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WO2018083112A1 - Dispositif d'exécution de mesures de la composition chimique de l'œil antérieur ainsi qu'une unité optique intégrée pour sa mise en œuvre - Google Patents

Dispositif d'exécution de mesures de la composition chimique de l'œil antérieur ainsi qu'une unité optique intégrée pour sa mise en œuvre Download PDF

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Publication number
WO2018083112A1
WO2018083112A1 PCT/EP2017/077952 EP2017077952W WO2018083112A1 WO 2018083112 A1 WO2018083112 A1 WO 2018083112A1 EP 2017077952 W EP2017077952 W EP 2017077952W WO 2018083112 A1 WO2018083112 A1 WO 2018083112A1
Authority
WO
WIPO (PCT)
Prior art keywords
eye
mirror
light
mirror element
light beam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/077952
Other languages
English (en)
Inventor
Shuo ZHANG
Toussaint Theresia Johannes Maria Berendschot
Roel Johan ERCKENS
Franciscus Hermanus Maria Jongsma
John DE BRABANDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Original Assignee
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Maastricht, Academisch Ziekenhuis Maastricht filed Critical Universiteit Maastricht
Publication of WO2018083112A1 publication Critical patent/WO2018083112A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6821—Eye

Definitions

  • Device for performing measurements of the chemical composition of the anterior eye as well as an integrated optical unit for implementation therein.
  • the invention relates to device for determining the chemical composition of a living eye
  • light emitting means for emitting a light beam
  • light guidance means having an entrance surface and an exit surface and arranged to be brought in optical contact with the eye for directing said light beam being emitted towards the eye, such that at least part of the eye is being illuminated with a light beam having an oblique angle of incidence with respect to the visual axis of the eye and for receiving and guiding at least a fraction of the light beam leaving the eye as a result of said illumination towards light detecting means for determining the chemical composition of said eye by analyzing said fraction of light.
  • the invention also relates to an integrated optical unit for implementation in such a device for performing measurements of the chemical composition of the anterior eye.
  • tissue measurements involve the measurement of the transparent media of the eye, as is applied, for example, in ophthalmology where proteins, pharmacological substances, or other molecules in aqueous humor are determined, wherein the presence of these substances provide an indication of the quality of the eye and sometimes information concerning underlying diseases.
  • Raman spectroscopy offers an opportunity to detect molecules qualitative as well quantitative and is a valuable tool to investigate biological materials in aqueous environments.
  • a light beam is focused in the tissue of interest and the back scattered light comprising the Raman signals is gathered, e.g. in a confocal device, and analyzed in a spectrometer.
  • WO2004/098397 discloses such an in vivo application of Raman spectroscopy, wherein an oblique illumination with respect to the visual axis of the eye of the anterior chamber of the eye is effectuated in such a way that the incident light beam is not aimed at the retinal tissue.
  • a focusing lens with a curvature conformal to the wave front of the light beam leaving the lens is implemented with the aim of avoiding directing or aiming light at fragile, retinal tissue, and thus limiting radiation damage.
  • optical solution suffers from the drawback of chromatic aberration.
  • the focusing lens causes different wavelengths of light beam to have different focal lengths at or in the part of the eye to be illuminated, resulting in a distorted back scattered light beam being reflected back from said illuminated part of the eye.
  • said distorted reflected light beam contains insufficient and incorrect Raman signals, which do not provide qualitative as well quantitative information as to the presence and composition of biological materials in the aqueous environment of the anterior chamber of the eye.
  • the present invention aims to provide a solution to the above problems, and to provide a more accurate device for the noninvasive measurement of qualitative as well quantitative information as to the presence and composition of biological materials in the aqueous environment of the anterior chamber of the eye.
  • said light guidance means comprises a system of at least a first mirror element, a second mirror element and a third mirror element, at least one of said three mirror elements having a non-planar mirror surface.
  • the first mirror element seen in the direction of propagation of said light beam being emitted from the light emitting means through the light guidance means towards the eye, is the mirror element having a non- planar mirror surface.
  • a proper reflection of the light beam entering the light guidance means is obtained towards the part of the eye to be illuminated wherein a maximum part of the entering light beam reaches said part of the eye.
  • Raman signals thus provide more (in terms of quality as well as quantity) information for analysis and diagnosis.
  • Said first mirror element having a non-planar mirror surface can be a convex mirror element or a spherical convex mirror element.
  • said convex mirror is an aspherical convex mirror, which may exhibit a sag z following the expression:
  • c is the curvature of the mirror surface
  • r is the radial coordinate (in mm)
  • k is the conic constant
  • k -1
  • c 1
