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WO2016203016A1 - Utilisation de matériaux en polyéthylène dans la production de récipients de liquide stérilisables - Google Patents

Utilisation de matériaux en polyéthylène dans la production de récipients de liquide stérilisables Download PDF

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Publication number
WO2016203016A1
WO2016203016A1 PCT/EP2016/064081 EP2016064081W WO2016203016A1 WO 2016203016 A1 WO2016203016 A1 WO 2016203016A1 EP 2016064081 W EP2016064081 W EP 2016064081W WO 2016203016 A1 WO2016203016 A1 WO 2016203016A1
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WO
WIPO (PCT)
Prior art keywords
liquid container
temperature
use according
liquid
polyethylene material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2016/064081
Other languages
English (en)
Inventor
Marnik Vaes
Bernardus Aldegonda Josephus RAVEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SABIC Global Technologies BV
Original Assignee
SABIC Global Technologies BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SABIC Global Technologies BV filed Critical SABIC Global Technologies BV
Priority to US15/736,591 priority Critical patent/US10828860B2/en
Priority to CN201680035446.5A priority patent/CN107750258A/zh
Priority to EP16733344.2A priority patent/EP3310550B1/fr
Publication of WO2016203016A1 publication Critical patent/WO2016203016A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B1/00—Layered products having a non-planar shape
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F110/00—Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F110/02—Ethene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/0005—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor characterised by the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/04—Extrusion blow-moulding
    • B29C49/0411—Means for defining the wall or layer thickness
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/071—Preforms or parisons characterised by their configuration, e.g. geometry, dimensions or physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/4273—Auxiliary operations after the blow-moulding operation not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/64—Heating or cooling preforms, parisons or blown articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B1/00—Layered products having a non-planar shape
    • B32B1/08—Tubular products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0207—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by material, e.g. composition, physical features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/0261—Bottom construction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F210/00—Copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F210/02—Ethene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/06—PE, i.e. polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7128—Bags, sacks, sachets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7148—Blood bags, medical bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7158—Bottles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2500/00—Characteristics or properties of obtained polyolefins; Use thereof
    • C08F2500/12—Melt flow index or melt flow ratio

Definitions

  • the present invention relates to the use of a polyethylene material in the production of liquid containers sterilisable at ⁇ 100 °C.
  • liquid containers for medical applications In order for liquid containers for medical applications to be suitable for a safe use in treatment of patients, as humans and animals, such containers are often used only once and subjected to a sterilisation treatment.
  • Polymer materials and especially polyethylene are thereby easy to process in a so called blow-fill-seal process, where the liquid container is formed especially for example by blow moulding, filled with a liquid and sealed.
  • Polyethylene can further be recycled, so that it is often used for such kind of application.
  • the sterilisation treatment is thereby directed at reducing the quantity of micro-organisms present in or on an object in such way as to reduce any associated risk to the health of the patient that undergoes a treatment involving such containers.
  • EP601631A1 Liquid containers for medical applications that may undergo sterilisation treatments are for example described in EP601631A1 .
  • EP601631A1 describes containers made from polyethylene compositions comprising 20-50 wt% linear low-density polyethylene having a density of 915-935 kg/m 3 and 50-80 wt% of a linear low-density polyethylene having a density of 920-965 kg/m 3 .
  • Such containers are subjected to sterilisation at 1 10°C. No indication is presented as to the period of sterilisation.
  • a disadvantage of such containers is that they comprise linear low-density polyethylene materials which, by nature of their production process, contain residues originating from catalysts. Such residues may for example include tetrahydrofuran, chromium, zirconium and/or hafnium. Because of the presence of such restudies, these materials are not suitable for certain medical applications.
  • US201 10120058A1 describes the use of linear low-density polyethylenes prepared using a zirconium-metallocene catalyst, in which the linear low-density
  • polyethylene has a density of 935 kg/m 3 , from which pouches are made that are subjected to sterilisation at 1 19°C for 15 minutes. Also for these containers, a disadvantage is that they comprise linear low-density polyethylene materials which again contains residues from the catalyst.
  • the use according to the present invention is preferably for example for disposable liquid containers, that may thus used only once.
  • the use according to the present invention moreover is preferably for example for aseptic packaging.
  • the density of the polyethylene material used according to the invention as determined according to ISO 1 183-1 (2012), method A may for example be ⁇ 950 kg/m 3 , alternatively ⁇ 940 kg/m 3 , alternatively ⁇ 935 kg/m 3 , alternatively ⁇ 930 kg/m 3 .
  • the density of the polyethylene material used according to the invention as determined according to ISO 1 183- 1 (2012), method A may for example be ⁇ 928 kg/m 3 .
