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WO2018075743A1 - Agent de couplage produit à partir d'additifs naturellement fermentés et durables - Google Patents

Agent de couplage produit à partir d'additifs naturellement fermentés et durables Download PDF

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Publication number
WO2018075743A1
WO2018075743A1 PCT/US2017/057344 US2017057344W WO2018075743A1 WO 2018075743 A1 WO2018075743 A1 WO 2018075743A1 US 2017057344 W US2017057344 W US 2017057344W WO 2018075743 A1 WO2018075743 A1 WO 2018075743A1
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Prior art keywords
composition according
composition
group
coupling agent
glycol
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English (en)
Inventor
Jon Wiesman
George Deckner
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Wiesman Holdings LLC
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Wiesman Holdings LLC
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Definitions

  • the invention relates to a coupling agent and, more particularly, a coupling agent containing naturally fermented and sustainable additives.
  • An ultrasound coupling agent otherwise known as a "gel” is designed to act as a conductive barrier between an ultrasound probe and the outer layer of skin, known as the epidermis.
  • a gel providing excellent acoustics is a necessity in order to produce the appropriate reflection of sound waves useful to a valid diagnosis.
  • the gel In order to properly transmit ultrasonic impulses, the gel must be a medium that can uniformly produce uninterrupted quantitative parameters for measurement of acoustic velocity, impedance, and attenuation. These parameters are all necessary to yield a competent diagnosis via ultrasound technology.
  • Ultrasound diagnostic procedures are used in assessing and diagnosing a wide variety of medical conditions related to internal organs. Perhaps the condition most familiar to the general public is with regard to development of a fetus during pregnancy.
  • Ultrasonography uses ultrasound scanning to produce images on a cathode ray tube or television screen. It is widely used in obstetrics for several purposes, including confirming pregnancy under circumstances where hormonal tests cannot be used, for establishing gestational age and the number of fetuses, for determining sex of the fetus, for detecting fetal abnormalities or fetal death, for monitoring fetal growth, as an adjunct to amniocentesis, etc. Ultrasound Doppler scanning may also be used to test fetal blood flow. Ultrasonography is a valuable technique, since it provides a safe alternative to roentographic or X-ray techniques.
  • the procedure typically will involve the application of a gel to the patient's abdomen.
  • a piezoelectric transducer that generates sound waves at a frequency in the range of 2.25 to 7.0 MHz is placed in the gel and moved across the abdomen to form images at different angles.
  • the sound waves reflect off tissues to produce an echo signal that can be converted to images that can be viewed on a screen and interpreted by a competent medical practitioner.
  • the gel lubricates the abdomen and prevents the sound waves from being trapped or reflected by air pockets that might distort the image and lead to an incorrect diagnosis.
  • any remaining gel is wiped off the patient's abdomen.
  • U.S. Patent No. 8,133,516 discloses lubricants used for medicinal purposes and to skin care compositions, and particularly to a therapeutic ultrasound gel used as a lubricant during ultrasonography procedures that enhances the transmission of sound waves and that also helps to prevent the formation of stretch marks.
  • Coupling agents have never fit into the "environmentally friendly and sustainable” category because of the chemical formulation(s) typically used in manufacturing.
  • the known commercially available coupling agents have high concentrations of known irritants like propylene glycol or suspected estrogen mimics such as parabens. These molecules are synthetically derived from other than renewable materials.
  • Propylene glycol is a known general purpose coupling agent that is often used in ambient temperature in thickness gauging applications on smooth surfaces.
  • Glycerin is also another known general purpose coupling agent, but it is more viscous and has higher acoustic impedance than propylene glycol. This property makes it a preferred coupling agent for rough surfaces and highly attenuating materials.
  • these and other known ultrasound coupling agents typically have high concentrations of known irritants and/or estrogen mimics.
  • many of these known coupling agents include one or more toxic components known to be toxic under California Proposition 65 (1986) (see http://oehha.ca.gov/proposition-65/proposition-65- list).
  • a coupling agent composition includes a plurality of non-toxic components derived from one or more natural resource materials and is an amount equal to or greater than 97 weight percent (wt %) of the composition.
  • the plurality of non-toxic components derived from one or more natural resource materials and is an amount equal to or greater than 97 weight percent (wt %) of the composition.
