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WO2017142057A1 - Composition dermatologique topique - Google Patents

Composition dermatologique topique Download PDF

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Publication number
WO2017142057A1
WO2017142057A1 PCT/JP2017/005845 JP2017005845W WO2017142057A1 WO 2017142057 A1 WO2017142057 A1 WO 2017142057A1 JP 2017005845 W JP2017005845 W JP 2017005845W WO 2017142057 A1 WO2017142057 A1 WO 2017142057A1
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WIPO (PCT)
Prior art keywords
powder
composition
skin
inorganic phosphor
external
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Ceased
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PCT/JP2017/005845
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English (en)
Japanese (ja)
Inventor
裕美子 楯
優 河合
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Rohto Pharmaceutical Co Ltd
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Rohto Pharmaceutical Co Ltd
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Priority to JP2018500221A priority Critical patent/JP7343976B2/ja
Publication of WO2017142057A1 publication Critical patent/WO2017142057A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to an external composition for skin.
  • Makeup cosmetics generally contain various powders as a base for applying to the skin and changing its texture. For example, in order to cover the dullness of the skin, the hue of the skin is changed using a pigment such as titanium dioxide or iron oxide, a lake pigment or an organic pigment. A pearl pigment such as interference pearl is also used to change the hue of the skin. However, it cannot be said that the effect of changing the skin hue sensation of cosmetics containing the pigments or interference pearls is sufficient (see Patent Document 1).
  • An object of the present invention is to provide a novel composition for external use in skin, which further improves the color developability (luminescence) in the composition for external use containing an inorganic phosphor.
  • the present inventor has enhanced the luminescence intensity of a composition containing an inorganic phosphor by blending powder and an inorganic phosphor in a composition for external use on the skin. I found out that I can.
  • the gist of the present invention is as follows.
  • An external composition for skin containing (A) powder and (B) inorganic phosphor, and the content of (B) inorganic phosphor is 0.0001 to 9.5% by mass relative to the entire composition object.
  • (A) The powder is at least one selected from the group consisting of talc, boron nitride, mica, pearl pigment, silicone resin, alkyl polyacrylate, urethane, nylon, and silica.
  • Powder is talc, boron nitride, synthetic phlogopite, titanium oxide-coated mica, titanium oxide-coated synthetic phlogopite, titanium oxide-treated mica, titanium oxide-treated talc, (dimethicone / vinyl dimethicone) crosspolymer, Polymethylsilsesquioxane, (diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxane) crosspolymer, (vinyldimethicone / methiconesilsesquioxane) crosspolymer, methylmethacrylate crosspolymer, nylon-12, (HDI / tri
  • the external composition for skin according to any one of [1] to [3], which is at least one selected from the group consisting of (methylolhexyl lactone) crosspolymer and silica.
  • the external composition for skin of the present invention contains (A) powder and (B) inorganic phosphor, so that even if the content of (B) inorganic phosphor is small, excellent color developability (light emitting property). ), It can be suitably used as cosmetics, especially makeup cosmetics such as foundations, eye shadows, and lipsticks, and cosmetics for sunscreen.
  • the external composition for skin of this invention contains (A) powder and (B) inorganic fluorescent substance. Moreover, the composition for external skin of this invention may contain another component in the range which does not impair the effect of this invention other than these essential components. Hereinafter, each of these components will be described.
  • the (A) powder in the present invention has an effect of enhancing the light emission intensity of a composition containing the inorganic phosphor (B) described later, among those commonly used in ordinary cosmetics.
  • color development means the property in which the color of the composition for external use of skin appears.
  • the color includes not only general colors but also colors that emit light such as fluorescent colors.
  • the light emitting property refers to a property of emitting light such as fluorescence, and is a concept partially shared with the color developing property and affects the color developing property.
  • the shape of the powder is not particularly limited as long as it can enhance the emission intensity of the composition containing (B) the inorganic phosphor.
  • the shape is spherical, plate-like, needle-like, spindle-like, hemispherical Etc.
  • B From the viewpoint of the effect of enhancing the emission intensity of the composition containing the inorganic phosphor, spherical and plate-like powders are preferable.
