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WO2017179979A1 - Support de capsule pour recevoir une capsule pour contenir un fluide à transporter à travers ou dans une barrière biologique, capsule, ensemble comprenant un support de capsule et une capsule et dispositif comprenant un support de capsule - Google Patents

Support de capsule pour recevoir une capsule pour contenir un fluide à transporter à travers ou dans une barrière biologique, capsule, ensemble comprenant un support de capsule et une capsule et dispositif comprenant un support de capsule Download PDF

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Publication number
WO2017179979A1
WO2017179979A1 PCT/NL2017/050229 NL2017050229W WO2017179979A1 WO 2017179979 A1 WO2017179979 A1 WO 2017179979A1 NL 2017050229 W NL2017050229 W NL 2017050229W WO 2017179979 A1 WO2017179979 A1 WO 2017179979A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
holder
receiving part
fluid
capsule holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2017/050229
Other languages
English (en)
Inventor
Bouke Jan BROUWERS
Arnoldus Maria Brouwers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMBRO BV
Original Assignee
AMBRO BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMBRO BV filed Critical AMBRO BV
Publication of WO2017179979A1 publication Critical patent/WO2017179979A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Definitions

  • the invention relates to a capsule holder according to claim 1 for a capsule for comprising at least one dose of fluid for transportation across or into a biological barrier.
  • the invention further relates to a capsule according to claim 3 for cooperation with the capsule holder.
  • the known system comprises a capsule that comprises a substrate from which two or more hollow micro needles project for penetrating the biological barrier; a reservoir for the fluid dose, which reservoir can be brought into fluid communication with the micro needles, wherein the fluid dose is transportable through the hollow micro needles across or into the biological barrier
  • the known system further comprises a device provided with a
  • the housing of the known device holds the capsule.
  • micro needle approach shows clear advantages over competing methods of transferring fluids through skin or other biological barriers.
  • micro needles reach into the dermis of the skin, where the immune system resides, and assure an intradermal drug delivery.
  • Hypodermic needles are used for subcutaneous or intramuscular drug delivery, which is less effective. Consequently, when using hollow micro needles, a lesser amount of drug is needed compared to using hypodermic needles, for instance for a vaccine only 10-20% of the amount is needed.
  • use of micro needles is relatively painless and drugs can be self-administered or administered by non-professionals. In addition, they overcome the molecular size limitations characteristic of conventional transdermal patches.
  • the known system provides a compact design with an elegant and simple operation.
  • the system is patient friendly and allows for self-injection. It is thus suitable for daily use by any individual. It is also suitable for use in large groups, particularly in case of vaccination, and even in case of urgent calamities, for instance due to an outbreak of a lethal virus, such as SARS, Ebola, et cetera.
  • a lethal virus such as SARS, Ebola, et cetera.
  • the known capsule is designed for use in the known device and comprises a substrate with an integrated reservoir having a dome shaped upper part that is deformable under force.
  • the know capsule is suitable for one time use only assuring optimal hygiene for users.
  • the invention has for its object to provide a capsule holder to allow quick and easy (re)placement of the capsule.
  • a further object of the invention is to provide an improved capsule for cooperation with the capsule holder that can be used for an even wider range of applications.
  • These objects are achieved by a capsule holder according to claim 1 and a capsule according to claim 3.
  • the cooperating protruding and receiving parts of the capsule according to the invention enclose the reservoir and advantageously allow for an adjustable reservoir volume by predetermining the position of the protruding part with respect to the receiving part.
  • the protruding part is arranged to be moved from a first position, wherein the volume of the reservoir is at a maximum, to a second position, wherein the volume of the reservoir is at a minimum.
  • the adjustable reservoir volume is a major advantage over the known capsule as varying applications require varying amounts of fluid per dose.
