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WO2018018352A1 - Procédé et dispositif d'affichage, de positionnement et de démarcation synchrones pour des images à contrastes multiples - Google Patents

Procédé et dispositif d'affichage, de positionnement et de démarcation synchrones pour des images à contrastes multiples Download PDF

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Publication number
WO2018018352A1
WO2018018352A1 PCT/CN2016/091525 CN2016091525W WO2018018352A1 WO 2018018352 A1 WO2018018352 A1 WO 2018018352A1 CN 2016091525 W CN2016091525 W CN 2016091525W WO 2018018352 A1 WO2018018352 A1 WO 2018018352A1
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Prior art keywords
window
image
contrast images
window image
images
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English (en)
Chinese (zh)
Inventor
朱艳春
付楠
张志诚
余绍德
陈昳丽
谢耀钦
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to PCT/CN2016/091525 priority Critical patent/WO2018018352A1/fr
Publication of WO2018018352A1 publication Critical patent/WO2018018352A1/fr
Anticipated expiration legal-status Critical
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis

Definitions

  • the invention relates to the technical field of medical clinical imaging, in particular to a method and a device for synchronous display and positioning calibration of multi-contrast images.
  • CT Computed Tomography
  • MRI Magnetic Resonance Imaging
  • US Ultrasound
  • PET Positron Emission Computed Tomography
  • DICOM Digital Imaging and Communication in Medicine
  • the embodiment of the invention provides a multi-contrast image synchronous display and positioning calibration method for synchronously displaying multiple contrast images and synchronously positioning calibration position information in multiple windows, the method comprising:
  • the window of the real mouse pointer is used as the target window, and the corresponding position on the other window image is calculated according to the position of the mouse pointer on the image of the target window and the position comparison result on the plurality of contrast images, and the virtual mouse pointer is displayed at the position.
  • scanning position information extraction and comparison calculation are performed on the plurality of contrast images, including extracting scan slice position information of the plurality of contrast images and position information in the scan layer, and performing comparison calculation deviation.
  • the plurality of contrast images are displayed in a window-by-window manner according to a position comparison result on the plurality of contrast images, including:
  • the position alignment result on the plurality of contrast images indicates that the scanning slice position information of the plurality of contrast images is different, the scanning layer thickness of the other window images according to the scanning layer number of the target window image and the scanning layer thickness, and The other window images are deviated from the scanning position of the target window image, and the adjacent layers of the other window images are searched for and displayed simultaneously.
  • the adjacent layers of other window images are searched for and displayed synchronously as follows:
  • N X Round [( ⁇ Z X + M ⁇ S) / S X ];
  • N X is the adjacent layer of the other window image
  • ⁇ Z X is the scanning position deviation of the other window image and the target window image
  • M is the scanning layer number of the target window image
  • S is the scanning layer thickness of the target window image
  • S X is Scanning layer thickness of other window images
  • Round[] indicates rounding calculation.
  • calculating a corresponding position on the other window image and displaying the virtual mouse pointer at the position according to the position of the mouse pointer on the target window image and the position comparison result on the plurality of contrast images including:
  • the position comparison result on the plurality of contrast images indicates that the position information in the scanning layer of the plurality of contrast images is different, according to the position of the mouse pointer on the target window image, and the intra-layer position deviation of the other window image and the target window image , calculate the corresponding position on the other window image and display the virtual mouse pointer at that position.
  • the corresponding position on the other window image is calculated and the virtual mouse pointer is displayed at the position as follows:
  • (X 1 , Y 1 ) is the corresponding position on the other window image
  • (X, Y) is the position of the mouse pointer on the target window image
  • ( ⁇ X 1 , ⁇ Y 1 ) is the intra-layer position of the other window image and the target window image. deviation.
  • the method further includes:
  • the result of the operation is synchronized in the other windows according to the operation of the mouse pointer on the target window image.
  • the embodiment of the invention further provides a device for synchronous display and positioning calibration of a multi-contrast image, which is used for synchronously displaying a plurality of contrast images and synchronously positioning calibration position information in a plurality of windows, the device comprising:
  • An image obtaining module configured to obtain a plurality of contrast images of the same part of the living body
  • a position comparison module configured to perform scanning position information extraction and comparison calculation on the plurality of contrast images
  • An image display module configured to perform window-by-window synchronization display on the plurality of contrast images according to a position comparison result on the plurality of contrast images
  • a positioning calibration module configured to use a window of the real mouse pointer as a target window, and calculate a corresponding position on the other window image according to the position of the mouse pointer on the target window image and the position comparison result on the plurality of contrast images, and display the position on the other window image Virtual mouse pointer.