  • components includes a carrier, at least one naturally derived water soluble polyol selected from the group consisting of propanediol, pentylene glycol, and butylene glycol in an amount of from about 1.0 to about 20.0 wt%, and a thickening agent in an amount of about 0.05 to about 5.00 wt %.
  • the balance of the composition is incidental impurities.
  • Figure 1 is a comparative chart displaying measured acoustic velocities for various known coupling agents and a proposed coupling agent according to the invention.
  • the terms "comprises,” “comprising,” “includes,” “including,” “has,” “having,” “contains,” or “containing,” or any other variation thereof, will be understood to imply the inclusion of a stated integer or group of integers but not the exclusion of any other integer or group of integers.
  • a composition, a mixture, a process, a method, an article, or an apparatus that comprises a list of elements is not necessarily limited to only those elements but can include other elements not expressly listed or inherent to such composition, mixture, process, method, article, or apparatus.
  • “or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).
  • invention or “present invention” as used herein is a non-limiting term and is not intended to refer to any single embodiment of the particular invention but encompasses all possible embodiments as described in the application.
  • the term "about" modifying the quantity of an ingredient or reactant of the invention employed refers to variation in the numerical quantity that can occur, for example, through typical measuring and liquid handling procedures used for making concentrates or solutions in the real world; through inadvertent error in these procedures; through differences in the manufacture, source, or purity of the ingredients employed to make the compositions or to carry out the methods; and the like.
  • the term “about” also encompasses amounts that differ due to different equilibrium conditions for a composition resulting from a particular initial mixture.
  • the claims include equivalents to the quantities.
  • the term “about” means within 10% of the reported numerical value, alternatively within 5% of the reported numerical value.
  • Biomass refers to a natural product containing hydrolyzable polysaccharides that provide fermentable sugars including any sugars and starch derived from natural resources such as corn, sugar cane, wheat, cellulosic or lignocellulosic material and materials comprising cellulose, hemicellulose, lignin, starch, oligosaccharides, disaccharides and/or monosaccharides, and mixtures thereof. Biomass may also comprise additional components such as protein and/or lipids. Biomass may be derived from a single source or biomass can comprise a mixture derived from more than one source.
  • biomass may comprise a mixture of corn cobs and corn stover, or a mixture of grass and leaves.
  • Biomass includes, but is not limited to, bioenergy crops, agricultural residues, municipal solid waste, industrial solid waste, sludge from paper manufacture, yard waste, waste sugars, wood and forestry waste.
  • biomass examples include, but are not limited to, corn grain, corn cobs, crop residues such as corn husks, corn stover, grasses, wheat, rye, wheat straw, barley, barley straw, hay, rice straw, switchgrass, waste paper, sugar cane bagasse, sorghum, sugar cane, soy, components obtained from milling of grains, trees, branches, roots, leaves, wood chips, sawdust, shrubs and bushes, vegetables, fruits, flowers, animal manure, and mixtures thereof.
  • mash, juice, molasses, or hydrolysate may be formed from biomass by any processing known in the art for processing the biomass for purposes of fermentation such as by milling, treating, and/or liquefying and comprises fermentable sugar and may comprise water.
  • cellulosic and/or lignocellulosic biomass may be processed to obtain a hydrolysate containing fermentable sugars by any method known to one skilled in the art.
  • An aqueous feed stream may be derived or formed from biomass by any processing known in the art for processing the biomass for purposes of fermentation such as by milling, treating, and/or liquefying and comprises fermentable carbon substrate (e.g., sugar) and may comprise water.
  • fermentable carbon substrate e.g., sugar
  • Feedstock as used herein means a feed in a fermentation process, the feed containing a fermentable carbon source with or without undissolved solids, and where applicable, the feed containing the fermentable carbon source before or after the fermentable carbon source has been liberated from starch or obtained from the breakdown of complex sugars by further processing such as by liquefaction, saccharification, or other process.
  • Feedstock includes or is derived from a biomass. Suitable feedstocks include, but are not limited to, rye, wheat, corn, corn mash, sugarcane, cane mash, barley, cellulosic material, lignocellulosic material, or mixtures thereof. Where reference is made to "feedstock oil,” it will be appreciated that the term encompasses the oil produced from a given feedstock.