  • the reservoir shape ensures an even distribution of fluid over all micro needles.
  • Both single reservoir and multiple reservoir embodiments form part of the invention.
  • the capsule holder according to the invention allows for a suitable accommodation for the improved capsule according to the invention.
  • the means for releasable attachment, respectively detachment, of the capsule holder to the device allow for a quick and reliable (re)placement of the capsule.
  • Reuse of the remaining part of the device comprising the displacement mechanism, also referred to as the applicator, is made easy.
  • the releasable attachment of the capsule holder allows for re-use or recycling of the capsule holder as well.
  • a one-time use only of the capsule holder is possible.
  • the hygiene for users is further optimised, as the abutment surface is brought into contact with a user's skin. The flat surface then automatically stretches the skin of the user facilitating penetration of the micro needles.
  • the capsule holder comprises a form-closed connection, such as a bayonet closure, for releasable attachment to the device for applying force to the capsule.
  • a form-closed connection such as a bayonet closure
  • the capsule comprises biasing means for biasing the capsule in a direction away from the bottom of the capsule holder.
  • the biasing means keep the micro needles inside the housing prior to use.
  • the biasing means ensure withdrawal of the micro needles into the capsule holder after use. Consequently, a detached assembly of a capsule holder and a capsule has no protruding parts that could otherwise form a danger and is no longer suitable for use.
  • the biasing means comprise resilient arms that extend around the circumference of the capsule near the substrate. Preferably the arms are at the outer ends provided with feet to rest on the bottom of the capsule holder.
  • the capsule is provided with spacers projecting outwardly from the receiving part to contact the housing of the capsule holder.
  • the spacers define ventilation channels between the capsule and the capsule holder for air enclosed between the substrate and the bottom to escape when the capsule is moved.
  • the spacers are ribs extending generally in longitudinal direction over the outer surface of the receiving part.
  • the arms extend between and substantially transverse to adjacent spacers.
  • the capsule is made of plastic, preferably polyethylene (PE), except for the microneedles.
  • Plastic, especially PE is a suitable material for contact with most fluids.
  • the protruding part is a plunger and the receiving part comprises a recess for the plunger.
  • the receiving part is substantially cup-shaped. This embodiment allows for accurate measurement of the fluid dose and has a minimal amount of dead volume.
  • the capsule comprises two or more sets of a receiving part and a protruding part, each set enclosing a separate reservoir for fluid.
  • each reservoir can be filled with a different fluid, whereby contact between the different fluids is avoided.
  • the capsule is now suitable for separate storage of the different components that make up so-called combination drugs and combination vaccines.
  • the required extensive tests directed to the activity and shelf life of known combination drugs or vaccines, wherein the different drug or vaccination components are mixed can be successfully avoided. This does not only speed up the introduction of a newly developed drug or vaccine into the market, but also saves a huge amount of costs related to testing.
  • the present invention also relates to an assembly of a capsule holder according to the invention and a capsule according to the invention, wherein the capsule is movable in the capsule holder from a starting position, wherein the micro needles are inside the housing, to a position of use, wherein the micro needles project out of the housing.
  • the assembly can be sealed for storage.
  • the present invention relates to a device for applying force to a capsule according to the invention, which device comprises a capsule holder according to the invention, wherein the device and the capsule holder are arranged for releasable attachment, which device comprises a displacement mechanism for moving the capsule according to the invention in the capsule holder towards the abutment surface and for subsequently moving the protruding part with respect to the receiving part towards the abutment surface.
  • the displacement mechanism comprises a ram having a sleeve that is movable with respect to the ram. After actuation the sleeve hits a striking surface on the receiving part of the capsule to move the capsule from the starting position to the position of use. The ram hits a striking surface of the protruding part and proceeds in moving the protruding part with respect to the receiving part from the first to the second position.
