WO2018059219A1 - Stent for implantation into blood vessel - Google Patents

Abstract

Disclosed is a stent (100, 200, 300, 400, 500, 600, 700, 800, 900) for implantation into a blood vessel, comprising a stent body (101, 201, 301, 401, 501, 601, 701, 801, 901). The stent body (101, 201, 301, 401, 501, 601, 701, 801, 901) is provided with a positioning component (802, 902). The positioning component (802, 902) has an extended portion (102, 202, 302, 402, 502, 602, 702) extending outwardly from the outside of the stent body (101, 201, 301, 401, 501, 601, 701, 801, 901), wherein the extended portion (102, 202, 302, 402, 502, 602, 702) is adapted to be inserted into a blood vessel wall. Since the stent body (101, 201, 301, 401, 501, 601, 701, 801, 901) is provided with the positioning component (802, 902), and the positioning component (802, 902) is provided with the extended portion (102, 202, 302, 402, 502, 602, 702) adapted to be inserted into the blood vessel wall, the probability of the stent (100, 200, 300, 400, 500, 600, 700, 800, 900) being displaced under the impact of a blood flow can be effectively reduced, and the treatment effect can be improved.

Description

Stent for implanting blood vessels

Cross-reference to related applications

The present application claims the benefit of and priority to the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the benefit of the disclosure of the disclosure of

Technical field

The present invention relates to a stent for implantation into a blood vessel.

Background technique

In recent years, minimally invasive endovascular treatment techniques for vascular surgery have made great progress, and vascular stents have been widely used in the treatment of systemic vascular diseases. According to different lesion distribution, different vascular stents can be mainly applied to peripheral vascular lesions, small arterial lesions, aortic lesions, and venous lesions; depending on the pathology, different vascular stents can be used for vascular traumatic lesions, vascular stenosis or Restenosis lesions, etc.

Although vascular stents have better therapeutic effects than surgery, they still have certain limitations. For example, when the stent is implanted into a blood vessel, the blood vessel exerts an impact force on the stent, so that the stent is easily displaced in the blood vessel.

Summary of the invention

In order to solve the above technical problems, the present invention provides a stent for implanting a blood vessel, the stent comprising:

a bracket body; the bracket body is provided with a positioning component; the positioning component has an extension extending outward from an outer side of the bracket body, the extension being adapted to be inserted into a blood vessel wall. In some embodiments, the extension does not penetrate the vessel wall.

In some embodiments, the extension forms an angle with the axis of the stent body of between 10[deg.] and 80[deg.].

In some embodiments, the end of the extension is the shortest to the outer surface of the stent body The distance is between 0.05mm and 1.1mm.

In some embodiments, the bracket body is provided with a plurality of the positioning components.

In some embodiments, the plurality of the positioning members are equally spaced along the circumference of the stent body.

In some embodiments, the plurality of positioning members are not disposed in the same circumferential direction. The plurality of positioning members are equally spaced along the axial direction of the bracket body.

In some embodiments, the ratio of the distance of the positioning member to one end of the bracket body that is further from the positioning member to the distance from the other end of the positioning member to the bracket body is between 4 and 50.

In some embodiments, the bracket body is laser cut; the positioning component is integrally formed with the bracket body, or the positioning component is fixedly coupled to the bracket body.

In some embodiments, the stent body is woven from a braided wire; the positioning component further has a connection for securing the extension to the stent body.

In some embodiments of the invention, the positioning component is disposed at a non-node location of the stent body.

In some embodiments, the connecting portion has a cavity through which the braided wire passes; the connecting portion is fixedly coupled to the braided wire passing through the cavity thereof.

In some embodiments, the connecting portion is integrally formed with the braided wire.

In some embodiments, the extension is integrally formed with the connecting portion, or the extension is fixedly coupled to the connecting portion.

In some embodiments, the diameter of the port at one end of the stent body is greater than the diameter of the port at the other end.

In some embodiments, the port of one end of the stent body expands radially into a flared shape, the flared port having a diameter that is between 0.5% and 200% greater than the diameter of the stent body. The positioning member is disposed at the other end of the bracket body opposite to the horn-shaped port.