  • the powder examples include spherical or plate-like organic powders such as polymer compounds and organic pigments; spherical inorganic powders such as silica; and plate-like inorganic powders such as mica, talc and boron nitride.
  • a plate-like powder such as a pearl pigment;
  • the particle diameter of (A) powder is not particularly limited as long as it is a size that can enhance the emission intensity of the composition containing (B) inorganic phosphor, but as an example, it is 1 ⁇ m or more, preferably 2 ⁇ m or more, more preferably May be 3 ⁇ m or more, more preferably 4 ⁇ m or more, and particularly preferably 5 ⁇ m or more.
  • the upper limit of the particle diameter of the powder is not particularly limited, as an example, it may be 300 ⁇ m or less, preferably 200 ⁇ m or less, more preferably 100 ⁇ m or less, still more preferably 50 ⁇ m or less, and particularly preferably 20 ⁇ m or less.
  • the light emission intensity of the composition containing (B) the inorganic phosphor can be more effectively increased by selecting and using one having a particle diameter of 5 ⁇ m or more. It has been confirmed that
  • Organic powder examples include polymer compounds and organic pigments.
  • polymer compound examples include thermoplastic resins such as silicone resin (silicone powder), polyalkyl acrylate, nylon, urethane, styrene resin, polyolefin, fluororesin, and polyester; thermosetting resins such as epoxy resin and phenol resin.
  • thermoplastic resins such as silicone resin (silicone powder), polyalkyl acrylate, nylon, urethane, styrene resin, polyolefin, fluororesin, and polyester
  • thermosetting resins such as epoxy resin and phenol resin.
  • examples thereof include spherical powders of organic polymers such as resins. Of these organic polymer spherical powders, (B) silicone resin (silicone powder), polyalkyl acrylate, nylon and urethane are preferred from the viewpoint of enhancing the light emission intensity of the composition containing the inorganic phosphor (B). .
  • silicone resins include silicone elastomers such as (dimethicone / vinyl dimethicone) crosspolymers; silicone powders such as polymethylsilsesquioxane (also referred to as a methylsiloxane network polymer); (diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxy).
  • silicone cross polymer silicone composite powder such as (vinyl dimethicone / methicone silsesquioxane) cross polymer, and the like.
  • silicone resin commercially available products may be used.
  • Trefill E506S (4 ⁇ m), EP-9215 Cosmetic Powder (4 ⁇ m), 9701 Cosmetic Powder (4 ⁇ m), EP-9801 (4 ⁇ m), Trefill E508 (4 ⁇ m), 9702 Powder (4 ⁇ m), EP-9289LL Cosmetic Powder (4 ⁇ m), BY29-129 (4 ⁇ m), PF-2001 PIF Emulsion (4 ⁇ m), 9546 Silicone Elastomer Blend, FB-9586 Elidene ); Tospearl 145A (4.5 ⁇ m), Tospearl 150KA (5 ⁇ m), Tospearl 2000B (6 ⁇ m), Tospearl 3000A (6 ⁇ m), Tospearl 1100A (11 ⁇ m) (made by Momentive Performance Materials Japan); KMP-591 (5 ⁇ m), KMP-599 (3 ⁇ m), KSP-100 (5 ⁇ m) ), KSP-105 (2 ⁇ m), KSP-300 (5 ⁇ m), X
  • the average primary particle diameter by microscopic observation is preferably 3 ⁇ m or more and 30 ⁇ m or less, more preferably 3 ⁇ m or more and 20 ⁇ m or less, and further preferably 5 ⁇ m or more and 20 ⁇ m or less.
  • the average particle size of the silicone resin is preferably a size exceeding 2 ⁇ m.
  • particle diameter means any 250 primary particles in an image from a 1,000 times image with a scanning electron microscope (manufactured by JEOL Ltd., JSM840F) unless otherwise specified.
  • Polyalkyl acrylate is a monomer constituting at least one kind of (meth) acrylate such as methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, etc. May be included. Further, the polyalkyl acrylate may contain a hydrocarbon monomer having a carbon-carbon unsaturated bond other than the (meth) acrylic acid ester as a constituent monomer.
