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WO2017025944A3 - Macrophage chimeric antigen receptor (moto-car) in imunotherapy - Google Patents

Macrophage chimeric antigen receptor (moto-car) in imunotherapy Download PDF

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Publication number
WO2017025944A3
WO2017025944A3 PCT/IB2016/056140 IB2016056140W WO2017025944A3 WO 2017025944 A3 WO2017025944 A3 WO 2017025944A3 IB 2016056140 W IB2016056140 W IB 2016056140W WO 2017025944 A3 WO2017025944 A3 WO 2017025944A3
Authority
WO
WIPO (PCT)
Prior art keywords
car
chimeric antigen
imunotherapy
moto
macrophage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2016/056140
Other languages
French (fr)
Other versions
WO2017025944A2 (en
Inventor
Kim O'NEILL
Scott Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020257006193A priority Critical patent/KR20250035602A/en
Priority to EA201890489A priority patent/EA201890489A1/en
Priority to EP16801306.8A priority patent/EP3334764A2/en
Priority to KR1020187007097A priority patent/KR20180054600A/en
Priority to CA2998406A priority patent/CA2998406A1/en
Priority to PCT/IB2016/056140 priority patent/WO2017025944A2/en
Priority to CN201680059778.7A priority patent/CN108137704A/en
Priority to AU2016305353A priority patent/AU2016305353B2/en
Application filed by Brigham Young University filed Critical Brigham Young University
Priority to US15/358,395 priority patent/US11352439B2/en
Publication of WO2017025944A2 publication Critical patent/WO2017025944A2/en
Publication of WO2017025944A3 publication Critical patent/WO2017025944A3/en
Anticipated expiration legal-status Critical
Priority to ZA2018/01636A priority patent/ZA201801636B/en
Priority to US17/833,149 priority patent/US20220372170A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4251—Kinases, e.g. Raf or Src
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02008—Hypoxanthine phosphoribosyltransferase (2.4.2.8)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Immunology (AREA)
  • Genetics & Genomics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
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  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
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Abstract

Modified macrophage immune cells are provided for treatment of cancer and other diseases. In particular said macrophages express chimeric antigen receptors (CAR). The single chain variable fragment (scFv) may be directed against thymidine kinase 1 (TK1)or hypoxanthine guanine phosphoribosyltransferase (HPRT). The signaling domain may be derived from a Toll-like receptor (TLR).
PCT/IB2016/056140 2015-08-13 2016-10-13 Macrophage car (moto-car) in imunotherapy Ceased WO2017025944A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN201680059778.7A CN108137704A (en) 2015-10-13 2016-10-13 Macrophage CAR in immunotherapy（MOTO-CAR）
EP16801306.8A EP3334764A2 (en) 2015-10-13 2016-10-13 Macrophage chimeric antigen receptor (moto-car) in imunotherapy
KR1020187007097A KR20180054600A (en) 2015-10-13 2016-10-13 The macrophage chimeric antigen receptor (MOTO-CAR)
CA2998406A CA2998406A1 (en) 2015-08-13 2016-10-13 Macrophage car (moto-car) in immunotherapy
PCT/IB2016/056140 WO2017025944A2 (en) 2015-08-13 2016-10-13 Macrophage car (moto-car) in imunotherapy
AU2016305353A AU2016305353B2 (en) 2015-08-13 2016-10-13 Macrophage chimeric antigen receptor (MOTO-CAR) in imunotherapy
EA201890489A EA201890489A1 (en) 2015-08-13 2016-10-13 CAR MACROPHAGES (MOTO-CAR) IN IMMUNOTHERAPY
KR1020257006193A KR20250035602A (en) 2015-10-13 2016-10-13 Macrophage chimeric antigen receptor (moto-car) in imunotherapy
US15/358,395 US11352439B2 (en) 2015-08-13 2016-11-22 Macrophage CAR (MOTO-CAR) in immunotherapy
ZA2018/01636A ZA201801636B (en) 2015-08-13 2018-03-09 Macrophage chimeric antigen receptor (moto-car) in imunotherapy
US17/833,149 US20220372170A1 (en) 2015-08-13 2022-06-06 Macrophage CAR (MOTO-CAR) In Immunotherapy

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US62/204,935 2015-08-13
US201562240528P 2015-10-13 2015-10-13
US62/240,528 2015-10-13
US201615236421A 2016-08-13 2016-08-13
US15/236,421 2016-08-13
PCT/IB2016/056140 WO2017025944A2 (en) 2015-08-13 2016-10-13 Macrophage car (moto-car) in imunotherapy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US201615236421A Continuation-In-Part 2015-08-13 2016-08-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US201615236421A Continuation 2015-08-13 2016-08-13
US15/358,395 Continuation US11352439B2 (en) 2015-08-13 2016-11-22 Macrophage CAR (MOTO-CAR) in immunotherapy

Publications (2)

Publication Number Publication Date
WO2017025944A2 WO2017025944A2 (en) 2017-02-16
WO2017025944A3 true WO2017025944A3 (en) 2017-04-27