In some embodiments, the surface of the stent is coated with a coating, wherein the coating comprises a drug that prevents restenosis of the blood vessel, the coating having a thickness between 0.1 um and 100 um.

In some embodiments, the medicament comprises at least one of an antithrombotic drug and an antiproliferative drug. For example, antithrombotic drugs include heparin, clopidogrel, aspirin, urokinase, dicoumarin, and derivatives thereof; antiproliferative drugs include rapamycin and paclitaxel.

Since the positioning member is provided on the bracket body, and the positioning member has a shape suitable for insertion into blood The extension of the tube wall can effectively reduce the probability of the stent being displaced due to the impact of the blood flow, and improve the therapeutic effect.

The blood vessel stent of the present invention includes, but is not limited to, an intravenous stent, a peripheral stent, an aortic stent graft, a carotid stent, an intra-orbital stent graft, and a radial artery stent graft.

DRAWINGS

1 is a schematic view of a stent for implanting a blood vessel according to Embodiment 1 of the present invention;

Figure 2 is an enlarged view of a portion A of Figure 1;

3 is a schematic view of a stent for implanting a blood vessel according to Embodiment 2 of the present invention;

Figure 4 is an enlarged view of a portion B of Figure 3;

Figure 5 is a schematic view of a stent for implanting a blood vessel according to Embodiment 3 of the present invention;

Figure 6 is an enlarged view of a portion C of Figure 5;

Figure 7 is a schematic view of a stent for implanting a blood vessel according to Embodiment 4 of the present invention;

Figure 8 is an enlarged view of a portion D of Figure 7;

9 is a schematic view of a stent for implanting a blood vessel according to Embodiment 5 of the present invention;

Figure 10 is an enlarged view of a portion E in Figure 9;

Figure 11 is a schematic view of a stent for implanting a blood vessel according to Embodiment 6 of the present invention;

Figure 12 is an enlarged view of a portion F of Figure 11;

Figure 13 is a schematic view of a stent for implanting a blood vessel according to Embodiment 7 of the present invention;

Figure 14 is an enlarged view of a portion G in Figure 13.

Figure 15 is a schematic view of a stent for implanting a blood vessel according to Embodiment 8 of the present invention;

Figure 16 is a schematic view of a stent for implanting a blood vessel according to Embodiment 9 of the present invention.

In the figure: 100, 200, 300, 400, 500, 600, 700, 800, 900-bracket, 101, 201, 301, 401, 501, 601, 701, 801, 901 - bracket body, 102, 202, 302, 402, 502, 602, 702 - extension of the positioning component, 103, 203, 403 - connection of the positioning component, 802, 902 - positioning component, 804, 904 - horn port, 805, 905 - the other end port, 104 , 204, 304, 404 - a braided wire constituting the stent body, 503, 603, 703 - a support rib of the stent body, 504, 604, 704 - a connecting rib of the stent body.

detailed description

The various aspects of the invention are described in detail below with reference to the drawings and specific embodiments. The components in the drawings are not necessarily drawn to scale, and the emphasis is on the principles of the invention.

In various embodiments of the invention, well-known structures or materials are not shown or described in detail. Also, the described features, structures, or characteristics may be combined in any manner in one or more embodiments. In addition, those skilled in the art should understand that the various embodiments described below are for illustrative purposes only and are not intended to limit the scope of the invention. It will also be readily understood that the components of the various embodiments described herein and illustrated in the Figures can be arranged and designed in a variety of different configurations or ratios.

Embodiments of the present invention provide a stent for implanting a blood vessel, the stent comprising a stent body having one or more positioning members disposed thereon, each of the positioning members having an outwardly extending outward from the outside of the stent body An extension adapted to be inserted into a vessel wall. Wherein, the end portion of the extending portion closer to the bracket body is a starting end, and the end portion opposite to the starting end is an end portion. In some embodiments of the invention, the extension does not penetrate the vessel wall.

In some embodiments of the invention, the extension forms an angle with the axis of the stent body of between 10[deg.] and 80[deg.]. For example, the extension forms an angle with the axis of the stent body of between 30 and 60 degrees. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be reduced, so that the stent can be firmly positioned. For example, the angle of the extension with the axis of the stent body is 45°. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be further reduced, so that the stent can be further firmly positioned.

