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WO2018064032A1 - Compositions de cire de tabac vaporisables et récipient associé - Google Patents

Compositions de cire de tabac vaporisables et récipient associé Download PDF

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Publication number
WO2018064032A1
WO2018064032A1 PCT/US2017/053416 US2017053416W WO2018064032A1 WO 2018064032 A1 WO2018064032 A1 WO 2018064032A1 US 2017053416 W US2017053416 W US 2017053416W WO 2018064032 A1 WO2018064032 A1 WO 2018064032A1
Authority
WO
WIPO (PCT)
Prior art keywords
tobacco
wax
pod
wax composition
tobacco wax
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/053416
Other languages
English (en)
Inventor
Joseph Fuisz
Seamus Henry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bond Street Manufacturing LLC
Original Assignee
Bond Street Manufacturing LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/276,902 external-priority patent/US10709165B2/en
Priority claimed from US15/403,472 external-priority patent/US20180084822A1/en
Application filed by Bond Street Manufacturing LLC filed Critical Bond Street Manufacturing LLC
Priority to JP2019538089A priority Critical patent/JP2019532671A/ja
Priority to EP17857276.4A priority patent/EP3518692A4/fr
Publication of WO2018064032A1 publication Critical patent/WO2018064032A1/fr
Priority to US16/159,015 priority patent/US10918127B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors

Definitions

  • This invention is directed towards tobacco wax, including methods of manufacture, tobacco wax compositions, and the vaporization of tobacco wax for use in a vaporizer-inhalation device.
  • the present invention also relates to a portion-sized container ("pod") of a tobacco wax composition for administration to a mammal or person.
  • the pod is intended for use in a personal (or other) vaporizer.
  • Tobacco wax or resin is dark brown in color, burns with the production of acrid fumes, and has a strong odor resembling that of an "old" pipe.”
  • the tobacco wax may be used as an insecticide or may be "returned to the residual tobacco leaves and also to untreated tobacco leaves to impart thereto desirable flavors.”
  • Garner teaches that the extracted tobacco is still suitable use in smoking and other tobacco products (US 2,128,043).
  • Keritsis et al (assigned to Philip Morris) (US 4,936,920) (1990) mentions tobacco wax in a list of saccharides and polysaccharides that may be used as a bonding agent when making manufactured tobacco (more typically referred to as reconstituted tobacco sheet). Renaud et al., in US 8,863,754 (assigned to Philip Morris) (2014) describe compositions for heat not burn applications.
  • Cisoprenc is a pyrolysis product of isoprenoicl compounds present in tobacco, for example in certain tobacco waxes, and can be present in the aerosol only if the strands o f homogenized tobacco material are heated to a temperature substantially higher than that required to generate an aerosol.
  • isoprene yield can be taken as representative or the amount of homogenized tobacco material that is ' ' over heated.”
  • Brown et al. (assigned to Lorillard) (US 9,038,644) (2015) teaches tobacco wax for use as a phase transition material to impart reduced ignition propensity to a cigarette.
  • the wax is applied to the cigarette paper using high precision wax jet printing.
  • compositions include USP (99.9% pure) nicotine oil as an ingredient, though zero-liquids without any nicotine are also used.
  • Heat not burn tobacco systems are known in the tobacco industry. Heat not burn systems like Pax Lab's Pax® and Philip Morris' IQOS® (as well as earlier versions of IQOS® sold as Heatbar® and Accord®) heat tobacco compositions substantially without burning the tobacco, thereby aerosolizing volatile constituents of the tobacco composition. After use, the non- vaporized components of the tobacco composition remain minus those components what were successfully vaporized (or inadvertently burned).
  • Pax is a loose-leaf style vaporizer for use with "loose-leaf plant material" supplied by the user herself (https: / /www.paxyapor.com/ support/pax-2-faq/#can-i-use-liquids-in-pax-2).
  • Philip Morris' IQOS is a more sophisticated product wherein the user uses a manufacturer- supplied "cigarette” in the heating device.
  • the cigarette itself is comprised of reconstituted tobacco sheet made with high amounts of humectant (glycerin) that, together with other volatiles, create a vapor like experience when used.
  • humectant glycolin
  • the present invention relates to a tobacco wax composition suitable for vaporization, comprising tobacco wax and at least one vapor agent.
  • the tobacco wax composition can have a nicotine content of greater than 2%.
  • the tobacco wax composition is preferably flowable.
  • the tobacco wax composition may further comprise at least one selected from the group of: an emulsifying agent, or a surfactant.
  • the tobacco wax composition is preferably substantially free of separation when stored at room temperature conditions for six months.
  • the tobacco wax composition preferably comprises 30% to 65% of a vapor agent.
  • the tobacco wax composition can be contained in a pod.
  • the pod may have a top porous layer.
  • the present invention also relates to a system for vaporization of a tobacco wax composition, comprising a device and a pod containing a tobacco wax composition, said tobacco wax composition comprising tobacco wax and at least one vapor agent.
  • the system may have vapor emissions with TSNA levels below quantifiable limits on a per puff basis, when measured using: 55mL puff/ 30 sec interval/ 3 sec duration, and the quantifiable limit is 0.20 ng/puff
  • the system may have formaldehyde emissions of below quantifiable limits on a per puff basis, when measured using: 55mL puff/ 30 sec interval/ 3 sec duration, and the quantifiable limit is 0.20 ⁇ g/puff
  • the system may have vapor emissions of formaldehyde of less than 50% of the IQOS Heet comparator, testing using the Canadian Intense smoking regime.
  • the system reaches operating temperature within ten seconds or less, more preferably within five seconds or less, even more preferably within three seconds or less.
  • the device has an operating temperature of 225°F to 350°F.
  • the pod may comprise airholes that align with device airholes.
  • the pressure drop of the system is 75 (mm H 2 0) to 130 mm (H 2 0).
  • the device may comprise a sleeve.
  • the system is preferably such that, when sufficiently heated, the tobacco wax composition vaporizers substantially without residue.
  • the present invention also relates to a method for manufacturing a heat not burn tobacco product, comprising extracting the wax partition from tobacco leaf, and mixing that extraction with a vapor agent.
  • the extraction method employed may be supercritical CO2 extraction.
  • Figure 1 is a perspective view showing a heating chamber containing a tobacco wax composition.
  • Figure 2 is an exploded perspective of the heating chamber sub assembly, including a ceramic heating chamber.
  • Figure 3 is a cross-sectional view of the heating chamber containing a tobacco wax composition.
  • Figure 4 is a cross section of the wall of the heating chamber casing.
