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WO2018026942A8 - Heteromeric polypeptides - Google Patents

Heteromeric polypeptides Download PDF

Info

Publication number
WO2018026942A8
WO2018026942A8 PCT/US2017/045139 US2017045139W WO2018026942A8 WO 2018026942 A8 WO2018026942 A8 WO 2018026942A8 US 2017045139 W US2017045139 W US 2017045139W WO 2018026942 A8 WO2018026942 A8 WO 2018026942A8
Authority
WO
WIPO (PCT)
Prior art keywords
heteromeric
polypeptides
heteromeric polypeptides
variants
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/045139
Other languages
French (fr)
Other versions
WO2018026942A1 (en
Inventor
Dewald VAN DYK
Melissa GEDDIE
Neeraj Kohli
Alexey Alexandrovich Lugovskoy
Bryce Nelson
Stephen L. SAZINSKY
Sachdev S. Sidhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto
Merrimack Pharmaceuticals Inc
Original Assignee
University of Toronto
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto, Merrimack Pharmaceuticals Inc filed Critical University of Toronto
Publication of WO2018026942A1 publication Critical patent/WO2018026942A1/en
Publication of WO2018026942A8 publication Critical patent/WO2018026942A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Proteins comprising CH3 variants for generation of heteromeric polypeptides are disclosed.
PCT/US2017/045139 2016-08-02 2017-08-02 Heteromeric polypeptides Ceased WO2018026942A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662370015P 2016-08-02 2016-08-02
US62/370,015 2016-08-02

Publications (2)

Publication Number Publication Date
WO2018026942A1 WO2018026942A1 (en) 2018-02-08
WO2018026942A8 true WO2018026942A8 (en) 2018-07-12

Family

ID=61072996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/045139 Ceased WO2018026942A1 (en) 2016-08-02 2017-08-02 Heteromeric polypeptides

Country Status (1)

Country Link
WO (1) WO2018026942A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020198683A1 (en) * 2019-03-28 2020-10-01 Ab Studio Inc. Heteromultimeric proteins and methods of use thereof
IL303344A (en) 2020-12-18 2023-08-01 Antlera Therapeutics Inc Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2023250402A2 (en) 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2022170619A1 (en) * 2021-02-11 2022-08-18 Adagene Pte. Ltd. Anti-cd3 antibodies and methods of use thereof
WO2025168716A1 (en) 2024-02-07 2025-08-14 Eyebiotech Limited Compositions, doses, and methods for treatment of ocular diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2235064E (en) * 2008-01-07 2016-03-01 Amgen Inc Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
CN110066339A (en) * 2010-04-20 2019-07-30 根马布股份公司 Albumen of the FC containing heterodimeric antibodies and preparation method thereof
RU2604490C2 (en) * 2010-11-05 2016-12-10 Займворкс Инк. DESIGN OF STABLE HETERODIMERIC ANTIBODY WITH MUTATIONS IN Fc DOMAIN
DK2927321T3 (en) * 2012-11-27 2021-03-15 Univ Ajou Ind Academic Coop Found CH3 DOMAIN VARIANT PAIRS INDUCING HEAVY CHAIN HETERODIMES CONSTANT REGION OF HIGH EFFICIENCY ANTIBODY, METHOD OF PREPARING THE SAME, AND USING IT

Also Published As

Publication number Publication date
WO2018026942A1 (en) 2018-02-08

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