In some embodiments of the invention, the shortest distance from the end of the extension to the outer surface of the stent body is between 0.05 mm and 1.1 mm. For example, the shortest distance from the end of the extension to the outer surface of the stent body is between 0.2 mm and 0.7 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be reduced, so that the stent can be firmly positioned. For example, the shortest distance from the end of the extension to the outer surface of the stent body is 0.5 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be further reduced, so that the stent can be further firmly positioned.

The material of the stent body is, for example, a nickel-titanium alloy, a cobalt-chromium alloy, a stainless steel, a polymer material, or a biodegradable material; and in terms of the type of the stent body, for example, a self-expanding stent or a ball expansion For the material of the extension portion of the positioning member, a material having a hardness greater than that of the blood vessel wall, such as an alloy or stainless steel, may be selected.

The stent for implanting a blood vessel provided by the present invention will be specifically described below in conjunction with specific embodiments. Bright.

[Embodiment 1]

As shown in FIG. 1, the bracket 100 has a bracket body 101 woven from a braided wire, and four positioning members are fixedly disposed on the bracket body 101, and each positioning member is disposed at a position close to the end of the bracket body 101 (to The distance between the distal end of the bracket body 101 and the end closer to the bracket body 101 is between 4 and 50, and each positioning component is disposed at a non-node position of the bracket body 101. The non-node position refers to a position on the bracket body 101 that deviates from the node (the intersection of the braided wires). Two of the positioning members are adjacent to one end of the bracket body 101, and the other two positioning members are adjacent to the other end of the bracket body 101. Of course, the embodiment of the present invention is not limited thereto. For example, four positioning members may be adjacent to the same end of the bracket body, or one of the positioning members may be adjacent to one end of the bracket body, and the other three positioning members are adjacent to the other end of the bracket body. . Figure 2 is an enlarged view of a portion A of Figure 1. As shown in FIG. 2, the positioning member includes an extension portion 102 and a connecting portion 103. The extension 102 extends outwardly from the outside of the stent body 101 and forms a sharpened end. The connecting portion 103 fixedly connects the extending portion 102 to the braided wire 104. Wherein, the connecting portion 103 has a cavity through which the braided wire 104 passes, and the connecting portion 103 is fixedly connected (for example, welded, bonded) to the braided wire 104. The extension portion 102 is integrally formed with the connection portion 103. Further, as shown in FIG. 1, the extension portions of the four positioning members each extend toward the same end side of the bracket 100. When the stent is placed in the blood vessel, the extension of the positioning member is oriented in the direction of blood flow in the blood vessel, so that the stent is more easily inserted into the blood vessel wall in the blood vessel for better positioning effect.

Of course, the embodiment of the present invention is not limited thereto. For example, the connecting portion 103 may be integrally formed with the braided wire 104, and the extending portion 102 may also be fixedly connected (for example, welded or bonded) to the connecting portion 103; Some or all of the positioning members are disposed on the nodes of the bracket body 101.

[Embodiment 2]

Fig. 3 shows a stent for implanting a blood vessel according to Embodiment 2 of the present invention. The bracket 200 in the second embodiment differs from the bracket 100 in the first embodiment in the structure of the positioning member. Other contents are the same as those in Embodiment 1, and are not described herein again. As shown in Figure 4, the extension 202 of the positioning member has two sharp ends, and the distance between the two sharp ends is between 0.1 mm and 0.5 mm, for example, the distance between the two ends. Between 0.2mm and 0.4mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be reduced, so that the stent can be firmly positioned. For example, 2 The distance between the ends is 0.3 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be further reduced, so that the stent can be further firmly positioned.

[Embodiment 3]

Fig. 5 shows a stent for implanting a blood vessel according to Embodiment 3 of the present invention. The bracket 300 in the third embodiment differs from the bracket 100 in the first embodiment in the structure of the positioning member. Other contents are the same as those in Embodiment 1, and are not described herein again. As shown in Figure 6, the positioning member includes an extension 302, wherein the extension 302 has three sharp ends. Also, the extension 302 is fixedly attached (eg, welded or bonded) to the braided wire. The distance between two adjacent ones of the three ends is between 0.1 mm and 0.4 mm, for example, the distance between adjacent two ends is between 0.2 mm and 0.3 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be reduced, so that the stent can be firmly positioned. For example, the distance between two adjacent ends is 0.25 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be further reduced, so that the stent can be further firmly positioned.