  • Figure 1 shows a cross sectional view on a preferred embodiment of a device comprising an assembly of figure 2A according to the invention
  • Figure 2A shows a cross sectional view of an assembly of a first preferred embodiment of a capsule according to the invention and a capsule holder with the capsule in a starting position
  • Figure 2B shows a cross sectional view of the assembly of figure 2A with the capsule in a position of use
  • Figure 2C shows a cross sectional view of the assembly of figure 2A with the capsule in an end position
  • Figure 3 shows a schematic view of the assembly of figure 2A according to the invention
  • Figure 4 shows a schematic view of a second preferred embodiment of a capsule according to the invention.
  • Figure 5 shows a schematic view of a third preferred embodiment of a capsule according to the invention.
  • Figure 6 shows a schematic view of a third preferred embodiment of a capsule according to the invention.
  • Figure 1 shows a cross sectional view on a preferred embodiment of an applicator 100 comprising the assembly of figure 2A according to the invention.
  • FIG 2A shows a cross sectional view of an assembly of a capsule 10 according to the present invention in a preferred embodiment and a capsule holder 50.
  • Figure 3 shows a schematic view of the assembly 10, 50.
  • the capsule holder 50 is arranged to accommodate any capsule according to the invention. Further embodiments of such capsules are shown in figures 4, 5 and 6.
  • Capsule 10 comprises a substrate 1 1 from which two or more hollow micro needles 12 project.
  • An example of a suitable type of hollow micro needles is described in the international patent application WO2014/077677 of the same applicant, which is incorporated herein by reference.
  • the capsule 10 comprises a receiving part 16 and a protruding part 13 to be received in the receiving part 16.
  • the parts 13 and 16 cooperate and enclose a fluid reservoir 14 between two of their opposing or facing surfaces.
  • the protruding part 13 is movable with respect to the receiving part 16.
  • the protruding part 13 is movable with respect to the receiving part 16 from a first position to a second position, wherein the volume of the reservoir 14 is larger in the first position than in the second position.
  • the first and/or the second position can be set in dependence of the application and the
  • the substrate 1 1 is comprised in the receiving part.
  • the reservoir is in fluid communication with the micro needles 12 in the substrate 31.
  • the hollow micro needles 12 are arranged for penetrating a biological barrier.
  • a fluid dose present in the reservoir 14 can be transported through the hollow micro needles 12 across or into the biological barrier substantially all at a time when a force is exerted on the protruding part 13 in a direction towards the substrate 1 1.
  • a plunger 13 forms the protruding part and the receiving part 16 comprises a recess 17 for receiving the plunger 13.
  • the receiving part 16 is substantially cup-shaped, wherein the substrate 1 1 forms the bottom of the cup and the walls of the cup define the recess 17.
  • Sealing means 15 are present between the receiving part 16 and the protruding part 13 to provide a fluid tight seal for the reservoir 14.
  • sealing means 35 are formed by a sealing edge 15.
  • the capsule holder 50 comprises an outer bottom surface or abutment surface 51 for abutting the biological barrier.
  • the abutment surface 51 is a substantially flat surface provided with micro openings 52 for the micro needles 12.
  • the capsule holder comprises a housing 53 having a receiving space 54 for the capsule. Walls 55 extend upwards to define an opening to a passage 56 for at least part of the displacement mechanism, said passage 56 extending to the receiving space 54.
  • the walls 55 are provided with means 59 for releasable attachment to the device 100.
  • the capsule holder 50 preferably comprises part of a form-closed connection, such as bayonet closure 59, for releasable attachment to the applicator.
  • the capsule holder 50 is arranged for releasable attachment to a device or applicator, such as applicator 100 shown in figure 1.
  • Applicator 100 comprises a displacement mechanism, such as a ram 1 12, for applying a force onto the capsule to move the capsule 10 in the capsule holder 50 towards the abutment surface 51.
  • the assembly further comprises biasing means 19 for biasing the capsule 10 in a direction away from the abutment surface 51.