  • hydrocarbon monomers having a carbon-carbon unsaturated bond include acrylic acid, methacrylic acid, styrene, methylstyrene, vinyltoluene, vinyl acetate, acrylonitrile, vinyl chloride, vinylidene chloride, chloroprene, isoprene, butadiene, and acrolein.
  • the monomer which alkyl acrylate contains is not restricted to 1 type, You may contain 2 or more types as a structural monomer.
  • Polyalkyl acrylates include those having a crosslinked structure and those having no crosslinked structure, but those having a crosslinked structure are preferred.
  • the crosslinked structure can be prepared by appropriately utilizing a known method used for polyalkyl acrylate polymers.
  • the crosslinking agent include divinylbenzene, ethylene dimethacrylate, triethylene glycol dimethacrylate, ethylene glycol dimethacrylate, 1,3-butylene dimethacrylate, allyl methacrylate, trimethylolpropane trimethacrylate, and the like. Is mentioned.
  • cross-linked polymethyl methacrylate (also referred to as methyl methacrylate crosspolymer) is particularly preferable.
  • methyl methacrylate crosspolymer there are commercially available powders of methyl methacrylate cross polymer, for example, Gantzpearl GMX-0610 (6 ⁇ m), GMX-0810 (8 ⁇ m), GMX-0820 (8 ⁇ m), GMX-2001 (20 ⁇ m). (Above, manufactured by Aika Kogyo Co., Ltd.), Microsphere M-100 (5 to 20 ⁇ m), Microsphere M-305 (5 to 20 ⁇ m), Matsumoto Microsphere M-310 and Matsumoto Microsphere M-311 (above And Matsumoto Yushi Seiyaku Co., Ltd.). The numbers in parentheses indicate the particle size.
  • the average primary particle diameter by microscopic observation is preferably 1 ⁇ m or more and 50 ⁇ m or less, more preferably 2 ⁇ m or more and 30 ⁇ m or less, and further preferably 3 ⁇ m or more and 30 ⁇ m or less. It is even more preferable that it is 5 ⁇ m or more and 30 ⁇ m or less.
  • urethane examples include (HDI / trimethylolhexyl lactone) crosspolymer, PLASTIC POWDER D-400 (12 ⁇ m to 18 ⁇ m), D-800 (5.5 ⁇ m to 8.0 ⁇ m), CS-400 (12 ⁇ m to 18 ⁇ m) made of silica. ), D-400HP (12 ⁇ m to 18 ⁇ m) (manufactured by Toyo Pigment); GRANDPEARL GU-1500 (15 ⁇ m) (manufactured by Aika Industry Co., Ltd.), which is a cross polymer (HDI / trimethylol hexyl lactone) The numbers in parentheses indicate the particle size.
  • nylon-12 such as SP-500 (manufactured by Dow Corning Toray) and GPA-550 (manufactured by Aika Industries). Both have a particle size of 5 ⁇ m.
  • Inorganic powders include spherical inorganic powders such as silica (including silicic anhydride, hydrous silicic acid, etc.); talc, mica, boron nitride, kaolin, muscovite, synthetic mica, phlogopite, red mica, biotite , Lithia mica, silicic acid, aluminum silicate, magnesium silicate, aluminum magnesium silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxyapatite, vermiculite, hydrite, bentonite, montmorillonite, hector Examples thereof include light, zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, glass, and plate-like inorganic powder such as silylated silica.
  • silica including silicic anhydride, hydrous silicic acid, etc.
  • talc mica, boron nitride
  • silica, mica, talc and boron nitride are preferable from the viewpoint of enhancing the luminescence intensity of the composition containing (B) the inorganic phosphor, and talc and boron nitride. Is more preferable.
  • silicic anhydride of the above silica include, for example, white silica, SILICA MICRO BEAD P-500 (2-20 ⁇ m) (manufactured by JGC Catalysts & Chemicals), silica beads SB-150 (5 ⁇ m), silica beads SB -300 (5 ⁇ m), silica beads SB-700 (7 ⁇ m), silica beads SBNP-810 (10 ⁇ m) (from Miyoshi Kasei Co., Ltd.), God Ball G-6C (3-5 ⁇ m) (manufactured by Suzuki Yushi Kogyo Co., Ltd.) Is mentioned. Numbers in parentheses indicate particle size.
