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WO2017089639A1 - Dispositif non invasif pour mesurer le taux de glucose dans le sang et méthode dans laquelle on utilise ledit dispositif - Google Patents

Dispositif non invasif pour mesurer le taux de glucose dans le sang et méthode dans laquelle on utilise ledit dispositif Download PDF

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Publication number
WO2017089639A1
WO2017089639A1 PCT/ES2016/070834 ES2016070834W WO2017089639A1 WO 2017089639 A1 WO2017089639 A1 WO 2017089639A1 ES 2016070834 W ES2016070834 W ES 2016070834W WO 2017089639 A1 WO2017089639 A1 WO 2017089639A1
Authority
WO
WIPO (PCT)
Prior art keywords
antennas
glucose level
blood glucose
ghz
frequency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2016/070834
Other languages
English (en)
Spanish (es)
Inventor
José María Sabater Navarro
German TORREGROSA PENALVA
Enrique BRONCHALO BRONCHALO
Ernesto AVILA NAVARRO
Oscar MORENO PÉREZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Miguel Hernandez de Elche UMH
Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la Comunitat Valenciana FISABIO
Original Assignee
Universidad Miguel Hernandez de Elche UMH
Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la Comunitat Valenciana FISABIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Miguel Hernandez de Elche UMH, Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la Comunitat Valenciana FISABIO filed Critical Universidad Miguel Hernandez de Elche UMH
Publication of WO2017089639A1 publication Critical patent/WO2017089639A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Definitions

  • the invention described herein is directed to the field of blood glucose level measurements, such as so-called glucometers.
  • this device describes a device belonging to the field of dielectric characterization of biological tissues, specifically in its non-invasive mode.
  • the application of this device is framed within the non-invasive measurement of blood glucose level, and in this sense it is contextualized in technology for medicine, specifically in electronic assistive devices for the treatment of diabetes.
  • the present invention aims to provide the user with the ability to monitor their blood glucose level whenever they wish, avoiding the uncomfortable and annoying punctures necessary for blood collection required by current level measurement devices. of glucose Thus, it falls within the field of non-invasive blood glucose level measurement.
  • One of the first works in this context is found in a device in contact with the eye responsible for detecting various physical and chemical parameters of the body and non-invasively supply different compounds according to the measurements obtained (US 7,403,805 B2).
  • the first non-invasive glucose level measurement systems are found in a device based on the transmission and reflection of ultrasound pulses (US 9,167,993 B2), as well as another one with similar characteristics that uses optical emitters and receivers ( US 7,251, 516 B2).
  • the present invention consists of a non-invasive device for measuring blood glucose level, a device that is based on an electronic sensor capable of determining the blood glucose level of an individual in a non-invasive manner.
  • the sensor is able to determine the level of blood glucose without coming into contact with the blood, and therefore without the need to extract any amount of blood from the individual himself.
  • the sensor consists of two resonating antennas at differentiated microwave frequencies, which act at different frequencies. Measuring frequencies are set within the microwave range, between 1 and 3 GHz.
  • the operation is based on the simultaneous measurement of the resonance frequency of both antennas, a frequency that varies according to the dielectric permittivity of the medium adjacent to the antenna.
  • the antennas are placed on a biological tissue, such as a user's tongue, their resonance frequencies will be affected by the permittivity of that language.
  • a biological tissue such as a user's tongue
  • their resonance frequencies will be affected by the permittivity of that language.
  • the dielectric permittivity of biological tissues is affected by the level of blood glucose.
  • both antennas are brought closer to the tongue, their resonance frequencies will change depending on the dielectric permittivity of the tongue, which in turn will be affected by the level of blood glucose (blood glucose).
  • the sensor is responsible for obtaining the two resonance frequencies of the resonant antennas and identifying in each of them the variation that has occurred with respect to the vacuum resonance frequency.
  • the antennas are developed using microstrip technology, which produces a fast and accurate response that is easily integrated with the rest of the electronics.
  • this technology allows to implement the antennas in a small size and suitable for a portable system that fits the dimensions necessary for a personal and portable system.
  • Figure 1.- Shows a flow chart of a possible mode of operation of the device object of the invention.
  • Figure 2. Shows a flow chart of a possible alternative mode of operation of the device object of the invention.
  • Figure 3. Shows an illustration showing the placement of the antennae with respect to the tongue to carry out the glucose measurement.
  • Figure 4.- Shows a perspective view of the device object of the invention where the antennas and the screen thereof are appreciated.
  • the means where the measurements are made is a biological tissue (4) of a user whose glucose level is to be determined.
  • the biological tissue (4) is tissue comprised in the language of the user whose glucose level is to be measured; the reasons for this selection are justified by various factors, on the one hand, its low fat content is very beneficial, since fat is an element with a greater presence in other parts of the body that hinders the variations of dielectric permittivity while on the other On the other hand, the low influence of saliva on the permittivity of the tongue, which allows the measures to be associated only with the permittivity of the blood circulating through the tongue.
  • the tongue comprises the appropriate biological tissue (4) because it is a very vascularized area that notably accuses the changes of permittivity in the blood.
  • the thermal stability that it usually enjoys is a new point in favor that indicates it as one of the ideal areas to perform this type of measurement, since the dielectric permittivity is severely affected by sudden changes in temperature.
  • a non-invasive device (1) for measuring blood glucose level which allows measurements to be made by at least two resonator antennas (21, 22) to microwave frequencies and developed in microstrip technology corresponding to the Antenna 1 and Antenna 2 blocks of figures 1 and 2, the biological tissue (4) of the user whose glucose level is to be measured is placed between both resonator antennas (21, 22) , the first antenna (21) being able to remain above the biological tissue (4) and the second antenna (22) below the biological tissue (4) but always at least partially opposite each other, also in this preferred embodiment each of the resonator antennas (21, 22) would be placed above and below the tongue respectively.
  • each of the resonator antennas (21, 22) can be measured separately as can be seen in Figures 1 and 2, but both perform it in the same medium and at the same time.
  • the two resonant antennas (21, 22) are placed opposite each other in a structure so that the biological tissue (4) of the user whose glucose level is to be measured can be placed between them, and remains as one of the antennas (21, 22) on the biological tissue (4) and the other below it have been described before, and they are operated simultaneously at frequencies between 1GHz and 3 GHz.
  • the resonant antennas (21, 22) are connected to a process unit (not shown in the figures) that contains a control electronics and a variable frequency signal generator (not shown in the figures) that scans in a frequency range between 1 GHz and 3 GHz, preferably 1 GHz centered on the resonant frequency of each antenna (21, 22), that is, from a frequency located 0.5 GHz below the resonant frequency to a situated 0.5 GHz above, for each of the resonant antennas (21, 22).
  • the response of the resonant antennas (21, 22) to this scan is also captured by the control electronics of the process unit and is subsequently sent to a processing electronics of the process unit, which will digitize the signals and process them for extract various parameters such as the resonant frequency of each of the resonant antennas (21, 22), the maximum amplitude of each signal or its mid-bandwidth (FWHM).
  • FWHM mid-bandwidth
  • the processing electronics proceed to calculate the blood glucose level of the individual.
  • the variations in the resonance frequencies in the resonator antennas (21, 22) produced by the changes in the dielectric permittivity of the medium are measured, and subsequently extracted from them the user's blood glucose level by correlation between changes and amount of glucose, all in a non-invasive way for it.
  • the responses are measured and analyzed in differential mode, not only taking into account the shifts of the resonance frequencies near the user with respect to those of the vacuum, but also the differences between the displacements observed in each of the antennas ( 21, 22) resonators.
  • the device (1) possess temperature and / or pressure sensors to be able to consider these data in the calculations.
  • the result of the measurement is visualized by means of a digital display (3).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif et une méthode dans laquelle on utilise ledit dispositif pour mesurer les taux de glucose dans le sang de manière non invasive. Pour ce faire, on fait appel à des antenne à ondes ultra-courtes résonantes disposées de manière opposée entre elles avec la langue de l'utilisateur, objet de la mesure, située entre les deux antennes. Les variations dans les fréquences de résonance des antennes produites par les changements de permittivité électrique du milieu, la langue, permettent de déterminer le taux de glucose de l'utilisateur dont le taux de glucose doit être mesuré, à partir des ces variations de sorte que les réponses aux changements peuvent être traitées par corrélation pour déterminer lesdits taux de glucose.
PCT/ES2016/070834 2015-11-24 2016-11-23 Dispositif non invasif pour mesurer le taux de glucose dans le sang et méthode dans laquelle on utilise ledit dispositif Ceased WO2017089639A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201531702A ES2621006B1 (es) 2015-11-24 2015-11-24 Dispositivo no invasivo para medir nivel de glucosa en sangre y método que hace uso del mismo
ES201531702 2015-11-24

