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WO2017103923A1 - Appareil et procédé cosmétique pour traitement cosmétique de tissu muqueux humain - Google Patents

Appareil et procédé cosmétique pour traitement cosmétique de tissu muqueux humain Download PDF

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Publication number
WO2017103923A1
WO2017103923A1 PCT/IL2016/051331 IL2016051331W WO2017103923A1 WO 2017103923 A1 WO2017103923 A1 WO 2017103923A1 IL 2016051331 W IL2016051331 W IL 2016051331W WO 2017103923 A1 WO2017103923 A1 WO 2017103923A1
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WO
WIPO (PCT)
Prior art keywords
energy
ems
fractionated
source
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2016/051331
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English (en)
Inventor
Zion Azar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pollogen Ltd
Original Assignee
Pollogen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/970,585 external-priority patent/US11590346B2/en
Application filed by Pollogen Ltd filed Critical Pollogen Ltd
Priority to CN202210311640.9A priority Critical patent/CN114796856A/zh
Priority to CN201680072518.3A priority patent/CN108366828B/zh
Priority to EP16875059.4A priority patent/EP3389532A4/fr
Priority to IL295965A priority patent/IL295965B2/en
Priority to IL259809A priority patent/IL259809B/en
Publication of WO2017103923A1 publication Critical patent/WO2017103923A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0521—Genital electrodes
    • A61N1/0524—Vaginal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1485—Probes or electrodes therefor having a short rigid shaft for accessing the inner body through natural openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0512—Anal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0521—Genital electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0548—Oral electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/005—Rectum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00553—Sphincter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00559—Female reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0605—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0608—Rectum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0611—Vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary

