WO2018032121A1 - Electret film for treating cough caused by increased cough reflex sensitivity, and use thereof - Google Patents

Abstract

An electret film for treating cough caused by increased cough reflex sensitivity, and a use thereof. The electret film comprises a single electret film (1) and an electret film composite structure; negative charges are injected into the electret film; the surface charge density σ of the electret film is 0.5×10^-6 C/m² to 5×10^-4 C/m²; the surface potential of the electret film is greater than or equal to 200 V; polarity is negative. The electret film has the following advantages: (1) working quickly; (2) having a good curative effect; (3) being safe without side effects; (4) being simple and comfortable to use; and (5) having a structure that facilitates automatic production.

Description

Electret membrane for treating cough caused by increased cough sensitivity and use thereof Technical field

The invention belongs to the technical field of medical devices, and particularly relates to an electret film for treating cough caused by increased cough sensitivity and use thereof.

Background technique

Cough is one of the main symptoms of respiratory diseases, and it is also the defensive nerve reflex of the body. The mechanism of cough is a complex neurological process caused by substances such as foreign bodies, irritating gases, respiratory secretions, and cough receptors in the respiratory mucosa (feeling mechanical stimulation of Aδ fibers and sensing chemical stimulation of lung C fibers). Activated, the transmitted impulse is transmitted to the brainstem cough center via the vagus nerve, and then the nerves activate the corresponding muscle groups, causing cough.

According to the type of cough receptors that are stimulated, cough is mainly divided into two categories: the first type is wet cough, which is more common in infectious cough, and the amount of sputum is high. The sputum in the respiratory tract stimulates the Aδ fiber rapid adaptation receptor (rapid adaption receptor). RAR), which produces nerve impulses, passes to the cough center and produces cough, which removes sputum, which is a stressful behavior of the body and has a protective effect. The second type is dry cough, cough without sputum or less sputum, usually non-infectious cough, more common in postinfectious cough, cough variant asthma. The reason for this type of cough is that the cough reflex sensitivity (CRS) of the lung C fiber in the airway is abnormally increased due to the lesion, and it is extremely sensitive to environmental changes. For example, slight changes in temperature, taste, dust, etc. are easy to activate. , produces nerve impulses, passes to the cough center to produce cough, cough and innocent, continuous and intense, such cough mostly occurs at night, in severe cases, people can not sleep all night, very painful; this cough chest X-ray examination shows no inflammation Sexual reactions, antibiotics and antiviral drugs are not effective.

At present, the general phlegm and cough medicine is mainly used to treat cough with phlegm, and there is no therapeutic effect on cough caused by increased sensitivity to airway cough. However, the existing central and peripheral cough medicines have a poor effect on cough treatment caused by increased sensitivity to airway cough.

Summary of the invention

In view of the deficiencies of the prior art, the present invention provides an electret film for treating cough caused by increased cough sensitivity and its use, which can effectively solve the above problems.

The technical solution adopted by the present invention is as follows:

A first object of the present invention is to provide an electret film for treating cough caused by an increased cough sensitivity, wherein the electret film has a negative charge and a surface charge density σ of 0.5 × 10 ^-6 C /m ² ～5×10 ^-4 / m ² , the surface potential is ≥200V, and the polarity is negative.

Preferably, the electret material used for the electret film for treating cough caused by increased cough sensitivity includes polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyvinylidene fluoride, polyethylene, polypropylene. At least one of silicon-based silicon dioxide and silicon-based silicon nitride.

Preferably, the electret mode of the electret film for treating cough caused by increased cough sensitivity includes corona method, electric breakdown method, thermal polarization method, low energy electron beam bombardment method and triboelectric charging law.

Preferably, the electret film for treating cough caused by increased cough sensitivity comprises a single electret film or an electret film composite structure; wherein the single electret film refers to one or more resident A single-layer or multi-layer structure film made of a polar body material, which is not covered with other materials; the electret film composite structure is a composite structure in which a single electret film is covered with other materials.

Preferably, the other material comprises a plating layer, an insulating protective layer or a tape.

Preferably, the electret film composite structure comprises a single electret film, a front insulating layer, a rear insulating layer, a medical tape and a debonded paper;

The front insulating layer and the rear insulating layer are respectively disposed on the front and rear sides of the single electret film; the debonded paper is disposed on the outer side of the rear insulating layer; and the medical tape is disposed around the front insulating layer The medical tape has a rearward exposed rubber surface; the exposed rubber surface of the medical tape is attached to the debonded paper.

