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WO2018032889A1 - Composition insecticide ayant un effet synergique - Google Patents

Composition insecticide ayant un effet synergique Download PDF

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Publication number
WO2018032889A1
WO2018032889A1 PCT/CN2017/091224 CN2017091224W WO2018032889A1 WO 2018032889 A1 WO2018032889 A1 WO 2018032889A1 CN 2017091224 W CN2017091224 W CN 2017091224W WO 2018032889 A1 WO2018032889 A1 WO 2018032889A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
avermectin
active ingredient
snails
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/091224
Other languages
English (en)
Chinese (zh)
Inventor
季红进
仲汉根
张明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Huifeng Agrochemical Co Ltd
Original Assignee
Jiangsu Huifeng Agrochemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Huifeng Agrochemical Co Ltd filed Critical Jiangsu Huifeng Agrochemical Co Ltd
Publication of WO2018032889A1 publication Critical patent/WO2018032889A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system

Definitions

  • the present invention relates to an insecticidal and acaricidal composition having improved properties, and more particularly to an insecticidal and acaricidal composition comprising a spirulina or a salt thereof and avermectin, and belongs to the field of pesticide preparations.
  • Niclosamide is a salicylamide derivative. Its anti-insect mechanism is to inhibit the mitochondrial oxidative phosphorylation process in the cells, and the production of ATP is reduced, which causes the aphid's head section and adjacent segments to deteriorate.
  • the intestinal wall is exfoliated with the feces. Ineffective for eggs.
  • Death tablets are easily digested by proteases in the intestine, releasing eggs and posing a risk of cysticercosis. In agriculture, it is mainly used to kill snails, snails, beef mites, snails, pork mites, fish mites, mites, mites, mites.
  • Abamectin is a class of 16-membered macrolide compounds with insecticidal, acaricidal and nematicidal activity produced by fermentation of Streptomyces avermitilis in Streptomyces.
  • Abamectin has stomach poisoning and contact killing on mites and insects and cannot kill eggs.
  • the mechanism of action differs from that of general insecticides in that it interferes with neurophysiological activities and stimulates the release of gamma-aminobutyric acid, which inhibits the nerve conduction of arthropods.
  • Adult mites, nymphs and insect larvae are paralyzed after contact with avermectin, inactive, not feeding, and die after 2 to 4 days. The avermectin lethal effect is slower because it does not cause rapid dehydration of insects.
  • the object of the present invention is to screen the insecticides of two different action principles for the resistance problem of the insecticide in practical application, so as to improve the effect of prevention and treatment, reduce the application amount and expand the scope of use.
  • the present invention provides a group of insecticidal and acaricidal compositions comprising two active ingredients A and B, active ingredient A is snail or a salt thereof, and active ingredient B is avermectin Prime.
  • the snail amine salt compound is preferably a snail amine ethanolamine salt.
  • the compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can broaden the spectrum of action and can delay the generation of insect resistance to a certain extent, and component A and component B There is no cross-resistance.
  • the present invention provides a preparation method comprising the two active ingredients A and B compositions and an application for controlling crop pests in the agricultural field.
  • the composition comprises two active components A and B, and the weight ratio between the two components is 1:40 to 40:1, preferably the weight ratio is 1:30 to 30:1, more preferably the weight.
  • the ratio is 1:20 to 20:1.
  • the two active components A and B can be selected from 40:1, 39:1, 38:1, 37:1, 36:1, 35:1, 34:1, 33:1, 32 : 1, 31: 1, 30: 1, 29: 1, 28: 1, 27: 1, 26: 1, 25: 1, 24: 1, 23: 1, 22: 1, 21: 1, 20: 1 , 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7 : 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1:1, 1: 2, 1:3, 1:4, 1:5, 1:6, 1:7 , 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1 :20, 1:2
  • the active ingredient snailamine salt compound in the present invention is preferably a snailamine ethanolamine salt.
  • the composition further contains an auxiliary agent, a solvent, and a carrier auxiliary component which are usually used in a pesticide preparation to prepare various dosage forms suitable for use in agriculture.
  • compositions of the present invention may be formulated with the active ingredients together with adjuvants or carrier adjunct ingredients in any of the dosage forms permitted in agriculture.
  • the mass of the active ingredient in the composition of the invention may range from 2 to 95%, preferably from 5 to 80%.
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
  • Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
  • ketones such as cyclohexanone
  • highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
  • vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • the method of application of the compositions of the present invention comprises the use of the compositions of the present invention in aerial parts of plants, including leaves or foliage.
  • the plant's growth site such as wheat
  • the plant's growth site such as wheat
  • the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant.
  • In vivo systemic action
  • compositions may be applied only by the active ingredient or may be used in combination with the additives, so that the composition of the present invention can be prepared into various dosage forms such as wettable powders, suspending agents, water-dispersible granules, aqueous emulsions, microemulsions. .
  • the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
  • the two active ingredients in the compositions of the present invention exhibit synergistic effects and are more pronounced than the individual activities of the individual compounds.
  • the synergistic effect is manifested by allowing for a reduced application rate, a broader insecticidal spectrum, a quicker effect, a more durable control effect, better control of the pest by only one or a few applications, and a widening of the possible application intervals. These characteristics are very important to solve the ubiquitous resistance problem of a single pesticide.
  • the composition of the present invention can be applied to the control of crop pests in the agricultural field, especially in the control of snails, snails or snails.
  • the insecticidal composition of the present invention is applied to various crops such as wheat, cotton, corn, soybean, vegetable, fruit tree and the like, and has good activity, and pests and scales of the sucker.
  • Hymenoptera such as hibiscus, leaf miner, thrips, aphids, etc., also have good activity.
  • the other characteristics of this product are mainly as follows: 1. It can be applied to various possible application methods such as spraying and mixing; 2. The chemical composition of the two single agents of the composition is very different, and the mechanism of action is completely different. , there is no cross-resistance, The problem of resistance caused by the two single agents being used alone can be delayed; 3. The compounding of the composition of the invention has obvious synergistic effect, and is safe and effective against crops. It has been proved by experiments that the composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.
  • the active ingredients of spirulina and avermectin are mixed with the dispersing agent, stabilizer, antifoaming agent and solvent in the proportion of the formula, ground in a sanding kettle, and then sent to a homomixer for mixing. Get the finished product evenly.
  • Example 1 31% snail-killing avermectin suspension
  • Example 2 31% streptozotomin and avermectin suspension
  • Example 3 11% snail-killing avermectin microemulsion
  • Example 4 11% snail-killing avermectin microemulsion
  • Example 5 10% snailamine ⁇ avermectin microemulsion
  • the active ingredients of spirulina and avermectin are uniformly mixed with a solvent and an auxiliary agent under mechanical stirring, and pulverized by an ultrafine pulverizer to obtain a wettable powder.
  • Example 6 21% snailamine ethanolamine salt avermectin wettable powder
  • Example 7 21% snail-killing avermectin wettable powder
  • spirulina 20% of avermectin, 4% of butyl hydroxyanisole, 5% of calcium lignosulfonate, 3% of alkyl polyoxyethyl ether sulfonate, 2% of bentonite, white carbon black 4 %, diatomaceous earth is made up to 100%.
  • Example 8 41% of snailamine ethanolamine salt ⁇ avermectin wettable powder
  • Example 9 41% snailamine ethanolamine salt ⁇ avermectin wettable powder
  • Example 1 Determination of the toxicity test of spirulina and avermectin
  • CTC virulence index-level co-toxicity coefficient
  • Measured virulence index (ATI) (standard drug LC50 / test drug LC50) * 100
  • Theoretical virulence index (TTI) A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture
  • CTC Co-toxicity coefficient [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100
  • CTC ⁇ 80 the composition showed antagonism, 80 ⁇ CTC ⁇ 120, the composition showed an additive effect, CTC ⁇ 120, and the composition showed synergistic effect.
  • Example 2 Determination of venom toxicity test by combination of snailamine ethanolamine salt and avermectin
  • the field efficacy test was repeated 4 times for each treatment, and the whole plant was evenly sprayed at the peak of the pest occurrence.
  • Each treatment plot immediately took 5 points, and 10 plants were calibrated at each point.
  • the number of insect populations was investigated before application, and the number of live insects was recorded 5 days after application, and the rate of reduction of insects was calculated, that is, the control effect.
  • the test crops were investigated for signs of phytotoxicity. Determine the safety of the agent.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition insecticide ayant un effet synergique. La composition comprend deux composants actifs a et B. Le composant actif a est un niclosamide ou un sel de celui-ci. Le composant actif B est choisi parmi l'abamectine. Le rapport en poids du composant A au composant B est de 1:40 à 40:1. L'invention concerne en outre un procédé de préparation de la composition et une application de celle-ci. Les résultats d'essai montrent que la composition insecticide présente un effet synergique remarquable. De plus, la dose peut être réduite, et les coûts de prévention peuvent être diminués. La composition insecticide peut lutter efficacement contre les escargots Pomacea canaliculata et les escargots Oncomelania. La coformulation d'insecticides ayant différents mécanismes d'action et approches d'action peut réduire efficacement la dose de chaque insecticide individuel et présente de bons effets en élargissant le spectre insecticide, en réduisant la résistance des insectes aux insecticides et en améliorant l'effet de lutte, et d'autres aspects.
PCT/CN2017/091224 2016-08-15 2017-06-30 Composition insecticide ayant un effet synergique Ceased WO2018032889A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610671997.2 2016-08-15
CN201610671997.2A CN107751219A (zh) 2016-08-15 2016-08-15 具有增效作用的杀虫剂组合物