  • Examples of the mica include PDM-5L (5.0 to 8.5 ⁇ m), PDM-10L (10 to 13 ⁇ m), PDM-20L (17 to 22 ⁇ m), PDM-40L (35 to 44 ⁇ m), and PDM-9WA. (10-13 ⁇ m), PDM-9WB (10-13 ⁇ m), PDM-10S (10-13 ⁇ m), PDM-1000 (10-13 ⁇ m), PDM-8W (10-13 ⁇ m), PDM-FE (5-8 ⁇ m) PDM-5L (S) (5.0 to 8.5 ⁇ m), PDM-10L (S) (10 to 13 ⁇ m), PDM-9WAT (10 to 13 ⁇ m), PDM-8W (S) (10 to 13 ⁇ m), Synthetic mica such as PDM-1000 (S), PDM-15NR (10 to 13 ⁇ m) (above, manufactured by Topy Industries); Y-1800 (10 ⁇ m), Y-3000 (23 ⁇ m), SA- 310 (26 ⁇ m), SA-350 (42 ⁇ m), TM-10 (11 ⁇ m), TM-20
  • synthetic mica is preferable from the viewpoint of the effect of improving the color developability (luminescence) of the composition for external use of the present invention.
  • synthetic mica does not have a dull color of the raw material itself, and, for example, hardly changes in color of the powder itself when mixed with sweat or sebum. Therefore, by adding synthetic mica to the composition for external use of the present invention, it is possible to improve the color developability (luminance), and it is difficult for color change to occur when used on the skin, and the desired hue is maintained for a long time. Can be maintained.
  • talc JA-46R 7.0 to 11.0 ⁇ m
  • talc MMR 4.4 ⁇ m or less
  • talc JA-13R 5.0 to 8.0 ⁇ m
  • talc JA-24R 6 0.0-9.0 ⁇ m
  • talc JA-68R 9.0-12.0 ⁇ m
  • talc JA-80R 10.0-14.0 ⁇ m
  • talc SW-special talc SW-A (above, Asada Milling) Etc.
  • talc may be treated with silicone or the like, and examples thereof include SA-talc JA-13R, SA-talc JA-46R, and SA-talc JA-68R (manufactured by Miyoshi Kasei Co., Ltd.).
  • the numbers in parentheses indicate the particle size.
  • boron nitride examples include CC6058 (11 ⁇ m), CC6097 (5 ⁇ m), CC6059 (6 ⁇ m), CC6069 (9 ⁇ m), CCS102-JA (15 ⁇ m), CC6004 (11 ⁇ m) (above, manufactured by Momentive Performance Materials) , RonaFair Boroneige SF-3 (2-5 ⁇ m), RonaFilair Boroneige SF-6 (4.5-8 ⁇ m), RonaFair Boroneige SF-9 (6-10.5 ⁇ m), RonaFlair9FonR15FonR9FonR9FonR9F9F9F12 Boroneige SF-15 (9.5 ⁇ m or less) (manufactured by MERCK, Inc.). The numbers in parentheses indicate the particle size.
  • the pearl pigment generally refers to a pigment obtained by coating the surface of a plate-like powder with a metal oxide (for example, a colored metal oxide).
  • a metal oxide for example, a colored metal oxide.
  • a specific color can be seen by thin film interference (interference type), or particles with a different refractive index (generally fine titanium oxide) are attached to the plate-like powder used as a substrate.
  • interference type thin film interference
  • particles with a different refractive index generally fine titanium oxide
  • a colored type in which the surface of the interference type is coated with a colored pigment such as iron oxide or an organic dye (for example, a tar dye).
  • Examples of the plate powder include mica, mica, sericite, talc, kaolin, synthetic mica, synthetic sericite, synthetic phlogopite, borosilicate, plate titanium dioxide, plate silica, plate aluminum oxide, Examples thereof include boron nitride, barium sulfate, plate-like titania / silica composite oxide, and among these, mica and synthetic mica are preferable.