Preferably, the periphery of the front insulating layer is in a blocking connection with the medical tape.

Preferably, the front insulating layer and the rear insulating layer have a resistivity of not less than 10 ¹⁰ Ω·m, and the insulating layer is a material that does not have long-term storage charge properties.

A second object of the present invention is to provide the use of the above electret film for treating cough caused by increased cough sensitivity, which is a type suitable for adherence to airway cough receptor concentration The site of stimulation, the electret film that coughs by inhibiting the action potential of the cough receptor that is too sensitive.

Preferably, the site where the electret film is used is the throat or the chest.

Preferably, when a single electret film or an electret film composite structure is in use, it should be ensured that the water vaporized by the surface of the body is able to pass through a single electret film or an electret film composite structure, and the overall water The vapor transmission rate should be greater than 1000g.m ^-2 24h ^-1 .

The electret film provided by the present invention for treating cough caused by increased cough sensitivity has the following advantages:

(1) The effect rate is fast, and it can be effective immediately after being attached;

(2) Good curative effect, not only has the effect of immediate cough, but also helps the over-sensitive cough receptors to return to normal, and further strengthen the time-effectiveness of cough;

(3) Safety without side effects: no pharmaceutical ingredients, no other physiological functions of the attached parts;

(4) Simple and comfortable to use: it can be attached, and the electret film composite structure ensures the comfort of using part;

(5) Structure is conducive to automated production: The structure of the electret film composite structure caused by cough sensitivity is simple, and the layers can be automatedly produced by adhesive connection.

DRAWINGS

1 is a schematic view showing the front structure of an electret film composite structure for treating cough caused by increased cough sensitivity according to the present invention;

2 is a schematic side view showing the structure of an electret film composite structure for treating cough caused by increased cough sensitivity according to the present invention;

Among them, 1-single electret film; 2-front insulating layer; 3-medical tape; 4-back insulating layer; 5-debonded paper.

detailed description

The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The inventors made a breakthrough discovery in the research process, the cough (dry cough) caused by increased cough sensitivity, when a negatively charged electret is attached to a site where the airway receptor is concentrated (such as the throat) In the body membrane, the small current released by the electret membrane and the continuous electrostatic field can affect the transmembrane transport of K ⁺ , Ca ²⁺ and H ⁺ ions in the cough receptor cells, thereby inhibiting the excessively sensitive airway cough. The receptor produces an action potential that ultimately inhibits the production of cough and has an excellent antitussive effect on cough after infection. Moreover, this treatment is not only the temporary suppression of the nerve impulses of the hypersensitive cough receptor, but the airway site with increased cough sensitivity is often accompanied by neurogenic inflammation, such as increased vascular permeability, plasma extravasation and Tissue edema and other reactions, these reactions will stimulate the sensitivity of cough, and the electret membrane can inhibit local inflammatory reaction, promote tissue repair, and restore the sensitivity of cough receptors to normal, thus enhancing the therapeutic effect.

Accordingly, the present invention provides an electret film for treating cough caused by increased cough sensitivity, which is mainly used for treating cough and cough variant asthma after infection, and has a rapid and excellent antitussive effect on cough caused by increased cough sensitivity. The electret film for treating cough caused by increased cough sensitivity is a single electret film or electret film composite structure, and the electret film is negatively charged, and its surface charge density σ is 0.5×10 ^-6 C. /m ² ~ 5 × 10 ^-4 C / m ² , its surface potential ≥ 200V, the polarity is negative.

It should be emphasized that the above indicators not only consider the initial indicators of the product, but also consider the continuous decay of the electric potential during use. If it is an electret film composite structure, because it is partially covered by insulating layer or tape, its surface charge density and surface potential will be affected, and its size is related to its coverage area. The charge density and surface potential have taken into account this effect, so the surface charge density and surface potential indicators described above are equally applicable to the electret film composite structure.