  • the second mirror element seen in the direction of propagation of said light beam being emitted from the light emitting means through the light guidance means towards the eye, is the mirror element having a non- planar mirror surface. Also with this embodiment similar improved results are obtained with regard to the maximum part of the light beam illuminating the part of the eye to be examined, and a significant backscatter part of light being reflected back from the eye with Raman signals thus providing more (in terms of quality as well as quantity) information for analysis and diagnosis.
  • c is the curvature of the mirror surface
  • r is the radial coordinate (in mm)
  • k is the conic constant
  • a is the semi major axis of the elliptical mirror surface (in mm)
  • b is the semi minor axis of the elliptical mirror surface (in mm).
  • the other mirror elements of said system of at least three mirror elements are planar mirrors.
  • the light beam which enters the light guidance means is only reflected via a system of mirror elements prior to entering and illuminating a part (the anterior chamber) of the eye. No distortion as with a system of lenses takes place, and from the resulting backscatter light beam with Raman signals more (in terms of quality as well as quantity) information for analysis and diagnosis can be obtained.
  • planar third mirror element is positioned directly near the eye for reflecting said light beam having an oblique angle of incidence with respect to the visual axis of the eye.
  • system of at least three mirror elements is rotational symmetric with respect to the visual axis of the eye simplifying the handling and operation of the device by a physician when performing Rama spectroscopy on an eye.
  • the light guidance means may comprise a collimating lens positioned before the first mirror element, seen in the direction of propagation of said light beam being emitted from the light emitting means through the light guidance means towards the eye.
  • said light guidance means consisting of said system of at least the first mirror element, the second mirror element and the third mirror element and optionally said collimating lens are constructed as an integrated optical unit. This also improves handling and operation of the device.
  • said light emitting means comprise a laser device, resulting in an parallel light beam when entering the light guidance means.
  • the invention also relates to an integrated optical unit for implementation in a device for performing measurements of the chemical composition of the anterior eye, wherein said integrated optical unit is functioning as light guidance means comprising an assembly of at least a first mirror element, a second mirror element and a third mirror element according to the invention.
  • Figure 1 a schematic view of an embodiment of a device according to the invention
  • Figure 2 an embodiment of light guidance means for implementation in a device for performing measurements of the chemical composition of the anterior eye according to the invention
  • FIGS 3a-3c side views from the embodiment of Figure 2;
  • Figures 4 another embodiment of light guidance means for implementation in a device for performing measurements of the chemical composition of the anterior eye according to the invention
  • Figures 6a-6g detailed views of an embodiment of the invention constituted as an integrated optical unit consisting of an assembly of mirror elements
  • Figure 7 a schematic view of another embodiment of a device according to the invention. DETAILED DESCRIPTION OF THE FIGURES
  • the present invention has three functions: focusing of a beam of excitation light in the eye in such a way that no direct light hits the retinal tissue, to preserve the optical quality of the excitation beam as is provided by the collection lens, and to collect, with a high aperture, the in the eye scattered light.
  • FIG. 1 A first embodiment of a device in which the present invention can be used is shown in Figure 1 in a schematic manner and not to scale.
  • the device denoted with numeral 1 of Figure 1 has light emitting means 5, e.g. a laser device, that emits an collimated and coherent laser beam 20.
  • the laser or light beam 20 has a constant or nearly constant diameter with a minimal divergence as it propagates through the device along it's optical path.
  • Light beam 20 passes a dichroic beam-splitting mirror 7 and enters light guidance means 10.
  • Light guidance means 10 are depicted in Figure 1 in a schematic manner as a box, but are composed of a system of at least three mirror element s, as it will be explained in more detail with reference to the Figures 2-5.
  • the light guidance means 10 are manufactured as an integrated optical unit with the three mirrors incorporated and assembled together.
  • Coherent laser or light beam 20 enters the light guidance means 10 via an entrance face 10a, propagates through the system of at least three mirror element s and leaves the light guidance means 10 via the exit face 10b before it enters and illuminates part of the eye 50 of a human or animal being for diagnosis purposes.
  • the exit face 10b of the light guidance means 10 is formed/shaped as to be placed against the eye ball with a minimum of discomfort, and usually a film of contact fluid is present between the exit face 10 and the eye 50.
  • the light guidance means 10 and in particular the system of at least three mirrors divert the light beam 20 from the visual axis 10' (see Figure 2) such that an oblique illumination with respect to the visual axis of the eye 50 of the anterior chamber of the eye 50 is effectuated in such a way that the incident light beam 20 is not aimed at the retinal tissue.
  • the impinging light beam 20 is back scattered, said back scattered light comprising the Raman signals.
  • Said Raman signals are representative to the qualitative as well quantitative information pertaining to the presence and composition of biological materials in the aqueous environment of the anterior chamber of the eye 50.
