WO2018040064A1

WO2018040064A1 - Composition comprising aqueous beads

Info

Publication number: WO2018040064A1
Application number: PCT/CN2016/097892
Authority: WO
Inventors: Yangdong CHEN; Thierry Cotton
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 2016-09-02
Filing date: 2016-09-02
Publication date: 2018-03-08
Anticipated expiration: 2019-03-02
Also published as: CN109640932A

Abstract

A composition comprising: a) aqueous beads comprising at least two gelling agents chosen from (hetero) polysaccharides; and b) at least one hydroxyalkylurea of formula (I), wherein: R1, R2, R3 and R4 each independently represent a hydrogen atom, a C ₁-C ₄ alkyl group or a C ₂-C ₆ hydroxyalkyl group that may contain from 1 to 5 hydroxyl groups, at least one of the radicals R1-R4 representing a hydroxyalkyl group, and also a salt, solvate, or isomer thereof; and c) at least one sodium salt.

Description

Composition comprising aqueous beads

FIELD OF THE INVENTION

The present invention relates to a composition comprising aqueous beads. It relates more particularly to a composition for caring for keratin materials, comprising a combination of aqueous beads and hydroxyalkylurea (s) . The invention also relates to a process for caring for keratin materials and in particular skin, by applying the composition of the present invention to the keratin materials.

BACKGROUND

It is always been an ultimate goal of the formulators in cosmetic filed to deliver high efficacy products that show skin benefits such as hydration, moisturizing, whitening, cleansing, and so on.

Among all the compositions for caring for skin, masks are known to have high penetration efficacy on the skin. As a result, a two-digit market growth of mask cosmetic products in China was seen.

Conventionally, the masks are grouped to three main categories: tissue masks, the dominant and most developed category； leave-on masks without tissue, such as sleeping masks used at night； and rinse-off masks without tissue, such as the clay mask for cleansing of the skin. More recently, leave-on or rinse-off masks without tissue are more and more favoured thanks to their easy usage.

Efforts have been made nowadays to formulate compositions for caring for keratin materials, in particular skin, rinse-off or leave-on, with or without tissue, comprising active ingredients for bringing to the skin benefits as mentioned above. Among which, hydration has always been one of the most interesting benefits. Thanks to the hydration effect of this type of cosmetic products, the skin barrier functions are expected to be improved.

Hydroxyalkylurea (s) is known as an effective hydration active ingredients in the cosmetic field, and therefore commonly used in conventional products for caring for the skin. In order to improve its hydration effect, various cosmetically acceptable medium are formulated. For example, different types of polymers are selected in order to form a film on the skin after application, so as to enhance the penetration of hydroxyalkylurea (s) .

However the hydration effect is still to be improved.

Moreover, the long-time hydration effect is to be improved, such as hydration effect after 6 hours or 24 hours of application.

Thus there exists a need for formulating a composition with an improved hydration effect when applying on the skin.

There also exist a need for formulating a composition as mentioned above which reduces water loss after application of the composition on the skin.

Furthermore, there exists a need for formulating a composition as described above, with sufficient stability over time, and in particular under high temperatures, such as 45 ℃.

SUMMARY OF THE INVENTION

The inventors found that the needs as mentioned above can be achieved by formulating a composition for caring for keratin materials, comprising specific aqueous beads and hydroxyalkylurea (s) .

Therefore, the present invention relates to a composition comprising:

a) aqueous beads comprising at least two gelling agents chosen from (hetero) polysacchairdes；

b) at least one hydroxyalkylurea of formula (I) ,

wherein:

R1, R2, R3 and R4 each independently represent a hydrogen atom, a C₁-C₄ alkyl group or a C₂-C₆ hydroxyalkyl group that may contain from 1 to 5 hydroxyl groups, at least one of the radicals R1-R4 representing a hydroxyalkyl group, and also a salt, solvate, or isomer thereof； and

c) at least one sodium salt.

The present invention also relates to a process for caring for keratin materials, in particular skin and lips, comprising the application to the keratin materials of the composition according to the invention.