Publications (1)

Publication Number Publication Date
WO2017089639A1 true WO2017089639A1 (fr) 2017-06-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2016/070834 Ceased WO2017089639A1 (fr) 2015-11-24 2016-11-23 Dispositif non invasif pour mesurer le taux de glucose dans le sang et méthode dans laquelle on utilise ledit dispositif

Country Status (2)

Country Link
ES (1) ES2621006B1 (fr)
WO (1) WO2017089639A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021245376A1 (fr) * 2020-06-02 2021-12-09 Applied Monitoring Limited Dispositif de détection de substance non invasive
WO2025175650A1 (fr) * 2024-02-20 2025-08-28 臻晟极点(上海)医疗科技有限公司 Glucomètre à micro-ondes non invasif pouvant être porté

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069791A1 (fr) * 2001-03-06 2002-09-12 Pendragon Medical Ltd. Procede et dispositif destines a determiner la concentration d'une substance dans un liquide corporel
US20080319285A1 (en) * 2005-07-06 2008-12-25 Ferlin Medical Ltd. Apparatus and Method for Measuring Constituent Concentrations within a Biological Tissue Structure
WO2012059741A1 (fr) * 2010-11-01 2012-05-10 University College Cardiff Consultants Limited Surveillance in vivo avec des micro-ondes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069791A1 (fr) * 2001-03-06 2002-09-12 Pendragon Medical Ltd. Procede et dispositif destines a determiner la concentration d'une substance dans un liquide corporel
US20080319285A1 (en) * 2005-07-06 2008-12-25 Ferlin Medical Ltd. Apparatus and Method for Measuring Constituent Concentrations within a Biological Tissue Structure
WO2012059741A1 (fr) * 2010-11-01 2012-05-10 University College Cardiff Consultants Limited Surveillance in vivo avec des micro-ondes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021245376A1 (fr) * 2020-06-02 2021-12-09 Applied Monitoring Limited Dispositif de détection de substance non invasive
WO2025175650A1 (fr) * 2024-02-20 2025-08-28 臻晟极点(上海)医疗科技有限公司 Glucomètre à micro-ondes non invasif pouvant être porté

Also Published As

Publication number Publication date
ES2621006A1 (es) 2017-06-30
ES2621006B1 (es) 2018-04-10

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