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WO2018029656A3 - Methods for making and using therapeutic exosomes - Google Patents

Methods for making and using therapeutic exosomes Download PDF

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Publication number
WO2018029656A3
WO2018029656A3 PCT/IB2017/054927 IB2017054927W WO2018029656A3 WO 2018029656 A3 WO2018029656 A3 WO 2018029656A3 IB 2017054927 W IB2017054927 W IB 2017054927W WO 2018029656 A3 WO2018029656 A3 WO 2018029656A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
making
exosomes
therapeutic exosomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2017/054927
Other languages
French (fr)
Other versions
WO2018029656A2 (en
Inventor
Richard KRAIG
Aya PUSIC
Kae PUSIC
Lisa Won
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Chicago filed Critical University of Chicago
Publication of WO2018029656A2 publication Critical patent/WO2018029656A2/en
Publication of WO2018029656A3 publication Critical patent/WO2018029656A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Methods and compositions involving human exosomes or lipid nanovesicles are provided. For example, certain aspects relate to compositions comprising exosomes obtained from human cells that have been induced to undergo oxidative stress. Furthermore, some aspects of the invention provide methods of treating a subject at risk or having a demyelinating disorder using the compositions.
PCT/IB2017/054927 2016-08-12 2017-08-11 Methods for making and using therapeutic exosomes Ceased WO2018029656A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662374560P 2016-08-12 2016-08-12
US62/374,560 2016-08-12

Publications (2)

Publication Number Publication Date
WO2018029656A2 WO2018029656A2 (en) 2018-02-15
WO2018029656A3 true WO2018029656A3 (en) 2018-05-11

Family

ID=61161828

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/054927 Ceased WO2018029656A2 (en) 2016-08-12 2017-08-11 Methods for making and using therapeutic exosomes

Country Status (1)

Country Link
WO (1) WO2018029656A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108753697A (en) * 2018-06-22 2018-11-06 天津市第三中心医院 A kind of method that induced multi-potent stem cell excretion body extracts culture medium and preparation method thereof and extracts excretion body using it
CN109602766A (en) * 2019-01-25 2019-04-12 汪泱 A kind of application of the excretion body in human pluripotent stem cells source
WO2020191392A1 (en) * 2019-03-21 2020-09-24 Applied Stemcell, Inc. Exosomes containing rna with specific mutation
WO2020227369A1 (en) 2019-05-06 2020-11-12 Malcolm Thomas Tailored hypoimmune nanovesicular delivery systems for cancer tumors
CN112007012A (en) * 2019-05-31 2020-12-01 广州北斗生物科技有限公司 Preparation method of lipid microcapsule with exosome-like structure
CN114555063A (en) * 2019-06-04 2022-05-27 托马斯杰斐逊大学 Oligodendrocyte-derived extracellular vesicles for the treatment of multiple sclerosis
BR112022001338A2 (en) * 2019-07-26 2022-06-07 Mayo Found Medical Education & Res Antioxidant and antiviral compositions and methods
WO2022250880A1 (en) * 2021-05-25 2022-12-01 Malcolm Thomas Tailored hypoimmune nanovesicular delivery systems for cancer tumors, hereditary and infectious diseases
CN116077531A (en) * 2021-11-05 2023-05-09 国典(北京)医药科技有限公司 Application of exosome in preparation of products for treating cerebral apoplexy
CN115006427A (en) * 2022-05-31 2022-09-06 尧舜泽生物医药(南京)有限公司 Application of bone marrow mesenchymal stem cell exosomes in the treatment of Parkinson's disease
WO2024130249A2 (en) * 2022-12-16 2024-06-20 Washington University Compositions and methods of treatment for neuroinflammation-related disorders
CN119732924A (en) * 2024-11-25 2025-04-01 中国福利会国际和平妇幼保健院 Ovarian targeted exosome loaded with antioxidant and preparation method thereof
CN119185157B (en) * 2024-11-27 2025-03-14 广州优特佳生物科技发展有限公司 Preparation method and application of umbilical cord extract for improving and repairing hair follicle micromation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120225480A1 (en) * 2009-11-12 2012-09-06 Technion Research & Development Foundatio Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120225480A1 (en) * 2009-11-12 2012-09-06 Technion Research & Development Foundatio Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BERGER ET AL.: "Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro", PLOS ONE, vol. 4, no. 8, 14 August 2009 (2009-08-14), pages e6645-1 - 8, XP055480922, Retrieved from the Internet <URL:https://doi.org/10.1371/journal.pone.0006645> *
MERAD ET AL.: "The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting", ANNU REV IMMUNOL., vol. 31, no. 10, 2013, pages 563 - 604, XP055297703, Retrieved from the Internet <URL:doi:10.1146/annurev-immunol-020711-074950> *
PUSIC ET AL.: "IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination", J NEUROIMMUNOL, vol. 266, no. 1-2, January 2014 (2014-01-01), pages 12 - 23, XP028548198, Retrieved from the Internet <URL:doi:10.1016/j.jneuroim.2013.10.014> *

Also Published As

Publication number Publication date
WO2018029656A2 (en) 2018-02-15

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