  • the biasing means comprise a number of resilient arms 19 extending substantially in the circumferential direction of the capsule 10.
  • the arms 19 are at the outer ends provided with feet 19A.
  • the applicator 100 and the capsule holder 50 are arranged for releasable attachment, preferably by a bayonet closure.
  • Applicator 100 is arranged for applying force to the capsule 10 and comprises a displacement mechanism for moving the capsule 10 in the capsule holder 50 towards the abutment surface 51 and for moving the protruding part
  • the Housing 1 1 1 is preferably a hand held housing.
  • the housing 1 1 1 is elongate and has a hollow inner space 1 1 1A.
  • the displacement mechanism comprises a ram 1 12 that is arranged movably in the hollow space 1 1 1 A of the housing 1 1 1 in a direction that is substantially perpendicular to the abutment surface 51.
  • the displacement mechanism further comprises pre-tensioning means for pre-tensioning the ram 1 12 in a starting position. This starting position is shown in figure 1.
  • the pre-tensioning means comprise a spring 1 13 and a drive 1 18 for eccentrically driving the ram 112.
  • the eccentrical drive 118 is placed in an off centre position.
  • the capsule 10 rests with the feet 19A on the inner bottom surface of the capsule holder 50 while the micro needles 12 partly extend in the holes 52 whereby the needle points remain inside the capsule holder 50.
  • FIG 2B the capsule is in a position of use.
  • the capsule 10 has been moved in the capsule holder 50 against the force of the biasing arms 19 by the ram 1 12 of the applicator.
  • the upper surface of the plunger 13 forms a striking surface 13S for the ram 1 12. Due to frictional forces the cup 16 will move together with the plunger 13.
  • the substrate 1 1 now contacts the inner bottom surface of the capsule holder 50 and the micro needles protrude out of the openings 52 in the abutment surface 51 for penetration of the biological barrier.
  • FIG 2C the ram is in an end position.
  • the protruding part 13 has been moved in the receiving part 16 from the first to the second position by the ram 112.
  • the reservoir volume 14 is much smaller than in figures 2A and 2B, preferably zero.
  • the fluid has been pushed out of the reservoir 14 through the micro needles 12 into the biological barrier.
  • FIG 1 an alternative preferred embodiment of the applicator is shown in which the ram 1 12 is provided with a sleeve 1 14 that is spring loaded by spring 1 15. In the initial position shown the ram 1 12 is retracted in the sleeve 1 14. When activating the system, the ram 1 12 and the sleeve 114 will move together, while the sleeve 114 hits the striking surface 16S of the receiving part 16 causing the capsule 10 to move to the position of figure 2B.
  • FIG 3 shows a schematic view of the assembly of figure 2A according to the invention.
  • the capsule 10 is provided with spacers 18 to create ventilation channels for air to escape from the receiving space 54 during movement of the capsule 10 in the capsule holder 50.
  • the spacers comprise mating ribs and grooves. Ribs 18 extend generally in longitudinal direction over the outer surface of the receiving part 16 and can be received in mating grooves on the inner surface of the capsule holder 50. The ribs 18 also serve for positioning the capsule 10 in its starting position in the capsule holder 50.
  • Figures 4, 5 and 6 each show a schematic view of a second, third and fourth preferred embodiment of a capsule according to the invention.
  • the capsule 20, 30 and 40 each have multiple reservoirs.
  • Capsule 20 comprises generally the same parts as capsule 10. In figure 4 reference numerals of like parts are incremented by 10 with respect to figure 3.
  • Receiving part 26 is divided into two receiving compartments 26A, 26B having recesses 27A, 27B and protruding part 23 comprises two plungers 23A, 23B to be received by the recesses 27A, 27B respectively. Consequently, capsule 20 comprises two sets of cooperating parts 23A, 26A; 23B, 26B, wherein each set encloses a separate reservoir for fluid.
  • Capsule 30 comprises generally the same parts as capsule 10. In figure
  • Capsule 30 comprises three sets of cooperating parts, wherein each set encloses a separate reservoir for fluid.
  • Protruding part 33 comprises three plungers 33A, 33B, 33C and receiving part 36 is divided into three receiving compartments having recesses 37A, 37B, 37C (of which only the last two are shown) for receiving the plungers.
  • Capsule 40 comprises generally the same parts as capsule 10. In figure
  • Capsule 40 comprises four sets of cooperating parts, wherein each set encloses a separate reservoir for fluid.