  • Figure 5 is a cross section of the receiver for the heating chamber, including the battery connection section.
  • Figure 6 is a cross section of the electrode.
  • Figure 7 is a cross section of the electrode insulator.
  • Figure 8 is a perspective view of a ceramic pod showing a printed or coated heating element and positive and negative electrical contacts.
  • Figure 9 is an exploded perspective view of a pod, a porous layer, and a barrier layer. Mode(s) for Carrying Out the Invention
  • the present invention teaches a composition that comprises tobacco wax and other ingredients suitable for vaporization and use by a mammal. Applicants have found that the vaporization of a tobacco wax based composition provides excellent organoleptics and nicotine delivery.
  • tobacco wax compositions of the present invention vaporize substantially in their entirety (i.e. substantially without residue).
  • Tobacco wax based compositions allow for a heat-not-burn tobacco product that is not a readily flowable liquid, and does not require specialized reconstituted sheet production or use, or use conventional tobacco leaf products (like Pax).
  • the role of plant wax for plants is understood. Plants secrete waxes into and on the surface of their cuticles as a way to control evaporation, wettability and hydration.
  • the epicuticular waxes of plants are mixtures of substituted long-chain aliphatic hydrocarbons, containing alkanes, alkyl esters, fatty acids, primary and secondary alcohols, diols, ketones, aldehydes. From the commercial perspective, the most important plant wax is carnauba wax, a hard wax obtained from the Brazilian palm Copernicia prunifera.
  • extraction methods include, without limitation, subcritical C02 extraction; supercritical C02 extraction; supercritical extraction with additional (non-C02) solvents; maceration; digestion (a heated form of maceration); decoction; percolation; hot continuous extraction (Soxlet); Aqueous Alcoholic Extraction by Fermentation; Counter-current Extraction; Ultrasound Extraction (Sonication); and the Phytonics Process.
  • Solvents used may be polar or non-polar. Various combinations and/ or sequential series of these methods can be used.
  • the non-limitative preferred embodiment is supercritical C02 extraction.
  • the use of supercritical C02 extraction to de-nicotinize tobacco is disclosed in Howell et al US 8,887,737 (2014), which is hereby incorporated by reference as if fully set forth herein.
  • Extraction can be used to generate several partitions form tobacco, broadly speaking, including oils and waxes. Both of these partitions contain nicotine.
  • the wax partition yield should exceed 1.5% of the starting tobacco weight, preferably 2% or greater, most preferably 4% or greater.
  • All forms of tobacco may be used including tobacco leaf, stem, and waste tobacco dust. Blends of tobacco may be employed. Cigar tobaccos may be employed. Tobacco varieties with high nicotine content are preferred. Because the extraction process may bring flavors and aromas from the leaf into the wax and oil, the tobacco inputs may be selected in whole or in part for taste. It may be desirable to pre-treat the tobacco prior to extraction with a basic agent (e.g. sodium carbonate) to encourage nicotine extraction from the tobacco.
  • a basic agent e.g. sodium carbonate
  • the tobacco blending process will be carried out prior to extraction, or after extraction.
  • a blend may be made of one or more tobaccos (e.g. flue cured, burley and Turkish) and extraction made therefrom.
  • the three tobaccos of the prior example may be separately extracted, and blended to taste and other characteristics using the extracted wax partitions (and oil partitions, optionally) of each extracted tobacco type.
  • extraction techniques to remove the wax partition may also function to extract undesired TSNA's from tobacco.
  • supercritical C02 extraction may solubilize TSNA's from the tobacco, concentrating them in the resulting wax and oil partitions. Since it is desirable to minimize TSNA's in the final product, it is desirable to use tobacco inputs with very low TSNA's. This will result in a product with low TSNA's without the need for optional pre or post processing steps to remove TSNA's from the wax partition.
  • the tobacco input have a TSNA level below 3 ppm, more preferable below 2 ppm, still more preferably below 1 ppm, and even more preferably below 0.3 ppm).
  • Extraction parameters may impact the nature of the wax partition, including various parameters including flavor, nicotine levels, TSNA levels, and the rheology of the wax partition itself. In certain embodiments, it may be desirable to extract a non-flowable wax partition, or a substantially non-flowable wax partition.
  • the wax partition may be viscous and somewhat flowable in certain embodiments.
  • oils may be mixed into the resulting wax to increase the yield of wax and nicotine.
  • High shear mixers and other mixing methods may be used for this purpose.
  • the mass of the oil partition added to the wax partition will be less than or about 75% of the mass of the wax partition, preferably less than or about 30% and most preferably less than 15% of the mass of the wax partition (measured by mass).
  • the oil partition can serve to increase nicotine, enhance flavor, increase vapor production and generally extend the yield from tobacco.
  • TSNA levels may concentrate in the oil partition, and so it is desirable to specifically monitor the TSNA level of the oil partition when considering the desired
  • Additional excipients may be employed to develop a final composition for vaporization.
  • Vapor agents may be added to the wax.
  • a vapor agent as a material that increases the vapor from the wax composition when heated.
  • Vapor agents may include, without limitation, vegetable glycerin, non-vegetable forms of glycerin, propylene glycol, polyethylene glycol, polysorbates including polysorbate 20 (polyoxyethylene sorbitan
  • Vapor agents may be added to about 70% of the composition (by mass), preferably 30-65% of the
  • composition (by mass), most preferably 45-55% (by mass) of the composition.
  • Lower levels, for example 10% and above, of vapor agents may also be employed, resulting in a stronger, more concentrated final composition. Above 60%, the final composition may become too flowable for certain vaporization devices.
  • substantially all of the vapor agent employed is vegetable glycerin. This is because vegetable glycerin has a relatively high viscosity, and flowability of the final composition is undesired in certain embodiments. For example, a flowable composition may "spill" out of the heating chamber when a vaporizer is left on its side.
  • film formers and gelling agents may optionally be employed to increase viscosity as needed.
  • the wax compositions of the present invention are generally not wickable — or capable of wicking or capillary action.
  • the device used to vaporize the wax compositions of the present invention is not a convention e-cigarette or personal vaporizer used for e-liquids.
  • High shear mixing is important to ensure uniform distribution of the vapor agent (or other added excipient) in the composition.
  • the tobacco wax may tend towards hydrophobicity, which may present mixing challenges.
  • the use of an emulsifying agent may be desired to assist in emulsifying the mixed composition.