  • Examples of the colored metal oxide include iron oxide, titanium oxide, copper oxide, cobalt oxide, chromium oxide, nickel oxide, gold, and silver. Among these, titanium oxide is preferable.
  • the pearl pigment in the present invention has an average primary particle size of usually 1 ⁇ m to 300 ⁇ m, preferably 2 ⁇ m to 300 ⁇ m, more preferably 10 ⁇ m to 200 ⁇ m, and even more preferably 2 ⁇ m to 150 ⁇ m by microscopic observation.
  • the pearl pigment changes the brightness of the surface of the object by changing the refractive index of the surface of the substrate material depending on the thickness of the coating layer of the metal oxide (for example, colored metal oxide), and the color of the light is changed by thin film interference.
  • the metal oxide for example, colored metal oxide
  • red, yellow, orange and gold are preferable.
  • the pearl pigment in the present invention may be one that has been surface-treated with a silicone compound, a fluorine compound, an amino acid, a fatty acid, or the like.
  • the method for producing the pearl pigment in the present invention is not particularly limited, and can be produced by methods well known to those skilled in the art. For example, it can be obtained by adding an aqueous solution of a colored metal oxide precursor to an aqueous dispersion of a plate-like powder and baking it. Furthermore, surface treatment may be performed with a silicone compound, a fluorine compound, an amino acid, a fatty acid, or the like.
  • Preferred pearl pigments in the present invention include titanium oxide-coated mica, titanium oxide-coated synthetic phlogopite, titanium oxide-treated mica, and titanium oxide-treated talc.
  • a pearl pigment can also use a commercial item.
  • pearl pigments include MERCK's Timiron series (interference type with titanium oxide coating), BASF's Flamenco series (interference type with titanium oxide coating) and Cloisonne series (coloring type with iron oxide or titanium oxide coating), There are FANTASPEARL series (silver type, titanium oxide-coated interference type, titanium oxide and iron oxide coloring type, iron oxide coloring type) manufactured by Nihon Koken Kogyo Co., Ltd.
  • Flamenco Silk Red or SA-Flamenco Silk Red manufactured by BASF; particle diameter 2 to 24 ⁇ m
  • Flamenco Sparkle Red manufactured by BASF; particle diameter 16 ⁇ m to 128 ⁇ m
  • Helios R100 While (Topy Kogyo particle size 35 [mu] m ⁇ 150 [mu] m), and the like as preferred but not limited to.
  • Examples of commercially available silver pigments include, but are not limited to, Timilon MP-115 or SA-Timiron MP-115 (manufactured by MERCK; particle diameter 10 to 60 ⁇ m).
  • pigments exhibiting yellow, gold, or orange interference light include SILSEEM Mystery Pearl YELLOW (Nippon Koken Kogyo Co., Ltd .; 5-20 ⁇ m), Timiron Silk Gold (MERCK Co., Ltd .: 5-25 ⁇ m), RonaFlair Balance Gold (manufactured by MERCK; particle diameter of 15 ⁇ m or less), Flamenco Silk Orange (manufactured by BASF; particle diameter of 16 to 128 ⁇ m), and the like are preferable, but are not limited thereto.
  • the content of the powder (A) in the external composition for skin of the present invention is not particularly limited as long as the effect of the present invention is exhibited.
  • the powder (A) is 0.0001 to 95 with respect to the entire composition. It is preferably contained in a proportion of about mass%, more preferably in a proportion of about 0.001 to 90 mass%.
  • the (A) spherical powder is preferably contained at a ratio of 0.01 to 20% by mass with respect to the entire composition. More preferably, it is contained in a proportion of 05 to 15% by mass, more preferably 0.1 to 10% by mass.
  • the powder is plate-like
  • the external composition for skin of the present invention contains (B) an inorganic phosphor, and emits red light when it receives external energy such as ultraviolet rays. Furthermore, since the emission intensity of red light emitted from the inorganic phosphor (B) is enhanced by including the powder (A) described above, even if the content of the inorganic phosphor (B) is small, The external composition for skin of the present invention exhibits excellent color development (luminescence).
