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WO2017135637A1 - Composition favorisant la pousse des cheveux ou évitant la chute des cheveux, comprenant de l'extrait de pédoncule floral de ginseng - Google Patents

Composition favorisant la pousse des cheveux ou évitant la chute des cheveux, comprenant de l'extrait de pédoncule floral de ginseng Download PDF

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Publication number
WO2017135637A1
WO2017135637A1 PCT/KR2017/000912 KR2017000912W WO2017135637A1 WO 2017135637 A1 WO2017135637 A1 WO 2017135637A1 KR 2017000912 W KR2017000912 W KR 2017000912W WO 2017135637 A1 WO2017135637 A1 WO 2017135637A1
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WO
WIPO (PCT)
Prior art keywords
composition
extract
hair
hair loss
promoting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2017/000912
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English (en)
Korean (ko)
Inventor
전희영
김아름
신승현
김수환
서대방
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Amorepacific Corp
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Amorepacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Publication of WO2017135637A1 publication Critical patent/WO2017135637A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present specification relates to a composition for promoting hair growth or preventing hair loss, including ginseng flower rapeseed extract as an active ingredient.
  • minoxidil has side effects such as hirsutism when taken orally
  • finasteride finasteride
  • side effects such as decreased libido, decreased ejaculation, and erectile dysfunction in about 1 to 2% of patients.
  • the inventors of the present invention have studied the ginseng flower stalk extract and found that the ginseng flower stalk extract has an effect of promoting hair growth or preventing hair loss.
  • One aspect of the present invention to provide a composition for promoting hair growth or hair loss prevention comprising ginseng flower rapeseed extract as an active ingredient.
  • the hair growth promoting or hair loss prevention composition is to provide a food, pharmaceutical or cosmetic composition.
  • One aspect of the present invention provides a composition for promoting hair growth or hair loss prevention comprising ginseng flower stalk extract as an active ingredient.
  • the extract is an extract extracted using water, C 1 -C 5 alcohol or C 1 -C 5 alcohol aqueous solution, provides a composition for promoting hair growth or hair loss prevention.
  • the concentration of the C 1 -C 5 alcohol aqueous solution is 40% to 90% (v / v), to provide a composition for promoting hair growth or preventing hair loss.
  • the C 1 -C 5 alcohol hair growth using any one or two or more selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol
  • a composition for promoting or preventing hair loss is provided.
  • the extract is an extract extracted using an aqueous ethanol solution of 60 to 80% (v / v) concentration, provides a composition for promoting hair growth or hair loss prevention.
  • the ginseng flower stalk is ginseng fruit is removed, provides a composition for promoting hair growth or hair loss prevention.
  • the composition provides a composition for promoting hair growth or preventing hair loss, which promotes the growth of dermal papilla cells.
  • the hair growth promoting or hair loss prevention composition provides a food, pharmaceutical or cosmetic composition.
  • the composition provides a composition formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, and sterile injectable solutions.
  • composition according to one aspect of the present invention has a hair loss prevention effect.
  • composition according to one aspect of the present invention has a hair growth promoting effect.
  • composition according to one aspect of the present invention has the effect of promoting the proliferation of dermal papilla cells.
  • One aspect of the invention has the effect of providing a food composition having a hair loss prevention or hair growth promoting effect.
  • One aspect of the present invention has the effect of providing a pharmaceutical composition having a hair loss prevention or hair growth promoting effect.
  • One aspect of the present invention has the effect of providing a cosmetic composition having a hair loss prevention or hair growth promoting effect.
  • composition according to one aspect of the present invention is generally effective in finding the value of the part discarded by recycling the ginseng flower stem discarded during ginseng processing.
  • Example 2 and 3 are photographs and graphs confirming hair growth through hair follicle organ culture of the ginseng flower stem extract of Example 1 according to the Inventive Example 2.
  • the ginseng refers to the ginseng root, which is the root of ginseng, which is used as a medicinal herb or has been ingested and cooked as food.
  • Ginseng Panax ginseng CA Meyer
  • anti-cancer activity immune function control action, anti-diabetic action, anti-diabetic liver effect, cardiovascular disorders improvement, blood pressure control action, menopausal disorders improvement, anti-stress and anti-fatigue effect, antioxidant activity and anti-aging effect.
  • Ginseng flower stalks are not usually used as a medicinal herb, it is difficult to find a history of ingestion in the form of food.
  • the ginseng flower stalk comes out in May-June, which is the fourth year of planting seeds, and is discarded along with the ginseng flower in June, before it blooms for the smooth growth of ginseng roots.
  • Ginsenoside a representative physiologically active ingredient of ginseng, is distributed evenly in the ground and underground parts of ginseng. It is known. These differences in composition make a difference in the presence or absence of various efficacy and cause different site-specific efficacy characteristics. For example, ginseng flower extract has been shown to have an excellent effect and about 23 times more effective in the prevention and treatment of diabetes compared to ginseng root extract.