Definitions

  • the present invention relates to the use of one or more treatment modalities in the cosmetic treatment of human mucosal tissue to provide, among other things, vaginal and anal tightening and urinary incontinence treatment.
  • Vaginal Relaxation Syndrome commonly called "loose vagina” is a quite common medical condition described as a loss of the optimal vaginal structure and is usually associated with vaginal child delivery and natural aging.
  • VSR loose vagina
  • VRS treatment options There is a large spectrum of various VRS treatment options on the market ranging from behavioral (Kegel exercises) through pharmacological therapies (hormonal, tightening creams and sprays) to various more-or-less invasive surgical procedures.
  • Surgical procedures require the cutting and rearrangement of vaginal and peripheral tissue in order to reduce the size of the vaginal canal.
  • Operating on or near sensitive vaginal tissue is inherently risky and can cause scarring, nerve damage and decreased sensation.
  • patients require an extended recovery period.
  • An objective of non-ablative photo-rejuvenation is to induce a thermal wound repair response in the papillary and upper reticular dermal compartments (approximately 100-400micro-meter below the surface of the skin) while sparing the epidermal compartment.
  • U.S. Pat. No. 6,311,090 describes using RF energy and an arrangement comprising RF electrodes that rest on the surface of the skin. A reverse thermal gradient is created that apparently does not substantially affect melanocytes and other epithelial cells.
  • noninvasive methods have the significant limitation in that energy cannot be effectively focused in a specific region of interest for example the dermis.
  • fractional laser skin resurfacing uses fractional Photothermolysis. It targets tissue with a pattern of dispersed spots. This results in a pattern of microscopic zones of tissue coagulation that heal over several weeks while the skin retains normal appearance. Rather than creating a global tissue effect at the surface of the target tissue, or in the dermis alone, this method creates injury in a small fraction of the skin treated, coagulating multiple columns of tissue, generally 70-100 micron in diameter, extending through the epidermis and deep into the dermis reaching up to generally 1 mm depth. These laser columns create micro thermal zones of tissue coagulation which is surrounded by healthy tissue.
  • the healthy tissue provides a generous reservoir of stem cells and melanocytes in the papillary dermis that are spared from wounding and accelerate the healing process.
  • the small size of the wounds and the short migratory paths for keratinocytes from the spared tissue result in rapid re-epitheliazation and fast epidermal repair.
  • Zones of collagen denaturation in the dermis cause upregulation of the inflammatory cascade, which leads to collagen remodeling to depths of generally 400- 700 microns resulting in skin tightening.
  • the fact that patients do not have open wounds leads to minimal downtime.
  • Fractional laser resurfacing is therefore a non-ablative procedure. It offers improved skin texture, tone, pigmentation, fine lines and skin tightening. Fractional resurfacing requires a series of 3-5 treatments as opposed to ablative lasers that require a single treatment.
  • Fractional vaginal rejuvenation systems exist in the market using C02 or Er: YAG lasers. These include, for example, IntimaLase by Fotona- a minimally-invasive, non- ablative Er: YAG laser vaginal tightening procedure utilizing photothermal laser- mucosa tissue interaction.
  • Another device is FemiLift by Alma Laser. This is a noninvasive Laser Vaginal Tightening device using C02 laser by thermal heating of the vaginal tissue inner layers inducing collagen and elastin contraction and regeneration of the proteins over time.
  • the present invention may be administered within the confines of a physician's or other operator's office environment, it is of sufficiently simple operation that it may be used in the privacy of the user's home.
  • the present invention may have a switch or other device so that the EMS function may be separable from the RF function so that a user can activate the EMS portion of the present apparatus without activating the RF function for training and/or vaginal tightening purposes.
  • a device which provides fractional treatment of a body orifice includes a source of fractionated energy; a source of electrical muscle (EMS) energy; a programmed controller to control the application of fractionated and/or EMS energy; a probe for insertion of its distal end into the body orifice.
  • the source of fractionated energy is positioned for transmitting fractionated energy from the source of fractionated energy through the probe to tissue in the vicinity around the body orifice; and, the source of EMS is positioned for transmitting EMS energy from the source of EMS energy through the probe to tissue in the vicinity around the body orifice;
  • the programmed controller is configured to control the activation of fractionated energy and EMS energy one of simultaneously or sequentially.
  • the body orifice may be selected from one of: a vaginal cavity; an anal cavity, the oral cavity or the aural cavity, and the treatment provides one of vaginal or anal tightening.
  • the fractionated energy is radio frequency (RF) energy or Ultrasound (US) energy or it may be light energy.
  • RF radio frequency
  • US Ultrasound
  • the controller may be configured to activate the EMS energy first, followed by activation of the RF energy, whereby the tissue in the vicinity of the body orifice is first drawn into contact with the probe, followed by activation of RF energy.
  • the controller may activate the application of EMS energy and then RF energy a selected number of times.
  • the source of fractionated energy may include electrodes mounted on an outer surface of the probe and may be mounted in the form of one or more spirals along the other surface of the probe.
  • the device may be for home use.
  • a method is providing for the fractional treatment of a body orifice and includes: transmitting fractionated energy from a source of fractionated energy through a probe inserted in the body orifice to tissue in the vicinity around the body orifice; and, transmitting EMS energy from a source of EMS energy through the probe to tissue in the vicinity around the body orifice.
  • a programmed controller is configured to control the transmitting of the one or more of fractionated and EMS energy one of simultaneously or sequentially.
  • the controller may activate the EMS energy first, followed by activation of the RF energy, whereby the tissue in the vicinity of the body orifice is first drawn into contact with the probe, followed by activation of RF energy.
  • the controller may activate the application of EMS energy and then RF energy a selected number of times.
  • the method may be practiced in one of an office or a home use.
  • the programmed controller may be configured to control the activation of fractionated energy and/or the EMS energy.
  • the EMS energy may be activated and the fractionated energy source not activated for purposes of tightening the body orifice, including vaginal or anal tightening.
  • FIG. 1 illustrates an overall schematic diagram of the system of the present invention.
  • FIGS. 2A and 2B illustrate a prior art probe and a probe of the present invention which may be utilized in connection with the system of the present invention.
  • FIGS. 2C through 2D illustrate a holder/mounter system for holding/mounting the probe of the present invention in situ.