  • “Fermentation medium” as used herein means the mixture of water, sugars, dissolved solids, optionally microorganisms producing alcohol, product alcohol, and all other constituents of the material held in the fermentation vessel in which product alcohol is being made by the reaction of sugars to alcohol, water, and carbon dioxide (CO. sub.2) by the microorganisms present. At the end of a fermentation run the sugars may be depleted from the fermentation medium. From time to time, as used herein the term “fermentation broth” and “fermented mixture” can be used synonymously with “fermentation medium.”
  • Fermentable carbon source or “fermentable carbon substrate” as used herein means a carbon source capable of being metabolized by the microorganisms disclosed herein for the production of fermentative alcohol.
  • Suitable fermentable carbon sources include, but are not limited to, monosaccharides such as glucose or fructose; disaccharides such as lactose or sucrose; oligosaccharides; polysaccharides such as starch or cellulose; C5 sugars such as xylose and arabinose; one carbon substrates including methane; and mixtures thereof.
  • “Fermentable sugar” as used herein refers to one or more sugars capable of being metabolized by the microorganisms disclosed herein for the production of fermentative alcohol.
  • “Sugar” as used herein refers to oligosaccharides, disaccharides, monosaccharides, and/or mixtures thereof.
  • saccharide also includes carbohydrates including starches, dextrans, glycogens, cellulose, pentosans, as well as sugars.
  • recombinant microorganism refers to microorganisms such as bacteria or yeast, that are modified by use of recombinant DNA techniques, for example, by engineering a host cell to comprise a biosynthetic pathway such as a biosynthetic pathway to produce an a polyol such as propanediol.
  • Renewable resource refers to a natural resource that can be replenished within a 100 year time frame.
  • the resource may be replenished naturally, or via agricultural techniques.
  • Renewable resources include plants, animals, fish, bacteria, fungi, and forestry products. They, may be naturally occurring, hybrids, or genetically engineered organisms. Natural resources such as crude oil, coal, and peat which take longer than 100 years to form are not considered to be renewable resources.
  • Organic natural resource materials are resources that can be replenished, either through biological reproduction or other naturally reoccurring processes in a finite amount of time.
  • Organic natural resources are known to be environmentally friendly and sustainable.
  • natural material is one which has been harvested, mined or collected, and which subsequently may have been processed, without chemical reaction, to yield a chemical or chemicals that are identifiable in the original source material.
  • the phrase “without chemical reaction” permits washing, decolorizing, distilling, grinding, milling, separating and/or concentrating the material by physical means.
  • naturally derived we mean materials wherein the majority of the molecule (by weight) is derived from natural materials.
  • an ultrasound coupling agent having a composition with one or more non-toxic components greater than 97 weight percent (wt %).
  • the coupling agent composition includes a
  • the one or more non-toxic components includes a carrier and an organic natural resource material.
  • the carrier is water, preferably deionized water or distilled water.
  • the parts of water are 75.00-98.00 wt % in the proposed coupling agent composition.
  • the proposed coupling agent composition includes a carrier having a wt % range of 85.00-90.00%.
  • the proposed coupling agent composition includes a carrier having a wt % range of 87.00-89.00%.
  • the carrier can be various known water types, including water that has been neutralized with an alkali hydroxide such as sodium hydroxide or potassium hydroxide to a pH value in the range of 6.0 to 8.0.
  • an alkali hydroxide such as sodium hydroxide or potassium hydroxide to a pH value in the range of 6.0 to 8.0.
  • the organic natural resource material is extracted and/or produced from one or more organic natural resources using known fermentation and/or
  • the fermentation and/or enzymatic synthesis may be a known natural chemical process in which bacteria or yeast converts organic materials, such as sugars or biomass waste streams, into various types of high value-added chemicals.
  • the organic natural resource material is at least one water soluble polyol.
  • the parts of soluble polyol are 1.00-25.00 wt %> in the proposed coupling agent composition.
  • the proposed coupling agent composition includes a soluble polyol having a wt %> range of 5.00-15.00%).
  • the proposed coupling agent composition includes a soluble polyol having a wt % range of 9.00-11.00%.
  • the at least one water soluble polyol is selected from the group consisting of
  • propanediol pentylene glycol
  • butylene glycol butylene glycol
  • Naturally fermented glycols such as propanediol, butylene glycol, and pentylene glycol are useful in the proposed coupling agent composition.
