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WO2017020279A1 - Utilisations d'une composition comprenant des racines de polygonum capitatum et de coptide dans la préparation de médicaments permettant de résister contre helicobacter pylori - Google Patents

Utilisations d'une composition comprenant des racines de polygonum capitatum et de coptide dans la préparation de médicaments permettant de résister contre helicobacter pylori Download PDF

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Publication number
WO2017020279A1
WO2017020279A1 PCT/CN2015/086156 CN2015086156W WO2017020279A1 WO 2017020279 A1 WO2017020279 A1 WO 2017020279A1 CN 2015086156 W CN2015086156 W CN 2015086156W WO 2017020279 A1 WO2017020279 A1 WO 2017020279A1
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WO
WIPO (PCT)
Prior art keywords
medicine
drug
phlegm
berberine
flower bud
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/086156
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English (en)
Chinese (zh)
Inventor
王子厚
周益成
张姝
丁莉梅
胡伏莲
罗昭逊
莫非
张丽艳
张淑华
金鑫
李正亮
周宏艳
何云
马领弟
郑伟霞
朱晓龙
赵书琴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Zhongkang Pharmaceutical Co Ltd
Original Assignee
Zhejiang Zhongkang Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Zhongkang Pharmaceutical Co Ltd filed Critical Zhejiang Zhongkang Pharmaceutical Co Ltd
Priority to PCT/CN2015/086156 priority Critical patent/WO2017020279A1/fr
Priority to PCT/CN2016/093626 priority patent/WO2017020861A1/fr
Publication of WO2017020279A1 publication Critical patent/WO2017020279A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention belongs to the field of traditional Chinese medicine, and particularly relates to a pharmaceutical composition comprising a flower bud and a berberine, and the use thereof for preparing an antibacterial, in particular, a medicament against Helicobacter pylori.
  • the head flower bud is the dry whole grass or aboveground part of the Polygonum capitatum Buch.-Ham.ex D.Don. It is a commonly used medicine in China's private and especially ethnic minority areas.
  • the head flower is sweet, spicy and cool; it has the functions of clearing away heat and dampness, detoxification and relieving pain, and blood stasis, diuretic and drenching.
  • pharmacological studies have shown that the head flower bud has a wide range of pharmacological activities, including analgesic, cooling, diuretic, anti-inflammatory, antibacterial and the like.
  • H.pylori H.p or HP in this context
  • HP infection is an important cause of a variety of chronic stomach diseases such as peptic ulcer, gastritis, and gastric cancer.
  • PPI proton pump inhibitor
  • expectorant the eradication rate is 90%.
  • these drug eradication programs have problems of toxic side effects, easy secondary resistance, double infection, and patient dependence.
  • H.pylori is a damp-heat and detoxification, which belongs to the category of "evil gas". It is difficult for a single Chinese medicine to cope with the complex and changeable condition of the disease. The role of the symptoms.
  • the invention is based on the single-flavored medicine of the head flower, and the other Chinese medicine is used to form the head flower bud composition, which improves the anti-Hp activity and has a good antibacterial effect on the gram-resistant bacteria, especially the methicillin-resistant epidermis.
  • Staphylococcus methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus.
  • the addition of heat-clearing and detoxifying, tonic, diuresis, qi, blood circulation, dehumidification, phlegm, blood circulation, warming, dispelling cold, digestion can reduce the adverse reactions of single-flavor drugs.
  • the use of the pharmaceutical composition of the present invention in the preparation of a medicament for anti-Helicobacter pylori has not been reported.
  • It is an object of the present invention to provide a pharmaceutical composition comprising a flower bud, a berberine, and a composition for the preparation of a medicament for the effective antibacterial, in particular inhibition of Helicobacter pylori.
  • a first aspect of the present invention provides a pharmaceutical composition, characterized in that the composition comprises a head flower bud and a berberine.
  • Preferred compositions include 20-60 parts by weight of the head flower and 2-6 parts by weight of the berberine.
  • the composition consists of the head bud, berberine, and a composition selected from any one or more of the following: (1) a heat-clearing drug; (2) a tonic drug; (3) Lishui osmotic medicine; (4) qi medicine; (5) phlegm; (6) blood circulation phlegm; (7) cooling blood hemostasis; (8) phlegm and blood stasis; (9) Wenyang Dispel cold medicine; (10) digestion medicine; (11) solution medicine.
  • the present invention also provides a process for the preparation of the above pharmaceutical composition extract.
  • the present invention also discloses formulations containing a pharmaceutical composition which is formulated with a pharmaceutically acceptable excipient into a pharmaceutically acceptable oral formulation.
  • the oral preparation is selected from various available regular release preparations and sustained release preparations.
  • the sustained-release preparation is selected from the group consisting of a skeleton type, a membrane-controlled type, an osmotic pump type, and a gastric retention type sustained-release preparation.
  • the gastric retention type sustained release preparation is preferably a gastric floating agent.
  • the invention also discloses the use of any one of the pharmaceutical compositions of the invention in the preparation of an antibacterial drug.
  • the pathogen is selected from the group consisting of Gram-positive methicillin-resistant Staphylococcus aureus S. aureus (Methicllin-resistant, MRSA), methicillin-sensitive Staphylococcus aureus S. aureus (Methicin-suseptable), methoxy Stalinococcus epidermidis (MRSE), methicillin-sensitive Staphylococcus epidermidis (MSSE), also selected from Gram-negative Escherichia coli, Eco + , large intestine H. (non-ESBLS) Escherichia Coli, Eco - , Klebsiella Klebsiella (ESBLs) K. penumonia, KPN + , Klebsiella pneumoniae (non-ESBLs) K. penumonia, Pseudomonas aeruginosa (PAE).
