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WO2017012031A1 - Dispositif de détection de nerf capable de supprimer une interférence interactive - Google Patents

Dispositif de détection de nerf capable de supprimer une interférence interactive Download PDF

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Publication number
WO2017012031A1
WO2017012031A1 PCT/CN2015/084602 CN2015084602W WO2017012031A1 WO 2017012031 A1 WO2017012031 A1 WO 2017012031A1 CN 2015084602 W CN2015084602 W CN 2015084602W WO 2017012031 A1 WO2017012031 A1 WO 2017012031A1
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Prior art keywords
sensing
signal
control signal
unit array
neuron
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PCT/CN2015/084602
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English (en)
Chinese (zh)
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林伯刚
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Priority to PCT/CN2015/084602 priority Critical patent/WO2017012031A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00

Definitions

  • the present disclosure relates to a neural sensing device, and more particularly to a neural sensing device having a suppression of interference to prevent neurons from being interfered with each other by a plurality of dense signals.
  • Second Sight Medical Products Inc. conducted a human transplant for the experimental electronic eye Argus I produced by six blind patients.
  • Argus I is a bionic eye. It has a resolution of 16 pixels, allowing blind patients to recognize the contour of the object through the difference in brightness reflected from the surface of the object.
  • the company released the second-generation Argus II, which upgrades image resolution to 60 pixels, providing users with better resolution and image recognition accuracy.
  • the prior art experimental electronic eye Argus II device includes an image pickup device disposed outside the user and an image receiving wafer disposed in the user body, wherein the image pickup device includes a frame, a miniature camera, and a Image processing unit, a wireless communication module.
  • the frame is removably disposed on the face of the user, and the micro camera and the wireless communication module are disposed thereon.
  • the miniature camera is used to pick up images in front of the user and generate a photographic information.
  • the image processing unit is disposed outside the frame and connected to the miniature camera. The image processing unit receives the photography information of the miniature camera and generates a digital image signal.
  • the wireless communication module receives the digital image information of the image processing unit, and transmits the digital image information to the image receiving wafer.
  • the image receiving wafer is disposed on the retina of the user and is coupled to at least one optic ganglion on the retina of the user.
  • the image receiving chip converts the digital image information into a nerve peak, and transmits the nerve peak to the user's brain through the at least one optic ganglion, so that the user perceives an image.
  • the image receiving chip needs to add more photosensitive cells to the finite-sized wafer to increase the pixel value in order to improve the resolution and recognition rate of the image by the user, and the gap between the photosensitive cells at this time. More recently, it will be easier to make the sense of each photosensitive unit work.
  • the measured signals interfere with each other, reducing the original effective pixel value. Referring to FIG. 1, when the sensing signals of two adjacent photosensitive cells 10 interfere with each other, the signal superimposed between the two adjacent photosensitive cells 10 is higher than a sensing valve of at least one of the user's optic ganglia.
  • At least one optic ganglion of the user will equally recognize the two photosensitive units 10 as a large-area photosensitive unit 11 and transmit the received sensing signals to the user's brain. If all the photosensitive cells 10 interfere with each other, the user will perceive a blurred light and shadow, and cannot recognize the image by the contour of the object, so that the image receiving wafer with high pixels loses the resolution and recognition rate of the user.
  • the present disclosure proposes a neural sensing device having an interference suppression and avoiding interference of a plurality of dense signals with each other, which has the characteristics of small volume and high neurosensory sensitivity and accuracy. It is indeed a technical problem that is urgently solved by all walks of life.
  • the main object of the present disclosure is to provide a neural sensing device with suppressed interference, which can prevent neurons from being subjected to multiple dense signals to each other without sacrificing resolution. Interference, thereby achieving the purpose of improving the sensitivity and accuracy of nerve sensing.
  • the present invention provides a neural sensing device with interference suppression interference, comprising: a sensing unit array configured with a plurality of sensing units, among the plurality of sensing units Each sensing unit generates a sensing signal; a control signal generator connected to the sensing unit array, generating a control signal and outputting the control signal to each of the plurality of sensing units Surrounding the sensing unit, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each sensing unit of the plurality of sensing units, so that Suppressing an interference; and a signal processing module coupled to the sensing unit array and the control signal generator, and generating a processing signal and outputting the processing signal to at least one neuron;
  • the sensing signal is higher than a sensing threshold of the at least one neuron, and the sensing signal is lower than a sensing valve of the at least one neuron value.
  • the sensing unit array may be a photodiode array of an electronic retina wafer, and each of the plurality of sensing units is a photodiode to replace the human retina Photoreceptor cell.
  • control signal generator is configurable on one side of the sensing unit array of an electronic retina wafer and transmits the control signal to the signal processing module.
  • the neural sensing device is directly connectable to at least one ganglion cell on the human retina.
  • the processing signal can be at least one spike.