  • the position comparison module is further configured to: extract scan slice position information of the plurality of contrast images and position information within the scan layer, and perform a comparison calculation deviation.
  • the image display module is further configured to:
  • the position alignment result on the plurality of contrast images indicates that the scanning slice position information of the plurality of contrast images is different, the scanning layer thickness of the other window images according to the scanning layer number of the target window image and the scanning layer thickness, and The other window images are deviated from the scanning position of the target window image, and the adjacent layers of the other window images are searched for and displayed simultaneously.
  • the image display module is further configured to find adjacent layers of other window images and display them synchronously according to the following formula:
  • N X Round [( ⁇ Z X + M ⁇ S) / S X ];
  • N X is the adjacent layer of the other window image
  • ⁇ Z X is the scanning position deviation of the other window image and the target window image
  • M is the scanning layer number of the target window image
  • S is the scanning layer thickness of the target window image
  • S X is Scanning layer thickness of other window images
  • Round[] indicates rounding calculation.
  • the positioning calibration module is further configured to:
  • the position comparison result on the plurality of contrast images indicates that the position information in the scanning layer of the plurality of contrast images is different, according to the position of the mouse pointer on the target window image, and the intra-layer position deviation of the other window image and the target window image , calculate the corresponding position on the other window image and display the virtual mouse pointer at that position.
  • the positioning calibration module is further configured to calculate a corresponding position on the other window image and display the virtual mouse pointer at the position according to the following formula:
  • (X 1 , Y 1 ) is the corresponding position on the other window image
  • (X, Y) is the position of the mouse pointer on the target window image
  • ( ⁇ X 1 , ⁇ Y 1 ) is the intra-layer position of the other window image and the target window image. deviation.
  • the apparatus further comprises:
  • the operation synchronization module is configured to synchronously display the operation result in other windows according to the operation of the mouse pointer on the target window image.
  • the plurality of contrast images are displayed in a window according to the position comparison result on the plurality of contrast images, thereby avoiding switching between the plurality of contrast images or displaying by using multiple screens;
  • the position of the mouse pointer on the image of the target window and the position comparison result on the plurality of contrast images the corresponding position on the other window image is calculated and the virtual mouse pointer is displayed at the position, thereby preventing the doctor from comparing with the naked eye or manually selecting the same image.
  • the position is compared; the implementation of the embodiment of the present invention is simple and efficient, and the accurate comparison can be easily realized. Even the comparison of high-resolution images does not add extra difficulty to the doctor.
  • FIG. 1 is a schematic diagram of a method for synchronous display and positioning calibration of multi-contrast images according to an embodiment of the present invention
  • FIG. 2 is a specific example diagram of multi-contrast image synchronous display and positioning calibration according to an embodiment of the present invention
  • FIG. 3 is a schematic diagram showing multi-window display of different data sources without scanning position deviation according to an embodiment of the present invention
  • FIG. 4 is a schematic diagram showing multi-window display of a layer deviation image source in an embodiment of the present invention.
  • FIG. 5 is a schematic diagram of calculation of a display layer when there is a layer deviation according to an embodiment of the present invention
  • FIG. 6 is a schematic diagram showing synchronous positioning display of each window when there is a positional deviation in a layer according to an embodiment of the present invention
  • FIG. 7 is a schematic diagram of synchronization operations of windows in an embodiment of the present invention.
  • FIG. 8 is a schematic diagram of an apparatus for synchronous display and positioning calibration of multi-contrast images according to an embodiment of the present invention
  • FIG. 9 is a view showing a specific example of an apparatus for synchronous display and positioning calibration of multi-contrast images according to an embodiment of the present invention.
  • the method may include:
  • Step 101 Obtain a plurality of contrast images of the same part of the living body
  • Step 102 Perform scanning position information extraction and comparison calculation on the plurality of contrast images
  • Step 103 Perform synchronous display of the plurality of contrast images according to position comparison results on the plurality of contrast images
  • Step 104 The window of the real mouse pointer is used as the target window, and according to the position of the mouse pointer on the image of the target window and the position comparison result on the plurality of contrast images, the corresponding position on the other window image is calculated and the virtual mouse pointer is displayed at the position. .
  • a plurality of contrast images of the same part of the living body are obtained first.
  • a variety of contrast images can be obtained by clinical imaging techniques, and can be a variety of scanning methods from an imaging modality, such as magnetic resonance imaging (MRI) transverse relaxation time weighted images (T2WI) and longitudinal relaxation time weighted images ( T1WI); can also be several sets of images from different imaging modalities, such as magnetic resonance images and positron emission computed tomography (PET).