  • MRSA methicillin-resistant Staphylococcus aureus
  • MRSA methicillin-sensitive Staphylococcus au
  • the invention also discloses the use of any one of the pharmaceutical compositions of the invention in the preparation of a medicament for preventing/treating Helicobacter pylori.
  • the present invention provides a novel pharmaceutical composition
  • a novel pharmaceutical composition comprising a head flower bud and a berberine.
  • Preferred compositions include 20-60 parts by weight of the head flower and 2-6 parts by weight of the berberine.
  • the composition consists of a flower bud, a berberine, and a composition selected from any one or more of the following: (1) a heat-clearing drug; (2) a tonic drug; 3) Lishui osmotic medicine; (4) qi medicine; (5) phlegm; (6) blood circulation phlegm; (7) cooling blood hemostasis; (8) phlegm and blood stasis; (9) temperature Yang disperse cold medicine; (10) digestion medicine; (11) solution medicine.
  • the heat-clearing medicine according to the present invention includes, but is not limited to, dandelion, andrographis, scutellaria, phellodendron, radix isatidis, sorghum, honeysuckle, Qinpi, nasturtium, yarrow, purple diced, peony bark, eucalyptus honey, water Tuanhua, medlar, Hedyotis diffusa, Scutellaria barbata, Radix Rehmanniae, Brucea javanica, Dalbergia; but does not include head flower buds, berberine.
  • the tonic drugs according to the present invention include, but are not limited to, licorice, Codonopsis, Atractylodes, Radix Paeoniae Alba, jujube, ginseng, tea, astragalus, and huangjing.
  • the water-wetting agent according to the present invention includes, but is not limited to, cockroaches, knotweed, and earthworms.
  • the qi medicines of the present invention include, but are not limited to, dried tangerine peel, woody fragrant, citrus aurantium, fragrant sage, perilla stalk, August stalk, and earthworm mustard.
  • the sputum medicine according to the present invention includes, but is not limited to, schisandra, medlar, pomegranate peel, ebony, and jellyfish.
  • the blood-activating and stasis-removing medicines of the present invention include, but are not limited to, Yanhusuo, Sanqi, Danshen, Shijiantong, Yujin, and Rhubarb.
  • the cooling blood hemostasis of the present invention includes, but is not limited to, white and mantle.
  • the phlegm-relieving peony of the present invention includes, but is not limited to, Pinellia ternata, Magnolia officinalis, Sinensis, and Ginkgo.
  • the Wenyang cold medicine according to the present invention includes, but is not limited to, Wujing, Galang, Pepper, Dried Ginger, and Wild Ai.
  • the anti-drug medicine of the present invention includes, but is not limited to, garlic, hawthorn, and betel nut.
  • the solution according to the present invention includes, but is not limited to, cassia twig, ginger, perilla leaf, and Bupleurum.
  • Preferred heat-clearing agents are selected from the group consisting of dandelion, cork, and xanthine
  • Preferred tonics are selected from the group consisting of Astragalus, Atractylodes, Angelica, and Polygonatum.
  • the preferred water-wetting type is selected from the group consisting of knotweed and earthworm.
  • Preferred gas types are selected from the group consisting of woody, citrus, and fragrant.
  • the preferred collection is selected from the group consisting of sea bream and medlar.
  • the preferred blood circulation is selected from the group consisting of Corydalis, Salvia, and Panax notoginseng.
  • the preferred cooling blood hemostasis is selected from white and white.
  • the preferred phlegm-resolving hydrazine is selected from the group consisting of Pinellia ternata and Magnolia officinalis
  • the preferred warming and dispelling cold is selected from Wujing and Galangal.
  • a preferred digestion drug is selected from the group consisting of hawthorn.
  • a preferred solution is selected from the group consisting of cassia twig, Bupleurum, and ginger.
  • compositions of the invention are as follows:
  • composition consists of any of the above-mentioned eleven types of medicinal properties.
  • composition is selected from any of the following groups:
  • composition of 1.1 includes a head flower bud, a berberine, and a heat-clearing drug.
  • the composition of 1.2 includes a head flower bud, a berberine, and a tonic drug.
  • the composition of 1.3 includes a head flower bud, a berberine, and a water-wetting agent.
  • composition described in 1.4 includes a head flower bud, a berberine, and a qi medicine.
  • the composition of 1.5 includes a head flower bud, a berberine, and a sputum.
  • composition described in 1.6 includes a head flower bud, a berberine, a blood stasis medicine.
  • composition described in 1.7 includes a head flower bud, a berberine, and a cooling blood hemostatic drug.
  • composition of 1.8 includes a head flower bud, a berberine, and a phlegm-relieving peony.
  • composition described in 1.9 includes the head flower bud, the berberine, and the warming and dispelling cold medicine.
  • the composition of 1.10 includes a head flower bud, a berberine, and a digestive.
  • the composition according to 1.11 includes a head flower bud, a berberine, and a solution.
  • composition is composed of a medicinal composition of any one of the above-mentioned eleven types of medicinal properties:
  • compositions include cep, berberine, and heat-clearing drugs.
