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WO2017019631A1 - Applicateur sous-cutané - Google Patents

Applicateur sous-cutané Download PDF

Info

Publication number
WO2017019631A1
WO2017019631A1 PCT/US2016/043928 US2016043928W WO2017019631A1 WO 2017019631 A1 WO2017019631 A1 WO 2017019631A1 US 2016043928 W US2016043928 W US 2016043928W WO 2017019631 A1 WO2017019631 A1 WO 2017019631A1
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
applicator
implant
degrees
guide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/043928
Other languages
English (en)
Inventor
William G.M. FISCHER
Christian S. Eversull
Stephen A. Leeflang
Wouter E. Roorda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nano Precision Medical Inc
Original Assignee
Nano Precision Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nano Precision Medical Inc filed Critical Nano Precision Medical Inc
Publication of WO2017019631A1 publication Critical patent/WO2017019631A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A61B2017/3405—Needle locating or guiding means using mechanical guide means

Definitions

  • implant applicators may be provided for subdermally inserting an implant.
  • Implants capable of long term drug delivery, and designed for insertion under the skin of a human or animal are being used in multiple therapeutic applications.
  • implant applicators used to insert the implants under the skin. Accordingly, further improvements may be had with implant applicators.
  • implant applicators may be provided for subdermally inserting an implant.
  • the implant applicators may be used for inserting a rod-like implant containing a therapeutic agent under the skin of a patient (e.g., human or animal).
  • an implant applicator may be provided.
  • the applicator may be for subdermally inserting an implant in a human or animal.
  • the applicator may include a housing.
  • a cannula may be provided with a distal tip, a longitudinal axis, and an insertion length extending from the housing in a distal direction.
  • the applicator may include a cannula guide extending from the housing in the distal direction.
  • the cannula guide may have a distal end and may be cantilevered over at least part of the insertion length of the cannula.
  • a handle section may be located on the housing and may be located proximal to the cannula guide.
  • the handle section may have a width substantially larger than the diameter of the cannula.
  • the handle may have a width between 0.5 inches - 1.25 inches in certain embodiments.
  • Embodiments may include a skin guide that is located on the housing at a site of entrance of the cannula into the housing.
  • the skin guide may have a beveled section at an angle between 20 and 60 degrees with the longitudinal axis of the cannula.
  • the cannula guide, the handle section, and the skin guide may be integrated with the housing into a single unit with functionally different sections.
  • an applicator for subdermally inserting an implant in a human or animal may be provided that includes a housing and a cannula having a
  • a cannula guide may be provided that extends from the housing in a distal direction.
  • the cannula guide may have a distal end and may be cantilevered over at least part of the insertion length of the cannula.
  • the distal end of the cannula guide may be flattened along a line oriented at an angle between 15 and 45 degrees with the longitudinal axis of the cannula.
  • an implanter may include a housing defining a body of the applicator, a cannula coupled with the housing and extending distally from the body of the applicator.
  • the cannula may have a distal tip, a longitudinal axis, and an insertion length.
  • a cannula guide may extend from the body of the applicator.
  • the cannula guide may have a distal end that is distal relative to the distal tip of the cannula and above the distal tip of the cannula.
  • “Above” should be understood to refer to a higher level when the device is positioned for use.
  • the distal end of the cannula guide may be distal relative to the distal tip of the cannula and above the distal tip of the cannula such that a straight line between the distal end of the cannula guide and the distal tip of the cannula forms an angle between 15 degrees and 45 degrees with the longitudinal axis of the cannula.
  • the straight line between the distal end of the cannula guide and the distal tip of the cannula may form an angle between 20 degrees and 40 degrees with the longitudinal axis of the cannula.
  • the straight line between the distal end of the cannula guide and the distal tip of the cannula forms an angle between 25 degrees and 35 degrees with the longitudinal axis of the cannula.