  • FIG. 3 graphically illustrates the operation of the system of the present invention in the provision of RF and EMS energy.
  • the system shown in FIG. 1 as reference numeral 10, includes a vaginal probe 12 which can be inserted into the vagina and is configured to provide a combination of two types of electrical signals to the vagina wall (not shown).
  • the systemlO also includes a power supply unit 14, a programmable controller 16 with a graphic user interface (GUI) 18.
  • GUI graphic user interface
  • EMS electrical muscle stimulation
  • RF radio frequency
  • pressure sensor 24 and temperature sensor 26 may be provided to provide feedback from the probe 12 before and/or during and/or after either one or both of the EMS unit and/or the RF unit are activated under control of the controller 16.
  • the feedback may include, by way of example only, as a measurement of the efficiency of the treatment in terms of time and extent of treatment.
  • a first electrical signal applied is, as mentioned above, an electrical muscle stimulation signal (EMS) which is purposed and designed when activated to contract the vaginal smooth muscle around a vaginal probe 12.
  • EMS electrical muscle stimulation signal
  • RF radio frequency
  • the EMS pulse serves to contract the vagina around the vaginal probe to create a proper electrical coupling between the inner vaginal tissue and the electrodes.
  • the pressure sensor 24 may be incorporated on the vaginal probe to measure to feedback for the pressure created by the vagina on the probe 12. The amount of pressure sensed may provide an indication of adequate or inadequate coupling of electrodes.
  • the EMS pulses applied activate the muscle and flatten the mucosal tissue such that the muscle are closer to the surface of the electrodes.
  • the controller may be disabled from activating the RF unit 22 until a selected pressure reading is detected, for example.
  • tissue impedance measurement by the treating electrodes by a set of dedicated electrodes may also be used, as known to those skilled in the art, to provide a feedback for the tissue- electrode coupling.
  • the temperature sensor 26 may provide temperature readings at the probe/vagina wall interface to make sure excessive heating does not occur. Excessive heating of the vagina tissue may cause the controller to stop activation of the EMS and/or RF units.
  • a treatment RF pulse is initiated after the EMS signal.
  • the EMS signals may be relatively short and may be in the range of 50 - 350 microsec. This signal may be repeated in a frequency of about 5-25 Hz.
  • the temperature sensor 26 may feedback to the controller 16 which is configured to control the RF pulse width.
  • RF may be bipolar or monopolar.
  • an external electrode on the pubis or lower back may be used.
  • EMS signals may use a dedicated electrode or the same electrodes used for the RF unit.
  • a diode bridge known to those skilled in the art may be provided to "cut" the AC RF signals to produce an effective DC signal in the range of 1 to 30 milliseconds. This configuration makes the whole system much simpler and easier to implement as a home-use device.
  • the DC EMS signal may cause the muscle to be smoothed out which in turn may induce contraction.
  • the system is configured to switch between EMS and RF signals.
  • An EMS signal followed by a RF treatment signal may create thermal damage to the adjacent vaginal tissue and cause its tightening.
  • RF only or EMS only signal may be used in order to heat or exercise the vagina respectively.
  • the order of the application of RF and EMS pulses may be in any order or sequence desired to achieve desirable treatment results.
  • the vagina is a hollow organ and is comprised of a smooth muscle. Smooth muscles are characterized by high elasticity which gives them the ability to stretch while still maintaining strong contractability. Smooth muscle cell cytoplasm is rich with myosin and actin molecules which provide a smooth muscle cell the ability to contract. Tensile structure between smooth muscle cells contains actin filaments of contractile units which are attached to dense bodies creating a network of contracting fibers. This network is neither in a parallel line orientation across nor along the vagina smooth muscle, rather in a more diagonal orientation. As a result, smooth muscle tends to contract in a spirally. Therefore, the most effective way to induce a stimulation of a smooth muscle may not be by providing parallel electrodes 102 along or across a prior art vaginal probe 100 shown in FIG.
  • spiral electrodes 104 are mounted or otherwise fixed onto and along a vaginal probe 1016. Spirally-oriented electrodes are believed to better suited to create an effective stimuli vector in a contacting spot, given the anatomy and arrangement of the contracting fibers in the smooth muscle of the vagina.
  • FIGS. 2C and 2D illustrate arrangements of jackets in which the vagina probe 12 of FIG. 1 may be inserted.
  • FIG. 2D illustrates a probe 200 with measurement markings 202, which may be every 5- 10mm.
  • the probe 200 may fit inside a sleeve 204 as shown in FIG. 2C.
  • the design of the combined unit includes insertion of the sleeve 204 into the vagina.
  • the probe 200 may then be inserted into the sleeve and thus vagina of the patient.
  • a portion of the sleeve 204 will remain outside of the patient's body and the doctor or other operator can read the degree of insertion by reading the measurement markings at position 202. This arrangement allows the doctor or other operator to selectively and/or sequentially treat various depths into the patient's vagina.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Cosmetics (AREA)
  • Electrotherapy Devices (AREA)
  • Laser Surgery Devices (AREA)
  • Radiation-Therapy Devices (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un dispositif pour effectuer un traitement fractionné d'un orifice corporel qui comprend une source d'énergie fractionnée et une source d'énergie musculaire électrique (EMS). Un dispositif de commande programmé commande l'application d'énergie fractionnée et/ou EMS. Une sonde est insérée par son extrémité distale dans l'orifice corporel. La source d'énergie fractionnée est positionnée pour transmettre l'énergie fractionnée depuis la source d'énergie fractionnée par l'intermédiaire de la sonde à un tissu environnant autour de l'orifice corporel ; et, la source d'EMS est positionnée pour transmettre l'énergie EMS depuis la source d'énergie EMS par l'intermédiaire de la sonde à un tissu environnant autour de l'orifice corporel. Le dispositif de commande programmé est configuré pour commander l'activation d'énergie fractionnée et d'énergie EMS simultanément ou séquentiellement.
PCT/IL2016/051331 2015-12-16 2016-12-13 Appareil et procédé cosmétique pour traitement cosmétique de tissu muqueux humain Ceased WO2017103923A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202210311640.9A CN114796856A (zh) 2015-12-16 2016-12-13 用于人体粘膜组织的美容治疗的装置和方法
CN201680072518.3A CN108366828B (zh) 2015-12-16 2016-12-13 用于人体粘膜组织的美容治疗的装置和方法
EP16875059.4A EP3389532A4 (fr) 2015-12-16 2016-12-13 Appareil et procédé cosmétique pour traitement cosmétique de tissu muqueux humain
IL295965A IL295965B2 (en) 2015-12-16 2016-12-13 Cosmetic device and method for cosmetic treatment of human mucosal tissue
IL259809A IL259809B (en) 2015-12-16 2016-12-13 Apparatus and cosmetic method for cosmetic treatment of human mucosal tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/970,585 2015-12-16
US14/970,585 US11590346B2 (en) 2009-11-16 2015-12-16 Apparatus and method for cosmetic treatment of human mucosal tissue

