethanolamine, glycerol polymethacrylate / 1,2-propanediol / PVM / MA copolymer at 50 ° C , sodium lactate, nicotinamide, ⁇ -glucan, lipoic acid, dipotassium glycyrrhizinate, stirred until completely dissolved; added below 45 ° C vitamin C, vitamin B 6 , citric acid, phenoxyethanol (preservative), ethyl Other raw materials such as hexyl glycerin, let cool, 0.22 ⁇ m
  • the masking rate of the mask product produced by the process of the invention is less than 0.5%, and has the value of mass production.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne un dispositif de remplissage aseptique de masque facial et un procédé de préparation de masque associé. Le dispositif comprend un four de séchage à haute température, un pot de stérilisation à haute température et à haute pression (1), un pipeline de transfert de stérilisation à la vapeur à haute température (2), une machine de remplissage de stérilisation à la vapeur à haute température (3) et une installation de remplissage de cent niveaux. Le dispositif peut fournir une bonne stérilisation pour des masques faciaux, aucun conservateur n'est ajouté aux masques faciaux et une asepsie des masques faciaux peut être garantie.
PCT/CN2017/099148 2017-02-08 2017-08-25 Dispositif de remplissage aseptique de masque facial et procédé de préparation de masque associé Ceased WO2018145446A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SG11201801259PA SG11201801259PA (en) 2017-02-08 2017-08-25 Facial mask aseptic-filling apparatus and Facial Mask Preparation Method Thereof
ZA2018/00673A ZA201800673B (en) 2017-02-08 2018-01-31 Facial mask aseptic-filling apparatus and facial mask preparation method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710069759.9 2017-02-08
CN201710069759.9A CN106829000B (zh) 2017-02-08 2017-02-08 灭菌灌装面膜的设备及其灭菌灌装方法

Publications (1)

Publication Number Publication Date
WO2018145446A1 true WO2018145446A1 (fr) 2018-08-16

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