  • the composition includes a head flower bud, a berberine, and a heat-clearing drug other than the head flower bud and the berberine.
  • the composition comprises a head flower bud, a berberine and a flower selected from the group consisting of dandelion, andrographis paniculata, scutellaria, phellodendron, radix isatidis, barley, honeysuckle, genus, nasturtium, yarrow, sage, peony, eucalyptus a composition of water, flower, scorpion, Hedyotis diffusa, Scutellaria barbata, Radix Rehmanniae, Brucea javanica, Dalbergia, and various heat-clearing drugs,
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and tonic.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and leachhinol.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and qi.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and sputum.
  • compositions are selected from any of the following groups:
  • composition consists of any of the first class of drugs, such as the head flower bud, the berberine, and the eleventh class of drugs.
  • composition described in 2.1 includes a head flower bud, a berberine, a heat-clearing drug, and a tonic drug.
  • composition described in 2.2 includes a head flower bud, a berberine, a heat-clearing drug, and a water-wetting agent.
  • composition described in 2.3 includes a head flower bud, a coptis, a heat-clearing drug, and a qi medicine.
  • the composition described in 2.4 includes a head flower bud, a berberine, a heat-clearing drug, and a sputum drug.
  • the composition of 2.5 includes a head flower bud, a berberine, a heat-clearing drug, a blood stasis drug.
  • composition described in 2.6 includes a head flower bud, a berberine, a heat-clearing drug, and a cooling blood hemostatic drug.
  • composition described in 2.7 includes a head flower bud, a berberine, a heat-clearing drug, and a phlegm-dampening phlegm.
  • the composition described in 2.8 includes a flower bud, a berberine, a heat-clearing drug, and a warming and dispelling cold medicine.
  • the composition described in 2.9 includes a head flower bud, a berberine, a heat-clearing drug, and a digestive drug.
  • composition described in 2.10 includes a flower bud, a coptis, a heat-clearing drug, and a drug.
  • the composition according to 2.11 includes a head flower bud, a berberine, a tonic drug, and a water-wetting agent.
  • composition described in 2.12 includes a head flower bud, a berberine, a tonic drug, and a qi medicine.
  • the composition according to 2.13 includes a flower bud, a berberine, a tonic, and a sputum.
  • composition according to 2.14 includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine.
  • composition according to 2.15 includes a head flower bud, a berberine, a tonic medicine, and a cooling blood hemostasis.
  • composition according to 2.16 includes a head flower bud, a berberine, a tonic drug, and a phlegm and blood stasis drug.
  • composition described in 2.17 includes the head flower bud, the berberine, the tonic medicine, and the warming and dispelling medicine.
  • composition according to 2.18 includes a flower bud, a berberine, a tonic, and a digestive.
  • the composition according to 2.19 includes a head flower bud, a berberine, a tonic drug, and a solution.
  • the composition according to 2.20 includes a head flower bud, a berberine, a water permeable medicine, and a qi medicine.
  • the composition according to 2.21 includes a flower bud, a berberine, a leachate, and a sputum.
  • composition according to 2.22 includes a flower bud, a berberine, a leachhin, a blood stasis drug.
  • composition according to 2.23 includes a head flower bud, a berberine, a water-wetting agent, and a blood-suppressing hemostatic agent.
  • composition according to 2.24 includes a flower bud, a berberine, a leachhin, and a phlegm.
  • composition according to 2.25 includes a head flower bud, a berberine, a water permeable medicine, and a warming and dispelling medicine.
  • composition according to 2.26 includes a head flower bud, a berberine, a leachhin, and a digestive.
  • the composition according to 2.27 includes a head flower bud, a berberine, a water-wetting agent, and a solution.
  • composition according to 2.28 includes a head flower bud, a berberine, a qi medicine, and a sputum medicine.
  • composition according to 2.29 includes the head flower bud, the berberine, the qi medicine, the blood circulation phlegm medicine.
  • the composition according to 2.30 includes a head flower bud, a berberine, a qi medicine, and a cooling blood hemostatic medicine.
  • composition according to 2.31 includes a head flower bud, a berberine, a qi medicine, and a phlegm phlegm.
  • the composition according to 2.32 includes a head flower bud, a berberine, a qi medicine, and a warming and dispelling medicine.
  • the composition according to 2.33 includes a head flower bud, a berberine, a qi medicine, and a digestive medicine.
  • composition according to 2.34 includes a head flower bud, a berberine, a qi medicine, and a prescription drug.
  • the composition according to 2.35 includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine.
  • composition according to 2.36 includes the head flower bud, the berberine, the phlegm, and the cooling blood hemostasis.
  • composition according to 2.37 includes a flower bud, a berberine, a phlegm, and a phlegm.
  • the composition according to 2.38 includes a head flower bud, a berberine, a sputum medicine, and a warming and dispelling medicine.
  • the composition according to 2.39 includes a flower bud, a berberine, a sputum, and a digestive.
  • composition according to 2.40 includes a flower bud, a berberine, a sputum, and a remedy.
  • composition described in 2.41 includes a head flower bud, a berberine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • composition according to 2.42 includes a flower bud, a berberine, a blood stasis phlegm, and a phlegm phlegm.
  • the composition according to 2.43 includes a flower bud, a berberine, a blood stasis medicine, and a warming and dispelling medicine.
  • the composition according to 2.44 includes a head flower bud, a berberine, a blood stasis medicine, and a digestive medicine.