  • Protruding part 43 comprises four plungers 43A, 43B, 43C, 43D.
  • Receiving part 46 is divided into four receiving compartments having recesses 47A, 47B, 47C, 47D (of which only the last two are shown) for receiving the plungers.
  • All parts of the capsule are preferably made of the same plastic material.
  • a very suitable plastic is polyethylene (PE).
  • PE polyethylene
  • a suitable coating may be used depending on the fluid to be transported.
  • the inner surface of the capsule holder is metallized to form a barrier against moisture and oxygen.
  • the capsule may be discarded and the pre- tensioning means can be reset to the initial position, in which the device 100 is ready for re-use.
  • the resetting can be performed manually or automatically.
  • the capsule holder may be discarded together with the capsule or be recycled.
  • the pre-tensioning means of the applicator 100 preferably comprise a spring 1 13.
  • the necessary force to be delivered by the spring depends on the application. When the target area to be reached by the micro needles lies in the epidermis of human skin a force of 150 - 500 Newton is expected to be sufficient.
  • pre-tensioning means include electrical or
  • electromechanical pre-tensioning means or pneumatical pre-tensioning means.
  • Alternative drives for the ram include a linear actuator or a pneumatic actuator.
  • the capsule, capsule holder and device according to the invention are suitable for use with humans as well as animals.
  • biological barriers include: skin, vessel walls, intestinal walls, the eye et cetera.
  • any fluid can be delivered using the micro needle devices described herein.
  • the fluid comprises an agent, which possesses therapeutic, prophylactic, or diagnostic properties in vivo, for example when administered to a human or an animal.
  • suitable therapeutic and/or prophylactic active agents include proteins, such as hormones, antigens, such as vaccines, and growth factors; nucleic acids, such as antisense molecules; and smaller molecules, such as antibiotics, steroids, decongestants, neuroactive agents, anaesthetics, and sedatives.
  • suitable diagnostic agents include radioactive isotopes and radio opaque agents, metals, metal oxides, gases and labels including chromatographic, fluorescent or enzymatic labels.
  • the reservoir is to provide suitable, leak-free storage of the agent composition before it is to be delivered.
  • a capsule is meant to be an enclosure (to be) filled with a fluid dose, i.e. a predetermined amount of fluid to be transported substantially all at a time.
  • the reservoirs are separate and are each in fluid communication only with a limited number of the needles present in the corresponding substrate parts. All fluid doses present in the reservoirs can be transported through the hollow micro needles across or into the biological barrier substantially all at a time when a force is exerted on the striking surface of the protruding part in a direction towards the substrate.
  • the number of reservoirs in the multiple reservoir embodiments can be designed for an envisaged application.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un support de capsule (50) pour recevoir une capsule (10) pour contenir au moins une dose de fluide à transporter à travers ou dans une barrière biologique à utiliser pour une administration intradermique de médicament. La présente invention concerne également une capsule (10) destinée à coopérer avec le support de capsule (50). L'invention concerne en outre un ensemble comprenant le support de capsule (50) et la capsule (10). L'invention concerne en outre un dispositif (100) pour appliquer une force sur la capsule (10), ledit dispositif comprenant le support de capsule (50), le dispositif et le support de capsule étant agencés pour une fixation détachable, ledit dispositif comprenant un mécanisme de déplacement (112, 113, 114, 115, 118) pour déplacer la capsule (10) dans le support de capsule (50) vers la surface de butée (51) et pour déplacer ensuite la partie saillante par rapport à la partie réceptrice vers la surface de butée.
PCT/NL2017/050229 2016-04-14 2017-04-13 Support de capsule pour recevoir une capsule pour contenir un fluide à transporter à travers ou dans une barrière biologique, capsule, ensemble comprenant un support de capsule et une capsule et dispositif comprenant un support de capsule Ceased WO2017179979A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2016604 2016-04-14
NL2016604A NL2016604B1 (nl) 2016-04-14 2016-04-14 Capsule holder for accomodating a capsule for comprising fluid for transportation across or into a biological barrier, capsule, assembly of a capsule holder and a capsule and device comprising a capsule holder.