  • Such density may for example contribute to a good shape stability during sterilisation. Shape stability can be understood to be the retention of the original shape of liquid container or filled liquid container during sterilisation. A liquid container that has good shape stability may for example not show thermal deformation or durable thermal deformation during sterilisation.
  • a liquid container that has good shape stability during sterilisation may thus for example preferably not demonstrate changes in shape, especially durable changes in shape, such as for example the formation of bumps, ripples, dents and/or bulges and/or sagging and/or changes of volume. Durable may thereby mean that persists and/or remains visible after sterilisation.
  • a liquid container that has good shape stability may for example preferably also not leak during sterilisation. A good shape stability during sterilisation thereby becomes increasingly important not only for aesthetic reasons but also because it strongly fosters the medical personnel's confidence and the ability to subject the liquid container to proper sterilisation as well as well as the trust in a quality treatment.
  • the melt mass flow rate of the polyethylene material used according to the invention as determined according to ISO 1 133-1 (201 1 ) at a temperature of 190°C and a load of 2.16 kg may for example be ⁇ 1.00 g/10 min, alternatively ⁇ 0.90 g/10 min, alternatively ⁇ 0.80 g/10 min, alternatively ⁇ 0.70 g/10 min, alternatively ⁇ 0.60 g/10 min.
  • the melt mass flow rate of the polyethylene material as determined according to ISO 1 133-1 (201 1 ) at a temperature of 190°C and a load of 2.16 kg may for example be ⁇ 0.30 g/10 min, alternatively ⁇ 0.35 g/10 min, alternatively ⁇ 0.40 g/10 min, alternatively ⁇ 0.45 g/10 min, alternatively ⁇ 0.50 g/10 min.
  • the melt mass flow rate of the polyethylene material as determined according to ISO 1 133-1 (201 1 ) at a temperature of 190°C and a load of 2.16 kg may for example be ⁇ 0.30 and ⁇ 1 .00 g/10 min, alternatively ⁇ 0.40 and ⁇ 0.80 g/10min, alternatively ⁇ 0.50 and ⁇ 0.60 g/10 min.
  • melt mass flow rate may for example result in a material having good processability in blow-fill-seal production processes.
  • Such melt mass flow rate may for example contribute to a good processability and/or a good melt stability in the parison blow moulding stage in the blow-fill-seal production process. Furthermore, it may also contribute to a good shape stability during sterilisation.
  • liquid containers may for example be bottles, vials, ampoules, tubes, bags or pouches.
  • the liquid containers may be flexible containers, such as flexible intravenous bag or flexible intravenous bottles, preferably a (pre- )filled with a liquid.
  • the liquid container can thereby for example contain for example liquids, solutions and/or suspensions of medical materials used for medical treatment of patients, including for example intravenous treatments.
  • the liquid containers may furthermore for example have a volume of ⁇ 0.100 I, alternatively ⁇ 0.200 I, alternatively ⁇ 0.400 I, alternatively ⁇ 0.500 I.
  • Such liquid containers may for example have a volume of ⁇ 2.000 I, alternatively ⁇ 1.500 I, alternatively ⁇ 1.000 I, alternatively ⁇ 0.750 I.
  • such liquid containers may have a volume of ⁇ 0.100 I and ⁇ 1.000 I, alternatively ⁇ 0.200 I and ⁇ 0.750 I.
  • Liquid containers according to the present invention may for example be sterilisable via a heat treatment.
  • this heat treatment may especially take place in the presence of steam and/or under pressure, especially in an autoclave.
  • pressure may be between 1 bar and 3 bar, preferably between 2 bar and 3 bar, further preferred ⁇ 10 bar.
  • the duration of the sterilisation process may for example be ⁇ 15 min, alternatively ⁇ 30 min, alternatively ⁇ 45 min, alternatively ⁇ 60 min, alternatively ⁇ 75 min.
  • the liquid containers according to the present invention may for example be sterilisable at temperatures of ⁇ 100 °C, alternatively ⁇ 105 °C, alternatively ⁇ 1 10 °C, preferably between 1 10 °C and 1 15 °C, even more preferred at 1 10 °C. At such high temperatures and especially for examples for duration of ⁇ 15 min shape stability becomes increasingly difficult to maintain.
  • the materials used according to the present invention have thereby surprisingly show very good shape stability even for sterilisation at relatively high temperatures and/or for long durations.
  • a liquid container may be for example pre-filled.
  • pre-filled is to be understood to be filled upon or right after production of the liquid container and/or prior to being subjected to a sterilisation process.
  • a pre-filled liquid container may for example be produced by filling the liquid container as part of its production process or right thereafter, especially for example in a so-called 'blow-fill-seal'- process (BFS-process).