  • the composition according to 2.45 includes a flower bud, a berberine, a blood stasis drug, and a remedy drug.
  • composition according to 2.46 includes the head flower bud, the berberine, the cooling blood hemostasis, the phlegm and blood stasis medicine.
  • composition according to 2.47 includes a flower bud, a berberine, a blood-suppressing hemostatic agent, and a warming and dispelling cold medicine.
  • the composition according to 2.48 includes a head flower bud, a berberine, a cooling blood hemostatic drug, and a digestive drug.
  • the composition according to 2.49 includes a head flower bud, a berberine, a cooling blood hemostatic drug, and a solution.
  • the composition according to 2.50 includes a flower bud, a berberine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition according to 2.51 includes a head flower bud, a berberine, a phlegm and blood stasis medicine, and a digestive medicine.
  • composition described in 2.52 includes a head flower bud, a berberine, a phlegm-dampening peony, and a remedy.
  • the composition described in 2.53 includes a head flower bud, a berberine, a warming and dispelling cold medicine, and a digestive medicine.
  • composition described in 2.54 includes the head flower bud, the berberine, the warming and dispelling cold medicine, and the solution medicine.
  • the composition of 2.55 includes a head flower bud, a coptis, an anti-drug, and a solution.
  • composition is composed of a medicinal composition of the first class of drugs, such as the first flower bud, the berberine, and the eleventh medicinal properties:
  • compositions include the head flower bud, berberine, tonic, and water-wetting.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, and qi.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, and expectorant.
  • compositions are selected from any of the following groups:
  • composition comprising the group of flower head, berberine, tonic, and warming cold medicine is selected from any one of the following groups:
  • composition comprising the group of flower head, berberine, tonic, and drug solution is selected from any one of the following groups:
  • compositions include scutellaria, berberine, lysine, and qi.
  • compositions are selected from any of the following groups:
  • compositions include scutellaria, berberine, lysine, and sputum.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, qi, and sputum.
  • compositions are selected from any of the following groups:
  • composition consists of the head flower bud, the berberine, and any of the above-mentioned eleven types of drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a water-wetting agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a cooling blood hemostatic drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a solution.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, and a gas-making drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a phlegm-receiving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a blood-activating and stasis drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a qi medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-removing drug, and a blood-activating phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-receiving drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a blood-activating phlegm, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a blood stasis drug, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a blood stasis drug, and a drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, and a phlegm-dampening drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a prescription drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic, a sputum, and a digestive.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm and blood stasis drug, and a digestive drug.
  • the composition includes a flower bud, a berberine, a tonic, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a warming and dispelling medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis drug.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, and a blood-suppressing hemostatic agent.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a leachate, a phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a leachate, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a blood stasis drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping drug, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood hemostatic drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening medicinal herb, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, an anti-drug, and a solution.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, and a warm-yang dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm and blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a digestion medicine, and a prescription medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, and a phlegm.
  • the composition includes a head flower bud, a berberine, a phlegm, a blood circulation phlegm, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, and a phlegm medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a phlegm, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a phlegm, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a sputum, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a phlegm dampness phlegm medicine, and a yang yang medicine.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a blood stasis drug, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a blood stasis, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostatic drug, a digestive drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a phlegm and blood stasis medicine, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a phlegm-dampening peony, a digestive medicinal agent, and a remedy drug.
  • the composition includes a flower bud, a berberine, a yangyang cold medicine, a digestive medicine, and a remedy.
  • composition is composed of a medicinal composition of the head bud, berberine, and any of the above eleven types of medicinal properties:
  • compositions include head flower buds, berberine, tonic medicine, water osmotic drug, and qi medicine.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, diuretic, and phlegm.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, qi, and phlegm.
  • compositions are selected from any of the following groups:
  • a preferred composition comprising a group of head flower buds, berberine, tonic medicine, Wenyang cold medicine, and a solution medicine is selected from any one of the following groups:
  • compositions include scutellaria, berberine, lysine, qi, and sputum.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above four drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a phlegm-receiving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a blood-activating and stasis drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a digestive drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a solution.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, and a sputum medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a qi medicine, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a sputum drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-activating phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a blood stasis drug, and a drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-suppressing hemostatic drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing drug, a tonic drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a qi medicine, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a gas-making drug, and a digestion drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-receiving drug, and a digestive drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm drug, and a food-eliminating drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-dampening phlegm, and a food-eliminating drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a warm-yang dispersing drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a warm-yang dispersing drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a digestion-eliminating drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostasis, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a qi medicine, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal herb, a blood-activating phlegm drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostasis medicine, and a warm-yang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-receiving medicinal herb, a phlegm-dampening phlegm drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal herb, a phlegm-dampening phlegm drug, and a digestive medicinal drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a sputum medicinal herb, a phlegm-dampening phlegm drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, a warming and dispelling cold medicine, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a Wenyang cold medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a sputum medicinal drug, a digestive medicinal drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood-activating phlegm, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a phlegm-dampening phlegm drug, and a digestion drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a phlegm-dampening phlegm drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood stopping medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a cooling blood-stopping drug, a warm-yang dispersing drug, and a solution-solving drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, a digestive drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, a digestive medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a leachhin, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a blood-activating phlegm, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a cooling blood hemostatic drug, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a phlegm-dampening phlegm, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a warming medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostasis, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm and yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm medicine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a flower bud, a berberine, a tonic, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum medicinal agent, a warming and dispelling medicinal agent, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum medicinal agent, a warming and dispelling cold medicine, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum drug, a digestive drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a phlegm dampness phlegm medicine, and a yang yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, a phlegm and blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a yangyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a tonic, a blood stasis, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a warming and dispelling medicine, a digestion drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a qi medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a phlegm medicine, and a phlegm phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a phlegm phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a blood stasis and a hemostatic.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-removing medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a leachate, a phlegm, a blood stasis, and a digestive.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, and a remedy.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, a cooling blood-stopping medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a phlegm, a phlegm and a phlegm.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a leachhin, a sputum, a stagnation, a stagnation, and a digestive.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving agent, a warm-yang dispersing medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a digestion-eliminating medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a solution-solving medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a phlegm-relieving phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a warm-yang dispersing medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, an anti-drug, and a solution.