Publications (1)

Publication Number Publication Date
WO2017179979A1 true WO2017179979A1 (fr) 2017-10-19

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Family Applications (1)

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PCT/NL2017/050229 Ceased WO2017179979A1 (fr) 2016-04-14 2017-04-13 Support de capsule pour recevoir une capsule pour contenir un fluide à transporter à travers ou dans une barrière biologique, capsule, ensemble comprenant un support de capsule et une capsule et dispositif comprenant un support de capsule

Country Status (2)

Country Link
NL (1) NL2016604B1 (fr)
WO (1) WO2017179979A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6734501B1 (ja) * 2020-03-09 2020-08-05 三島光産株式会社 マイクロニードル用アプリケータ
JP2022110172A (ja) * 2021-01-16 2022-07-29 シンクランド株式会社 アプリケータ及びアプリケータ用カートリッジ

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187395A1 (en) * 2002-04-02 2003-10-02 Gabel Jonathan B. Intradermal delivery device
US20120109065A1 (en) * 2010-11-03 2012-05-03 Tyco Healthcare Group Lp Transdermal Fluid Delivery Device
WO2013043052A1 (fr) 2011-09-23 2013-03-28 Ambro B.V. Système de transport de fluide à travers ou dans une barrière biologique, dispositif et capsule comme partie du système
US20130345638A1 (en) * 2012-06-25 2013-12-26 Flugen, Inc. Multiple drug delivery device
WO2014077677A1 (fr) 2012-11-13 2014-05-22 Ambro B.V. Micro-aiguille pour transporter un fluide à travers ou dans une barrière biologique, et procédé de production d'une telle micro-aiguille
EP3037124A1 (fr) * 2014-12-22 2016-06-29 Universite Libre De Bruxelles Dispositif d'administration de médicament à micro-aiguilles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187395A1 (en) * 2002-04-02 2003-10-02 Gabel Jonathan B. Intradermal delivery device
US20120109065A1 (en) * 2010-11-03 2012-05-03 Tyco Healthcare Group Lp Transdermal Fluid Delivery Device
WO2013043052A1 (fr) 2011-09-23 2013-03-28 Ambro B.V. Système de transport de fluide à travers ou dans une barrière biologique, dispositif et capsule comme partie du système
US20130345638A1 (en) * 2012-06-25 2013-12-26 Flugen, Inc. Multiple drug delivery device
WO2014077677A1 (fr) 2012-11-13 2014-05-22 Ambro B.V. Micro-aiguille pour transporter un fluide à travers ou dans une barrière biologique, et procédé de production d'une telle micro-aiguille
EP3037124A1 (fr) * 2014-12-22 2016-06-29 Universite Libre De Bruxelles Dispositif d'administration de médicament à micro-aiguilles

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6734501B1 (ja) * 2020-03-09 2020-08-05 三島光産株式会社 マイクロニードル用アプリケータ
WO2021181471A1 (fr) * 2020-03-09 2021-09-16 三島光産株式会社 Applicateur de microaiguille
JP2022110172A (ja) * 2021-01-16 2022-07-29 シンクランド株式会社 アプリケータ及びアプリケータ用カートリッジ
JP7734362B2 (ja) 2021-01-16 2025-09-05 シンクランド株式会社 アプリケータ及びアプリケータ用カートリッジ

Also Published As

Publication number Publication date
NL2016604A (en) 2017-10-31
NL2016604B1 (nl) 2017-11-15

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