  • Said back scattered light will follow the same optical path through the light guidance means 10 in the direction of the dichroic beam-splitting mirror 7, where the back scattered light, now denoted with reference numeral 20' is collected and reflected to light detection means 6, where it is analyzed.
  • Said light detecting means 6 may comprise a spectrometer with a sensor, such as a charge coupled device (CCD) or such as a photo multiplier.
  • CCD charge coupled device
  • the light detection means 6 are not part of the light emitting means 5.
  • both the light detection means 6 and the light emitting means 5 can be incorporated in one construction device, thereby obviating the mirror 7.
  • FIG. 2 and Figure 3a-3b-3c disclose a first embodiment of the light guidance means 10 according to the invention.
  • the light guidance means 10 are constructed preferably as an integrated optical unit which is rotational symmetric around an axis, in the Figures represented as and coinciding with the visual axis 10' of the eye 50.
  • the invention relates to Raman spectroscopy wherein light is directed into a part of the eye, in particular the anterior chamber 52.
  • light is entering the anterior chamber 52 of the eye 50 at an oblique angle of incidence with respect of the axis 10' of the eye 50.
  • fragile tissue such as the eye lens 53, the vitreous humour 54, the retina 55 or the optical nerve 56.
  • the integrated optical unit forming the light guidance means 10 exhibit an entrance face 10a and an exit face 10b/131 .
  • the exit face 10b/131 is formed or shaped conformal to the curvature of the eye ball 51 of the eye 50 allowing a proper optical contact with the eye and to minimize any discomfort for the human or animal being under examination.
  • the light guidance means 10 comprise an assembly or a system of at least three mirror elements denoted with reference numerals 1 1 , 12 and 13.
  • the three mirror elements 1 1 , 12 and 13 are accommodated in and more in particular assembled together as the integrated optical unit 10.
  • the first mirror element 1 1 , the second mirror element 12, and the third mirror element 13 are positioned such that the light beam 20 follows a propagation path, such that it is reflected in a sequential order via the first, second and third mirror elements 1 1 , 12, 13 before it enters the part of the eye 50 to be illuminated, in particular the anterior chamber 52.
  • At least one mirror of said system of three mirror elements 1 1 , 12, 13 exhibits a non-planar reflection surface.
  • it is the first mirror element 1 1 seen in the direction of propagation of the light beam 20 that exhibits said non-planar reflection surface 1 1 a.
  • the other two mirror elements 12-13 of said optical system of mirrors have a planar reflection surface denoted with reference numerals 12a and 13a respectively.
  • a collimated and coherent laser beam 20 is directed parallel to the optical axis 10' of the eye 50 (which also corresponds with the rotational symmetric axis of the light guidance means 10) and impinges on the non-planar reflection surface 1 1 a of the first mirror 1 1.
  • Light beams 20a are reflected from said first mirror 1 1 and impinge on the planar mirror surface 12a of the second mirror 12.
  • Light beams 20b being reflected from the planar mirror surface 12a of the second mirror 12 enters the (forward) entrance surface 13b of the third mirror 13 and are subsequently reflected at the planar mirror surface 13a at the back side of the third mirror 13 (seen in the direction of propagation of the light beams 20b).
  • the non-planar mirror surface 1 1 a of the first mirror element 1 1 is preferably a convex mirror or a spherical convex mirror.
  • said convex mirror exhibits an aspherical convex mirror surface which may exhibit a sag z following the expression:
  • c is the curvature of the non-planar mirror surface 1 1 a
  • r is the radial coordinate relative to the optical axis 10'
  • k is the conic constant.
  • the light beam 20 entering the light guiding means 10 via the entrance surface 10a is only reflected.
  • a maximum part of the light beam entering the light guidance means 10 can reach the part of the eye of interest, in particular the anterior chamber of the eye.
  • a larger amount of light entering the anterior chamber of the eye will generate a more significant backscatter part of light, that is being reflected back from the eye with Raman signals towards the light detection means 6 (see Figure 1 ).
  • this integrated optical unit provides more information for analysis and diagnosis of the presence and composition of biological materials in the aqueous environment of the anterior chamber of the eye, both in terms of quality as well as in quantity.
  • the second mirror 12 forms an open annulus through which the light beam 20 can enter via entrance face 10a in the direction of the reflective mirror surface 1 1 a of the first mirror 1 1 .
  • the first mirror 1 1 is positioned between the second mirror 12 which is orientated parallel with the entrance surface 10a of the light guidance means 10, and the third mirror 13 which forms the exit surface 10b/131 of the light guidance means 10.
  • the light guidance means are depicted with reference numeral 100.
  • the light guidance means 100 can be constructed as an integrated optical unit which is rotational symmetric around the optical axis 100'.
  • first mirror 1 1 and the third mirror 13 are planar mirrors, whereas the second mirror 12 has a non-planar mirror surface 12a.
  • non-planar mirror surface 12a of the mirror 12 has a concave mirror surface and more in particular an elliptical concave mirror exhibiting a sag z following the expressions:
  • c is the curvature of the non-planar mirror surface 12a
  • r is the radial coordinate (in mm) relative from the optical axis 100'
  • k is the conic constant
  • a is the semi major axis (in mm) of the elliptical mirror surface 12a
  • b is the semi minor axis (in mm) of the elliptical mirror surface 12a.