  • the composition includes a flower bud, a berberine, a water-wetting drug, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping agent, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, a digestion-eliminating drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, a digestive medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm phlegm medicine, and a food consuming medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a Wenyang cold medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes the head flower bud, the berberine, the qi medicine, the blood circulation phlegm medicine, the phlegm and blood stasis medicine, and the warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a phlegm phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a warm yang medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm and blood stasis medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, a digestion medicine, and a prescription medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a warming and dissipating cold medicine.
  • the composition includes a flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a phlegm medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a diarrhea.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a digestive, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a sputum medicinal medicine, a cooling blood stopping medicine, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostasis, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic, a digestive, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, a phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a drug, and a drug.
  • the composition includes a head flower bud, a berberine, a sputum medicinal medicine, a warming and dispelling medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a blood circulation phlegm, a blood circulation hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a blood circulation hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, a phlegm medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a phlegm phlegm, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a yangyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, a phlegm, a remedy.
  • composition is composed of a head bud, a berberine, and any four of the above eleven drugs in a pharmaceutical composition:
  • compositions include the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, and blood-activating phlegm medicine selected from the group consisting of:
  • compositions include the head flower bud, berberine, heat-clearing medicine, tonic medicine, phlegm-dampening phlegm medicine, and Wenyang chilling medicine selected from the group consisting of:
  • compositions include cep, berberine, tonic, diuretic, qi, and phlegm.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above nine drugs.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a gas-making drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a cool blood-stopping Blood medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a blood-activating phlegm drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm drug, and a digestion-eliminating drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a blood-activating phlegm drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispelling medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-dampening phlegm, and a food-eliminating drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostasis, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion-eliminating medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a digestion medicine, and a solution medicine.
  • composition is composed of a flower bud, a berberine, and any five of the above eleven drugs in a pharmaceutical composition:
  • compositions include the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, blood circulation phlegm medicine, phlegm and blood stasis medicine.
  • compositions are selected from the group consisting of:
  • compositions include head flower buds, berberine, heat-clearing drugs, tonics, water-wetting drugs, qi medicines, blood-activating phlegm drugs, and remedies.
  • compositions are selected from the group consisting of:
  • composition consists of the head bud, berberine, and any of the above-mentioned eleven classes of drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi-drug, a blood-activating phlegm, and a food-eliminating drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood-stopping medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood-stopping medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a phlegm Peony and solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a digestion drug, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm-dampness phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a sputum medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a warm-yang dispersing medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • composition is composed of a medicinal composition of the first six classes of drugs, such as scutellaria, berberine, and the above eleven types of medicinal properties:
  • compositions include the head flower bud, the berberine, the tonic medicine, the water-wetting drug, the qi medicine, the phlegm medicine, the warm-yang powder medicine, and the solution medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above seven drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm-dampness phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a warm-yang powder medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a gas medicine, a sputum medicine, a digestion medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a warm-yang medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a warm-yang powder medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • composition is composed of a medicinal composition of the genus, berberine, and any of the eleven types of drugs mentioned above:
  • compositions include head flower bud, berberine, tonic medicine, water-wetting drug, qi medicine, phlegm medicine, blood-activating phlegm medicine, phlegm-dampening phlegm medicine, and warm-yang dispersing medicine.
  • compositions are selected from the group consisting of:
  • the composition consists of the first eight types of drugs, such as the head bud, the berberine, and the above eleventh medicinal properties.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-sparing osmotic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, Promote blood circulation to remove phlegm, cool blood to stop bleeding drugs, digestion drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a warm-yang medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes the head flower bud, the berberine, the tonic medicine, the diarrhea medicine, the qi medicine, the phlegm medicine, the blood circulation phlegm medicine, the cooling blood hemostasis medicine, the phlegm and blood stasis medicine, the Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • composition is composed of a medicinal composition of the genus, berberine, and any of the above-mentioned eleven types of medicinal properties:
  • compositions include head flower buds, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm, blood circulation hemostasis, phlegm and blood stasis medicine, and warming medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head bud, berberine, and any of the nine drugs listed above.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, a blood circulation hemostasis medicine, a phlegm and blood stasis medicine, a yangyang cold medicine, a digestion medicine, Solution medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestion drug, and a solution.
  • Table medicine a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestion drug, and a solution.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea dialysis medicine, qi medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution Table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, cooling blood to stop bleeding medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, Wenyang cold medicine, digestion medicine, solution medicine .