  • the ginseng stalk extract has a hair loss prevention or hair growth promotion and hair health promoting effect.
  • One aspect of the present invention provides a composition for promoting hair growth or hair loss prevention comprising ginseng flower stalk extract as an active ingredient.
  • One aspect of the present invention is a method for promoting hair growth or preventing hair loss of the subject, the method provides a method comprising the step of administering an effective amount of the ginseng flower bud extract to a subject in need of promoting hair growth or preventing hair loss do.
  • One aspect of the invention provides the use of ginseng flower stalk extract in the preparation of a composition for promoting hair growth or preventing hair loss.
  • One aspect of the present invention provides a ginseng flower belt extract for promoting hair growth or preventing hair loss.
  • Ginseng flower stalk as used herein is the axial portion of the ginseng flower peduncle and flower stem.
  • extract includes any material obtained by extracting a component therefrom from a natural product, regardless of the method of extraction or the kind of the component.
  • it is a broad concept including the thing which extracted the component melt
  • the organic solvent is not particularly limited, C1 ⁇ C5 lower alcohol, glycerol, ethylene, such as methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol
  • Polyhydric alcohols such as glycol, propylene glycol, 1,3-butylene glycol, hydrocarbon solvents such as methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane, chloroform, petroleum ether, methyl acetate
  • Non-polar organic solvents such as benzene, hexane, chloroform, methylene chloride, dimethyl ether, ethyl acetate and the like.
  • the extract may be an extract extracted with water, in particular hot water.
  • the extract may be an extract extracted with C 1 -C 5 alcohol.
  • the extract may be an extract extracted with ethanol, but is not limited thereto.
  • the extract is an extract extracted using water, C 1 -C 5 alcohol or C 1 -C 5 alcohol aqueous solution, provides a composition for promoting hair growth or hair loss prevention.
  • the concentration of the C 1 -C 5 alcohol aqueous solution is 40% to 90% (v / v), to provide a composition for promoting hair growth or preventing hair loss.
  • the concentration of the C 1 -C 5 alcohol aqueous solution is at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 66%, at least 67%, 68% Or at least 69%, at least 70%, at least 71%, at least 72%, at least 73%, at least 74%, at least 75%, or at least 80%.
  • the concentration of the C 1 -C 5 alcohol aqueous solution is 90% or less, 85% or less, 80% or less, 75% or less, 74% or less, 73% or less, 72% or less, 71% or less, 70% or less, 69 Up to 68%, up to 67%, up to 65%, or up to 60%.
  • concentration of the C 1 -C 5 alcohol aqueous solution is within the above range, the hair loss prevention or hair growth promoting effect is excellent.
  • the C 1 -C 5 alcohol hair growth using any one or two or more selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol
  • a composition for promoting or preventing hair loss is provided.
  • the C 1 -C 5 alcohol aqueous solution 60 to 80% (v / v) of the aqueous solution of ethanol, provides a composition for promoting hair growth or hair loss.
  • the ginseng flower rapeseed extract may be included in 0.1 to 90% by weight based on the total weight of the composition. In one embodiment, the ginseng flower blotch extract may be included 10 to 85% by weight based on the total weight of the composition. In another embodiment, the ginseng flower blotch extract may be included 20 to 80% by weight based on the total weight of the composition.
  • the ginseng flower stalk is ginseng fruit is removed, provides a composition for promoting hair growth or hair loss prevention.
  • the composition provides a composition for promoting hair growth or preventing hair loss, which promotes the growth of dermal papilla cells.
  • the hair growth promoting or hair loss prevention composition provides a food, pharmaceutical or cosmetic composition.
  • the composition provides a composition formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, and sterile injectable solutions.
  • the pharmaceutical composition may further comprise, in one aspect, suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.
  • suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.
  • the carriers, excipients and diluents that may be included in the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
  • the pharmaceutical composition may be formulated in the form of powder, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, oral formulations, external preparations, suppositories, and sterile injectable solutions according to conventional methods. .
  • Solid preparations for oral administration may include tablets, pills, powders, granules, capsules and the like. Such solid preparations may include at least one excipient such as starch, calcium carbonate, sucrose or lactose, gelatin, in addition to the active ingredient. In addition to simple excipients, lubricants such as magnesium styrate talc may also be included.
  • Oral liquid preparations include suspensions, solvents, emulsions, syrups, and the like, and various excipients such as wetting agents, sweeteners, fragrances, preservatives, etc., in addition to commonly used simple diluents such as water and liquid paraffin.
  • Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • the non-aqueous solvent and suspending agent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used.