The invention also relates to the use of the composition according to the invention for caring for keratin materials, in particular the skin and lips.

The composition according to the present invention is preferably used as a leave-on mask, such as sleeping mask.

By “keratin materials” we intend to mean human keratin materials and more specifically skin and lips.

By “hydration effect” we intend to mean a fresh, hydration, and moisturizing feeling on the skin after application of the composition of the invention. According to the present invention, it is measured and demonstrated by the hydration and TEWL (water loss) values measured by the equipment Corneometer and Vapometer.

More particularly, the hydration and TEWL values are measured at different times, on the bare skin and on the skin where the composition of the present invention is applied on. The evolution of the values are then calculated using the following equation:

wherein:

T_n-product represents the values at different time (1 hour, 6 hours, or 24 hours) on the skin where the compositions to be tested are applied on；

T_n-bareskin represents the values at different time (1 hour, 6 hours, or 24 hours) on the bare skin；

Baseline_product or Baseline_bareskin represents the values of the skin immediately after the compositions to be tested are applied on, or the values of bare skin, at T0.

The higher the evolution of the hydration effect is, the better hydration effect the formula represents.

The lower the TEWL value is, the less water loss the formula represents.

“Stable over time” is understood to mean compositions of the present invention which, after storage at all temperatures between 4℃ and 45℃ for 2 months, do not exhibit any macroscopic change in colour, smell or viscosity, any variation in pH or any variation in microscopic appearance.

Other subjects and characteristics, aspects and advantages of the invention will emerge even more clearly on reading the description and the examples that follows.

In that which follows and unless otherwise indicated, the limits of a range of values are included within this range, in particular in the expressions "of between" and "ranging from ... to ... " .

Moreover, the expression "at least one" used in the present description is equivalent to the expression "one or more" .

DETAILED DESCRIPTION OF THE PRESENT INVENTION

Aqueous beads

The composition according to the invention comprises aqueous beads comprising at least 2 gelling agents chosen from (hetero) polysaccharides.

By “bead” in the sense of the present invention it is meant a solid of substantially spherical or ovoid shape.

Preferably, the aqueous beads according to the invention have an average particle size ranging from 0.2 to 3.0 mm, preferably from 1.0 to 2.0 mm.

The (hetero) polysaccharides may be chosen from polysaccharides, such as polymer of galactose obtained from red seaweeds, such as for example agarose, like agar-agar； alginic acid or alginate salts； (co) polymers of glucosamine, such as chitosan or its salts ； heteropolysaccharides such as carrageenan, and mixtures thereof.

The (hetero) polysaccharides may be chosen from polysaccharides, such as polymers of galactose obtained from red seaweeds. In a particular embodiment, the (hetero) polysaccharide is chosen from agaroses, such as agar-agar. Advantageously, the average number molecular weight of this (hetero) polysaccharide is ranging from 110 000 to 160 000.

The (hetero) polysaccharides may be chosen from alginic acid or alginate salts.

Alginic acid is a natural substance extracted from brown algae or bacteria. Alginic acid is a polyuronic acid with 2 uronic acids linked by (1, 4) -glycosidic bonds: β-D-mannuronic acid (M) and α-L-glucuronic acid (G) .

Alginic acid forms water-soluble salts (alginates) with alkali metals, such as sodium, calcium, potassium, lithium； (C₁-C₈) alkylamines and (C₁-C₈) alkyl ammoniums such as methylamine, ethanolamine, diethanolamine, triethanolamine. These alginates are water soluble at pH ＝ 4, but dissociate in alginic acid at pH below 4.

In a preferred embodiment, the aqueous beads according to the inventions comprise (hetero) polysaccharide (s) in an amount ranging from 0.1 to 10％by weight, preferably from 0.2 to 8％by weight, even more preferably from 1 to 5％by weight relative to the total weight of the beads.

In a preferred embodiment, the aqueous beads according to the invention comprise agar-agar and alginic acid or alginate salts.

Preferably, the aqueous beads comprise agar-agar and alginic acid or alginate salts in a weight ratio of agar-agar/alginic acid or alginate salts ranging from 0.01 to 0.5, and more preferably ranging from 0.05 to 0.1.