  • emulsifying agents are examples of emulsifying agents that may be employed: agar, albumin, alginates, casein, ceatyl alcohol, cholic acid, desoxycholic acid, diacetyl tartaric acid esters, egg yolk, glycerol, gums, carrageenan, lecithin, mono- and diglycerides, monosodium phosphate, monostearate, ox bile extract, propylene glycol, soaps, or taurocholic acid (or its sodium salt).
  • non-glycerol emulsifying agents are preferred.
  • surfactants may be employed in certain embodiments to promote mixing.
  • Surfactants lower tension between a surface and a liquid or between two or more immiscible
  • Anionic surfactants contain anionic functional groups at their head, such as sulfate, sulfonate, phosphate, and carboxylates.
  • Prominent alkyl sulfates include ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS, or SDS), and the related alkyl- ether sulfates sodium laureth sulfate (sodium lauryl ether sulfate or SLES), and sodium myreth sulfate.
  • Others include: Docusate (dioctyl sodium sulfosuccinate)
  • PFOS Perfluorooctanesulfonate
  • Alkyl-aryl ether phosphates Perfluorobutanesulfonate
  • Alkyl ether phosphates Perfluorooctanesulfonate
  • Carboxylates are the most common surfactants and comprise the alkyl carboxylates (soaps), such as sodium stearate. More specialized species include sodium lauroyl sarcosinate and carboxylate-based fluorosurfactants such
  • Certain surfactants contain cationic head groups.
  • Zwitterionic (amphoteric) surfactants have both cationic and anionic centers attached to the same molecule.
  • the cationic part is based on primary, secondary, or tertiary amines or quaternary ammonium cations.
  • the anionic part can be more variable and include sulfonates, as in the sultaines CHAPS (3-[(3-Cholamidopropyl)dimethylammonio]-l- propanesulfonate) and cocamidopropyl hydroxysultaine.
  • Betaines such as cocamidopropyl betaine have a carboxylate with the ammonium.
  • the most common biological zwitterionic surfactants have a phosphate anion with an amine or ammonium, such and
  • phospholipids phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelins.
  • Many long chain alcohols exhibit some surfactant properties. Prominent among these are the fatty alcohols, cetyl alcohol, stearyl alcohol, and cetostearyl
  • a wetting agent may be employed.
  • a wetting agent is a surfactant that, when dissolved in water, lowers the advancing contact angle, aids in displacing an air phase at the surface, and replaces it with a liquid phase.
  • Examples of application of wetting to pharmacy and medicine include the displacement of air from the surface of sulfur, charcoal, and other powders for the purpose of dispersing these drugs in liquid vehicles; the displacement of air from the matrix of cotton pads and bandages so that medicinal solutions can be absorbed for application to various body areas; the displacement of dirt and debris by the use of detergents in the washing of wounds; and the application of medicinal lotions and sprays to surface of skin and mucous membranes
  • Tween is a nonionic surfactant and emulsifier that is particularly useful in connection with certain embodiments of the present invention.
  • Various Tweens can be used, including inter alia Tween 20 and Tween 80.
  • Tobacco leaf may be added to the wax composition, in any known form, including without limitation shreds, dust, particles and the like.
  • Said tobacco leaf may be leaf from which the tobacco wax was extracted in certain embodiments.
  • Tobacco leaf, including reconstituted tobacco leaf may be present from .01 to 30% mass of the composition in certain embodiments. Adding tobacco leaf to the composition can provide a look and feel of the product akin to Shisha tobacco.
  • the nicotine content of the final composition is preferably less than 12%, more preferably less than 7.5% and most preferably 1.5-4% (by mass). Low nicotine compositions with nicotine less than 1.5% may also be made for users seeking lower nicotine delivery. Nicotine, natural or synthetic, may be added where the tobacco extraction yields a less than desired level.
  • the product can be made from low-nicotine containing tobacco to achieve a low nicotine level, or otherwise subject to known processes to dinicotinize the composition or starting input tobacco.
  • Flavors may be added to the wax. Flavors may be synthetic or natural. For purposes hereunder, menthol, wintergreen, peppermint and similar oils used in menthol tobacco products are understood to be flavors, together with traditional flavors (e.g. grape, cherry etc). Menthol crystals may be employed. Tobacco flavors, and traditional tobacco top flavors may be used to impart a rich tobacco flavor. Sustained release flavors, coated particle flavor systems, and flavor capsules with volatile flavors may all be employed. Flavors may comprise 0.25% to 20%, preferably 2.5% to 12.5% of the final composition. Special concern should be paid to miscibility of the flavor with the wax composition.
  • Penetration agent(s) may be added to the tobacco wax.
  • penetration agents we mean an agent that promotes transfer of the active—i.e., a substance that enhances absorption through the mucosa, mucosal coating and epithelium, otherwise known (see U.S. Patent Application Publication No. 2006/0257463 Al, the content of which is incorporated herein by reference).
  • the penetration agent may comprise but is not limited to polyethylene glycol (PEG), diethylene glycol monoethyl ether (Transcutol), 23-laury] ether, aprotinin, azone, benzalkomin chloride, cetylperidium chloride, cetylmemylammonium bromide, dextran sulfate, ] uric acid, lauric aad /propylene glycol, lysophosphatilchol ine, menthol, methoxysalicylate, oleic acid,
  • PEG polyethylene glycol
  • Transcutol diethylene glycol monoethyl ether
  • 23-laury] ether aprotinin
  • azone benzalkomin chloride
  • cetylperidium chloride cetylmemylammonium bromide
  • dextran sulfate ] uric acid
  • lauric aad /propylene glycol lysophosphat
  • bile salts such as sodium deoxycholate, sodium glycodeoxycholate, sodium taurocholate and sodium glycocholate
  • surfactants such as sodium lauryl sultate, polysorbate 80, laureth-9, benzalkonium chloride, cetyipyridiniurn chloride and polyoxyethylene monoalkyi ethers such as the BRIJ® and MYRJ® series
  • benzoic acids such as sodium salicylate and methoxy salicylate
  • fatty acids such as lauric acid, oleic acid, undecanoic acid and methyl oleate
  • fatty alcohols such as octanoi and rionanol, laurocaprarn
  • the polyols propylene glycol and glycerin, cyclodextrins
  • the sulfoxides such as dimethyl sulfoxide and dodecyl methyl sulfoxide
  • the terpenes such as menthol
  • Buffer agents may be added to the tobacco wax, including without limitation to create static or a dynamic buffer systems.
  • the buffer agent is used to raise the pi I of the mouth in order to increase nicotine absorption in the buccal cavity in a manner which is based on pka and the Henderson Hasselbach equation.
  • the pH of the mouth is increased to 7 to 10, preferably 7.8 to 10, most preferably from 8.5 to 9.5.