In practical applications, as long as the electret film is a negatively charged electret film and satisfies the above parameters of surface charge density and surface potential, it has the effect of treating cough caused by increased cough sensitivity. The present invention is not limited to the electret material and the electret mode. For example, the electret material used in the electret film includes, but is not limited to, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyvinylidene fluoride, poly At least one of propylene, polyethylene, silicon-based silica, and silicon-based silicon nitride. Among them, polytetrafluoroethylene, fluorinated ethylene propylene copolymer and polyvinylidene fluoride are used to make a common electret film; and polypropylene is used to make a microfiber electret film. The electret modes employed in the electret film include, but are not limited to, corona, electrical breakdown, thermal polarization, low energy electron beam bombardment, and triboelectric charging. The electret film comprises a single electret film or an electret film composite structure; wherein the single electret film refers to a single or multi-layer structure film made of one or more electret materials, which is not covered thereon. Other materials; the electret film composite structure is a composite structure in which a single electret film is covered with other materials, for example, an electret film composite structure composed of a plating layer, a protective layer or a tape on a single electret film.

In addition, in order to make the structure of the electret film easy to be fixed on the skin and improve the comfort feeling of the user, the present invention also provides a cough electret film composite structure caused by increased cough sensitivity, which is a five-layer structure. The above-mentioned electret film, front insulating layer, rear insulating layer, medical tape and degummed paper for treating cough caused by increased cough sensitivity;

Wherein, the electret film is located and fixed by the front and rear insulating layers, and the electret film has a large amount of negative charges; the front insulating layer and the rear insulating layer are used to protect the electret film from directly contacting the outside, and the front insulating layer is surrounded by the front insulating layer. Set medical tape, medical tape can adhere to the skin, it should be emphasized that here, the medical tape only adheres to the edge portion of the front insulating layer, does not penetrate the entire front insulating layer, which is beneficial to the overall breathability, and Ensure that the entire electret film structure is soft and adheres well to the skin. It is more comfortable when it is attached to the neck of the throat. The outer layer of the back insulation layer is provided with debonded paper, and the exposed rubber surface of the medical tape is attached to the debonded paper. As a protective layer of the electret material in the storage state, both the insulating layer and the debonded paper need to be stripped during use.

The front insulating layer and the rear insulating layer have a resistivity of not less than 10 ¹⁰ Ω·m, and the insulating layer is a material which does not have long-term storage charge properties.

An electret film for treating cough caused by an increase in cough sensitivity is an electret film for sticking to the throat or chest and suppressing cough by suppressing the action potential of the airway sensitive receptor site.

The cough electret film composite structure caused by the increased sensitivity of cough provided by the invention is as follows:

(1) Use part: peel off the debonded paper and the back insulation layer during use, and stick the electret film on the front of the neck or the chest.

(2) Quantity: Generally 1 piece at a time.

(3) Onset time: It works immediately, and the effect can be felt within 1 minute. The reason is: the body itself is a conductor, the current electric field can be effective immediately, so it can be effective immediately after being attached;

(4) Use time: Generally, the duration of one piece of use is 4-8 hours;

(5) course of treatment: cough after infection is generally used for 3 days, mild once.

Note: (1) Do not use it in the presence of sweat, it will affect the effect of the product.

(2) Cough with sputum is not recommended.

It should be emphasized that the single electret film or electret film composite structure is used under the condition that the water evaporated by the body surface can pass through the single electret film or the electret film composite structure. The overall water vapor transmission rate should be greater than 1000g.m ^-2 24h ^-1 . The reason is: if water does not easily pass through the electret film and stays between the skin and the electret film, causing local high humidity, which will accelerate the loss of electret film charge and affect the product effect.

The following is a clinical trial to prove the therapeutic effect of the electret film composite structure provided by the present invention on coughing caused by increased cough sensitivity:

1, the treatment object:

A total of 120 outpatients of a Chinese medicine hospital were selected, 120 patients were diagnosed as patients with cough and cough variant asthma after infection, and 120 patients were randomly divided into treatment group and control group, 60 cases each. Among them, the treatment group included 33 females, 27 males, with an age distribution of 18 to 70 years old, and a course of treatment of 3 days. The control group included 31 females and 29 males with an age distribution of 18 to 70 years and a course of treatment of 3 days. There were no significant differences in gender, age, and condition between the two groups, which were comparable.

2, treatment

Control group: The patient was administered a commercial Suhuang Zhike Capsule, orally, 3 times a day, 3 times a day.

Treatment group: The patient adhered to the electret film composite structure in the anterior neck of the neck. Among them, the surface of the electret film was randomly charged with a negative charge, and the charge density σ was not less than 0.5×10 ^-5 C/m ² . The potential is ≥2000V and the polarity is negative.

One piece lasts for 8 hours; one day, for 3 days.