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, digestion medicine, solution medicine .
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Solution medicine.
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Digestive medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a warm-yang dispelling medicinal agent, a digestive medicinal drug, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing blood-suppressing medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine The composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing blood-suppressing medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine The composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , digestion drugs.
  • the composition includes a flower bud, a peony root, a heat-clearing drug, a tonic drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a food-disinfecting drug, and a solution table. medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a cooling blood hemostasis medicine, a phlegm-dampening phlegm medicine, a Wenyang cold medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang-yang medicine, a solution Table medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-receiving medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a phlegm-dampening phlegm drug, a warm-yang dispersing drug, a digestion drug, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping drug, a warm-yang dispersing drug, a digestive drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi-drug, a blood-activating phlegm, a phlegm-dampening phlegm, a yang-yang medicinal agent, a digestion-preventing drug, and a solution. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood circulation Peony, cooling blood to stop bleeding, phlegm and blood stasis, Wenyang cold medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, Digestive medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-receiving medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestive medicinal drug, and a remedy drug. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a Wenyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a warm-yang powder medicine, a digestion medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang medicine, and a food-eliminating medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine.
  • composition is composed of a head bud, a berberine, and any of the above nine drugs in a pharmaceutical composition:
  • compositions include head flower bud, berberine, heat-clearing medicine, tonic medicine, water-wetting drug, qi medicine, phlegm medicine, blood-activating phlegm medicine, cooling blood-stopping medicine, phlegm-dampening phlegm medicine, Wenyang powder Cold medicine, solution medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the eleven types of drugs mentioned above.
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , digestion drugs, solution drugs.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion. Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang medicine, and a food-eliminating medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine, digestion medicine.
  • composition consists of a medicinal composition of the genus, berberine, and any of the eleven classes of drugs mentioned above:
  • compositions include head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion
  • the group of medicines is selected from any of the following groups:
  • compositions include the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, Wenyang cold medicine, digestion medicine, solution medicine Groups are selected from any of the following groups:
  • composition consists of any of eleven drugs of the above ten medicinal properties.
  • composition is composed of a medicinal composition of the eleventh medicinal herb, a berberine, and any eleven drugs of the above-mentioned eleven types of medicinal properties:
  • compositions include head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion Medicine, solution medicine.
  • compositions are selected from the group consisting of:
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting the head flower buds and other medicinal materials with an inorganic or organic solvent alone or in a mixed solvent.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and mixing the head flower buds and other medicinal materials with two or more mixed solvents of water and ethanol, acetone, and ethyl acetate.
  • a pharmaceutical composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5-30 times of water from the head flower and other herbs.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5-30 times of a 30-100% organic solution of the head flower buds and other medicinal materials.
  • the pharmaceutical composition according to the first aspect of the present invention characterized in that the composition is extracted from 5-30 times of 30-99% of lower alcohol (C1-C5), acetone, acetic acid solution by head flower buds and other medicinal materials. And get.
  • lower alcohol C1-C5
  • acetone acetic acid solution by head flower buds and other medicinal materials. And get.
  • composition obtained by extracting 5-30 times of a 30-99% aqueous solution of ethanol as an extraction solvent.
  • the aqueous ethanol solution is preferably a 70% ethanol solution, and the solution is selected to be 6-8 times.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and mixing 5-15 times of a mixed solution of an alcohol and an ester of 5-95% of an anthraquinone and other medicinal materials.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and extracting 5-15 times of a mixed solution of 5-95% ethanol and ethyl acetate as an extraction solvent. .
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5 to 20 times of ethyl acetate, petroleum ether and diethyl ether from the head flower and other herbs.
  • composition prepared according to the method comprising the steps of: 5 to 30 times (e.g., 5 to 15 times, for example, 6 to 12) of the medicinal material constituting the composition.
  • water water
  • ethanol ethanol aqueous solution decoction and / or reflux extraction 1 to 5 times (for example, 2 to 3 times)
  • each 0.5 to 5 hours for example, 0.5 to 3 hours, for example, 1 to 3 hours
  • the filtrate was concentrated and dried.
  • composition prepared according to the method comprising the steps of: taking a medicinal material constituting the composition, adding 5 to 30 times (for example, 5 to 15 times, for example, 6 to 12 times) water is decoctioned at 50-100 ° C for 1 to 5 times (for example, 2 to 3 times), 0.5 to 5 hours each time (for example, 0.5 to 3 hours, for example, 1 to 3 hours), filtered and combined
  • the extract is concentrated to a thick paste having a relative density of 1.1 to 1.5 (for example, 1.2 to 1.4), and dried under reduced pressure.
  • composition prepared according to the method comprising the steps of: taking a medicinal material constituting the composition, adding 5 to 30 times (for example, 5 to 15 times, for example, 6 to 12 times) 30-99% ethanol aqueous solution is refluxed for 1 to 5 times (for example, 2 to 3 times) for 0.5 to 5 hours each time (for example, 0.5 to 3 hours, for example, 1 to 3 hours), and the extracts are filtered and combined. It is concentrated to a thick paste having a relative density of 1.1 to 1.5 (for example, 1.2 to 1.4) at 60 to 90 ° C (for example, 65 to 75 ° C), and dried under reduced pressure.