  • the buffer agent increases the pH of the oral cavity for a period of ten minutes or more after administration
  • Buffering agents may be used to control pH, including without limitation, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, dipotassium phosphate, potassium citrate, sodium phosphate and any other such buffer system.
  • the buffer system may be designed to dynamically control the pH of the product taking into consideration the ef fect ot saliva during use, i.e., a dynamic bu ffer system.
  • buffer systems to obtain the preferred pH include dibasic sodium phosphate and monobasic sodium phosphate. Both are FDA accepted buffer materials used and listed in the inactive ingredients list.
  • the ratio of monobasic/ dibasic can be 4.6/8.6; for a pH of 7.5 the ratio of monobasic/ dibasic can be 1.9/11.9; and for a pH of 8.0 the ratio of monobasic/ dibasic can be 0.6 /13.4.
  • Nicotine salts may be employed in certain embodiments. This involves complexing nicotine with an acid, to form a salt. Suitable acids may include without limitation: pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid. US 9,215,895 (Nicotine salt formulations for aerosol devices and methods thereof) is hereby incorporated by reference as if fully stated herein.
  • the extracted nicotine oil is complexed with an acid and then mixed with the wax partition.
  • the nicotine salt may also be mixed with glycerin and then mixed with the wax.
  • the acid is complexed with the wax partition to form the salt. Crystallization inhibitors may be employed, including inter alia to avoid precipitation of the nicotine salt when the acid is complexed with the nicotine. Crystallization inhibitors are described in US 2016/0038406 (Chemically stable and oromucosally absorbable gel
  • compositions of a pharmaceutical active agent in a multi-chambered delivery system are provided.
  • Preservatives may be added to the tobacco wax to preserve freshness and inhibit microbial growth.
  • a pasteurization process step may be employed, inter alia, to prohibit microbial growth.
  • the tobacco may be pasteurized prior to extraction, or the extracted partitions themselves may be subject to pasteurization.
  • the composition maintains a wax like or relatively high viscosity and/ or consistency despite the addition of any excipients. It is generally advantageous that the tobacco wax composition does not readily flow until under heavy-vaporizing heat. However, it may be beneficial to adjust the rheological properties of the tobacco wax composition. For example, a reduced viscosity and or surface tension may be desired for various reasons, such as packaging convenience (e.g., a squeezable tube may be easier to use with reduced viscosity). The use of PG as a vapor agent may serve this purposes, having a much lower viscosity than vegetable glycerin.
  • Rheology agents may be employed to adjust the viscosity, surface tension and other rheological properties of the final product.
  • Suitable excipients including film formers, gelling agents, and surfactants.
  • film formers are used 0.01%-20%
  • gelling agents are used 0.01% - 20%
  • surfactant 0.01% - 5%.
  • a solvent may be used and then removed as
  • the resulting wax composition may be used by itself, or mixed with other vaporizable compositions both solid and liquid formats. Such mixing may be done by the manufacturer or by the user.
  • Liquid formats including without limitation e-liquid type products.
  • Solid formats include without limitation other waxes from tobacco or other plant or botanical materials.
  • the wax composition of the present invention is intended to be vaporized.
  • Suitable devices include any device capable of sufficiently heating the composition to cause it to vaporize and still not substantially burn the composition.
  • Non-limitative examples of suitable devices include devices marketed as dry herb vaporizers.
  • Suitable temperature ranges for the vaporizer heating element range from temperature needed to vaporize the composition and below the auto ignition temperature of the composition.
  • Suitable battery parameters ranging from lAmp continuous output to 30Amp continuous output.
  • the wax composition of the present invention is substantially vaporizable, meaning that it will be substantially vaporized when heated in a suitable device. It is desirable in certain embodiments that residue is minimized, including inter alia to avoid the need to clean the device between uses. Where a pod is used, residue is of less concern, since the pod is removable regularly replaced by the user, typically after the pre-filled portion of tobacco wax composition has been substantially or fully used.
  • the tobacco wax composition of the present invention when vaporized, emits lower levels or harmful or potentially harmful constituents (HPHC's) than conventional tobacco products, e.g. cigarettes.
  • HPHC's harmful or potentially harmful constituents
  • the tobacco wax composition when used in a suitable vaporizer, results in less than 25%, on average or for an individual HPCH, of the levels of HPHC's from a US-sold Marlboro Red (using comparable methods to measure e.g. Canadian method), preferable less than 10% and more preferably less than 5% and even more preferable less than 1%.
  • HPHC levels that are substantially below those of the IQOS system with a full flavor Heet, on an individual basis, or taking together as an average, or any average basket of all of, or any group of, the following enumerated analytes (such sole analyte or basket, the "comparator").
  • HPHC's may include, inter alia, Acetaldehyde, Acrolein, Acrylonitrile, 4-Aminobiphenyl, 1 - Aminonaphthalene, 2-Aminonaphthalene, Ammonia, Benzene, Benzo[a]pyrene, 1,3-Butadiene, Crotonaldehyde, Formaldehyde, Isoprene, NNN, or NN .
  • the tobacco wax composition may yield HPHC levels that are 50% lower than IQOS-Heet comparator, preferably, 75% lower, most preferably 90% lower. Such comparisons may be made using any known smoking regime, including ISO, Canadian intense, Massachusetts, FTC, etc.
  • toxicants measure below quantifiable limits. It is desirable to mitigate the levels of tobacco specific nitrosamines in the composition.
  • the tobacco wax composition has TNSA levels preferably less than 10 parts per million (ppm), more preferably less than 3 ppm, more preferably less than 1 ppm, and most preferably below quantifiable limits As shown in the examples, when vaporized the emissions of the tobacco wax composition may result in TSNA levels below quantifiable limits.
  • the present invention relates to a portion-sized container ("pod") of a tobacco wax composition for administration to a mammal or person.
  • the pod is intended for use in a personal (or other) vaporizer.
  • the pod is most commonly in a cup like shape.
  • the top is commonly open, and temporarily covered by a covering that is removed just prior to, or in connection with use of the portion sized container.
  • the portion may be for multiple uses and sessions by the user.
  • the tobacco wax composition portion may range from 1 mg to 3 grams, preferably from 250 mg to 2 grams, most preferably 400 mg to 1.2 grams.
  • the pod is received, or mated to a receiving chamber.
  • the receiving chamber comprises— or is adjacent to— the heating system.
  • the receiving chamber and pod are shaped to maintain close contact, with the absence or substantial absence of air between the two respective surfaces (so the pod surfaces are substantially in contact with the receiving chamber). This promotes heat transfer from the receiving chamber to the pod.