The aqueous beads comprise water. The water content is preferably ranging from 80 to 98％by weight, preferably from 90 to 97％by weight, even more preferably from 92 to 95％by weight, relative to the total weight of the aqueous beads.

In a particular embodiment, the aqueous beads according to the invention may further comprise various additives, such as actives, fragrance, preservatives, water-soluble salts, water-soluble solvents, and mixtures thereof.

In a particular embodiment, the aqueous beads according to the invention are transparent. In a particular embodiment, the aqueous beads according to the invention are transparent when suspended in water.

The aqueous beads according to the invention may be present in the composition in an amount ranging from 2 to 50％by weight in active material, preferably from 3 to 40％by weight in active material, and more preferably from 5 to 30％by weight in active material, relative to the total weight of the composition.

The aqueous beads according to the invention may be prepared according to the process described in US 6,467,699 patent.

Hydroxyalkylurea (s)

The hydroxyalkylureas in accordance with the invention are chosen from those corresponding to general formula (I) :

in which R1, R2, R3 and R4 each independently represent a hydrogen atom, a C₁-C₄ alkyl group or a C₂-C₆ hydroxyalkyl group that may contain from 1 to 5 hydroxyl groups, at least one of the radicals R₁-R₄ representing a hydroxyalkyl group, and also the salts, solvates and isomers thereof.

In formula (I) , among the alkyl groups, mention may in particular be made of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and tert-butyl groups.

The compounds of formula (I) that are preferred are those that contain only one hydroxyalkyl group, i.e. those for which R1 is a hydroxyalkyl group and R2, R3 and R4 represent, independently of one another, a hydrogen atom or a C₁-C₄ alkyl group. The compounds of formula (I) for which R1 is a hydroxyalkyl group and R2, R3 and R4 each represent a hydrogen atom are more particularly preferred.

Among the hydroxyalkyl groups, preference is given to those containing a single hydroxyl group, and in particular hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxypentyl and hydroxyhexyl groups. The hydroxyethyl group is preferred.

As compounds of formula (I) that are preferred, mention may be made of N- (2-hydroxy-ethyl) urea； N- (2-hydroxypropyl) urea； N- (3-hydroxypropyl) urea； N- (2, 3-dihydroxypropyl) urea； N- (2, 3, 4, 5, 6-pentahydroxyhexyl) urea； N-methyl-N- (1, 3, 4, 5, 6-penta-hydroxy-2-hexyl) urea； N-methyl-N’ - (1-hydroxy-2-methyl-2-propyl) urea； N- (1-hydroxy-2-methyl-2-propyl) urea； N- (1, 3-dihydroxy-2-propyl) urea； N- (trishydroxymethylmethyl) urea； N-ethyl-N’ - (2-hydroxyethyl) urea； N, N-bis- (2-hydroxyethyl) urea； N, N’ -bis- (2-hydroxyethyl) urea； N, N-bis- (2-hydroxypropyl) urea； N, N’ -bis- (2-hydroxypropyl) urea； N, N-bis- (2-hydroxyethyl) -N’ -propylurea； N, N-bis- (2-hydroxypropyl) -N’ - (2-hydroxyethyl) urea； N-tert-butyl-N’ - (2-hydroxyethyl) -N’ - (2-hydroxypropyl) urea； N- (1, 3-dihydroxy-2-propyl) -N’ -(2-hydroxyethyl) urea； N, N-bis- (2-hydroxyethyl) -N’ , N’ -dimethylurea； N, N, N’ , N’ -tetrakis- (2-hydroxyethyl) urea； and N’ , N’ -bis- (2-hydroxyethyl) -N’ , N’ -bis- (2-hydroxypropyl) urea.

A compound that is particularly preferred for use in the present invention is N- (2-hydroxyethyl) urea, hereinafter referred to as “hydroxyethylurea” .