  • the above pharmaceutical composition further comprises one or more other drugs selected from the group consisting of: an antimicrobial agent, a proton pump inhibitor, a gastric mucosal protective agent, an antacid, and an H 2 receptor antagonist.
  • Preferred antimicrobial agents include, but are not limited to, penicillins such as amoxicillin, macrolides such as clarithromycin, and nitrazoles such as metronidazole.
  • Preferred proton pump inhibitors include, but are not limited to, omeprazole, lansoprazole, pantoprazole
  • Preferred gastric mucosal protective agents include, but are not limited to, sucralfate, smecta
  • Preferred antacids such as aluminum hydroxide magnesium
  • H 2 receptor antagonists such as cimetidine, ranitidine, famotidine.
  • the invention also discloses a method for preparing a pharmaceutical composition extract, characterized in that the step of the method is selected from any one or more of the following:
  • (1-7) is obtained by extracting and obtaining 5 to 15 times of a mixed solvent of 5 to 95% of an alcohol and an ester;
  • the invention includes all of the pharmaceutical composition extracts prepared by the above methods.
  • a second aspect of the invention provides a pharmaceutical formulation composition.
  • compositions of the present invention further comprise one or more non-toxic physiologically acceptable carriers.
  • the acceptable carriers include any excipients known in the art and excipients that function as controlled release. Commonly used excipients include diluents, binders, wetting agents, disintegrants, lubricants, glidants, porogens, plasticizers, fillers, solubilizers, and emulsifiers.
  • the diluent may be, but not limited to, starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, etc.;
  • the humectant may be but not Limited to water, ethanol, isopropanol, etc.
  • the binder may be starch slurry, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic, gelatin pulp, sodium carboxymethyl cellulose, methyl fiber , hydroxypropyl methylcellulose, ethyl cellulose, acrylic resin, carbomer, polyvinylpyrrolidone, polyethylene glycol, etc.
  • disintegrants can be, but are not limited to, dry starch, microcrystalline cellulose, low substitution Hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, croscarmellose sodium, sodium carboxymethyl star
  • the excipient that acts to slow release is selected from one or more of a hydrophilic gel material, a waxy material, and an insoluble material.
  • the hydrophilic gel material may be selected from the group consisting of hydroxypropylmethylcellulose, carbopol, sodium carboxymethylcellulose and alginate
  • the waxy lipid material may be selected from the group consisting of cetyl alcohol and ten.
  • the insoluble material may be selected from the group consisting of ethyl cellulose, acrylic resin, polyoxyethylene and polyethylene.
  • coloring agents may also be added to the pharmaceutical preparations as needed.
  • the invention also relates to formulations comprising a pharmaceutical composition and a pharmaceutically acceptable carrier.
  • a pharmaceutical composition Any dosage form suitable for human or animal use can be prepared by combining the composition with one or more pharmaceutically acceptable solid or liquid excipients and/or adjuvants.
  • the formulation can be prepared according to methods well known in the art.
  • the composition of the present invention is usually contained in a pharmaceutical preparation in an amount of 6 to 12 g.
  • the pharmaceutical preparation of the present invention is preferably an oral preparation for the purpose of administration and enhancing the therapeutic effect.
  • Oral preparation prepared by the pharmaceutical composition of the present invention includes granules, tablets, pills, capsules, oral liquid preparations And related sustained-release preparations and sustained-release preparations, the sustained-release preparations include skeletal type, membrane-controlled type, osmotic pump type, gastric retention type sustained release controlled release preparation, microcapsules, nanoparticles, lipids
  • the drug is a new carrier sustained-release controlled release preparation
  • the gastric retention-type sustained-release preparation is preferably a gastric floating agent.
  • the preparation process of the preparation is as follows:
  • the raw material was 31% of the composition, 31% of the IV acrylic resin, 31% of stearyl alcohol, 7% of MCC101, and an appropriate amount of magnesium stearate was added, and the film was directly compressed by a dry method to obtain a floating tablet of the first calyx composition.
  • a third aspect of the invention provides the use of a pharmaceutical composition for the preparation of an antibacterial agent.
  • the use according to the second aspect of the present invention is characterized in that the pathogen is selected from the group consisting of Gram-positive methicillin-resistant Staphylococcus aureus S. aureus (Methicllin-resistant, MRSA), methicillin-sensitive golden yellow Staphylococcus epidermidis (MRSE), methicillin-sensitive Staphylococcus epidermidis (MSSE), also selected from Gram-negative bacteria large intestine ESBLS Escherichia Coli, Eco + , Escherichia coli (non-ESBLS) Escherichia Coli, Eco - , Klebsiella Klebsiella (ESBLs) K. penumonia, KPN + , Klebsiella pneumonia (non-ESBLs) K. penumonia , Pseudomonas aeruginosa (PAE), Helicobacter pylori.
  • MRSA methicillin-resistant Staphylococcus aureus
  • MRSE me
  • extraction may be impregnation at normal temperature, or extraction at elevated temperatures (e.g., boiling and/or reflux), or a combination of these modes of operation. It may further comprise further processing the extract, such as further purification, such as solvent removal, precipitation removal impurities, solvent extraction, resin adsorption separation, and the like.
  • extract will include extracts of any purity that can be used to achieve any of the objectives of the invention, and the extraction purity of the extract can vary over a wide range.