  • the receiving chamber comprises a ceramic type material (e.g. porcelain or ceramic).
  • the ceramic type material is a positive temperature coefficient (PTC) ceramic, allowing the receiving chamber itself to serve as a heating element or heat source.
  • PTC positive temperature coefficient
  • the PTC ceramic (or comparable receiving chamber material) is composed such that the Curie point discourages or retards heating of the tobacco wax composition above a high (upper) threshold.
  • heating element(s) are coated and/ or printed (or otherwise applied) directly onto the ceramic heating chamber. Such an approach enables various heating element patterns and shapes to readily be made, which will generally be optimizes for desired heating characteristics (e.g. even heating, speed of heating). Such application of the heating element may similarly be performed on non-ceramic heating chambers.
  • the receiving chamber itself is a comprised of heating elements.
  • the receiving chamber may be comprised of a bottom heating element which mates to the bottom of the pod, and one or more heating loops that hold in place the higher portions of the pod.
  • High threshold s may be associated with toxicant and degradant production and are to be avoided regardless of the method in which the receiving chamber is heated. It is preferable that the tobacco wax composition in the pod not be heated to greater than 750F, preferably less than 550F, more preferably less than 450F, still more preferably less than 350 F, still more preferably less than 325 F, yet still more preferably under 300F, and most preferably under 260 F.
  • Relatively low temperatures may be employed given the propensity of the tobacco wax composition of the present invention to vaporize.
  • a preferred operating temperature range is 225F to 350F, or 250F to one of the temperature bounds set forth in this paragraph.
  • an upper threshold temperature is not exceeded, or not generally or likely to be exceeded in normal consumer use.
  • the device be capable of rapidly reaching operating temperatures (without overshooting target operating temperatures or exceeding high threshold temperatures), or otherwise sufficient temperatures.
  • the device is capable of heating the tobacco wax composition in the pod reach the preferred operating temperature range rapidly, meaning in less than 10 seconds, preferably in less than 5 seconds, more preferably in less than 3 seconds, most preferably in less than 1 second.
  • the device has a warm up phase of ten seconds or less, with subsequent puffs being achieved more rapidly. Multiple preheat cycles may be employed on the same pod in the event that the user does not consume the product in one event.
  • the Heatstick comprises reconstituted tobacco that is pierced by the IQOS heating blade, when heated the reconstituted tobacco will tend to lose plasticity, and may adhere or otherwise crumble into or stick to the IQOS device after use. Accordingly, IQOS provides extensive instructions on how to "release any Heatstick fragments"
  • IQOS IQOS
  • This description of IQOS provides a number of difficulties for a user: the need to wait twenty seconds for the device to reach operating temperature; the need to consumer the entire heat stick within six minutes, need to recharge from the larger battery back (the "holder") every fourteen puffs.
  • Bottom airflow is the primary design currently used in cigarettes and vapor pens. Bottom airflow directs air directly over the heating coil (where vapor is created) . The wick for e-liquid helps to prevent leaking of the e-liquid.
  • the tobacco wax composition containing pod is heated. Vapor forms — often at the bottom and sides of the pod closest to the heat, and the wax product is vaporized (and climbs through the top of the wax product).
  • Side airflow may enter through the sides of the pod.
  • the pod itself has holes that correspond to side airholes located in the sides of the receiving chamber (and permitting airflow, being connected to the outside of the vaporizer).
  • Such side holes in the pod are covered prior to use (to protect the product), and such cover is removed by the user prior to use or automatically by the device.
  • the device it is also possible for the device to create side airholes in the pod material (as opposed to removing the covering from pre-formed airholes), where a relatively weak material is used that can be readily punctured.
  • the side airflow must enter above the tobacco wax composition product fill level (as distinct from the top of the pod).
  • the product fill level must be calibrated to the location of the side airholes, if any, in the sides of the pod.
  • Side airflow may also enter from the side of the receiving chamber above the top of the pod. Where there are side airholes above the top of the pod, similarly the product fill level is still calibrated to the distance from the product fill to the airholes. If the distance is too short, blockage is more likely. Similarly, if the distance is too long vapor production will be lessened.
  • the side airholes are less than 4 mm from the starting product fill level, preferably less than 2 mm from the starting product fill level, preferably more than .5 mm from the starting fill level, more preferably more than 1 mm from the starting fill level.
  • Side airholes may be directed downwards (i.e. at a downwards trajectory) to increase the air vortices and turbulence.
  • Airholes may be protected from wax blockage in a number of ways.
  • a physical obstruction e.g. a physical lip. Such physical obstructions can make it harder for melted wax to flow into the airhole (particularly when the user physically moves the pen during use— for example, starting with a vaporizer perpendicular to the flow and then moving the vaporizer to a parallel position for use).
  • materials including coatings
  • materials may be selected to minimize or direct the flow of liquid wax away from the airholes to prevent blockage.
  • Physical channels e.g.) grooves may be similarly employed to direct the flow if liquid wax away from the airholes.
  • Placement of airhole locations can be oriented to avoid or reduce blockage.
  • the personal vaporizer may be raised to mouth of a user and held parallel to the ground when used.
  • a conventional heat button can be readily used by the thumb or an opposing finger, and is not a good predictor for orientation (although the user will typically have the battery button pointing up or down).
  • the mouthpiece however can be shaped in such a way that is intuitive to the user to orient the vaporizer in a certain direction (as a non-limitative example, a plastic cigarillo tip is typically formed in a way that a user would know how to orient the cigarillo).
  • the side airholes can be oriented such that the airholes are biased to the up-wards plane when the vaporizer is oriented parallel to the ground plane (since we know how the user will orient the vaporizer because of the mouthpiece.
  • three airholes may be used (in the receiving chamber potentially with aligned pod holes) that are positioned with a bias against the downward side (meaning the airholes are biased towards the upward side when the device is uses as expected including through use of a shaped or marked mouthpiece).
  • the vaporizer, pod and/ or receiving chamber may have up to ten side airholes, preferably 2-6 side airholes most preferably 3-5 side airholes. Where a mesh or similar covers the airhole opening, the number of airholes would be understood to be the number of air channels.
  • the device may similarly be marked or shaped on a part of the device other than the mouthpiece to indicate a desired orientation (with corresponding placement of airholes as described above to reduce blockage potential).
  • shape indentations may be provided to signal a desired holding of the device in the hand.
  • the pod has a diameter of 3-15 mm, preferably 6-10 mm (with a corresponding internal diameter for the receiving chamber).