The hydroxyalkylureas of formula (I) can be prepared as described in application DE-27 03 185. Among these, hydroxyethylurea is also commercially available, in the form of a mixture at 50％by weight in water, from the company National Starch under the trade name

Among the salts, mention may be made of salts of inorganic acids, such as sulphuric acid, hydrochloric acid, hydrobromic acid, hydriodic acid, phosphoric acid or boric acid. Mention may also be made of the salts of organic acids, which may contain one or more carboxylic, sulphonic or phosphonic acid groups. They may be linear, branched or cyclic aliphatic acids or else aromatic acids. These acids may also contain one or more hetero atoms chosen from O and N, for example in the form of hydroxyl groups. Mention may in particular be made of propionic acid, acetic acid, terephthalic acid, citric acid and tartaric acid.

The term “solvate” is intended to mean a stoichiometric mixture of said compound of formula (I) with one or more molecules of water or of organic solvent, such a mixture being derived from the synthesis of the compound of formula (I) .

The hydroxyalkylureas in accordance with the invention are preferably present in the compositions in accordance with the invention at contents of from 0.01 to 40％by weight, and more preferably from 0.1 to 20％, and even more preferably from 0.5 to 10％by weight, relative to the total weight of the composition.

Sodium salt (s)

The composition of the present invention comprises at least one sodium salt.

The sodium salt used in the present invention is intended to reduce the hardness of the aqueous beads, so that upon application, such as massaging keratin materials wherein the composition of the present invention is applied, the beads break on the keratin materials.

The breakage of the beads on one hand enhances the penetration of the active ingredients, such as Hydroxyalkylurea (s) of the composition on the keratin materials, by both massaging and forming of a film on the keratin materials.

The sodium salt (s) that is useful to the present invention can be inorganic or organic sodium salt.

Examples of inorganic sodium salts include sodium chloride, sodium bicarbonate, and sodium carbonate.

Examples of organic sodium salts include sodium EDTA, sodium citrate, sodium lauryl ether sulfate.

Preferably, the sodium salt of the present invention is chosen from organic sodium salts, preferably chosen from disodium EDTA, sodium citrate, or a mixture thereof.

The sodium salt (s) in accordance with the invention is (are) preferably present in the compositions in accordance with the invention at contents of from 0.01 to 2％by weight, and more preferably from 0.05 to 1％, and even more preferably from 0.1 to 0.5％by weight, relative to the total weight of the composition.

Aqueous phase

The composition of the invention further comprises at least one aqueous phase.

Preferably the composition of the present invention is an aqueous composition.

According to an embodiment, the aqueous composition of the present invention includes water, as the case may be, in a mixture with water-soluble additives and/or solvents.

The aqueous phase may also comprise organic solvents miscible with water (at room temperature 25℃) such as for example monoalcohols having from 2 to 6 carbon atoms, beside those claimed as ingredient (c) above, polyols notably having from 5 to 20 carbon atoms, preferably from 5 to 10 carbon atoms, atoms, such as pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol； glycol ethers (notably having from 3 to 16 carbon atoms) such as mono-, di-or tri-propylene glycol (C₁-C₄) alkyl ethers, mono-, di-or tri-ethylene glycol (C₁-C₄) alkyl ethers and mixtures thereof.

According to an embodiment, the aqueous phase of the compositions of the invention comprises a polyol notably caprylyl glycol.

The amount of aqueous phase may range, for example, from 50％to 100％by weight, preferably from 70％to 100％by weight relative to the total weight of the composition.

The aqueous phase may also contain other additives such as water-soluble active ingredients, preservatives, salts, additional gelling agents, fillers, additional water-soluble or water-dispersible polymers, water-soluble dyes, and so on.

Preferably, the composition of the present invention comprises at least one gelling agent, preferably being a hydrophilic gelling agent.

For the purpose of the present invention, the term "hydrophilic gelling agent" means a compound that is capable of gelling the aqueous phase of the compositions according to the invention.

The gelling agent is hydrophilic and is thus present in the aqueous phase of the composition.

The gelling agent may be water-soluble or water-dispersible.

As stated above, the aqueous phase of a composition according to the invention is gelled with at least one hydrophilic gelling agent chosen from synthetic polymeric gelling agents. For the purposes of the invention, the term "synthetic" means that the polymer is neither naturally existing nor a derivative of a polymer of natural origin.