3. Efficacy criteria:

Cure: the symptoms of cough disappear;

Significant effect: the symptoms of cough basically disappeared;

Effective: Reduced cough symptoms;

Invalid: no significant improvement in cough after treatment or worsening of symptoms.

4, the results

The clinical efficacy of the two groups of patients is shown in Table 1:

Table 1

cure Significant effect effective invalid Treatment group (60) 26 twenty three 8 3 Control group (60) 7 18 17 18

As can be seen from Table 1, the cure rate (the ratio of cure and marked effect) in the treatment group was much higher than that in the control group.

The present invention provides an electret film for treating cough caused by increased cough sensitivity, and a treatment for cough caused by an increase in cough sensitivity, and is a physical therapy method for relieving cough by inhibiting an action potential of a cough receptor. Has the following advantages:

(1) The effect rate is fast, and it can be effective immediately after being attached;

(2) Good curative effect, not only has antitussive effect, but also inhibits neurogenic inflammation of airway, helps over-sensitive cough receptors to return to normal, and achieves the effect of coughing from the source to treat infection;

(3) Safe and no side effects: no pharmaceutical ingredients, and will not inhibit other physiological functions of the attached parts;

(4) Simple and comfortable to use: it can be attached, and the electret film structure ensures the comfort of using part;

(5) The structure is conducive to automated production: the electret film composite structure is simple, and the layers can be automatedly produced by adhesive connection.

The above description is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can also make several improvements and retouchings without departing from the principles of the present invention. The scope of protection of the invention should be considered.

Claims (11)

An electret film for treating cough caused by increased cough sensitivity, characterized in that the electret film is filled with a negative charge and its surface charge density σ is 0.5×10 ^-6 C/m ² ~5 × 10 ^-4 / m ² , its surface potential ≥ 200V, the polarity is negative. The electret film for treating cough caused by increased cough sensitivity according to claim 1, wherein the electret used for treating an electret film caused by cough sensitivity is increased The material includes at least one of polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyvinylidene fluoride, polyethylene, polypropylene, silicon-based silica, and silicon-based silicon nitride. The electret film for treating cough caused by an increase in cough sensitivity according to claim 1, wherein the electret method for treating an electret film caused by cough sensitivity is increased Including corona method, electric breakdown method, thermal polarization method, low energy electron beam bombardment method and triboelectric method. The electret film for treating cough caused by increased cough sensitivity according to claim 1, wherein the electret film for treating cough caused by increased cough sensitivity includes a single electret film Or an electret film composite structure; wherein the single electret film refers to a film of a single layer or a multilayer structure made of one or more electret materials, which is not covered with other materials; the electret The membrane composite structure is a composite structure in which a single electret film covers other materials. The electret film for treating cough caused by an increase in cough sensitivity according to claim 4, wherein the other material comprises a plating layer, an insulating protective layer or a tape. The electret film for treating cough caused by increased cough sensitivity according to claim 4, wherein the electret film composite structure comprises a single electret film, a front insulating layer, a rear insulating layer, Medical tape and debonded paper; The front insulating layer and the rear insulating layer are respectively disposed on the front and rear sides of the single electret film; the debonded paper is disposed on the outer side of the rear insulating layer; and the medical tape is disposed around the front insulating layer The medical tape has a rearward exposed rubber surface; the exposed rubber surface of the medical tape is attached to the debonded paper. The electret film for treating cough caused by an increase in cough sensitivity according to claim 6, wherein a periphery of the front insulating layer is adhered to the medical tape. The electret film for treating cough caused by increased cough sensitivity according to claim 6, wherein the front insulating layer and the rear insulating layer have a resistivity of not less than 10 ¹⁰ Ω·m, and The insulating layer is a material that does not have long-term storage charge properties. Use of an electret film for treating cough caused by increased cough sensitivity according to any one of claims 1-8, characterized in that the electret film is used for sticking to the airway The cough receptor concentrates a site that is susceptible to irritation, and an electret film that coughs by suppressing the action potential of the cough receptor that is too sensitive. The use of an electret film for treating cough caused by an increase in cough sensitivity according to claim 9, wherein the site where the electret film is used is a throat or a chest. The use of an electret film for treating cough caused by increased cough sensitivity according to claim 9, wherein a single electret film or an electret film composite structure is required to be covered when in use. The evaporation of water from the body surface can pass through a single electret film or electret film composite structure, and the overall water vapor transmission rate should be greater than 1000g.m ^-2 24h ^-1 .

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