  • the inorganic phosphor is preferably an activated phosphor comprising a crystal matrix and an activator.
  • the crystal matrix preferably contains a metal oxide, a metal sulfide, a metal sulfate, a halophosphate compound, or the like.
  • metal oxides are preferred, and Al (aluminum), Ti (titanium), Zn (zinc), Ge (germanium), Si (silicon), Fe (iron), Zr (zirconium), Mn (manganese), A metal oxide of Mg (magnesium) is more preferable.
  • metal oxides of Al (aluminum) and Ti (titanium) are more preferable.
  • the activator examples include Mn (manganese), Eu (europium), Cr (chromium) Ce (cerium), Pr (praseodymium), La (lanthanum), Gd (gadolinium), Tb (terbium), Dy (dysprosium), Ho (holmium), Er (erbium), Tm (thulium), Yb (ytterbium), Fe (iron), Zn (zinc), or the like is used.
  • aluminate phosphors such as CaAl 12 O 19 : Mn 4+ , CaAl 12 O 19 : Cr 3+ , Ca 3 Al 2 O 6 : Eu 3+ ; and titanate phosphors such as Mg 2 TiO 4 : Mn are more suitable. preferable.
  • calcium aluminate activated with manganese or europium is more preferable, following formula (1); Ca X Al y O (2X + 3Y + 4Z) / 2 : Mn 4+ Z (1) Particularly preferred is calcium manganese aluminate activated with manganese represented by:
  • the compound represented by the above formula (1) is a compound obtained by doping Mn 4+ into a compound represented by Ca X Al y O (2X + 3Y + 4Z) / 2 .
  • CaAl 12 O 19 : Mn 4+ is a red phosphor developed in 1971 (eg, A. Bergstein et al, “Manganese-Activated Luminescence in Sr Al12 O19 and Ca Al12O19” J. Electrochem. Soc., 118 , p116 (1971))).
  • Mn 4+ is reported to exhibit red emission near 657 nm by replacing the octahedral site of CaAl 12 O 19 .
  • magnesium titanate activated with manganese or europium is more preferable, and magnesium titanate activated with manganese is particularly preferable.
  • X is more than 0.9 and more preferably less than 1.0.
  • Z is more preferably greater than 0.001 and less than 0.05.
  • the particle diameter of the inorganic phosphor is preferably 1 ⁇ m to 100 ⁇ m, more preferably 1 to 50 ⁇ m, further preferably 1 to 20 ⁇ m, particularly preferably 1 to 15 ⁇ m, and particularly preferably 1 to 6 ⁇ m. By setting the particle diameter within this range, the usability of the external composition for skin of the present invention can be improved, and the color developability (luminance) can be made higher.
  • particle diameter is an arbitrary value in the image from a 1,000 times image with a scanning electron microscope (JSM840F, manufactured by JEOL Ltd.) unless otherwise specified. The average value (average primary particle diameter) of the values measured on the basis of the major axis of the particles for 250 primary particles.
  • the inorganic phosphor can be expected to have the effect of improving the blood flow of the skin and improving the complexion color because the emitted red light increases the gene expression of the vasodilator.
  • An inorganic phosphor having a dominant wavelength in the region of 600 to 750 nm is preferable.
  • the manufacturing method of inorganic fluorescent substance is not specifically limited, For example, it aims at the compound (for example, manganese source compound) corresponding to the compound (for example, alkaline source metal etc.) which is a raw material, an aluminum source compound, and the doped ion. It can obtain by baking after making a precursor by mixing in the ratio according to the molar ratio of a compound.
  • the compound for example, manganese source compound
  • the compound for example, alkaline source metal etc.
  • the inorganic phosphor can be blended in the composition for external use as it is, but may be blended after various surface treatments are carried out by a conventionally known method, if necessary.
  • these surface treatments may be one kind, or several kinds may be laminated or mixed.