  • Pentylene glycol is a humectant used in cosmetics and beauty products that is also secondarily used as a solvent and preservative potentiator. It is both water- and oil-soluble and can have moisture-binding and antimicrobial properties that are well known to one skilled in the art.
  • the at least one water soluble polyol is propanediol, and more specifically is 1, 3 -propanediol.
  • the propanediol is a colorless and highly pure glycol derived from a known sustainable and renewable corn sugar fermentation process. This is a 100 percent bio- based ingredient that boosts preservative efficacy and eliminates skin irritation caused by glycols used in known coupling agents.
  • known 1, 3 -propanediol such as the brand Zemea® (DuPont Tate & Lyle Bio Products) can be used to replace non-biologically derived glycols used in known coupling agents, such as propylene glycol (1, 2-propanediol), butylene glycol (1,3-/1/4- butanediol), and glycerin.
  • the pentylene glycol is 1, 5-pentanediol and may be used as the at least one water soluble polyol.
  • the 1, 5-pentanediol is used as an alternative to known glycols and may be derived through known processes such as hydrogenation of glutaric acid and its derivatives or hydrogenation of furfural followed by hydrogenolysis of the substituted
  • known pentylene glycol such as the brand Diol PDTM (Kokyu Alcohol Kogyo Co. Ltd.) can be used to replace synthetically derived glycols used in known coupling agents, such as propylene glycol (1, 2-propanediol) or glycerin.
  • the at least one water soluble polyol is butylene glycol, and more specifically is 1, 3-butanediol.
  • the butylene glycol is used as an alternative to known glycols and may be derived from biomass-derived glucose using known processes. In one known process, genetically- and metabolically-engineered Escherichia coli are cultured in fed-batch fermentation.
  • the 1,3- butylene glycol metabolic pathway consists of four enzymatic steps from acetyl-CoA and uses phaA encoding acetyl-CoA acetyltranferase from Ralstonia eutropha; phaB encoding NADPH-dependent acetacetyl-CoA reductase from R. eutropha; bid encoding butyryl- CoA dehydrogenase from Clostridium saccharoperbutylacetonicum; and adh encoding alcohol dehydrogenase inherent in the host strain E. coli BW lacl q .
  • a fermentation and/or enzymatic synthesis uses bacteria or yeast to convert organic materials, such as sugars or biomass waste, into the water soluble polyol.
  • the water soluble polyol is then combined with the carrier to provide a proposed coupling agent composition.
  • the thickening agent is a rheology modifier with parts of the composition of 0.00-5.00 wt %.
  • the proposed coupling agent composition includes a thickening agent having a wt % range of 0.10-1.00%.
  • the proposed coupling agent composition includes a thickening agent having a wt % range of 0.05-0.70%.
  • the thickening agent is a non-toxic soluble or swellable polymer.
  • the thickening agent may be a cross-linked polymer selected from a group consisting of hydrophobic polyacrylate or hydrophilic polyacrylate.
  • the thickening agent may be natural or synthetic. If the thickening agent is synthetic, then the thickening agent portion of the proposed coolant gel composition is less than or equal to 3.00 wt %, according to an exemplary embodiment of the invention.
  • the thickening agent may include a crosslinked polyacrylate, which may be selected from a group consisting of carbomer, sodium acryloyldimethyltaurate/VP Crosspolymer, acrylates/C 10-30 alkyl acrylate crosspolymer, or crosslinked PVP.
  • the proposed coupling agent composition includes a crosslinked polyacrylate having a wt % range of 0.10-2.00%).
  • the crosslinked polyacrylate is carbomer, which is used to achieve desired rheological properties in the proposed coupling agent composition. For instance, known carbomer, such as the brand Carbopol® Ultrez 30 Polymer (The Lubrizol Corporation, Wickliffe, OH) can be used.
  • the crosslinked polyacrylate is a sodium
  • the sodium acryloyldimethyltaurate/VP crosspolymer may be used to achieve desired rheological properties in the proposed coupling agent composition.
  • known sodium acryloyldimethyltaurate/VP crosspolymer such as the brand
  • Aristoflex® (AVS) (Clariant Corporation, Charlotte, NC) can be used.
  • the crosslinked polyacrylate is an acrylate/ClO-30 alkyl acrylate crosspolymer, which may be used to achieve desired rheological properties in the proposed coupling agent composition.