The synthetic polymeric hydrophilic gelling agent under consideration according to the invention may or may not be particulate.

For the purposes of the invention, the term "particulate" means that the polymer is in the form of particles, preferably spherical particles.

Advantageously, a composition according to the invention comprises a polymeric hydrophilic gelling agent chosen from crosslinked acrylic homopolymers or copolymers； associative polymers, in particular associative polymers of polyurethane type； polyacrylamides and crosslinked and/or neutralized 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers； modified or unmodified carboxyvinyl polymers, and mixtures thereof.

More preferably, the composition of the present invention comprises at least one modified or unmodified carboxyvinyl polymer.

Examples that may be mentioned include the products sold by Lubrizol under the names Carbopol 910, 934, 940, 941, 934 P, 980, 981, 2984, 5984 and Carbopol Ultrez 10 Polymer, or by 3V-Sigma under the name

K,

L or

M. If exists, the hydrophilic gelling agent is present in the composition in an amount ranging from 0.1％to 5％by weight of solids relative to the weight of the aqueous phase, in particular from 0.2％to 2％by weight, relative to the total weight of the composition.

Additives

In a known manner, the composition of the invention may also contain one or more additives that are common in cosmetics or dermatology.

Examples of additives that may be mentioned include additional emulsifiers, active agent (s) , antioxidant (s) , fragrance (s) , basic agent (s) (triethanolamine, diethanolamine or additional sodium hydroxide) or acidic agent (s) (citric acid) , and also lipid vesicles or any other type of vector (nanocapsules, microcapsules, etc. ) , and mixtures thereof.

Preferably, according to the present invention, there is provided a composition for caring for caring for keratin materials, comprising:

(a) from 5 to 30％by weight of aqueous beads comprising at least two gelling agents chosen from (hetero) polysacchairdes；

(b) from 0.5 to 10％by weight of at least one hydroxyalkylurea of formula (I) ,

wherein:

(c) from 0.1 to 0.5％by weight of at least one sodium salt,

wherein the weight is relative to the total weight of the composition.

Method and use

The composition of the present invention can be used for a process, such as a cosmetic process or method, for caring for keratin materials, such as skin and lips, in particular the face and the lips, by being applied to the keratin materials.

The present invention relates to a process for caring for keratin materials, comprising the application, to the keratin materials, of at least one composition of the invention, wherein the keratin material is preferably skin and lips, in particular face.

The invention also relates to a use of the composition of the present invention in caring for keratin materials, in particular skin and lips.

The examples that follow are aimed at illustrating the compositions and processes according to this invention, but are not in any way a limitation of the scope of the invention.

EXAMPLES

Example 1 Preparation of Invention and Comparative formulas

Formulas according to the invention and outside of the invention (comparative) were prepared according to the concentration given in table 1.

Table 1: Invention formula A, and Comparative formula A1, A2

Comparative formulas A1 and A2 do not contain the aqueous beads as claimed. Specifically, the Comparative formula A1 contains the aqueous beads broken by turbine in the formula, therefore the formula does not contain beads as claimed, but the ingredients in the beads； the Comparative formula A2 does not contain ingredients of the aqueous beads, regardless of any form.

The Invention and Comparative formulas were prepared following the steps of:

1. heat phase A to 75℃ for 10 min, stir until totally solubilized. Then cool down the mixture to 55 ℃；

2. introduce phase A2 to the mixture obtained above at 55 ℃ and stir for 10 min， until totally homogeneous；

3. introduce phase B to the mixture obtained above at 55℃ and turbine for 10 min, until totally homogeneous；

4. introduce phase C to the mixture obtained above at 40℃ and stir for 10min； then introduce phase D to the mixture and stir for 10 min and cool down to 25℃；

5. introduce phase F, and G respectively to the mixture obtained above at 25℃, and stir for 10min；

6. introduce phase H at 25℃, stir slowly 3 min until totally homogeneous. For preparing of the Comparative A1, the phase H is added in the formula and turbine until the beads break in the formula.