  • the control signal generator generates a control signal and outputs the control signal to each of the plurality of sensing units when the neural sensing device provided with the present disclosure provides interference suppression Surrounding, a sensing signal is used to isolate between the sensing units of the plurality of sensing units to suppress interaction interference, thereby preventing the at least one neuron from malfunctioning.
  • each of the plurality of sensing units configured on the sensing unit array is based on the image and/or the light source
  • the light intensity distribution in the space generates a sensing signal, and since each of the foregoing control signals is isolated between the plurality of sensing signals, when the sensing unit array senses a densely distributed light intensity change
  • the image and/or the light source are used, at least one of the neurons can be prevented from being interfered with each other by the plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the nerve sensing.
  • FIG. 1 is a schematic view showing that sensing signals of two adjacent photosensitive cells of a prior art experimental electronic eye interfere with each other;
  • FIG. 2 is a block diagram showing a circuit according to a first embodiment of the present invention, with a neural sensing device for suppressing crosstalk according to the present disclosure
  • FIG. 3 is a schematic diagram showing the appearance of a sensing unit array according to a first embodiment, in accordance with the present disclosure
  • FIG. 4 is a schematic diagram of a neural sensing device with suppression of crosstalk according to the present disclosure, showing a coupling of a sensing signal and a control signal according to the first embodiment;
  • FIG. 5 is a neural sensing device with suppression of crosstalk according to the present disclosure, showing a functional block diagram according to a first embodiment.
  • a neural sensing device with suppressed interference is described below.
  • the neural sensing device with interference suppression interference includes: a sensing unit array 20 , a control signal generator 30 and a signal processing module 40 .
  • the sensing unit array 20 is configured with a plurality of sensing units 21, and each of the plurality of sensing units 21 generates a sensing signal, wherein each sensing signal is higher than one of the at least one neuron 50.
  • the threshold is sensed to cause at least one neuron 50 to sense valid information and transmit the valid information to the brain 60.
  • the sensing unit array 20 is a photodiode array of an electronic retina wafer, and each of the plurality of sensing units 21 is a photodiode, Replacing a photoreceptor cell on the human retina, that is, each of the plurality of sensing units 21 as one pixel for sensing a picture, which is used to inject a plurality of senses from the outside
  • the plurality of photon energies of each of the sensing units 21 are converted into electron free energy and output electrical energy to generate a sensing signal corresponding to the plurality of photon energies, and the sensing signals are transmitted to the signal processing module 40.
  • the control signal generator 30 can be connected to the sensing unit array 20 , and can generate a control signal and output the control signal to each of the plurality of sensing units 21 . Surrounding, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each of the plurality of sensing units to suppress interference; and Each control signal is below the sensing threshold of at least one neuron 50 to avoid sensing at least one neuron 50 of valid information.
  • At least one neuron 50 has a refractory period for a period of time after being stimulated by an action potential due to the inactivation of the sodium ion (Na + ) channel.
  • the first embodiment of the present disclosure temporarily causes at least one neuron 50 around each of the plurality of sensing units 21 to be in an unresponsive period by the feature, and suspends the generation of the at least one sensing unit 21.
  • control signal generator 30 may be disposed on one side of sensing unit array 20 of an electronic retina wafer and may transmit control signals to signal processing module 40.
  • the signal processing module 40 can be coupled to the sensing unit array 20 and the control signal generator 30, which can generate a processing signal and output the processed signal to at least one neuron 50.
  • the neural sensing device can be directly coupled to at least one ganglion cell on the human retina to cause the signal processing module 40 to replace the bipolar cell on the human retina And/or horizontal cells, wherein each of the at least one ganglion cell is a nodular construct composed of at least one neuron 50 of identical function.
  • Bipolar cells are used to enhance signal edge differences and improve the sharpness of images perceived by brain 60, ie sharpens; horizontal cells are used to attenuate image edge differences and reduce the sharpness of images perceived by brain 60, ie Blurring.
  • the processing signal may be at least one spike.
  • the signal processing module 40 couples the sensing signals of each of the plurality of sensing units 21 with the control signals, at least one spike is generated and output to the at least one neuron 50.
  • the sensing unit array 20 is first disposed on a user's retina, and at least one sensing unit 21 on the sensing unit array 20 is oriented toward the outside of the user to sense the user's retina. External image. Additionally, the signal processing module 40 is coupled to the human retina At least one ganglion cell transmits a processing signal to at least one neuron 50. Next, the control signal generator 30 generates a control signal and outputs the control signal to the periphery of each of the plurality of sensing units 21 for isolating between the respective sensing units of the plurality of sensing units. The sensing signal is configured to suppress the plurality of sensing signals from interfering with each other while avoiding malfunctioning of at least one of the neurons 50.
  • each of the plurality of sensing units 21 configured on the sensing unit array 20 is in space according to the image and/or the light source.
  • the light intensity distribution generates a sensing signal, and since each of the foregoing control signals is isolated between the respective sensing signals, when the sensing unit array 20 senses a densely distributed image and/or light source whose intensity is weakly changed, The at least one neuron 50 is prevented from being interfered with each other by a plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the neural sensing.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Solid State Image Pick-Up Elements (AREA)