  • the external composition for skin of the present invention preferably contains (B) an inorganic phosphor in a proportion of 0.0001 to 9.5% by mass, and 0.001 to 9.5% by mass with respect to the entire composition. More preferably, 0.01 to 9.5% by mass is further preferable, 0.01 to 7% by mass is even more preferable, 0.01 to 5% by mass is particularly preferable, and 0.01 to 3% by mass is particularly preferable. .
  • the blending ratio (mass ratio) of (A) powder and (B) inorganic phosphor is 0.0001 to 100 parts by mass of (A) powder with respect to 1 part by mass of (B) inorganic phosphor. The amount is preferably 0.0005 to 50 parts by mass.
  • the blending ratio (mass ratio) of (A) powder with respect to 1 part by mass of (B) inorganic phosphor may be 0.0001 to 20 parts by mass, or may be 0.001 to 10 parts by mass.
  • the composition for external use of skin of this invention can improve color developability (luminescent property) more by containing (A) powder and (B) inorganic fluorescent substance with the said compounding ratio.
  • composition for external use of the skin comprises, in addition to the above essential components, an ultraviolet absorbing component, (B) inorganic particles other than the inorganic phosphor, oil, lipophilic nonionic surfactant, hydrophilic, depending on various purposes.
  • Nonionic surfactants other surfactants, sequestering agents, natural water-soluble polymers, semi-synthetic water-soluble polymers, synthetic water-soluble polymers, inorganic water-soluble polymers, gelled hydrocarbons
  • Oily bases such as various extracts, moisturizing ingredients, polyhydric alcohols, scrubbing agents, UV scattering ingredients, astringent ingredients, peptides or derivatives thereof, amino acids or derivatives thereof, washing ingredients, keratin softening ingredients, cell activation ingredients
  • Other components such as anti-aging component, blood circulation promoting component, whitening component, component having DNA damage prevention and / or repair activity, anti-inflammatory component, antioxidant component, vitamins, sebum adsorbing component, antibacterial component, etc.
  • the present invention Effect may be contained in an amount that does not impair the.
  • UV-B B-wave (UV-B) absorbers such as 2-ethylhexyl paramethoxycinnamate, phenylbenzimidazolesulfonic acid, isopropyl methoxycinnamate, octyl methoxycinnamate, para- Aminobenzoic acid, ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, homosalate, ethylhexyl salicylate, 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid, camphor benzalkonium methosulfate, polyacrylamide Methylbenzylidene camphor, diethylhexylbutamide triazone, octyl triazone, disodium phenyldibenzimidazole tetrasulfon
  • the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin.
  • the content is 0.1 to 15% by mass.
  • the above-mentioned other components may be used alone or in combination of two or more. These components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi drugs, cosmetics, and the like, and arbitrary components can be appropriately selected and used.
  • the method for producing the composition for external use of the skin of the present invention is not particularly limited, and a component appropriately selected from the essential components (A) powder, (B) inorganic phosphor, and other components is blended, and is usually added. It can be mixed and manufactured by the method.
  • makeup foundations such as powder foundation, liquid foundation, makeup base, lipstick, lip balm
  • sunscreen cosmetics It can be used in basic cosmetics such as moisturizing liquids, milky lotions, cosmetic liquids, packs, hand creams, body lotions and body creams; cleansing cosmetics such as facial cleansers, makeup removers and body shampoos.
  • multifunctional formulation which put together the function of these formulations in one formulation is also mentioned.
  • make-up cosmetics such as liquid foundations, makeup bases, lipsticks, lip balms; sunscreen cosmetics, lotions, moisturizers, emulsions, serums, packs, hand creams, body lotions, body creams
  • Basic cosmetics such as: preferably used in cleansing cosmetics such as face wash, makeup remover, body shampoo, more preferably used in makeup cosmetics or sunscreen cosmetics, and makeup More preferably, it is used in cosmetics.
  • the present invention is a method for enhancing the fluorescence intensity of a composition for external use of skin containing (B) an inorganic phosphor, comprising (A) blending powder, and (B) component in the entire composition obtained Also included is a method characterized in that the content is 0.0001 to 9.5% by mass.
