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WO2017146660A1 - Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels - Google Patents

Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels Download PDF

Info

Publication number
WO2017146660A1
WO2017146660A1 PCT/TR2016/000018 TR2016000018W WO2017146660A1 WO 2017146660 A1 WO2017146660 A1 WO 2017146660A1 TR 2016000018 W TR2016000018 W TR 2016000018W WO 2017146660 A1 WO2017146660 A1 WO 2017146660A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood flow
decreasing system
flow decreasing
electrodes
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2016/000018
Other languages
English (en)
Inventor
Yusuf Ozgur CAKMAK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koc Universitesi
Original Assignee
Koc Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koc Universitesi filed Critical Koc Universitesi
Priority to PCT/TR2016/000018 priority Critical patent/WO2017146660A1/fr
Publication of WO2017146660A1 publication Critical patent/WO2017146660A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3785—Electrical supply generated by biological activity or substance, e.g. body movement

Definitions

  • Heart attack is a medical condition, in which blood flow stops to a part of the heart causing damage to the heart muscle.
  • cardiac massage should be applied to the patient.
  • blood flow of the abdomen area of the patient should be decreased to shift the blood from abdominal arteries to the heart including coronary arteries and myocardium.
  • Another object of the present application is to provide a wearable system for hypotension, hypoglycemia and heart attack based on segmental sympathetic stimulation of a specific organ and their arterial smooth muscles.
  • Blood flow decreasing system of the present application comprises at least one sensor for determining at least one blood related medical condition, such as hypotension, hypoglycemia and heart attack, of a patient; at least two electrodes that are placed to skin dermatomal (a skin area that is supplied by a nerve) of said patient; at least one stimulator that sends electrical signals to said electrodes; and at least one control unit, which controls said stimulator according to the medical condition that is determined by said sensor.
  • Said system may further comprise at least one power source (for example a rechargeable battery) for energizing the control unit and/or electrodes.
  • blood flow decreasing system comprises a power generator that generated electrical power from the body (skin) of the user for energizing the control unit and/or electrodes.
  • said sensor measures the blood pressure level of the patient.
  • said electrodes are placed over the T10- S2 dermatomes (preferably T12 and/or L4), wherein one of said electrodes is used as anode and other one is used as cathode.
  • a predetermined level such as when systolic blood pressure reduces below 90 mmHg or diastolic blood pressure reduces below 60 mmHg, it is determined that hypotension situation occur.
  • said control unit activates said stimulator in order to send signals to the T12 and/or L4 dermatomes through the electrodes.
  • said sensor measures the blood glucose level of the patient.
  • said electrodes are placed over the T7-S2 dermatomes (preferably T10 and/or L5), wherein one of said electrodes is used as anode and other one is used as cathode.
  • Glucagon is also act on kidney to produce glucose via gluconeogenesis (new glucose production) so that non-invasive stimulation of sympathetic nerves over the common hepatic artery with corresponding skin stimulation is also stimulates the glucose production of kidney with aid of glucagon secretion in the pancreas.
  • blood flow decreasing system comprises at least one input means (for example a keyboard or a touchscreen) to control signal parameters.
  • users are able to enter their age, weight, height, and gender information through said input means.
  • users directly changes optimum signal parameters manually.
  • optimum parameters for one individual may be found by a physician prior to use of the blood flow decreasing system.
  • said control unit comprises means for monitoring the current level of the signal that are sent to said electrodes.
  • blood flow decreasing system comprises at least one temperature sensor, which measures the temperature of the electrodes and skin of the user, and at least one temperature adjusting unit, which adjusts the temperature of the electrode according to the temperature values measured by said temperature sensor.
  • said temperature adjusting unit decreases the temperature of the electrode.
  • said temperature adjusting unit increases the temperature of the electrodes. Therefore, it is ensured that said electrodes do not damage the skin of the user because of a high or low temperature.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un système non effractif de diminution du débit sanguin qui diminue le débit sanguin dans un organe interne d'un patient pour atténuer des états pathologiques associés à une faible stimulation sympathique segmentaire et à un débit sanguin élevé d'organes internes spécifiques, tels qu'une hypotension, une hypoglycémie et une crise cardiaque. Ledit système de diminution du débit sanguin comprend au moins un capteur destiné à déterminer au moins un état pathologique affectant le sang ; au moins deux électrodes qui sont placées sur le dermatome cutané dudit patient ; au moins un stimulateur qui envoie auxdites électrodes des signaux électriques avec une plage spécifique de fréquences et au moins une unité de commande qui commande ledit stimulateur en fonction de l'état pathologique qui est déterminé par ledit capteur.
PCT/TR2016/000018 2016-02-24 2016-02-24 Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels Ceased WO2017146660A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/TR2016/000018 WO2017146660A1 (fr) 2016-02-24 2016-02-24 Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TR2016/000018 WO2017146660A1 (fr) 2016-02-24 2016-02-24 Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels

Publications (1)

Publication Number Publication Date
WO2017146660A1 true WO2017146660A1 (fr) 2017-08-31

Family

ID=55759910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2016/000018 Ceased WO2017146660A1 (fr) 2016-02-24 2016-02-24 Système permettant de diminuer le débit sanguin dans un organe interne pour atténuer une hypotension, une hypoglycémie et un infarctus du myocarde à l'aide d'une stimulation segmentaire non effractive de l'innervation sympathique d'organes internes spécifiques et de leurs muscles lisses artériels

Country Status (1)

Country Link
WO (1) WO2017146660A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12408974B2 (en) 2014-12-03 2025-09-09 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue
US12478806B2 (en) 2012-03-08 2025-11-25 Medtronic Ireland Manufacturing Unlimited Company Catheter-based devices and associated methods for immune system neuromodulation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607454A (en) * 1993-08-06 1997-03-04 Heartstream, Inc. Electrotherapy method and apparatus
US20030114900A1 (en) 2001-12-14 2003-06-19 Mellen Craig R. Electrical stimulation device and methods of treatment of various body conditions
US7226615B2 (en) 2000-11-07 2007-06-05 Cryolife, Inc. Expandable foam-like biomaterials and methods
WO2011094464A1 (fr) * 2010-01-28 2011-08-04 Medtronic, Inc. Dispositifs, systèmes et procédés pour administrer une stimulation électrique à une zone cible sur un patient au moyen d'un dispositif de stimulation auto-alimenté portable
US20150005680A1 (en) * 2011-02-23 2015-01-01 John D. LIPANI System and Methods for Diagnosis and Treatment of Discogenic Lower Back Pain
US20160015978A1 (en) * 2013-05-15 2016-01-21 Koc Universitesi System for decreasing the blood flow of a targeted organ's artery with an electrical stimulation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607454A (en) * 1993-08-06 1997-03-04 Heartstream, Inc. Electrotherapy method and apparatus
US7226615B2 (en) 2000-11-07 2007-06-05 Cryolife, Inc. Expandable foam-like biomaterials and methods
US20030114900A1 (en) 2001-12-14 2003-06-19 Mellen Craig R. Electrical stimulation device and methods of treatment of various body conditions
WO2011094464A1 (fr) * 2010-01-28 2011-08-04 Medtronic, Inc. Dispositifs, systèmes et procédés pour administrer une stimulation électrique à une zone cible sur un patient au moyen d'un dispositif de stimulation auto-alimenté portable
US20150005680A1 (en) * 2011-02-23 2015-01-01 John D. LIPANI System and Methods for Diagnosis and Treatment of Discogenic Lower Back Pain
US20160015978A1 (en) * 2013-05-15 2016-01-21 Koc Universitesi System for decreasing the blood flow of a targeted organ's artery with an electrical stimulation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478806B2 (en) 2012-03-08 2025-11-25 Medtronic Ireland Manufacturing Unlimited Company Catheter-based devices and associated methods for immune system neuromodulation
US12408974B2 (en) 2014-12-03 2025-09-09 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue

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