Machine: the homogenizer VMI sold by the company i-Tech Machine.

Example 2: Evaluation of the Invention and Comparative formulas

The stability and hydration effect of the Invention and Comparative formulas were evaluated.

The stability of the formulas were evaluated by leaving the formulas at 4℃, 25℃, and 45℃ for 2 months, and observing the formulas using microscope under polarized light.

The hydration effect in 24 hours of the Invention and Comparative formulas were evaluated following the steps of:

3 areas of skin on the forearm of the women models were marked, one for measuring hydration effect, one for measuring TEWL value (water loss) , another for measuring values of bare skin, at different time；

the Invention and Comparative formulas were respectively applied on the forearms of 24 women models (with a range of age between 30 to 60, and hydration value of the skin of 30±15) ；

The hydration and TEWL values of the skin of the forearms were acquired using Corneometer and Vapometer, respectively, on the bareskin without formula, at T0 (immediately after application) , T1 (1 hour after application) , T6 (6 hours after application) , and T24 (24 hours after application) ；

finally, the percentages of evolution of the values were calculated, using the follow equation:

wherein:

T_n-product represents the values at different time (1 hour, 6 hours, or 24 hours) on the skin where the formulas were applied on；

T_n-bareskin represents the values at different time (1 hour, 6 hours, or 24 hours) on the bare skin without using formulas；

Baseline_product or Baseline_bareskin represents the values of the skin immediately after the formulas were applied on, or the values of bare skin without applying formulas, at T0.

The lower the TEWL value is, the less water loss the formula represents.

The results of the evaluation are as follow:

The hydration effects of the formulas:

Formulas	T1	T6	T24
A	36.59％	26.42％	17.14％
A1	30.56％	23.61％	13.57％
A2	31.21％	24.00％	15.00％

The TEWL values of the formulas:

Formulas	T1	T6
A	-45.12％	-27.34％
A1	-31.55％	-16.84％
A2	-34.61％	-15.29％

All the Invention and Comparative formulas are stable.

It is observed according to the results above that, while all the invention and comparative formulas are stable, the Invention formula A shows much better hydration effect, immediately after application, and long-time hydration, and much less water loss at different time point after application on the skin, comparing to the Comparative formula A1 and A2.

Claims

A composition comprising:

a) aqueous beads comprising at least two gelling agents chosen from (hetero) polysacchairdes；

b) at least one hydroxyalkylurea of formula (I) ,

wherein:

R1, R2, R3 and R4 each independently represent a hydrogen atom, a C₁-C₄ alkyl group or a C₂-C₆ hydroxyalkyl group that may contain from 1 to 5 hydroxyl groups, at least one of the radicals R1-R4 representing a hydroxyalkyl group, and also a salt, solvate, or isomer thereof； and