Publications (1)

Publication Number Publication Date
WO2018032889A1 true WO2018032889A1 (fr) 2018-02-22

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CN (1) CN107751219A (fr)
WO (1) WO2018032889A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN115211430A (zh) * 2021-09-07 2022-10-21 广西益才农业发展有限公司 一种高稳定性阿维菌素组合物及制剂

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CN110999915A (zh) * 2019-12-25 2020-04-14 佛山市盈辉作物科学有限公司 一种含有氯硝柳胺乙醇胺盐与阿维菌素的杀螺组合物

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ZA842571B (en) * 1983-04-07 1985-11-27 Merck & Co Inc Novel synergistic antiparasitic combinations
CN104082335A (zh) * 2014-06-22 2014-10-08 江苏辉丰农化股份有限公司 具有增效作用的杀虫杀螨剂组合物
CN104996452A (zh) * 2015-07-03 2015-10-28 天峨县科学技术情报研究所 一种含杀螺胺和噻虫啉的农药组合物
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115211430A (zh) * 2021-09-07 2022-10-21 广西益才农业发展有限公司 一种高稳定性阿维菌素组合物及制剂
CN115211430B (zh) * 2021-09-07 2024-03-29 本生(惠州)生物技术有限公司 一种高稳定性阿维菌素组合物及制剂

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