  • the invention has the beneficial effects that the composition improves the single anti-Helicobacter pylori activity of the head flower bud, and the minimum antibacterial requirement of the water extract composition A for Hp ATCC700392 is 9.84 mg/ml, and the crude drug content of berberine is 0.98mg/ml, lower than the requirement of unilateral calyx unilateral (36.68mg/ml) and berberine unilateral (1.37mg/ml), enhancing the antibacterial synergistic effect between the head flower bud and the berberine; alcohol extracting composition A, composition B.
  • the minimum antibacterial requirement of the composition C to Hp ATCC700392 is 3.63, 19.48, 17.16 (mg/ml), which is lower than the requirement of the first flower (40.44 mg/ml);
  • the minimum antibacterial requirement of the composition A, the composition B and the composition C for Hp SS1 was 3.63, 2.44, 2.15 (mg/ml), respectively, which was lower than that of the head flower (5.06 mg/ml).
  • the required content; the minimum antibacterial requirement of the alcohol extracting composition B for the metronidazole-resistant strain is 4.87 mg/ml, which is lower than that required for the single flower (10.11 mg/ml).
  • the composition has good antibacterial activity.
  • the minimum antibacterial crude drug content of the water extracting composition A against Gram-positive bacteria was ⁇ 0.082 mg/ml, and the crude drug content of Rhizoma Coptidis and the head flower buds were 0.204 and 0.621 mg/ml, respectively; the lowest against Gram-negative bacteria
  • the crude drug content of the bacteria was ⁇ 0.0824 mg/ml, and the crude drug content of the berberine unilateral and the head flower buds were 0.204 and 5.175 mg/ml, respectively.
  • Figure 1 shows the results of clinical drug-resistant strain verification.
  • Figure 2 shows the results of in vitro inhibition of the composition against H. pylori.
  • Example 2 Referring to the same method as in Example 1, except that 750 g of medicinal herbs, 75 g of fried berberine, 250 g of Codonopsis pilosula, 250 g of medlar, and 150 g of dried tangerine peel were weighed, and the extract powder of the present example was obtained, 154 g.
  • Example 2 The same procedure as in Example 1 was carried out, except that 900 g of the medicinal material calyx was weighed and extracted, and 89 g of the extract powder of this example was obtained.
  • Example 2 The same procedure as in Example 1 was carried out, except that 660 g of the medicinal material of Rhizoma Coptidis was weighed, and 133 g of the extract powder of this example was obtained.
  • the method was the same as in the same manner as in Example 5 except that 300 g of medicinal materials, 30 g of fried berberine, 100 g of Codonopsis pilosula, 100 g of medlar, and 60 g of dried tangerine peel were weighed, and the extract powder of this example was obtained, 95 g.
  • Example 5 Referring to the same method as in Example 5, except that 300 g of the medicinal flower head flower, 30 g of fried berberine, 100 g of Codonopsis pilosula, 100 g of medlar, and 100 g of Schisandra were weighed, and the extract powder of this example was obtained, 102 g.
  • Example 5 The same procedure as in Example 5 was carried out, except that 1000 g of the medicinal material calyx was weighed and extracted, and the extract powder of this example was obtained, 109 g.
  • Example 5 The same procedure as in Example 5 was carried out except that 520 g of the Rhizoma Coptidis medicinal material was weighed, and the extract powder of this example was obtained, 95 g.
  • Example 2 Referring to the same method as in Example 1, the difference was that 80 kg of head flower buds, 8 kg of fried berberine, and 16 kg of raw licorice were weighed and extracted to obtain 8.1 kg of the extract powder of this example.
  • Example 2 Referring to the same method as in Example 1, the difference was that 54 kg of the flower head flower, 5.6 kg of fried berberine, 17.6 kg of Codonopsis pilosula, 17.6 kg of medlar, and 10.4 kg of dried tangerine peel were weighed, and the extract powder of this example was obtained, 17.0 kg.

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Abstract

L'invention concerne une composition pharmaceutique comprenant des racines de Polygonum capitatum et de coptide, un procédé de préparation associé et leurs utilisations dans la préparation de médicaments pour résister contre des bactéries, en particulier Helicobacter pylori.
PCT/CN2015/086156 2015-08-05 2015-08-05 Utilisations d'une composition comprenant des racines de polygonum capitatum et de coptide dans la préparation de médicaments permettant de résister contre helicobacter pylori Ceased WO2017020279A1 (fr)

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PCT/CN2015/086156 WO2017020279A1 (fr) 2015-08-05 2015-08-05 Utilisations d'une composition comprenant des racines de polygonum capitatum et de coptide dans la préparation de médicaments permettant de résister contre helicobacter pylori
PCT/CN2016/093626 WO2017020861A1 (fr) 2015-08-05 2016-08-05 Application d'une composition de polygonum capitatum pour résister à helicobacter pylori

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PCT/CN2015/086156 WO2017020279A1 (fr) 2015-08-05 2015-08-05 Utilisations d'une composition comprenant des racines de polygonum capitatum et de coptide dans la préparation de médicaments permettant de résister contre helicobacter pylori

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CN118909852A (zh) * 2024-07-30 2024-11-08 内蒙古自治区人民医院（内蒙古自治区肿瘤研究所） 芪连芩英汤对幽门螺旋杆菌的抑制方法

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CN118909852A (zh) * 2024-07-30 2024-11-08 内蒙古自治区人民医院（内蒙古自治区肿瘤研究所） 芪连芩英汤对幽门螺旋杆菌的抑制方法

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