Abstract

L'invention concerne un dispositif de détection de nerf capable de supprimer une interférence interactive, qui comprend un réseau d'unités de détection (20), un générateur de signal de commande (30) et un module de traitement de signal (40). Le réseau d'unités de détection (20) comprend de multiples unités de détection (21). Chacune des multiples unités de détection (21) génère un signal de détection. Le générateur de signal de commande (30) est relié au réseau d'unités de détection (20), génère un signal de commande et délivre le signal de commande à la circonférence de chacune des multiples unités de détection (21). L'intensité de signal du signal de commande est inférieure à l'intensité de signal du signal de détection, pour isoler des signaux de détection parmi les unités de détection (21) des multiples unités de détection (21), de façon à supprimer une interférence interactive. Le module de traitement de signal (40) est relié au réseau d'unités de détection (20) et au générateur de signal de commande (30), génère un signal de traitement, et délivre le signal de traitement à au moins un neurone (50). Le signal de détection est supérieur à un seuil de détection dudit neurone (50), et le signal de commande est inférieur à un seuil de détection dudit neurone (50).
PCT/CN2015/084602 2015-07-21 2015-07-21 Dispositif de détection de nerf capable de supprimer une interférence interactive Ceased WO2017012031A1 (fr)

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PCT/CN2015/084602 WO2017012031A1 (fr) 2015-07-21 2015-07-21 Dispositif de détection de nerf capable de supprimer une interférence interactive

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PCT/CN2015/084602 WO2017012031A1 (fr) 2015-07-21 2015-07-21 Dispositif de détection de nerf capable de supprimer une interférence interactive

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1438906A (zh) * 2000-05-04 2003-08-27 奥普托拜奥尼克斯公司 改进的人造视网膜治疗器及其固定方法
CN1961850A (zh) * 2006-12-07 2007-05-16 上海交通大学 可植入的视觉假体
CN102160831A (zh) * 2011-05-16 2011-08-24 北京大学人民医院 一种用于人工视觉领域的视网膜前微电极阵列芯片
TWM437713U (en) * 2012-04-13 2012-09-21 Bo-Gang Lin Improved artificial electronic retina structure
US20130304155A1 (en) * 2012-05-09 2013-11-14 Po-Kang Lin Structure of Artificial Electronic Retina
CN103732287A (zh) * 2011-05-12 2014-04-16 皮埃尔和玛利居里大学(巴黎第六大学) 控制助视器的方法和设备

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1438906A (zh) * 2000-05-04 2003-08-27 奥普托拜奥尼克斯公司 改进的人造视网膜治疗器及其固定方法
CN1961850A (zh) * 2006-12-07 2007-05-16 上海交通大学 可植入的视觉假体
CN103732287A (zh) * 2011-05-12 2014-04-16 皮埃尔和玛利居里大学(巴黎第六大学) 控制助视器的方法和设备
CN102160831A (zh) * 2011-05-16 2011-08-24 北京大学人民医院 一种用于人工视觉领域的视网膜前微电极阵列芯片
TWM437713U (en) * 2012-04-13 2012-09-21 Bo-Gang Lin Improved artificial electronic retina structure
US20130304155A1 (en) * 2012-05-09 2013-11-14 Po-Kang Lin Structure of Artificial Electronic Retina

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