[Embodiment 4]

Fig. 7 shows a stent for implanting a blood vessel according to Embodiment 4 of the present invention. The bracket 400 in the fourth embodiment differs from the bracket 100 in the first embodiment in the structure of the positioning member. Other contents are the same as those in Embodiment 1, and are not described herein again. As shown in Fig. 8, the extension portion 402 of the positioning member has five sharp ends, and the distance between two adjacent ones of the five ends is between 0.1 mm and 0.4 mm, for example, two adjacent The distance between the ends is between 0.2 mm and 0.3 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be reduced, so that the stent can be firmly positioned. For example, the distance between two adjacent ends is 0.25 mm. Thereby, the resistance of the stent release and the resistance of the insertion into the blood vessel wall can be further reduced, so that the stent can be further firmly positioned.

[Embodiment 5]

Fig. 9 shows a stent for implanting a blood vessel according to Embodiment 5 of the present invention. As shown in FIG. 9, the bracket 500 has a bracket body 501 cut by laser, that is, the bracket 500 has a bracket body 501 formed by cutting a corresponding mesh structure or other hollow structure on the pipe by a laser, and the bracket body 501 has a plurality of supporting ribs 503 and a plurality of connecting ribs 504, wherein a plurality of supporting ribs 503 are disposed along the axial direction of the bracket body 501, and the adjacent two supporting ribs 503 are connected by a plurality of connecting ribs 504 disposed along the circumference. . The support rib 503 has a wavy annular structure, and the connecting rib 504 has an S-shaped structure. Four positioning members are fixedly disposed on the bracket body 501, and each positioning member is disposed at a position close to the end of the bracket body 501 (the distance from the far end of the bracket body 501 to the bracket body) The distance between the closer ends of the 501 is between 4 and 50, wherein two positioning members are close to one end of the bracket body 501, and the other two positioning members are adjacent to the other end of the bracket body, and two positioning members are adjacent to the same end. The stent bodies 501 are circumferentially equally spaced. Of course, the embodiment of the present invention is not limited thereto. For example, four positioning members may be adjacent to the same end of the bracket body, or one of the positioning members may be adjacent to one end of the bracket body, and the other three positioning members are adjacent to the other end of the bracket body. . Fig. 10 is an enlarged view of a portion E in Fig. 9. As shown in FIG. 10, the positioning member has an extending portion 502 extending outward from the outer side of the bracket body 501, and the extending portion 502 is directly coupled to the supporting rib 503 of the bracket body 501. The extension portion 502 is integrally formed with the support rib 503 (the extension portion 502 is cut according to a predetermined shape when the stent body 501 is cut, and the cut extension portion 502 is tilted toward the outside of the stent body 501 and heat-set). Unlike the positioning members in the first to fourth embodiments, the extending portion 502 of the positioning member in the fifth embodiment does not have a sharp end, but forms a blade portion suitable for insertion into the blood vessel wall at the distal end. Further, as shown in FIG. 9, the extension portions of the four positioning members each extend toward the same end side of the stent 500, and when the stent is placed in the blood vessel, the positioning member extension portion faces the blood flow direction in the blood vessel.

Of course, the embodiment of the present invention is not limited thereto. For example, the extension portion 502 may be fixedly connected (for example, welded or bonded) to the support rib 503. In addition, the supporter 503 may also be used according to actual needs by those skilled in the art. Alternatively, the connecting rib 504 is provided in other shapes. For example, the supporting rib 503 may be provided as a spiral annular structure, and the connecting rib 504 may be provided as a linear structure or the like.