  • the present invention also relates to a method for improving the light-emitting property (color-developing property) of the composition for external use of skin containing (B) an inorganic phosphor, wherein (A) the powder is blended, and the whole composition obtained And the content of the component (B) is 0.0001 to 9.5% by mass.
  • cosmetics especially foundations, eye shadows, and the like exhibit excellent light emission intensity and light emission (color development) even if the content of the inorganic phosphor (B) in the composition for external use is small. It can be suitably used as makeup cosmetics such as lipsticks and as sunscreen cosmetics.
  • makeup cosmetics such as lipsticks and as sunscreen cosmetics.
  • inorganic phosphor (B) inorganic fluorescent substance the description of the above-mentioned external composition for skin of this invention is applicable.
  • the solid obtained by evaporating and drying the mixed slurry at 130 ° C. was crushed in a mortar to obtain a calcined precursor powder.
  • 15 g of the calcined precursor was filled in an alumina crucible, heated to 1600 ° C. at 200 ° C./hour in the atmosphere, held for 3 hours, and then cooled to room temperature at 200 ° C./hour.
  • the obtained fired product was crushed in a mortar to produce inorganic particles containing an aluminate phosphor.
  • the titanate phosphor magnesium manganese titanate
  • the captured images of Comparative Example 1 and Examples 4 and 9 are shown in FIG. 1, and the captured images of Comparative Example 2 and Example 11 are shown in FIG.
  • Table 1 compared with the composition for external skin of Comparative Example 1, the composition for external skin of Examples 1 to 10 has high fluorescence intensity (luminance) and excellent color developability (luminance). It was.
  • FIG. 1 it was also visually determined that the compositions for external use in Examples 4 and 9 had significantly higher luminance than Comparative Example 1.
  • the skin external compositions of Examples 11 and 12 have higher fluorescence intensity (luminance) and color developability (luminance) than the skin external composition of Comparative Example 2. It was excellent.
  • the components used in this test were the same as those described in Test Example 1, and calcium manganese aluminate having a particle diameter of 6 (D50: ⁇ m) was used.
  • the composition for external use of the skin containing the combination of various (A) powders was more fluorescent than the comparative example containing (B) only the inorganic phosphor. It was confirmed that the intensity (brightness) was high and the color development (luminescence) was excellent.
  • the fluorescence intensity (brightness) enhancement effect of the present invention is enhanced when (B) the inorganic phosphor has a high content of 10% by mass or more and exhibits high color development (high light emission) by itself. However, when the content of the inorganic phosphor (B) was low, the enhancement effect was remarkable and was very beneficial.
  • the components used in this test are the same as those described in Test Example 1 except for the (vinyl dimethicone / methicone silsesquioxane) crosspolymer, and the calcium manganese aluminate has a particle size of 35 (D50: ⁇ m).
  • the formulation of each composition for external use on skin prepared in this test and the evaluation result are shown in Table 7 below.
  • formulation examples of the external composition for skin of the present invention are shown below. Any of them can be prepared by a conventional method. The present invention is not limited to these pharmaceutical formulation examples.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'objet de la présente invention est de fournir une nouvelle composition dermatologique topique contenant une substance luminescente inorganique, ladite composition présentant des propriétés chromogènes (propriétés électroluminescentes) améliorées. La présente invention concerne une composition dermatologique topique contenant une poudre (A) et une substance luminescente inorganique (B), la quantité de substance luminescente inorganique (B) étant de 0,0001 à 9,5 % en masse par rapport à la composition totale. La poudre (A) a de préférence une morphologie sphérique ou plane. La poudre (A) est de préférence d'au moins un type de poudre choisi dans le groupe constitué par le talc, le nitrure de bore, le mica, un pigment nacré, une résine de silicone, un polyacrylate d'alkyle, de l'uréthane, du nylon, et de la silice.
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JP2020148610A (ja) * 2019-03-13 2020-09-17 株式会社豊田中央研究所 潤滑剤の分布状態測定システム及び潤滑剤の分布状態測定方法
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JP2020066599A (ja) * 2018-10-25 2020-04-30 ロート製薬株式会社 複合粉体、皮膚外用組成物、及び無機蛍光粉体の蛍光強度増強方法
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