  • Multi-contrast images can also be referred to as multi-image data sources. As shown in FIG. 2, each contrast image is used as an image source, and each image source can be unified into the same format, such as DICOM format, and the number of image sources can be increased or decreased according to clinical diagnosis needs.
  • the medical image in DICOM format contains a sweep
  • the scanning position information of the DICOM image of different image data sources needs to be extracted and compared.
  • the scan location information can include a variety of information related to the scan location.
  • performing scan position information extraction and comparison calculation on a plurality of contrast images may include extracting scan slice position information of a plurality of contrast images and position information within the scan layer, and performing a comparison calculation deviation.
  • the scanning plane position information may include a scanning layer number and a scanning layer thickness.
  • the medical image in DICOM format contains all the information such as image acquisition, archiving, communication, display and query.
  • the DICOM file of each image source is first read, and the image scanning position information is preprocessed.
  • the scanning position information of each image source is the same, for example, various scanning protocols in magnetic resonance imaging are used.
  • the same positioning parameter, or multi-modal imaging (such as PET / MRI) simultaneous scanning, etc. at this time the multi-data source has the same scanning plane position information and position information within the scanning layer.
  • pre-processing it is checked whether the multi-data source has the scanning position deviation in the X, Y or Z direction.
  • the obtained image source can be directly imported into each window for comparison display.
  • the number of windows can be determined by the number of data sources, which can be automatically optimized for adjustment on the display according to the number of windows.
  • 3 is a schematic diagram showing multi-window display of different data sources without scanning position deviation according to an embodiment of the present invention. As shown in FIG. 3, three kinds of contrast image sources are displayed layer by layer in three image display windows, and image sources displayed by each window are respectively displayed. In the same position, only the image contrast of each image source is different.
  • each image source has a positional deviation
  • the positional deviation may be in the layer direction, that is, the Z direction, or may be the positional deviation inside the layer, that is, the X, Y direction.
  • registration calculations are required for each data source, and the positional deviation of each data source is calculated.
  • This positional deviation includes the stiffness deviations in the three directions of X, Y, and Z, which are well known to those skilled in the art.
  • the calculation of the positional deviation can be implemented by a corresponding algorithm.
  • the plurality of contrast images are displayed in a window according to the position comparison result on the plurality of contrast images, including: if the position comparison result on the plurality of contrast images indicates that the scanning plane position information of the plurality of contrast images is different, According to the scanning layer number of the target window image and the scanning layer thickness, the scanning layer thickness of other window images, and the scanning positions of other window images and the target window image are deviated, and the adjacent layers of other window images are searched for and displayed simultaneously.
  • FIG. 4 is a schematic diagram showing multi-window display with a layer deviation image source in an embodiment of the present invention.
  • the target window can be any window, depending on where the real mouse pointer is located.
  • the target window is fixed, as shown in Figure 4, and the second window is defined as the target window.
  • the second picture is illustrated as a target window in FIG. 3-7, and any window may be selected as the target window in the actual application.
  • N X Round [( ⁇ Z X + M ⁇ S) / S X ];
  • N X is the adjacent layer of the other window image
  • ⁇ Z X is the scanning position deviation of the other window image and the target window image
  • M is the scanning layer number of the target window image
  • S is the scanning layer thickness of the target window image
  • S X is Scanning layer thickness of other window images
  • Round[] indicates rounding calculation.
  • FIG. 5 is a schematic diagram of calculation of a display level when there is a layer deviation according to an embodiment of the present invention. As shown in FIG. 5, when the target window stays at the Mth level, the remaining windows 1 and 2 respectively stay at the level closest to the target window, that is, : Round [( ⁇ Z 1 + M ⁇ S 2 ) / S 1 ] and Round [( ⁇ Z 2 + M ⁇ S 2 ) / S 3 ].
  • the corresponding position on the other window image is calculated according to the position of the mouse pointer on the target window image and the position comparison result on the plurality of contrast images, and the virtual mouse pointer is displayed at the position.
  • the mouse pointers are all in the same position.
  • the position comparison result on the plurality of contrast images indicates that the position information in the scanning layer of the plurality of contrast images is different, according to the position of the mouse pointer on the target window image, and the layers of the other window image and the target window image.
  • the internal position deviation calculates the corresponding position on the other window image and displays the virtual mouse pointer at that position.