  • the pod has a height of .5 to 22 mm, preferably 2 to 10 mm (with a corresponding size for the receiving chamber).
  • the pod itself may comprise the heating chamber, optionally including the heating element as a component of the pod. While this embodiment may be more costly to manufacture (as compared with a pod that merely mates with a heating chamber), such embodiment offers the advantage of providing a fresh heating elements with each pod. Such advantage may be associated with increased puff consistency since degradation of the heating element is avoided through less use (i.e. replacement or substantial replacement with each new pod).
  • Heated tobacco wax compositions in a pod can be explosive (in terms of physical motion— not ignition) when wax at the bottom of a pod is vaporized, and the vapor pressure is such as to disrupt the wax above to allow the vapor to escape.
  • shield a physical obstruction that prevents direct passage of heated tobacco wax composition material from the pod or cup to the mouthpiece.
  • the shield is attached to the mouthpiece (but it may equally attach to other parts of the vaporizer).
  • the shield may also employ features intended to increase airflow turbulence, without adversely affecting the user's "draw” on the vaporizer.
  • the Pod may similarly be designed to minimize the possibility of wax explosions.
  • a rim or brim on the pod may act in the same manner as the shield to obstruct wax explosions from traversing the mouth piece.
  • the pod-receiving chamber may have a rail, slot or comparable alignment interface to ensure the pod is appropriately aligned in the receiving chamber, including for other reasons, so that the airholes from the receiving chamber align or substantially align with the pod airholes.
  • the pod has complimentary features to mate with the alignment interface.
  • alignment may also be used for other purposes, i.e. to facilitate other connections between pod and receiving chamber (e.g. data link, ejector system, etc).
  • the vaporization device may have an ejection system to facilitate ejection of the pod from the receiving chamber (as opposed to relying upon shaking or use of inertia to evacuate the pod).
  • Such system may comprise, without limitation, a physical ejector to lift the pod out of the receiving chamber.
  • a mouthpiece sits above the pod-receiving chamber assembly.
  • the mouthpiece employs a combination of distance and relatively low heat transfer properties to ensure the mouthpiece is not uncomfortably warm for the user.
  • the mouthpiece may be integrated with a shield and/ or a device to increase turbulent airflow.
  • a sleeve designed to ease cleaning of the mouthpiece. Wax may form on the inside mouthpiece during use of the material, either from explosion of wax or from condensation of materials. Such remainder wax may be unsightly and require manual cleaning.
  • a sleeve may be shaped such that it adheres or substantially adheres to the mouthpiece.
  • the sleeve may be disposable, allowing a user to simply dispose of the sleeve (rather than cleaning the mouthpiece), akin to a disposable coffee filter.
  • the sleeve may comprise any suitable material, including without limitation, a paper, pressed paper, cardboard, a cellulosic, or other suitable material.
  • the selected material for the sleeve should resist formation from air vortices, or from trapped wax or condensate.
  • the sleeve material may be coated. Coatings may be designed (and sleeve materials selected) to resist adhesion of wax (to encourage the adhered material to drop back to the heating chamber), or to encourage adhesion. Encouraging adhesion may useful to avoid contact of the user with condensate when removing the sleeve.
  • the sleeve may be absorbent to better catch the wax or condensate.
  • a reusable sleeve may also be employed in certain embodiments.
  • the sleeve may be removed, cleaned, and replaced.
  • any suitable material may be employed that can be readily re -used.
  • the mouthpiece For embodiments for which the mouthpiece can be used with a sleeve, the mouthpiece must be capable of being easily placed into the mouthpiece, as well as capable of being readily released by the user for disposal or cleaning.
  • a latch or locking mechanism may be employed.
  • the sleeve is held in place by simple screwing the mouthpiece onto the heating chamber.
  • the sleeve can be released in less than 5 seconds by the user, preferably in less than 2 seconds, most preferably in less than one second.
  • the sleeve may be any suitable color.
  • a shade of brown may be used to better mask the appearance of the adhered or trapped wax.
  • dark colors are preferred.
  • the pod itself may be fashioned from a material that heats, e.g. a PTC ceramic. Other materials may also be used that heat when electric current is supplied.
  • the receiving chamber acts as a physical receiving area, may provide airflow (airholes) and may integrate power to the pod.
  • the pod may further comprise a thermistor to measure temperature, either of the pod itself or wax contained therein.
  • Empty pods may also be offered to allow the user to treat the device as an open system (meaning they can use their own vaporizable materials).
  • the pod may be made from any suitable material. Special care must be given that the pod material does not emit undesirable elements when heated.
  • the material will generally be a solid material, but flexible materials may also be employed.
  • a pod with a flat or substantially flat bottom surface is desirable for handling by the consumer, other shapes may be used. Specifically, a shape whereby the cup is half a circle will mean reduce mean geographic distance from the receiving chamber walls. Other shapes can be selected with this same purposes, i.e. to reduce geographic distance. Corners may, ceteris paribus, create higher heat areas within the tobacco wax contained in the pod.
  • the pod may be integrated with the sleeve function.
  • the pod may be in the shape of a circular cauldron— which is heated— connected to an upper conical shape that prevents the mouthpiece from getting wax or wax condensate adhered.
  • the pod may be comprised of multiple materials— the lower portion designed for heating, and a separate upper material that is designed to function as a sleeve.
  • it may be desirable to have a separating material between the heatable portion of the pod and the sleeve portion. It in cases where adequate power is available, the design may allow the sleeve to heat. Such heat may be useful to reduce adhered wax composition.
  • the top of the pod is covered with a porous layer which remains on top of the pod during use.
  • This porous layer is sufficiently porous to allow for transmission of sufficient vapor for the user.
  • the porous layer is similarly sufficiently porous not to interfere or prevent a desired pressure drop.
  • the pressure drop of the device used to vaporize the tobacco wax composition, inclusive of the pod if any will have a pressure drop of 20 (mm H20) to 175 (mm H20), preferably 75 (mm H20) to 130 mm (H20), most preferably 90 (mm H20) to 110 (mm H20).
  • the porous layer is sufficiently non-porous to prevent (or substantially prevent or partly prevent) parts of the wax composition from exploding upwards and escaping from the heating chamber to whence they may adhere to the mouthpiece.
  • the porous layer may be made from any suitable material.
  • a thermo- conductive material is used, such that the permeable layer. Thermo-conduction may be used to encourage parts of the wax composition that are caught or trapped on the permeable layer to drip off and re-join the wax composition in the heating chamber (and/ or themselves be vaporizer).
  • the porous layer may be selected or coated so as to resist adhesion of wax composition components to the layer.