  • an applicator that includes a housing defining a body of the applicator.
  • a cannula may be coupled with the housing and may extend distally from the body of the applicator.
  • the cannula may have a distal tip, a longitudinal axis, and an insertion length.
  • a cannula guide may extend from the body of the applicator.
  • the cannula guide may have a distal end that is distal relative to the distal tip of the cannula and above the distal tip of the cannula.
  • the distal end of the cannula guide may include a beveled surface that is beveled at an angle between 15 degrees and 45 degrees with the longitudinal axis of the cannula.
  • the beveled surface may be at an angle between 20 degrees and 40 degrees with the longitudinal axis of the cannula. In some embodiments, the beveled surface is at an angel between 25 degrees and 35 degrees with the longitudinal axis of the cannula.
  • an applicator may include a housing defining a body of the applicator and a cannula coupled with the housing and extending distally from the body of the applicator.
  • the cannula may have a distal tip, a longitudinal axis, and an insertion length.
  • a cannula guide may extend from the body of the applicator.
  • the cannula may extend from a distal surface of the body of the applicator.
  • the distal surface of the body of the applicator may define a skin guide having a surface at an angle between 20 degrees and 60 degrees with the longitudinal axis of the cannula. In some embodiments, the surface of the skin guide may be at an angle between 35 and 45 degrees with the longitudinal axis of the cannula.
  • the cannula of any of the described applicators may be slideably coupled with the housing and may be retractable proximally into the body of the housing.
  • an obdurator may be provided that extends into the cannula from a proximal end of the cannula.
  • the obdurator may be fixedly attached to the housing such that the cannula may move proximally relative to the obdurator during retraction of the cannula proximally into the body of the housing.
  • a user actuator may be provided that is operably coupled with the cannula and slidable in a proximal direction in a track of the applicator which may retract the cannula in the proximal direction.
  • a safety lock mechanism may be provided that is operably coupled with the user actuator.
  • the safety lock mechanism may include a deformable protrusion that extends into a slot in the housing to bias the user actuator against moving in the proximal direction.
  • the safety lock mechanism may be user moveable in the track of the applicator in the proximal direction to deform the protrusion of the safety lock mechanism such that the protrusion is urged out of the slot in the housing.
  • the user actuator may be unlocked for movement in the proximal direction.
  • the slot may extend from the track in a direction transverse to the track.
  • an implant delivery system may be provided, the implant delivery system may include an applicator described herein and where the cannula includes an implant holding section where an inner surface of the cannula is inwardly indented.
  • An implant may be provided that is friction fit within the implant holding section of the cannula.
  • an implant delivery system may include an applicator described herein and the implant disposed within the cannula of the applicator.
  • a cannula guard may be disposed over the distal tip of the cannula and may be removable therefrom.
  • the cannula guard may include a push rod that extends proximally (from the inner surface of the guard) into the distal tip of the cannula when the cannula guard is disposed over the distal tip of the cannula so as to prevent the implant from escaping from within the cannula.
  • the implant may be constructed of a metal material.
  • the implant may be made of a titanium material and may be configured to deliver one or more drugs to a patient once implanted.
  • Figure 1 A illustrates an exemplary applicator and its alignment with a surface of a skin according to some embodiments of the disclosure.
  • Figure IB illustrates the exemplary applicator of Figure 1 A further modified with cannula guide having a beveled distal end according to some embodiments of the disclosure.
  • Figure 2A illustrates another exemplary applicator according to some embodiments of the disclosure that is repositioned relative to the skin surface after initial insertion of the cannula into the skin.
  • Figure 2B illustrates the exemplary applicator of Figure 2 A inserted into the skin a desired insertion distance.
  • Figure 3 A and Figure 3B illustrate another exemplary applicator with an obdurator according to some embodiments.