  • 6 is a schematic diagram showing synchronous positioning display of each window when there is a positional deviation in a layer according to an embodiment of the present invention. As shown in FIG. 6, when the position deviation of each data source appears inside the layer, that is, in the X, Y direction, according to the target window. The position where the mouse pointer stays, and the position of the remaining window pointers is calculated.
  • the corresponding position on the other window image can be calculated according to the following formula and the virtual mouse pointer is displayed at the position:
  • (X 1 , Y 1 ) is the corresponding position on the other window image
  • (X, Y) is the position of the mouse pointer on the target window image
  • ( ⁇ X 1 , ⁇ Y 1 ) is the intra-layer position of the other window image and the target window image. deviation.
  • the positional deviations of the remaining window and the image source of the target window are ( ⁇ X 1 , ⁇ Y 1 ) and ( ⁇ X 2 , ⁇ Y 2 ), respectively.
  • the mouse pointer of the window stays at the (X a , Y b ) position
  • the mouse pointer corresponding to the image of the remaining window 1 stays at (X a + ⁇ X 1 , Y a + ⁇ Y 1 )
  • the mouse pointer corresponding to the image of the remaining window 2 Stay at the position of (X a + ⁇ X 2 , Y a + ⁇ Y 2 ).
  • the corresponding mouse pointer when the real mouse pointer appears in a certain window (ie, the target window), the corresponding mouse pointer also appears in the remaining windows.
  • the mouse pointer is a virtual mouse pointer, and can also be defined as the remaining pointers.
  • the position of the image data source pointed by the mouse pointer of each sub-window is consistent.
  • the display of multiple data source images is synchronized and positional calibration can be performed simultaneously.
  • the remaining window images are automatically synchronized according to the position of the target window image, and the multi-data source image synchronization comparison display is realized.
  • the real mouse pointer stays in the data source of the target window, the mouse pointer appears in the same image position in the remaining windows.
  • the method of the embodiment of the present invention may further include: synchronously displaying the operation result in the other windows according to the operation performed by the mouse pointer on the target window image.
  • the rest of the windows will also be synchronized.
  • the remaining windows also perform corresponding actions.
  • the other windows also perform the same action response at the corresponding position.
  • FIG. 7 is a schematic diagram of synchronization operations of windows in an embodiment of the present invention. As shown in Fig.
  • each window data source when performing various operations on the target window image, such as delineating the region of interest, measuring the signal mean and variance of the region of interest, the remaining windows are also operated at the same position, and each image source has a position. In the case of deviation, the operation is performed on the basis of the positional deviation.
  • This can provide synchronization of each window data source, not only can synchronous page turning, but also can accurately synchronize the positioning of different window tissues, so that doctors can compare the performance of each image source corresponding to the same tissue position.
  • an apparatus for synchronous display and positioning calibration of multi-contrast images is also provided in the embodiment of the present invention, as described in the following embodiments. Since the principle of solving the problem of the device is similar to the method of multi-contrast image synchronous display and positioning calibration, the implementation of the device can be referred to the implementation of the multi-contrast image synchronous display and the positioning calibration method, and the repeated description will not be repeated.
  • FIG. 8 is a schematic diagram of an apparatus for synchronous display and positioning calibration of multi-contrast images according to an embodiment of the present invention.
  • the device can realize synchronous display and synchronous position calibration of the same position, multiple contrast images.
  • the apparatus may include:
  • the image obtaining module 801 is configured to obtain a plurality of contrast images of the same part of the living body
  • a position comparison module 802 configured to perform scanning position information extraction and comparison calculation on the plurality of contrast images
  • the image display module 803 is configured to perform the window-by-window synchronous display on the plurality of contrast images according to the position comparison result on the plurality of contrast images;
  • the positioning calibration module 804 is configured to use a window where the real mouse pointer is located as a target window, and calculate a corresponding position on the other window image according to the position of the mouse pointer on the target window image and the position comparison result on the plurality of contrast images. Display a virtual mouse pointer.
  • the location comparison module 802 may be further configured to: extract scan slice location information of the plurality of contrast images and position information within the scan layer, and perform a comparison calculation deviation.
  • the image display module 803 can be further configured to:
  • the position alignment result on the plurality of contrast images indicates that the scanning slice position information of the plurality of contrast images is different, the scanning layer thickness of the other window images according to the scanning layer number of the target window image and the scanning layer thickness, and The other window images are deviated from the scanning position of the target window image, and the adjacent layers of the other window images are searched for and displayed simultaneously.