  • As the base of the suppository witepsol, macrogol, tween 61, laurin, cacao butter, glycerogelatin and the like can be used.
  • the dosage of the extracts disclosed herein may vary depending on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration, and the duration and may be selected from the ranges commonly used in the art.
  • the daily dose of the active ingredient may be 0.0001 to 1000 g / kg on a dry weight basis, and in one aspect, 0.001 to 1 g / kg.
  • the composition may be a cosmetic composition.
  • Cosmetic compositions herein can be prepared in any formulation commonly prepared in the art, including, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto.
  • the composition may be a food composition, for example, various foods, beverages, gums, teas, vitamin complexes, dietary supplements, and the like, and may be used in the form of powders, granules, tablets, capsules, or beverages. Can be.
  • the food composition of each formulation may be suitably selected by a person skilled in the art according to the formulation or purpose of use in addition to the active ingredient, and may be synergistic when applied simultaneously with other raw materials.
  • the amount of the active ingredient included in the food or beverage may generally include 1 to 5% by weight of the total food, if the health food composition, the health beverage composition is 0.02 to 10g based on 100ml, 0.3 in one aspect To 1 g.
  • the composition may contain other ingredients and the like that can give a synergistic effect to the main effect within a range that does not impair the main effect of the present invention.
  • it may further include additives such as perfumes, pigments, fungicides, antioxidants, preservatives, moisturizers, thickeners, inorganic salts, emulsifiers and synthetic polymer materials to improve physical properties.
  • additives such as perfumes, pigments, fungicides, antioxidants, preservatives, moisturizers, thickeners, inorganic salts, emulsifiers and synthetic polymer materials to improve physical properties.
  • supplementary ingredients such as water soluble vitamins, oil soluble vitamins, polymer peptides, polymer polysaccharides and seaweed extract may be further included.
  • the components may be appropriately selected and blended by those skilled in the art according to the formulation or purpose of use, and the amount of the additives may be selected within a range that does not impair the object and effect of the present invention.
  • the amount of the components added may range from 0.01-5% by weight, more specifically 0.01-3% by weight, based on the total weight of the composition.
  • compositions according to the invention may be in various forms, such as solutions, emulsions, viscous mixtures, tablets, powders, and the like, which may be administered by various methods such as simple drinking, injection, spray or squeeze.
  • ginseng flower stalk extract In the case of ginseng flower stalk extract, the ginseng flower stalks were collected and the fruit parts were separated and then dried in daylight or hot air to prepare ginseng flower stalk as a raw material. Thereafter, 70% ethanol (Example 1) or 10L (Example 2) of water was added to 1 kg of dried ginseng flower stalk and refluxed, filtered and concentrated under reduced pressure at 40 to 45.
  • the ginseng flower stalk extract obtained through the above process was used in the following experimental example.
  • PVGDPLTt sa produced by transfecting a polyomavirus large T gene that encodes a temperature sensitive T antigen to a PVG vibrissa dermal papilla cell 6.
  • DP cells a polyomavirus large T gene that encodes a temperature sensitive T antigen to a PVG vibrissa dermal papilla cell 6.
  • W. Filsell Universality of Cambridge, UK was used to evaluate the donation, and evaluated the effect of promoting the growth of the dermal papilla cells of the ginseng flower extract of Examples 1 to 2.
  • DP cells were prepared in 96-well plates at a concentration of about 10 4 cells / well per well. After dissolving the ginseng blotch extracts of Examples 1 and 2 in DMSO (dimethyl sulfoxide) or ethanol, respectively, serial dilution was performed with DMEM medium having a 5% FBS serum concentration so that the final concentration was 0.1, 1, or 10 ppm. It was. After adding 200 ⁇ l of the medium and the control medium to which the ginseng blotch extracts of Examples 1 to 2 were added per well, the cells were cultured in 37 and 5% CO 2 incubators for about 3 days.
  • DMSO dimethyl sulfoxide
  • each MTT solution 50 ⁇ l of each MTT solution was added at a concentration of 2 mg / ml, and then left in the same incubator for 4 hours. After the MTT reagent was absorbed into the intracellular mitochondria, the supernatant was removed, and 150 ⁇ l of DMSO was added, followed by stirring for 10 minutes to uniformly dissolve promazan dye. Then, using an ELISA reader, O.D. The value was measured, and the cell number was measured according to a standard curve prepared in advance. Based on the number of cells measured, percent of papillary cell proliferation promoting ability was calculated.
  • the dermal papilla cell growth promoting ability according to the above experiment is shown in FIG. 1.
  • the ginseng flower extract of Example 1 (70% ethanol extraction) and Example 2 (water extraction) was confirmed to have a capacity-dependent excellent dermal papilla cell proliferation effect. Therefore, the ginseng flower stalk extract was found to have an excellent effect of promoting hair papilla cell proliferation, preventing hair loss, promoting hair growth, and further promoting hair health.
  • -Culture medium William's E media with L-glutamine (2mM), hydrocortisone (10ng / ml), antibiotics (1%), insulin (10 ⁇ g / ml) fungizone (0.1%), medium exchange every 3 days