  • a maximum part of light is only reflected through the optical guidance means 100 towards the anterior chamber of the eye and no distortion as with a system of lenses will take place.
  • a maximum part of light entering the eye will be backscattered with Raman signals containing more in terms of quality as well as quantity information for analysis and diagnosis.
  • Figures 6a-6g depict in more detail an embodiment of the optical unit 10 as previously depicted and described in Figure 2 and 3 in its disassembled state (figures 6a-6b) as well as in its assembled state (Figure 6c-6g).
  • the second mirror 12 is shaped as a hollow cylindrical optical element, having an open annulus 10a which acts as entrance face for the light beam 20 in the direction of the reflective mirror surface 1 1 a of the first mirror 1 1 .
  • the hollow cylindrically shaped second mirror 12 exhibit an open inner space 120, which exposes the reflective mirror surface 1 1 a of the first mirror 1 1 to the impinging light beams 20a.
  • the first mirror 1 1 is shaped as a disc-shaped element, which fits accurately in a circular recess 132 present in the optical element 13, which functions as the third mirror.
  • the disc-shaped first mirror 1 1 and the recess 132 are preferably circular, due to the rotational symmetric design of the integrated optical unit 10 around the axis 10' (see Figure 2). However also other shapes, such as a square shape are possible depending on the design of the optical unit 10.
  • First mirror element 1 1 preferably exhibits an outer dimension which is slightly larger than the inner dimensions of the recess 132, allowing the first mirror 1 1 being press fit into the recess 132 of the third mirror element 13 without using additional adhesives, such as glue, which might adversely affect the optical transmission of the light beams 20 through the integrated optical unit 10.
  • Second mirror element 12 and third mirror element 13 are assembled together, preferably also with the means of a press fit connection, thereby obviating adhesives.
  • the contact surfaces of the second and third mirror elements 12- 13 are positioned outside the propagation path of the impinging light beams 20a-20b-20c as well as the reflected Raman signals back towards the light detecting means 6 (see Figure 1 ) with the first mirror element 1 1 accommodated in the recess 132 of the third mirror element 13, an adhesive can be used, as no disturbance of the impinging light beams and returning Raman signals will occur.
  • the light beams 20 enter the optical unit 10 via entrance face or opening 10a, propagate through the open inner space 120 of the hollow cylindrically shaped second mirror element 12 and impinge on the non-planar reflection surface 1 1 a of the first mirror 1 1 .
  • Light beams 20a are reflected from said non-planar reflection surface 1 1 a and impinge on the planar mirror surface 12a of the second mirror 12.
  • Light beams 20b being reflected from the planar mirror surface 12a of the second mirror 12 enters the (forward) entrance surface 13b of the third mirror element 13 and are subsequently reflected at the planar mirror surface 13a at the back side of the third mirror 13 (seen in the direction of propagation of the light beams 20b).
  • the exit surface 10b of the third mirror 13 is formed as an circular dent having an inner surface dimension or surface contour 131 , which is conformal to the curvature of the eye ball 51 of the eye 50 allowing a proper optical contact with the eye and to minimize any discomfort for the human or animal being under examination (not shown in Figures 6a-6g, but see Figure 2).
  • said light guidance means 10 further comprises a collimating lens 15 positioned before the first mirror element 1 1 , seen in the direction of propagation of said light beam being emitted.
  • the device 5 exhibits a laser device 7, that emits a non-collimated laser beam 2.
  • the laser or light beam 2 enters the collimating lens element 15 resulting in collimated and coherent laser beam light 20 having a constant or nearly constant diameter with a minimal divergence as it propagates through the integrated optical unit 10 along it's optical path towards the first mirror element 1 1.
  • the collimating lens element 15 can be integrated with the integrated optical unit 10, where lens element 15 is mounted/connected against the entrance face 10a of the second mirror element 12.
  • the device according to the invention can also be used for measuring biomaterials in the anterior eye or for monitoring changes in the chemical composition of tissues or biomaterials.
  • the device according to the invention is also suitable for monitoring ocular pharmacokinetics.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne un dispositif de détermination de la composition chimique d'un œil vivant comprenant des moyens d'émission de lumière afin d'émettre un faisceau de lumière ; les moyens de guidage de lumière présentant une surface d'entrée et une surface de sortie et disposé pour être porté en contact optique avec l'œil pour diriger ledit faisceau de lumière qui est émis vers l'œil, de sorte qu'au moins une partie de l'œil soit éclairée par un faisceau de lumière présentant un angle oblique d'incidence par rapport à l'axe visuel de l'œil et afin de recevoir et de guider au moins une fraction du faisceau de lumière quittant l'œil en résultat dudit éclairage vers des moyens de détection de lumière afin de déterminer la composition chimique dudit œil en analysant ladite fraction de lumière. L'invention concerne également une unité optique de mise en œuvre dans un tel dispositif afin d'exécuter des mesures de la composition chimique de l'œil antérieur.
PCT/EP2017/077952 2016-11-01 2017-11-01 Dispositif d'exécution de mesures de la composition chimique de l'œil antérieur ainsi qu'une unité optique intégrée pour sa mise en œuvre Ceased WO2018083112A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16196751.8 2016-11-01
EP16196751 2016-11-01