  • Figure 4 illustrates another exemplary applicator with a cannula guard according to some embodiments.
  • Figure 5 illustrates an exemplary needle lock mechanism that may be used with embodiments of the applicator.
  • Figure 6A shows a side view of an implant holder section of an exemplary cannula that may be used with embodiments of the applicator.
  • Figure 6B shows a top view of the cannula shown in Figure 6A.
  • distal refers to an orientation towards a patient
  • proximal refers to an orientation towards a user of the device
  • the cannula When subdermally inserting an implant through the skin of a patient, it may be important to position the cannula at a preferred angle relative to the skin surface prior to penetrating the skin with the cannula in order to insert an implant correctly under the skin of the patient. Failure to do so may lead to incorrect placement of the implant under the skin.
  • the preferred angle may be between 15 and 45 degrees, more preferably between 20 and 40 degrees (e.g., between 25-35 degrees or the like).
  • at least some embodiments of the applicators described herein may include a cannula guide that helps a user align and position the applicator at the desired angle relative to the skin surface prior to insertion of the cannula into the skin and insertion of the implant.
  • the cannula guide may extend at least in part over the cannula and may be connected with a housing of the applicator.
  • a portion of the housing of the applicator may form or otherwise define the cannula guide.
  • the cannula guide may be integrated into the housing of the applicator.
  • Embodiments of the applicator may further include a housing that defines a body of the applicator.
  • the cannula and the cannula guide may extend distally from the body of the applicator.
  • the body of the applicator may define a handle section of the applicator.
  • a distal surface of the body from which the cannula extends may define a skin guide.
  • the cannula guide, the handle section, and the skin guide may be integrated with the housing into a single unit with functionally different sections.
  • Figure 1 A illustrates an exemplary applicator 100 and its alignment with a surface of a skin 102 according to some embodiments of the disclosure.
  • the exemplary applicator 100 may include a cannula guide 101 and a cannula 103, each extending distally from a body 104 of the applicator 100.
  • Cannula guide 101 may be cantilevered over cannula 103 and may extend beyond cannula 103 such that a distal end 105 of cannula guide 101 is distal relative to the distal tip 106 of cannula 103.
  • a straight line between the distal end 105 of cannula guide 101 to the distal tip 106 of cannula 103 may form an angle ⁇ with a longitudinal axis 107 of the cannula 103.
  • Angle ⁇ may be between 15 degrees and 45 degrees in some embodiments. In certain embodiments, angle ⁇ may be between 20 and 40 degrees (e.g., 25-35 degrees or the like).
  • a medical practitioner may place the device 100 on the skin 102 of a patient, as illustrated in Figure 1 A, with the tip 106 of cannula 103 and the distal end 105 of cannula guide 101 touching skin 102, for the purpose of positioning cannula 103 at a preferred angle (e.g., 15-45 degrees) relative to the skin surface 102.
  • a preferred angle e.g. 15-45 degrees
  • Figure IB illustrates the exemplary applicator 100 of Figure 1A further modified with cannula guide 101 having a beveled distal end 105a according to some embodiments of the disclosure.
  • the distal end 105a of cannula 101 may be flattened or beveled at an angle ⁇ between 14 and 45 degrees with the longitudinal axis 107 of cannula 103. In some embodiments, this angle ⁇ may be between 25 and 35 degrees.
  • a medical practitioner may place the device on skin 102 of a patient, as illustrated in Figure IB, with the flattened or beveled distal end 105a of cannula guide 101 touching skin 102, thereby positioning cannula 103 at a desired angle for penetrating skin 102.
  • cannula guide 101 may be slightly shorter than shown in Figure IB with respect to cannula 103 and may not be positioned on skin 102 during alignment, but may be held above the skin surface 102.
  • cannula guide 101 may, by virtue of the shape of the flattened end, be used as a visual indicator to position cannula 103 at the desired angle relative to skin 102.
  • the guide 101 may be 0.1 - 0.5 inches above the cannula 103.
  • Figure 2A illustrates exemplary applicator 200 according to some
  • FIG. 2B illustrates the exemplary applicator 200 of Figure 2A inserted into the skin 205 a desired insertion distance.
  • handle section 201 may be defined by a housing 202 of the device 200.
  • the handle 201 may be located proximal to the cannula guide 203 on a main body of applicator 200.