Family

ID=62299116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/056140 Ceased WO2017025944A2 (en) 2015-08-13 2016-10-13 Macrophage car (moto-car) in imunotherapy

Country Status (4)

Country Link
EP (1) EP3334764A2 (en)
KR (2) KR20250035602A (en)
CN (1) CN108137704A (en)
WO (1) WO2017025944A2 (en)

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US11517589B2 (en) 2015-02-19 2022-12-06 Myeloid Therapeutics, Inc. Chimeric antigen receptor dendritic cell (CAR-DC) for treatment of cancer
US11628218B2 (en) 2020-11-04 2023-04-18 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
US12030938B2 (en) 2021-03-17 2024-07-09 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof

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US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
KR102697827B1 (en) 2015-07-28 2024-08-23 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Modified monocytes/macrophages expressing chimeric antigen receptors and uses thereof
US11352439B2 (en) 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
US20200055917A1 (en) 2016-09-27 2020-02-20 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
US10415017B2 (en) 2017-05-17 2019-09-17 Thunder Biotech, Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
AU2017414703B2 (en) * 2017-05-17 2025-02-06 Thunder Biotech Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
FI3688032T3 (en) 2017-09-26 2025-12-09 Cero Therapeutics Holdings Inc CHIMERIC INVASIVE RECEPTOR MOLECULES AND METHODS OF USE
EP3774906A1 (en) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
AU2019243154A1 (en) 2018-03-28 2020-10-01 Cero Therapeutics, Inc. Cellular immunotherapy compositions and uses thereof
WO2020016897A1 (en) * 2018-07-19 2020-01-23 Oncohost Ltd Il-31 improves efficacy of macrophage-based adoptive cell therapy for cancer
CN110872354B (en) * 2018-09-04 2022-11-01 华瑞同康生物技术（深圳）有限公司 Chicken-derived monoclonal antibody and single-chain antibody of mammal cell recombinant anti-human TK1, and preparation method and application thereof
JP6935383B2 (en) * 2018-09-27 2021-09-15 公益財団法人実験動物中央研究所 Immunodeficient mouse
CN109266618B (en) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 Macrophage capable of targeting tumor cells and preparation method thereof
US20220169746A1 (en) * 2019-02-26 2022-06-02 The University Of Vermont And State Agricultural College Antibodies to neoantigens and uses thereof
GB2600834B (en) * 2019-04-30 2024-07-17 Myeloid Therapeutics Inc Engineered chimeric fusion protein compositions and methods of use thereof
KR20220097875A (en) 2019-09-03 2022-07-08 마이얼로이드 테라퓨틱스, 인크. Methods and compositions for genomic integration
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
CA3161488A1 (en) * 2019-12-11 2021-06-17 Daniel Getts Therapeutic cell compositions and methods for manufacture and uses thereof
EP4161536A4 (en) 2020-06-04 2024-08-14 Carisma Therapeutics Inc. NEW CONSTRUCTS FOR CHIMERIC ANTIGEN RECEPTORS
CN111925448B (en) * 2020-08-03 2022-06-21 山东大学 Preparation method of in vivo-generated CAR-macrophage and application of in vivo-generated CAR-macrophage in tumor immunotherapy
KR102829018B1 (en) * 2021-03-03 2025-07-04 서울대학교산학협력단 Method for preparing car-macrophage exprssing chimeric antigen receptor and use of the same
US20240066059A1 (en) * 2021-03-03 2024-02-29 Seoul National University R&Db Foundation Method for producing chimeric antigen receptor-macrophages and use of same cells
KR20220131801A (en) 2021-03-22 2022-09-29 주식회사 이뮤노로지컬디자이닝랩 Transformed professional antigen presenting cells specifically binding to antigen containing chimeric antigen receptor(CAR) and uses thereof
KR20220132401A (en) 2021-03-23 2022-09-30 주식회사 이뮤노로지컬디자이닝랩 Transformed professional antigen presenting cells specifically binding to antigen containing chimeric antigen receptor(CAR) and uses thereof
EP4337268A4 (en) 2021-05-11 2025-06-04 Myeloid Therapeutics, Inc. METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION
WO2022248602A1 (en) * 2021-05-25 2022-12-01 Institut Curie Myeloid cells overexpressing bcl2
CN115011561A (en) * 2022-06-22 2022-09-06 深圳先进技术研究院 A kind of chimeric antigen receptor macrophage and its preparation method and application

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US11517589B2 (en) 2015-02-19 2022-12-06 Myeloid Therapeutics, Inc. Chimeric antigen receptor dendritic cell (CAR-DC) for treatment of cancer
US11918605B1 (en) 2015-02-19 2024-03-05 Myeloid Therapeutics, Inc. Chimeric antigen receptor dendritic cell (CAR-DC) for treatment of cancer
US11918604B2 (en) 2015-02-19 2024-03-05 Myeloid Therapeutics, Inc. Chimeric antigen receptor dendritic cell (CAR-DC) for treatment of cancer
US11628218B2 (en) 2020-11-04 2023-04-18 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
US12030938B2 (en) 2021-03-17 2024-07-09 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof

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