[Embodiment 6]

Fig. 11 shows a stent for implanting a blood vessel according to Embodiment 6 of the present invention. As shown in FIG. 11, the bracket 600 has a bracket body 601 cut by laser, and two positioning members are fixedly disposed on the bracket body 601, and each positioning component is disposed at a position close to the end of the bracket body 601 (to the bracket The distance from the farther end of the body 601 to the distance from the proximal end of the bracket body 601 is between 4 and 50). Fig. 12 is an enlarged view of a portion F in Fig. 11. The structure of the bracket body in the embodiment 6 and the connection structure between the positioning component and the bracket body are as described in Embodiment 5, and details are not described herein again. As shown in FIG. 12, the positioning member has an extending portion 602 that extends outward from the outside of the bracket body 601. Unlike the extending portion 502 of the positioning member in Embodiment 5, the extending portion 602 in Embodiment 6 has two sharp ends. Further, as shown in FIG. 11, the extension portions of the two positioning members each extend toward the same end side of the stent 600, and when the stent is placed in the blood vessel, the positioning member extension portion faces the blood flow direction in the blood vessel.

[Embodiment 7]

Fig. 13 shows a stent for implanting a blood vessel according to Embodiment 7 of the present invention. The bracket 700 in the seventh embodiment differs from the bracket 600 in the sixth embodiment in the structure of the positioning member. The other content is the same as that described in Embodiment 6, and details are not described herein again. As shown in Figure 14, the extension 702 of the positioning member has only one sharp end.

Of course, embodiments of the present invention are not limited to, except that the positioning member is disposed at a position close to the end of the bracket body, and those skilled in the art can also position the positioning member at other positions, such as the intermediate position of the bracket body, according to actual needs.

[Embodiment 8]

Fig. 15 shows a stent for implanting a blood vessel according to Embodiment 8 of the present invention. The bracket 800 in the eighth embodiment differs from the bracket 100 in the first embodiment in the shape of the bracket body and the position of the positioning member. As shown in FIG. 15, the bracket 800 has a bracket body 801 woven from a braided wire. The bracket body has a cylindrical shape, and a port 804 at one end of the bracket body 801 is flared in a radial direction, and the diameter of the flared port 804 is as shown in FIG. The diameter of the port 805 that is larger than the other end of the bracket body opposite to the flared port 804 is fixedly disposed at the other end (for example, near the port 805) with four positioning members 802 distributed at equal intervals along the circumferential direction of the bracket body 501. In the present embodiment, the diameter of the flared port 804 is larger than the diameter of the bracket body. For example, the diameter of the flared port 804 is 50% larger than the diameter of the bracket body, and may alternatively be between 0.5% and 200% larger. Any value.

Of course, the embodiment of the present invention is not limited thereto. For example, one, two, three or more positioning components may be fixedly disposed, and the positioning components may be fixedly disposed at a position of the bracket body away from the other end port of the horn port. It is also possible to arrange several of them in the middle position of the bracket body, and several others are disposed at positions close to the other end port, and those skilled in the art can also set the positioning components in any other position according to actual needs.

The structure of the positioning component can be the same as that of the above embodiments, and details are not described herein again.

The embodiment of the present invention is not limited to the bracket body in the form of a cylinder, and is not limited to the one end port being flared, or may be a tapered bracket or the like, as long as the diameter of one end port of the bracket body is larger than the diameter of the other end port. Such a stent is easily caught at a branch of a blood vessel through a large port and is not easily moved.

In addition, the embodiment of the present invention is not limited to the woven bracket body, and the bracket body may be laser-cut, and the positioning component may be integrally formed on the bracket body.

[Embodiment 9]

Fig. 16 shows a stent for implanting a blood vessel according to Embodiment 9 of the present invention. The bracket 900 in the ninth embodiment differs from the bracket 800 in the eighth embodiment in the position of the positioning member. Other contents are the same as those in Embodiment 8, and are not described herein again. As shown in FIG. 16, the four positioning members 902 are disposed in different circumferential directions at positions close to the other end port 905 of the bracket body opposite to the flared port 904, that is, the four positioning members 902 are not disposed in the same circumferential direction of the bracket body. . For example, the four positioning members can be arranged equidistantly from each other in the axial direction, that is to say in the axial direction, with the same distance from one another, or also in an axially unequal distance from one another.