Publications (1)

Publication Number Publication Date
WO2017103923A1 true WO2017103923A1 (fr) 2017-06-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2016/051331 Ceased WO2017103923A1 (fr) 2015-12-16 2016-12-13 Appareil et procédé cosmétique pour traitement cosmétique de tissu muqueux humain

Country Status (4)

Country Link
EP (1) EP3389532A4 (fr)
CN (2) CN114796856A (fr)
IL (2) IL259809B (fr)
WO (1) WO2017103923A1 (fr)

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US11141219B1 (en) 2016-08-16 2021-10-12 BTL Healthcare Technologies, a.s. Self-operating belt
US11185690B2 (en) 2016-05-23 2021-11-30 BTL Healthcare Technologies, a.s. Systems and methods for tissue treatment
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11247063B2 (en) 2019-04-11 2022-02-15 Btl Healthcare Technologies A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11266852B2 (en) 2016-07-01 2022-03-08 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11464994B2 (en) 2016-05-10 2022-10-11 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11484727B2 (en) 2016-07-01 2022-11-01 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11491329B2 (en) 2020-05-04 2022-11-08 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
US11633596B2 (en) 2020-05-04 2023-04-25 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11896823B2 (en) 2017-04-04 2024-02-13 Btl Healthcare Technologies A.S. Method and device for pelvic floor tissue treatment
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EP3389532A4 (fr) 2019-01-02
CN108366828B (zh) 2022-04-15
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CN108366828A (zh) 2018-08-03
CN114796856A (zh) 2022-07-29
IL259809A (en) 2018-07-31
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IL295965B1 (en) 2024-04-01
IL295965B2 (en) 2024-08-01

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