  • the image display module 803 can be further configured to find adjacent layers of other window images and display them synchronously according to the following formula:
  • N X Round [( ⁇ Z X + M ⁇ S) / S X];
  • N X is the adjacent layer of the other window image
  • ⁇ Z X is the scanning position deviation of the other window image and the target window image
  • M is the scanning layer number of the target window image
  • S is the scanning layer thickness of the target window image
  • S X is Scanning layer thickness of other window images
  • Round[] indicates rounding calculation.
  • the positioning calibration module 804 can be further used to:
  • the position comparison result on the plurality of contrast images indicates that the position information in the scanning layer of the plurality of contrast images is different, according to the position of the mouse pointer on the target window image, and the intra-layer position deviation of the other window image and the target window image , calculate the corresponding position on the other window image and display the virtual mouse pointer at that position.
  • the positioning calibration module 804 can be further configured to calculate a corresponding position on the other window image according to the following formula and display the virtual mouse pointer at the position:
  • (X 1 , Y 1 ) is the corresponding position on the other window image
  • (X, Y) is the position of the mouse pointer on the target window image
  • ( ⁇ X 1 , ⁇ Y 1 ) is the intra-layer position of the other window image and the target window image. deviation.
  • FIG. 9 is a view showing a specific example of an apparatus for synchronous display and positioning calibration of multi-contrast images according to an embodiment of the present invention. As shown in FIG. 9, in this example, the apparatus shown in FIG. 8 may further include:
  • the operation synchronization module 901 is configured to synchronously display the operation result in the other windows according to the operation performed by the mouse pointer on the target window image.
  • multiple contrast images are displayed in a window according to position comparison results on multiple contrast images, thereby avoiding switching between multiple contrast images or displaying through multiple screens;
  • the embodiment of the present invention according to the position of the mouse pointer on the target window image and the position comparison result on the plurality of contrast images, the corresponding position on the other window image is calculated and the virtual mouse pointer is displayed at the position, thereby preventing the doctor from comparing with the naked eye, or Manually selecting the same position of each image for comparison;
  • the embodiment of the present invention is simple and efficient in implementation, and can accurately achieve accurate comparison, even if the contrast of high-resolution images does not add extra difficulty to the doctor.
  • embodiment of the present invention further provides synchronization of each window data source, which not only can synchronously turn pages, but also accurately synchronize the organization positions of different windows, so that the doctor can compare the performances in the image sources corresponding to the same tissue position.
  • embodiments of the present invention provide a solution that facilitates multi-window diagnostics, comparison, and measurement.
  • embodiments of the present invention can be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment, or a combination of software and hardware. Moreover, the invention can take the form of a computer program product embodied on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) including computer usable program code.
  • computer-usable storage media including but not limited to disk storage, CD-ROM, optical storage, etc.
  • the computer program instructions can also be stored in a computer readable memory that can direct a computer or other programmable data processing device to operate in a particular manner, such that the instructions stored in the computer readable memory produce an article of manufacture comprising the instruction device.
  • the apparatus implements the functions specified in one or more blocks of a flow or a flow and/or block diagram of the flowchart.
  • These computer program instructions can also be loaded onto a computer or other programmable data processing device such that a series of operational steps are performed on a computer or other programmable device to produce computer-implemented processing for execution on a computer or other programmable device.
  • the instructions provide steps for implementing the functions specified in one or more of the flow or in a block or blocks of a flow diagram.

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Abstract

L'invention concerne un procédé et un dispositif d'affichage, de positionnement et de démarcation synchrones pour des images à contrastes multiples. Le procédé consiste à : obtenir des images à contrastes multiples de la même partie d'un corps vivant; effectuer une extraction d'informations de position de balayage et un calcul comparatif sur les images à contrastes multiples; en fonction d'un résultat de comparaison de position des images à contrastes multiples, à afficher de manière synchrone les images à contrastes multiples dans des fenêtres de séparation; et à prendre une fenêtre dans laquelle un pointeur de souris réel est situé en tant que fenêtre cible, calculer les positions correspondantes sur les autres images de fenêtre selon la position d'un pointeur de souris sur une image de fenêtre cible et un résultat de comparaison de position des images à contrastes multiples, et à afficher un pointeur de souris virtuel en position. Le procédé peut réaliser un affichage synchrone d'images à contrastes multiples dans de multiples fenêtres et un positionnement et une démarcation synchrones d'informations de position.
PCT/CN2016/091525 2016-07-25 2016-07-25 Procédé et dispositif d'affichage, de positionnement et de démarcation synchrones pour des images à contrastes multiples Ceased WO2018018352A1 (fr)

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