Of course, the embodiments of the present invention are not limited to the number and position of the positioning components, and those skilled in the art can also set the positioning components at any other position according to actual needs, for example, at an intermediate position of the bracket body.

In order to prevent the phenomenon of restenosis of the blood vessel after the stent is implanted into the blood vessel, in other embodiments of the present invention, the surface of the stent is coated with a coating, wherein the coating includes a medicament for preventing restenosis of the blood vessel, for example, including : at least one of an antithrombotic drug and an antiproliferative drug. The thickness of the coating is between 0.1 um and 100 um.

Among them, antithrombotic drugs include, for example, heparin, clopidogrel, aspirin, urokinase, dicoumarin, and derivatives thereof. Antiproliferative drugs include, for example, rapamycin and paclitaxel.

Since the positioning body is provided on the stent body, and the positioning member has an extension suitable for insertion into the blood vessel wall, the occurrence probability of the stent displacement can be effectively reduced, and the therapeutic effect can be improved.

The terms and words used in the description are for the purpose of illustration and description It will be understood by those skilled in the art that various changes may be made in the details of the embodiments described above without departing from the basic principles of the disclosed embodiments. Therefore, the scope of the invention is to be determined by the appended claims, and the claims

Claims (22)

A stent for implanting a blood vessel, the stent comprising a stent body, wherein Positioning components are disposed on the bracket body; The positioning member has an extension extending outwardly from the outside of the stent body, the extension being adapted to be inserted into a vessel wall. The stent of claim 1 wherein: The extension does not penetrate the vessel wall. The stand according to claim 2, wherein The extension forms an angle with the axis of the stent body of between 10 and 80 degrees. The stent of claim 3 wherein the shortest distance from the end of the extension to the outer surface of the stent body is between 0.05 mm and 1.1 mm. A stent according to any one of claims 1 to 4, wherein A plurality of the positioning members are disposed on the bracket body. A stand according to claim 5, wherein The plurality of positioning members are equally spaced along the circumferential direction of the bracket body. The stent according to claim 5, wherein said plurality of positioning members are not disposed in the same circumferential direction of said holder body. The stent according to claim 7, wherein said plurality of positioning members are equally spaced along an axial direction of said stent body. A stent according to any one of claims 1 to 4, wherein The ratio of the distance of the positioning member to one end of the bracket body far from the positioning member to the distance from the positioning member to the other end of the bracket body is between 4 and 50. A stent according to any one of claims 1 to 4, wherein The bracket body is formed by laser cutting; The positioning component is integrally formed with the bracket body, or the positioning component is fixedly coupled to the bracket body. A stent according to any one of claims 1 to 4, wherein The bracket body is woven from a braided wire; The positioning member also has a connecting portion for fixing the extension to the bracket body. A stand according to claim 11 wherein: The positioning component is disposed at a non-node position of the bracket body. A stand according to claim 11 wherein: The connecting portion has a cavity through which the braided wire passes; The connecting portion is fixedly coupled to a braided wire passing through its cavity. A stand according to claim 11 wherein: The connecting portion is integrally formed with the braided wire. The bracket according to claim 13 or 14, wherein the extending portion is integrally formed with the connecting portion, or the extending portion is fixedly coupled to the connecting portion. The stent according to any one of claims 1 to 4, wherein the one end port of the stent body has a larger diameter than the other end port. The bracket according to claim 16, wherein one end port of the bracket body is flared in a radial shape, and the positioning member is disposed at the horn end of the bracket body The opposite end of the mouth. The stent of claim 17 wherein said flared port has a diameter that is between 0.5% and 200% greater than the diameter of said stent body. A stent according to any one of claims 1 to 4, wherein The surface of the stent is coated with a coating, wherein the coating includes a drug that prevents restenosis of the blood vessel. The stent of claim 19 wherein said coating has a thickness between 0.1 um and 100 um. A stand according to claim 19, wherein The drug includes at least one of an antithrombotic drug and an antiproliferative drug. The stent according to claim 21, wherein said antithrombotic drug is selected from the group consisting of heparin, clopidogrel, aspirin, urokinase, dicoumarin, and derivatives thereof, said antiproliferative drug being selected from the group consisting of: Papamycin and paclitaxel.

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