c) at least one sodium salt.
Composition of claim 1, wherein the aqueous beads comprise (hetero) polysaccharides chosen from polymers of galactose obtained from red seaweeds, alginic acid or alginate salts； (co) polymers of glucosamine, and mixtures thereof； more preferably comprise agar-agar and alginic acid or alginate salts.
Composition of any one of any one of the preceding claims 1 to 2, wherein the weight ratio of agar-agar and alginic acid or alginate salts ranges from 0.01 to 0.5, preferably from 0.05 to 0.1.
Composition of any one of the preceding claims 1 to 3, wherein the average particle size of the aqueous beads ranges from 0.2 to 3.0 mm, preferably from 1.0 to 2.0 mm.
Composition of any one of the preceding claims 1 to 4, wherein the aqueous beads are present in the composition in an amount ranging from 2 to 50％ by weight in active material, preferably from 3 to 40％ by weight in active material, and more preferably from 5 to 30％ by weight in active material, relative to the total weight of the composition.
Composition of any one of the preceding claims 1 to 5, wherein in the formula (I) , R1 is a hydroxyalkyl group and R2, R3 and R4 represent, independently of one another, a hydrogen atom or a C₁-C₄ alkyl group； preferably R1 is a hydroxyalkyl group and R2, R3 and R4 each represent a hydrogen atom.
Composition of any one of the preceding claims 1 to 6, wherein the the compound of formula (I) is chosen from N- (2-hydroxyethyl) urea； N- (2-hydroxypropyl) urea； N- (3-hydroxypropyl) urea； N- (2, 3-dihydroxypropyl) urea； N- (2, 3, 4, 5, 6-pentahydroxyhexyl) urea； N-methyl-N- (1, 3, 4, 5, 6-pentahydroxy-2-hexyl) urea； N-methyl-N’- (1-hydroxy-2-methyl-2-propyl) urea； N- (1-hydroxy-2-methyl-2-propyl) urea； N- (1, 3-dihydroxy-2-propyl) urea； N- (trishydroxymethylmethyl) urea； N-ethyl-N’- (2-hydroxyethyl) urea； N, N-bis- (2-hydroxyethyl) urea； N, N’-bis- (2-hydroxyethyl) urea； N, N-bis- (2-hydroxypropyl) urea； N, N’-bis- (2-hydroxypropyl) urea； N, N-bis- (2-hydroxyethyl) -N’-propylurea； N, N-bis- (2-hydroxypropyl) -N’- (2-hydroxyethyl) urea； N-tert-butyl-N’- (2-hydroxyethyl) -N’- (2-hydroxy-propyl) urea； N- (1, 3-dihydroxy-2-propyl) -N’- (2-hydroxyethyl) urea； N, N-bis- (2-hydroxyethyl) -N’, N’-dimethylurea； N, N, N’, N’-tetrakis- (2-hydroxyethyl) urea； and N’, N’-bis- (2-hydroxyethyl) -N’, N’-bis- (2-hydroxypropyl) urea； preferably N- (2-hydroxyethyl) urea.
Composition of any one of the preceding claims 1 to 7, wherein the hydroxyalkylurea of formula (I) is present in the composition in an amount ranging from 0.01 to 40％ by weight, and more preferably from 0.1 to 20％, and even more preferably from 0.5 to 10％ by weight, relative to the total weight of the composition.
Composition of any one of the preceding claims 1 to 8, wherein the sodium salt is selected from the group consisting of sodium chloride, sodium bicarbonate, sodium carbonate, disodium EDTA, sodium citrate, sodium lauryl ether sulfate, or a mixture thereof； preferably selected from the group consisting of disodium EDTA, sodium citrate, or a mixture thereof.
Composition of any one of the preceding claims 1 to 9, wherein the sodium salt is present in the composition in an amount ranging from 0.01 to 2％ by weight, and more preferably from 0.05 to 1％, and even more preferably from 0.1 to 0.5％ by weight, relative to the total weight of the composition.
Composition of any one of the preceding claims 1 to 10 further comprises at least one hydrophilic gelling agent.
Composition of any one of the preceding claims 1 to 11, wherein the hydrophilic gelling agent is present in the composition in an amount ranging from 0.1％ to 5％ by weight of solids relative to the weight of the aqueous phase, in particular from 0.2％ to 2％ by weight, relative to the total weight of the composition.
A composition for caring for keratin materials, comprising:

(a) from 5 to 30％ by weight of aqueous beads comprising at least two gelling agents chosen from (hetero) polysacchairdes； and

(b) from 0.5 to 10％ by weight of at least one hydroxyalkylurea of formula (I) ,

wherein:

R1, R2, R3 and R4 each independently represent a hydrogen atom, a C₁-C₄ alkyl group or a C₂-C₆ hydroxyalkyl group that may contain from 1 to 5 hydroxyl groups, at least one of the radicals R1-R4 representing a hydroxyalkyl group, and also a salt, solvate, or isomer thereof； and

(c) from 0.1 to 0.5％ by weight of at least one sodium salt,

wherein the weight is relative to the total weight of the composition.
A process for caring for keratin materials, preferably a cosmetic process for caring for the keratin materials, such as the skin and lips, in particular the face and the lips, by applying the composition of any one of the claims 1 to 13 on the keratin materials.
Use of the composition of any one of the preceding claims 1 to 13 in caring for keratin materials, in particular skin and lips.