  • a known acrylate/ClO-30 alkyl acrylate crosspolymer such as the brand Carbopol® Ultrez 21 (The Lubrizol Corporation, Wickliffe, OH), can be used.
  • the crosslinked polyacrylate is crosslinked polyvinylpyrrolidone (PVP).
  • PVP polyvinylpyrrolidone
  • the crosslinked PVP is used to achieve desired rheological properties in the proposed coupling agent composition.
  • a known crosslinked PVP such as the brand FlexiThixTM (Ashland Inc., Covington, KY), can be used.
  • the thickening agent may include one or more naturally derived additives.
  • the proposed coupling agent composition includes one or more naturally derived additives having a wt % range of 0.50-3.00%.
  • the one or more naturally derived additives is a soluble polymer and may be selected from a group consisting of xanthan gum, guar, locust bean, sodium hyaluronate, glucomannan, carrageenan, sodium alginate, acacia, tara gum, tamarind seed, mannan, succinoglycan, microcrystalline cellulose, and scleroglucan.
  • the proposed coupling agent composition includes a thickening agent additive having a wt %> range of 0.10-3.00%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a thickening agent additive having a wt %> range of 0.2-2.00%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a thickening agent additive having a wt %> range of 0.10-0.30%. In yet another exemplary embodiment of the invention, the proposed coupling agent composition includes a thickening agent additive having a wt %> range of 1.60-1.80%).
  • the proposed coupling agent composition may include a biocide agent.
  • the biocide agent may be in a range of .25 to 1 weight percent of the proposed coupling agent composition.
  • the biocide agent may be selected from a group consisting of phenoxyethanol, benzyl alcohol, caprylyl glycol, ethylhexylglycerin, decylene glycol, glyceryl caprylate, and 1,2-hexanediol.
  • the proposed coupling agent composition includes a biocide agent having a wt %> range of 0.10-1.00%. In another exemplary embodiment of the invention, the proposed coupling agent composition includes a biocide agent having a wt %> range of 0.25-0.60%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a biocide agent having a wt %> of 0.50%>.
  • the proposed coupling agent composition may also include a neutralizing agent.
  • the neutralizing agent may be in a range of 0.05 to 0.50 weight percent of the proposed coupling agent composition.
  • the neutralizing agent may be selected from a group consisting of sodium hydroxide, triethanolamine, tromethamine, arginine, and lysine.
  • the proposed coupling agent composition includes a neutralizing agent having a wt %> range of 0.00-1.00%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a neutralizing agent having a wt %> range of 0.10-0.30%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a neutralizing agent having a wt %> range of 0.20-0.25%).
  • the proposed coupling agent composition may also include a chelating agent.
  • the chelating agent may be in a range of 0.025 to 0.10 weight percent of the proposed coupling agent composition.
  • the neutralizing agent may be selected from a group consisting of disodium EDTA and sodium phytate.
  • the proposed coupling agent composition includes a chelating agent having a wt %> range of 0.01-1.00%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a chelating agent having a wt %> range of 0.03-0.07%). In another exemplary embodiment of the invention, the proposed coupling agent composition includes a neutralizing agent having a wt %> of 0.05%>. [0060] According to the invention, the proposed coupling agent composition may include filler materials or have a balance of incidental impurities.
  • the present invention can be illustrated by the following examples of proposed coupling agent compositions according to the invention without being limited by them. Each of the following examples was prepared being dependent on an organic natural resource material in view of overall percentage of non-toxic component.
  • Table 1 shows an exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 2 shows another exemplary embodiment of a proposed coupling agent
  • Thickening agent additive 0.10-0.30%
  • Table 3 shows an exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 4 shows another exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 5 shows another exemplary embodiment of a proposed coupling agent composition according to the invention. TABLE 5:
  • Table 6 shows another exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 7 shows another exemplary embodiment of a proposed coupling agent composition according to the invention. TABLE 7:
  • Table 8 shows an exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 9 shows an exemplary embodiment of a proposed coupling agent composition according to the invention.
  • Table 10 shows an exemplary embodiment of a proposed coupling agent composition according to the invention.
  • a coupling agent composition according to the invention is processed according to the following steps. However, one skilled in the art should appreciate that the following steps are merely exemplary and are used to enable one skilled in the art to process proposed coupling agent compositions according to the invention.
