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WO2017006335A1 - Procédé de préparation de monohydrate de 7-[(3r)-3-amino-1-oxo-4-(2,4,5trifluorophényl)butyl]- 5,6,7,8-tétrahydro-3-(trifluorométhyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate et sa nouvelle forme cristalline h - Google Patents

Procédé de préparation de monohydrate de 7-[(3r)-3-amino-1-oxo-4-(2,4,5trifluorophényl)butyl]- 5,6,7,8-tétrahydro-3-(trifluorométhyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate et sa nouvelle forme cristalline h Download PDF

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Publication number
WO2017006335A1
WO2017006335A1 PCT/IN2015/000329 IN2015000329W WO2017006335A1 WO 2017006335 A1 WO2017006335 A1 WO 2017006335A1 IN 2015000329 W IN2015000329 W IN 2015000329W WO 2017006335 A1 WO2017006335 A1 WO 2017006335A1
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WO
WIPO (PCT)
Prior art keywords
butyl
amino
tetrahydro
triazolo
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000329
Other languages
English (en)
Inventor
Vijay Trimbak KADAM
Nareesh SARANAPU
Sri Hari SINGAMPALLI
Harpreet Singh Minhas
Gurpreet Singh MINHAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harman Finochem Ltd
Original Assignee
Harman Finochem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harman Finochem Ltd filed Critical Harman Finochem Ltd
Publication of WO2017006335A1 publication Critical patent/WO2017006335A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne un procédé de préparation de monohydrate de 7-[(3R)-3-amino-1-oxo-4- (2,4,5trifluorophényl)butyl]-5,6,7,8-tétrahydro-3-(trifluorométhyl)-1,2,4-triazolo[4,3- a]pyrazine phosphate.
PCT/IN2015/000329 2015-07-03 2015-08-24 Procédé de préparation de monohydrate de 7-[(3r)-3-amino-1-oxo-4-(2,4,5trifluorophényl)butyl]- 5,6,7,8-tétrahydro-3-(trifluorométhyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate et sa nouvelle forme cristalline h Ceased WO2017006335A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2561MU2015 2015-07-03
IN2561/MUM/2015 2015-07-03

Publications (1)

Publication Number Publication Date
WO2017006335A1 true WO2017006335A1 (fr) 2017-01-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000329 Ceased WO2017006335A1 (fr) 2015-07-03 2015-08-24 Procédé de préparation de monohydrate de 7-[(3r)-3-amino-1-oxo-4-(2,4,5trifluorophényl)butyl]- 5,6,7,8-tétrahydro-3-(trifluorométhyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate et sa nouvelle forme cristalline h

Country Status (1)

Country Link
WO (1) WO2017006335A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651373A (zh) * 2017-10-11 2019-04-19 江苏瑞科医药科技有限公司 一种西格列汀磷酸盐单水合物晶型的制备方法
CN112745320A (zh) * 2019-10-31 2021-05-04 浙江苏泊尔制药有限公司 一种磷酸西他列汀单水合物晶型的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009070314A2 (fr) * 2007-11-26 2009-06-04 Teva Pharmaceutical Industries Ltd. Forme cristalline de sitagliptine
US20090247532A1 (en) * 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009070314A2 (fr) * 2007-11-26 2009-06-04 Teva Pharmaceutical Industries Ltd. Forme cristalline de sitagliptine
US20090247532A1 (en) * 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651373A (zh) * 2017-10-11 2019-04-19 江苏瑞科医药科技有限公司 一种西格列汀磷酸盐单水合物晶型的制备方法
CN112745320A (zh) * 2019-10-31 2021-05-04 浙江苏泊尔制药有限公司 一种磷酸西他列汀单水合物晶型的制备方法

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