  • the porous layer includes heating element(s).
  • the top of the pod is covered with two layers.
  • the outer layer is an impermeable or semi-impermeable layer for barrier purposes (i.e. product stability and freshness) (a "barrier layer"). Underneath the outer layer is the porous layer which remains on during use.
  • porous materials akin to those described for the porous top layer, may be used to cover sideholes or other airholes.
  • the top of the pod may be configured to allow for easy access by a consumer. This allows a consumer to add other waxes or extracts to the Pod. Conversely, the system may be configured to make it difficult for a consumer to add their own materials to the pod.
  • a temperature meter can be built into the pod, the receiving chamber, or both.
  • the pod and receiving chamber are used as part of a vaporizing system, further comprising a power source (typically electric, but it may also be a carbon-based source, or butane based source or other source of heat), and a control module that allows the user to select heat settings, turn the device on or off, as well as other features.
  • the device may be able to store and communicate use data.
  • the Pod may be able to communicate to the device (or the device determine from the Pod) the type of Pod (flavor, quantity of wax composition, nicotine strength, etc).
  • Pod will give additional flexibility to the wax composition formulation, because non-vaporizable ingredients may be used in the composition without leaving the non-vaporizable ingredients as residue that require cleaning by a user.
  • Film formers or molasses are non-limitative examples of non-vaporizable ingredients that may be employed.
  • the use of the pod is not limited to tobacco wax compositions but may also be employed with other botanical or plant wax compositions, as well as e-liquids. Such materials may be used in combination with tobacco wax. References herein to tobacco wax compositions can also refer to these products and compositions comprising them.
  • the IQOS device has an operational temperature of 350 C; in contrast the GLO uses has a lower operating temperature of 240 C.
  • This difference in operating heating temperatures can likely be explained by the different heating configurations of the two devices.
  • IQOS employs a flat, thin, heated blade or knife upon which the tobacco stick is impaled. The knife does not reach the outer edges of the heat stick (tobacco stick) (otherwise it would destroy the tipping paper on the outside of the tobacco stick). Approximately, it can be thought of as having the width of .8 of the tobacco stick.
  • GLO reportedly heats from the circumference surrounding the tobacco stick. Assuming a heating element of the same length, the
  • the tobacco wax of the composition has no or substantially air spaces. In various embodiments, it is a solid, semi-solid or viscous liquid. All of these embodiments substantially lack air spaces. The result is that the tobacco wax composition has efficient heat transfer attributes. Glycerin and propylene glycol both have excellent heat transfer properties
  • the tobacco wax composition is heated in preferred embodiments with the absence or substantial absence of air convection to heat the tobacco wax composition.
  • the tobacco wax composition of the present invention has a thermal conductivity at 300k (80.3 F) of greater than .1, preferably greater than .2, more preferably greater than .25 (W/m K).
  • the substantial absence of air in the tobacco wax composition may also serve to prevent or reduce oxidation when the tobacco wax composition is heated.
  • the relatively low vapor production of reconstituted tobacco heat burn products may be improved by the addition of tobacco wax and/ or tobacco wax compositions to the reconstituted sheet.
  • compositions may be added to the matrix prior to casting or creating the reconstituted sheet, or added to after the reconstituted sheet is formed.
  • the tobacco wax composition may be positioned in a product separately from the reconstituted tobacco.
  • a cigarette form may comproise a tobacco wax composition, and separately, a plug of reconstituted tobacco.
  • the lower temperatures needed to vaporize tobacco wax compositions may be desireable here to produced effluent vapor while the reconstituted sheet is still in warm up phase.
  • tobacco wax compositions can be used with separarly contained liquids, akin to BAT's iFUSE product.
  • Figure 1 is a perspective view showing a l l heating chamber containing a 10 tobacco wax composition.
  • the outside of the heating chamber assembly is 12.
  • the tobacco wax composition is in a pod.
  • FIG 2 is an exploded perspective of the heating chamber sub assembly, including a ceramic heating chamber 11, which may contain a pod or may comprise itself a pod.
  • the 13 heating element may be printed or coated onto the heating chamber, which in preferred embodiments in ceramic.
  • 12 is the wall of the heating chamber casing.
  • 14 is an air flow slot for the heating chamber or pod receiver.
  • 15 is an airhole in the heat chamber or pod receiver (other airhole figurations may be employed in different embodiments).
  • 16 is an electrode insulator.
  • 17 is the electrode.
  • 18 is the mouthpiece screw thread.
  • Figure 3 is a cross-sectional view of the heating chamber containing a tobacco wax composition. 10 is the tobacco wax composition; other numbers are as above.
  • Figure 4 is a cross section of the wall of the 12 heating chamber casing.
  • Figure 5 is a cross section of the receiver for the heating chamber or pod, including the battery connection section. 19 is the battery screw thread.
  • Figure 6 is a cross section of the 17 electrode.
  • Figure 7 is a cross section of the 16 electrode insulator.
  • Figure 8 is a perspective view of a pod (or heating chamber) showing a 13 printed or coated heating element and 20 positive and 21 negative electrical contacts.
  • Figure 9 is an exploded perspective view of a 11 pod, a 23 porous layer, and a 22 barrier layer.
  • the tobacco wax composition is contained and bounded by the pod shape, or otherwise by the heating chamber. When used in a device, it typically comprises no substrate, paper or tipping paper. This absence distinguishes the product from typical heat not burn products like IQOS or GLo.
  • Tobacco wax was removed from tobacco leaf using supercritical C02 extraction. Tobacco oil was mixed in with the wax, while retaining a wax consistency. The material was fragrant and dark brown in color. A nicotine assay indicated a nicotine strength for the tobacco wax of 4%. The wax was placed in a dry herb vaporizer and vaped by a healthy adult male. The tobacco wax vaporized creating a nice vapor volume. The nicotine delivery was strong and the product was fragrant with tobacco fragrance. The tobacco wax substantially vaporized leaving minimal residue on the heating coil.
  • Example A The tobacco wax of Example A was taken and 10% of vegetable glycerin and 5% of propylene glycol (measuring by weight of the final composition) was added. The tobacco wax accepted the addition of these vapor agents. The resulting composition was placed in a dry herb vaporizer and used by a healthy adult male. The flavor was excellent and the vapor production was increased from Example A.
  • Example A The tobacco wax of Example A was taken and grape flavor from Tobacco Technology, Maryland was added, at 3.5% of the composition.
  • the resulting tobacco wax composition was placed in a dry herb vaporizer and used by a healthy adult male. The grape taste was enjoyed by the user.