  • Handle section 201 may have a width that is substantially larger than the diameter of cannula 204 and may be ergonomically shaped to provide a user sufficient grip on the device 200 to perform the steps necessary for insertion of the implant under the skin 205.
  • handle section 201 may include protrusions that may further enhance a medical practitioners grip on the device 200 during deployment of the implant.
  • a user may grip the device 200 by handle section 201, and place cannula 204 and cannula guide 203 on or above the skin 205 of a patient at a desired angle, as described above.
  • the user may penetrate the skin 205 with cannula 204, and may thereafter or simultaneously angle the device 200 down to a position where the cannula 204 is approximately parallel the surface of the skin 205.
  • the user may then advance the device 200 in a distal direction relative to the skin 205, to insert cannula 204 with the implant under the skin 205 to a desired depth for positioning of the implant.
  • skin guide 206 may be provided at a site where the cannula 204 extends from the housing 202.
  • the skin guide 206 may be defined by a distal surface of the main body of the housing 202.
  • the skin guide 206 may be angled in a way that facilitates sliding of the skin 205 under the housing 202.
  • the skin guide 206 may have a beveled configuration with a beveled surface at an angle between 20 and 60 degrees to the longitudinal axis 207 of the cannula 204 to guide the skin 205 of a patient underneath the device 200 during insertion of the cannula 204, and to reduce the risk of painful skin 205 buckling against the housing 202 during the insertion of cannula 204.
  • Figure 3A and Figure 3B illustrate another applicator 300 with an obdurator
  • cannula 303 may further include an obudrator 306 and cannula retractor mechanism 308.
  • Obdurator 306 may be disposed within at least a part of cannula 303 from a proximal end of cannula 303 and may be provided proximal to implant 307 in cannula 303.
  • Cannula retractor mechanism 308 may comprise any desired motion transfer mechanism, such as a direct connection, a geared system, a system comprising levers and or hinges, a spring-loaded system, etc.
  • the cannula retractor mechanism 308 includes a user actuator 310 mechanically coupled with the cannula 303.
  • cannula retractor mechanism 308 and obdurator 306 may be employed by a user to retract cannula 303 from underneath skin 309, while keeping implant
  • the cannula 303 may be retracted proximally relative to the housing 302 such that a portion (or the entirety) of the cannula 303 may be retracted therein.
  • a user may retract the cannula 303 by sliding the user actuator 310 in a track of the applicator 300 in the proximal direction. With the user actuator 310 mechanically linked to the cannula 303, the cannula 303 will also move in the proximal direction relative to the housing 302 during movement of the user actuator 310 in the proximal direction.
  • the obdurator 306 may be fixed within housing 302 such that during cannula 303 retraction, the cannula 303 moves proximally relative to the obdurator 306. Additionally, during cannula 303 retraction, the proximal end of the implant 307 may engage with a distal end of the obdurator 306 which may keep the implant 307 in a preferred location under the skin 30 during cannula 303 retraction.
  • Figure 4 illustrates another exemplary applicator 400 with a cannula guard 410 according to some embodiments.
  • the cannula guard 410 may be configured to cover a distal end of cannula 403 when the applicator 400 is packaged or when the applicator 400 is handled prior to use to limit accidental injury from the distal end of the cannula 303 prior to applicator use for inserting the implant 307.
  • the cannula guard 410 may be dimensioned to slide over the distal end of the cannula 403.
  • an internal push rod 411 may extend from an internal surface of the distal end of cannula guard 410 in the proximal direction.
  • the internal push rod 411 may extend into the distal end of the cannula 403 a distance which may hold the implant 307 at a preferred location within the cannula 403 prior to removal of cannula guard 410 and insertion of implant 407.
  • implant 407 may be secured in cannula 403 between push rod 411 of cannula guard 410 and a distal end of obdurator 406 that extends into cannula 403 from a proximal end of cannula 403.
  • FIG. 5 illustrates an exemplary needle lock mechanism 500 that may be used with embodiments of the applicator described herein.
  • the needle lock mechanism 500 may be used to prevent premature deployment of the implant (e.g., implant 407) from the implanter.