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WO2018083112A1 true WO2018083112A1 (fr) 2018-05-11

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025220292A1 (fr) * 2024-04-19 2025-10-23 株式会社シード Dispositif optique d'oculaire, système de mesure optique et procédé de mesure optique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350163A (en) * 1980-05-29 1982-09-21 Ford Jr Norman C Method and apparatus for analyzing contaminants in aqueous humor
WO1997013448A2 (fr) * 1995-10-14 1997-04-17 Laser- Und Medizin-Technologie Gmbh Berlin Dispositif de dosage de la glycemie
EP1475033A1 (fr) * 2003-05-05 2004-11-10 Universiteit Maastricht Dispositif et méthode d'exécution de mesures de la composition chimique de l'antérieur de l'oeil
WO2011089427A1 (fr) * 2010-01-21 2011-07-28 Christopher Glynn Spectrophotomètre non invasif et procédé associé
EP3081149A1 (fr) * 2015-04-12 2016-10-19 Taiwan Biophotonic Corporation Dispositif et procédé d'alignement

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350163A (en) * 1980-05-29 1982-09-21 Ford Jr Norman C Method and apparatus for analyzing contaminants in aqueous humor
WO1997013448A2 (fr) * 1995-10-14 1997-04-17 Laser- Und Medizin-Technologie Gmbh Berlin Dispositif de dosage de la glycemie
EP1475033A1 (fr) * 2003-05-05 2004-11-10 Universiteit Maastricht Dispositif et méthode d'exécution de mesures de la composition chimique de l'antérieur de l'oeil
WO2004098397A1 (fr) 2003-05-05 2004-11-18 Universiteit Maastricht Dispositif et methode de mesure de la composition chimique de l'oeil anterieur
WO2011089427A1 (fr) * 2010-01-21 2011-07-28 Christopher Glynn Spectrophotomètre non invasif et procédé associé
EP3081149A1 (fr) * 2015-04-12 2016-10-19 Taiwan Biophotonic Corporation Dispositif et procédé d'alignement

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025220292A1 (fr) * 2024-04-19 2025-10-23 株式会社シード Dispositif optique d'oculaire, système de mesure optique et procédé de mesure optique

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