  • Tobacco wax was extracted from a different of blend tobacco leaf using supercritical C02 extraction.
  • the tobacco wax was dark with a slightly green tinge.
  • the nicotine content of the tobacco wax was approximately 1.5%.
  • Nicotine glycerin solution (10%) was added to 10% of the final composition weight.
  • the product vaped well but the flavor notes where not as attractive as the tobacco wax of Example A. It was observed that additional flavors could improve the product.
  • Example D Oil from the extraction of tobacco described in Example D was added to the tobacco wax of Example D, and the composition was mixed using strong shear forces. The resulting product vaped well and left very little residue.
  • Tobacco wax from Example A was placed in a vaporizer.
  • a small amount of zero nicotine flavored e-liquid was added to the vaporizer.
  • the two were not otherwise mixed other than to insert them together.
  • the wax and the zero were vaporized together.
  • a fair amount of residue was left by this mix in the vaporizer.
  • the exercise was repeated with a yet smaller amount of e- liquid with improve results including much less residue.
  • Tobacco wax from Example A was compounded with a small amount of sodium carbonate as a buffer agent to affect a more basic pH.
  • Tobacco wax was extracted from flue cured tobacco with low TSNA levels. The extraction was performed using supercritical C02 extraction. The wax partition was approximately 4% of the mass of the starting tobacco. Tobacco wax was also extracted from burley tobacco with low TSNA levels, again using supercritical C02 extraction, and again with a yield of approximately 4%.
  • Example H The tobacco wax partitions of Example H were blended, at a ratio of 70% flue cured to 30% burley. The combined wax partition was then mixed with vegetable glycerin, for a final composition of 50% tobacco wax, and 50% vegetable glycerin.
  • Example I The final composition of example I was sent to a third party laboratory for nicotine testing.
  • the composition was measured to contain 3.3% nicotine, implying that the blended wax partition had a starting nicotine level of 6.6% (prior to dilution with vegetable glycerin).
  • LOQ for the testing was 0.16%.
  • Example I The final composition of Example I was sent to a third party laboratory for emissions testing. Results were as follows.
  • the smoke regime for the above testing was: 55mL puff/ 30 sec interval/ 3 sec duration.
  • the composition was vaporized in a vaporization pen, on high heat.
  • the basis for this surprising result may reflect in part reduced energy requirements to volatilize the tobacco wax compositions of the present invention, as compared to the energy requirements needed aerosolize the components contained in the solid matrix which is the reconstituted tobacco comprising the Heat Stick used in IQOS.
  • below quantifiable limits indicates that no amount of the analyte exists above the limit of quantification.
  • the analyte is understood to exist at a level ranging from zero to less than the quantifiable limit.
  • Polysorbate Teween 20 was added to the composition of Example I, and the resulting composition was placed in 5 ml tubes, alongside of 5 ml tubes filled with the composition of I. It was noted that the addition of polysborbate substantially reduced separation of the vegetable glycerin from the tobacco wax.
  • the blend was particularly pleasant, offered excellent tobacco flavor and rich tobacco satisfaction.
  • a healthy male volunteer took a Ploom Model 2 device, and removed the tobacco from the product's pod, and replaced this tobacco with the tobacco wax composition of L.
  • the Model 2 was then started in accordance with its directions.
  • the Model 2 has a thirty second warm up period, and reaches an operating temperature of 175 C/ 347 F.
  • the tobacco wax composition violently vaporized during the warm up phase (the indicating light blinks during said phase), and bubbled out of the mouthpiece.
  • the tobacco wax composition in certain embodiments of the present invention, readily vaporizes under 347 F.
  • the inventors attributed the ability of the tobacco wax vaporization to be readily vaporized— using on-off heating (as opposed to a prolonged warm up stage— meaning a warm up stage taking over 3, 4 or 5 seconds).

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Abstract

L'invention concerne des compositions de cire de tabac appropriées pour être utilisées dans un vaporisateur. La cire de tabac peut comprendre des excipients supplémentaires comportant des agents en phase vapeur, des agents de pénétration, des agents tampons et des agents rhéologiques. La composition contient de la nicotine. La composition de cire de tabac laisse un minimum de résidus dans le vaporisateur lorsqu'elle est utilisée. Selon un autre aspect, l'invention concerne un récipient de conditionnement unitaire (« dosette ») d'une composition de cire de tabac destinée à être administrée à un mammifère ou à une personne. La dosette est destinée à être utilisée dans un vaporisateur personnel (ou autre).
PCT/US2017/053416 2016-09-27 2017-09-26 Compositions de cire de tabac vaporisables et récipient associé Ceased WO2018064032A1 (fr)

Priority Applications (3)

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JP2019538089A JP2019532671A (ja) 2016-09-27 2017-09-26 気化性タバコワックス組成物及びその容器
EP17857276.4A EP3518692A4 (fr) 2016-09-27 2017-09-26 Compositions de cire de tabac vaporisables et récipient associé
US16/159,015 US10918127B2 (en) 2016-09-27 2018-10-12 Vaporizable tobacco wax compositions and container thereof

Applications Claiming Priority (6)

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US15/276,902 2016-09-27
US15/276,902 US10709165B2 (en) 2016-09-27 2016-09-27 Vaporizable tobacco wax compositions
US15/403,472 2017-01-11
US15/403,472 US20180084822A1 (en) 2016-09-27 2017-01-11 Vaporizable Tobacco Wax Compositions and Container thereof
US15/638,609 US20180084823A1 (en) 2016-09-27 2017-06-30 Vaporizable Tobacco Wax Compositions and Container thereof
US15/638,609 2017-06-30

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US15/923,587 Continuation-In-Part US20180199618A1 (en) 2016-09-27 2018-03-16 Vaporizable Tobacco Wax Compositions and Container thereof

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JP2022505851A (ja) * 2018-11-01 2022-01-14 ニコベンチャーズ トレーディング リミテッド エアロゾル化可能な配合物
JP2022515021A (ja) * 2018-12-31 2022-02-17 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 水不混和性溶媒を含む液体ニコチン製剤
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JP2021525539A (ja) * 2018-06-07 2021-09-27 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム エアロゾル形成基体を加熱するための電気加熱組立品
JP7399890B2 (ja) 2018-06-07 2023-12-18 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム エアロゾル形成基体を加熱するための電気加熱組立品
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KR102879206B1 (ko) 2018-06-07 2025-11-03 필립모리스 프로덕츠 에스.에이. 에어로졸 형성 기재를 가열하기 위한 전기 가열 조립체
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