  • the needle lock mechanism 500 comprises a locking element 501 and a sliding finger grip 502 (e.g., user actuator).
  • the sliding finger grip 502 may be configured to be slideable (e.g., in a track) in the proximal direction for retraction of the cannula into the housing 506 as described above.
  • the locking element 501 may be braced against the sliding finger grip 502 and may have a flexible or deformable distal protrusion 503 which extends into or may be slid into a groove or slot 504 on the housing 506.
  • the locking element 501 may bias the user actuator 502 against moving in the proximal direction along the track.
  • the user wants to disengage the locking element 501, the user may slide the locking element 501 proximally away from the user actuator 502 which deforms the flexible distal protrusion 503 and withdraws it from the groove 504. Thereafter, the finger grip 502 may be slid freely in the proximal direction along the track.
  • the locking element 501 may or may not slide in the same track as the sliding finger grip 502.
  • the groove 504 may extend from the track in a direction transverse to the track.
  • the implant may be secured in the cannula in various manners.
  • the implant may be secured by a friction-fit engagement.
  • Figure 6A shows a side view of an implant holder section of an exemplary cannula 601 that may be used with embodiments of the applicator to friction fit an implant held therein.
  • Figure 6B shows a top view of the cannula 601 shown in Figure 6 A.
  • the cannula 601 may have an implant holder section 602 where an inner surface of the cannula 601 may protrude inwardly, producing an area where the lumen of the cannula reduces in size.
  • the section 602 with the reduced lumen size may form a friction fit with the implant 603, thus securing the implant 603 within the cannula 601 prior to insertion.
  • the reduced lumen size may be produced by a cut into the wall of cannula 601 which bends the cannula 601 inward.
  • a user may first remove the device from a packaging material (not shown).
  • the user holds the device by handle section 402, removes needle guard 410 and places the device on the skin under the correct angle, aided by cannula guide 401.
  • the user then penetrates the skin with cannula 403 and angles the device to a position substantially parallel to the skin, thereby lifting the skin of the patient slightly up.
  • the user then moves the entire device forward, thereby inserting cannula 403 under the skin to the desired distance. Movement of the device over the skin is facilitated by skin guide 408.
  • fingergrip 404 of cannula retractor mechanism 405 in an appropriate manner, for instance by sliding the fingergrip 404 in a proximal direction. Any desired manipulation of fingergrip 404 may be employed, including sliding, rotating, using a push button, etc.
  • Cannula retractor mechanism 405 retracts cannula 403 in a proximal direction, removing cannula 403 from underneath the skin. Contrary to cannula 403, obdurator 406 is in a fixed position in housing 409. Therefore, implant 407 is held in a stationary position underneath the skin, while cannula 403 is being retracted. Finally, obdurator 406 is removed from underneath the skin (e.g., by moving applicator 400 proximally), and the skin incision made by cannula 403 may be closed with a steristrip.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne, de manière générale, des dispositifs, des systèmes et des procédés médicaux. Dans des modes de réalisation particuliers, des applicateurs d'implant peuvent être prévus pour l'introduction sous-cutanée d'un implant. Dans certains aspects, un applicateur peut comprendre un boîtier définissant un corps de l'applicateur, et une canule accouplée au boîtier et s'étendant de façon distale depuis le corps de l'applicateur. Dans certains modes de réalisation, un guide de canule peut s'étendre depuis le corps de l'applicateur et peut aider un utilisateur à aligner l'applicateur à un angle souhaité par rapport à la surface de peau avant l'introduction de la canule dans la peau. L'applicateur peut en outre comprendre un guide de peau qui limite le plissement de peau contre le boîtier d'applicateur pendant l'introduction de canule dans la peau. La canule peut avoir une section de maintien d'implant, une surface intérieure de la canule étant dentelée vers l'intérieur de telle sorte que la surface intérieure de la canule s'ajuste par frottement avec un implant.
PCT/US2016/043928 2015-07-25 2016-07-25 Applicateur sous-cutané Ceased WO2017019631A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562196998P 2015-07-25 2015-07-25
US62/196,998 2015-07-25
US201662278428P 2016-01-13 2016-01-13
US62/278,428 2016-01-13