  • a thickening agent such as a cross- linked polyacrylate
  • a first batch of thickening agent additive such as a soluble polymer
  • a first batch of a carrier such as deionized water
  • the thickening agent and the thickening agent additive are dispersed into the carrier to prepare a first mixture.
  • a first batch of organic natural resource material such as a polyol
  • a chelating agent and a biocide agent is then added to the first mixture of the carrier and the thickening agent.
  • a slurry is prepared from a second batch of an organic natural resource material and a second batch of a thickening agent additive. This slurry is added to the mixture of the chelating agent, the first batch of organic natural resource material, the biocide agent, the first mixture of the carrier, and the thickening agent in order to form a source mixture.
  • a second batch of a carrier is measured out and combined with a neutralizing agent to form a neutralizing mixture. Finally, this neutralizing mixture is combined with the source mixture.
  • the coupling agent is in a clear gel form.
  • the coupling agent has a viscosity greater than or equal to 10,000 centipoise (cP). According to an embodiment of the invention, the coupling agent has a viscosity between 25,000 - 100,000 cP. According to another embodiment of the invention, the coupling agent has a viscosity between 75,000-90,000 cP. In yet another embodiment of the invention, the coupling agent has a viscosity between 83,200 cP. In yet another embodiment of the invention, the coupling agent has a viscosity between 81,667 cP.
  • the proposed coupling agent composition according to the invention has excellent acoustics characteristics.
  • Performance specifications (ranges) of the proposed coupling agent composition that would make it useful in medical procedures, including ultrasonic diagnostic procedures, include (1) acoustic velocity, (2) impedance, (3) attenuation, and (4) resolution.
  • the proposed coupling agent composition has acoustical velocities very close to that of blood at various temperatures.
  • the limited amount of entrapped air in the tested coupling agents minimized signal attenuation.
  • Table 11 lists measured acoustic velocities for various known coupling agents and the proposed coupling agent according to the invention tested at 23C, 32C and 40C. Additionally, Table 11 displays the calculated water velocity taken using the Bilaniuk and Wong equation as a marker for test methodology.
  • Figure 1 illustrates a comparative chart displaying measured acoustic velocities for various known coupling agents and the proposed coupling agent according to the invention when tested at 23C, 32C and 40C. Additionally, Figure 1 displays the calculated water velocity taken using the Bilaniuk and Wong equation as a marker for test methodology. As shown, the measured acoustic velocity of the proposed coupling agent is minimally affected by an increase in temperature, as compare to the prior art coupling agents.
  • the proposed coupling agent provides more consistent acoustic velocity verses prior art couplants.
  • the test demonstrates more drastic changes in acoustic velocity with increased temperature. When used in imaging, this deviation in acoustic velocity could alter the interpretation of a sonogram, for instance.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
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  • Compositions Of Macromolecular Compounds (AREA)
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Abstract

Une composition d'agent de couplage est fournie et comprend une pluralité de composants non toxiques dérivés d'un ou plusieurs matériaux de ressources naturelles et est une quantité égale ou supérieure à 97 pour cent en poids (% en poids) de la composition. La pluralité de composants non toxiques comprend un support, au moins un polyol hydrosoluble dérivé naturellement choisi dans le groupe constitué par le propanediol, le pentylène glycol, et le butylène glycol en une quantité d'environ 1,0 à environ 20,0 % en poids, et un agent épaississant en une quantité d'environ 0,05 à environ 5,00 % en poids. Le reste de la composition est des impuretés incidentes.
PCT/US2017/057344 2016-10-19 2017-10-19 Agent de couplage produit à partir d'additifs naturellement fermentés et durables Ceased WO2018075743A1 (fr)

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US15/297,762 US10646597B2 (en) 2016-10-19 2016-10-19 Coupling agent produced from naturally fermented and sustainable additives

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US20250269071A1 (en) 2025-08-28
US20180104363A1 (en) 2018-04-19
US10646597B2 (en) 2020-05-12
US20200306388A1 (en) 2020-10-01
US20230390420A1 (en) 2023-12-07
US12290578B2 (en) 2025-05-06
US11241508B2 (en) 2022-02-08
US11786614B2 (en) 2023-10-17
US20220118115A1 (en) 2022-04-21

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