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Abstract

La présente invention concerne une composition destinée à favoriser la pousse des cheveux ou à prévenir la chute des cheveux, comprenant un extrait de pédoncule floral de ginseng comme principe actif. L'extrait est obtenu par extraction en utilisant de l'eau, des alcools C1-C5 ou une solution alcoolique aqueuse C1-C5. La composition peut être utilisée comme composition alimentaire, composition pharmaceutique ou composition cosmétique. En outre, la composition favorise la prolifération des cellules du derme papillaire et présente ainsi un excellent effet stimulant sur la pousse des cheveux ou de prévention de la chute des cheveux.
PCT/KR2017/000912 2016-02-02 2017-01-25 Composition favorisant la pousse des cheveux ou évitant la chute des cheveux, comprenant de l'extrait de pédoncule floral de ginseng Ceased WO2017135637A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0012863 2016-02-02
KR1020160012863A KR20170091939A (ko) 2016-02-02 2016-02-02 인삼 꽃대 추출물을 포함하는 육모 촉진 또는 탈모 방지용 조성물

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WO2017135637A1 true WO2017135637A1 (fr) 2017-08-10

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TW (1) TW201729825A (fr)
WO (1) WO2017135637A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107744486A (zh) * 2017-11-30 2018-03-02 山西中医药大学 人参花组合物及其制备方法和应用
CN107929123A (zh) * 2017-11-30 2018-04-20 山西中医药大学 人参花提取物的用途及含人参花提取物的化妆品

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KR20080035453A (ko) * 2006-10-18 2008-04-23 성인환 진세노사이드 성분 함량이 많은 인삼열매와 인삼화병의제조방법
KR20090129928A (ko) * 2008-06-13 2009-12-17 (주)아모레퍼시픽 인삼 꽃 추출물을 함유하는 피부 외용제 조성물
KR20120005195A (ko) * 2010-07-08 2012-01-16 세명대학교 산학협력단 인삼 열매 추출물을 포함하는 탈모 방지 및 모발 성장 촉진용 조성물
KR20120055269A (ko) * 2010-11-23 2012-05-31 (주)아모레퍼시픽 인삼 꽃 파우더 및 그 제조방법, 및 이를 함유하는 화장료 조성물

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KR20080035453A (ko) * 2006-10-18 2008-04-23 성인환 진세노사이드 성분 함량이 많은 인삼열매와 인삼화병의제조방법
KR20090129928A (ko) * 2008-06-13 2009-12-17 (주)아모레퍼시픽 인삼 꽃 추출물을 함유하는 피부 외용제 조성물
KR20120005195A (ko) * 2010-07-08 2012-01-16 세명대학교 산학협력단 인삼 열매 추출물을 포함하는 탈모 방지 및 모발 성장 촉진용 조성물
KR20120055269A (ko) * 2010-11-23 2012-05-31 (주)아모레퍼시픽 인삼 꽃 파우더 및 그 제조방법, 및 이를 함유하는 화장료 조성물

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KIM , HA-JUNG ET AL: "Ginsenosides Contents of Ginseng Leaf, Stalk and Red Ginseng Marc", THE KOREAN SOCIETY OF MEDICINAL CROP SCIENCE 2012 SYMPOSIUM AND SPRING CONFERENCE, 3 May 2012 (2012-05-03), pages 203 - 204, XP055600496 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107744486A (zh) * 2017-11-30 2018-03-02 山西中医药大学 人参花组合物及其制备方法和应用
CN107929123A (zh) * 2017-11-30 2018-04-20 山西中医药大学 人参花提取物的用途及含人参花提取物的化妆品

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KR20170091939A (ko) 2017-08-10

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