Publications (1)

Publication Number Publication Date
WO2017019631A1 true WO2017019631A1 (fr) 2017-02-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/043928 Ceased WO2017019631A1 (fr) 2015-07-25 2016-07-25 Applicateur sous-cutané

Country Status (1)

Country Link
WO (1) WO2017019631A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230149635A1 (en) * 2021-11-12 2023-05-18 Lupin Inc. Applicator for Implant Insertion
US20230173242A1 (en) * 2021-12-02 2023-06-08 Eastern Virginia Medical School Device for subdermal insertion of solid media
US20240016573A1 (en) * 2022-07-12 2024-01-18 Merit Medical Systems, Inc. Mechanism for retaining a marker

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3324854A (en) * 1964-04-23 1967-06-13 Harry Swartz Apparatus for facilitating the insertion of a hypodermic syringe needle
EP0596161A1 (fr) * 1992-11-06 1994-05-11 Texas Instruments Incorporated Dispositif pour l'introduction souscutanée d'une aiguille
WO1998013091A1 (fr) * 1996-09-27 1998-04-02 American Home Products Corporation Dispositif medical permettant de mettre en place des matieres solides
US20100036465A1 (en) * 2008-08-07 2010-02-11 Arkady Glukhovsky Insertion tools and methods for an electrical stimulation implant
WO2011112916A1 (fr) * 2010-03-12 2011-09-15 Sid Technologies, Llc Ensemble à utiliser avec une seringue
WO2014137901A1 (fr) * 2013-03-04 2014-09-12 Sid Technologies, Llc Adaptateurs intradermiques à adjonction latérale

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3324854A (en) * 1964-04-23 1967-06-13 Harry Swartz Apparatus for facilitating the insertion of a hypodermic syringe needle
EP0596161A1 (fr) * 1992-11-06 1994-05-11 Texas Instruments Incorporated Dispositif pour l'introduction souscutanée d'une aiguille
WO1998013091A1 (fr) * 1996-09-27 1998-04-02 American Home Products Corporation Dispositif medical permettant de mettre en place des matieres solides
US20100036465A1 (en) * 2008-08-07 2010-02-11 Arkady Glukhovsky Insertion tools and methods for an electrical stimulation implant
WO2011112916A1 (fr) * 2010-03-12 2011-09-15 Sid Technologies, Llc Ensemble à utiliser avec une seringue
WO2014137901A1 (fr) * 2013-03-04 2014-09-12 Sid Technologies, Llc Adaptateurs intradermiques à adjonction latérale

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230149635A1 (en) * 2021-11-12 2023-05-18 Lupin Inc. Applicator for Implant Insertion
US20230173242A1 (en) * 2021-12-02 2023-06-08 Eastern Virginia Medical School Device for subdermal insertion of solid media
WO2023102155A1 (fr) * 2021-12-02 2023-06-08 Eastern Virginia Medical School Dispositif d'insertion sous-cutanée de milieux solides
US20240016573A1 (en) * 2022-07-12 2024-01-18 Merit Medical Systems, Inc. Mechanism for retaining a marker

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