  • BFS-process 'blow-fill-seal'- process
  • liquid containers may be produced by an extrusion blow moulding process, in which directly upon moulding of the liquid container or right thereafter, it is filled with a liquid material and sealed.
  • liquid containers may be also produced by extrusion blow moulding and filled at a later stage.
  • the polyethylene material used according to the present invention may for example be a polyethylene material comprising ⁇ 90.0 mol-%, alternatively ⁇ 95.0 mol-%, alternatively ⁇ 98.0 mol-%, alternatively ⁇ 99.0 mol-%, alternatively ⁇ 99.9 mol-%, of structural units in the polymer chains deriving from ethylene monomers. It may also preferably for example not comprise catalyst/metal residues, such as especially metallocene residues, and/or any LLDPE.
  • the polyethylene material used according to the present invention may preferably for example be produced in a high-pressure free-radical polymerisation process.
  • the polyethylene material may for example be produced in a tubular reactor.
  • the polyethylene may for example be produced in a polymerisation process operated at a pressure of ⁇ 1600 bar, alternatively ⁇ 1800 bar, alternatively ⁇ 2000 bar, alternatively ⁇ 2200 bar, alternatively ⁇ 2400 bar.
  • the polyethylene material may for example be produced in the presence of a free- radical initiator and/or without using a catalyst and/or without using any metal containing compound.
  • the production method thereby for example influences the structure, crystallinity and/or molecular weight distribution of the polyethylene material and thereby contributes both to a good processability and a very good shape stability during sterilisation.
  • the use according to the present invention may be for liquid containers that can for example comprise multiple layers. Alternatively, use according to the present invention may be for liquid containers that preferably consist of a single layer.
  • the use according to the present invention may be for liquid container produced via a process comprising the steps of: a) providing a melt comprising the polyethylene material;
  • liquid container may be subjected to a sterilisation treatment at a temperature of ⁇ 100 °C during a period of ⁇ 15 minutes.
  • Said melt may thereby be provided by subjecting the polyethylene material to a melt extrusion process.
  • Said parison may be produced for example by feeding the molten material from the melt extrusion process into a mold having the shape of the parison.
  • the pressurised gas may be a sterilized and/or medical grade gas.
  • the use according to the present invention may be for liquid container with a wall thickness of ⁇ 200 ⁇ , alternatively ⁇ 150 ⁇ , alternatively ⁇ 100 ⁇ .
  • such layer may have a thickness of ⁇ 20 ⁇ , alternatively ⁇ 50 ⁇ .
  • such layer may have a thickness of ⁇ 20 and ⁇ 150 ⁇ , alternatively ⁇ 50 and ⁇ 100 ⁇ .
  • the use according to the present invention may be for liquid container produced via a process in which the sealing step f) is performed by
  • Liquid containers were prepared in the same way for example I and II on a Rommelag Bottlepack 321 Blow-Fill-Seal machine. The only difference thus being in the material used.
  • Example I was performed according to the invention; example II was performed using a polyethylene material for comparative purposes.
  • PE-A was a polyethylene of the grade SABIC® LDPE PCG06 obtainable from SABIC, produced in a tubular high-pressure free-radical polymerisation process at a pressure of 2800 bar;
  • PE-B was a polyethylene of the grade PE3020D obtainable from LyondellBasell.
  • the density was determined in accordance with ISO 1 183-1 (2012), relating to methods for the determination of density of non-cellular plastics, using method A.
  • the melt mass flow rate was determined in accordance with ISO 1 133-1 (201 1 ), relating to the determination of the melt mass-flow rate and the melt volume-flow rate of thermoplastics, at a temperature of 190°C and a load of 2.16 kg.
  • Shape stability on sterilisation is determined by subjecting liquid containers obtained from examples I and II to a sterilisation treatment with steam in an autoclave at a temperature of 106°C for 85 minutes. After that sterilisation treatment shape stability during sterilisation has been assessed visually.
  • the presented examples show that the use of a polyethylene material having a density of ⁇ 928 kg/m 3 as determined according to ISO 1 183-1 (2012), method A, and a melt mass flow rate of ⁇ 0.30 and ⁇ 1.00 g/10 min as determined according to ISO 1 133-1 (201 1 ) at a temperature of 190°C and a load of 2.16 kg, produced in a high-pressure free-radical polymerisation process at a pressure of ⁇ 1600 bar for the production of liquid containers sterilisable at ⁇ 100 °C can surprisingly lead to an significantly increased shape stability during sterilisation compared to the use of an industry standard material, frequently used for such application and having otherwise very similar properties.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Geometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ceramic Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne l'utilisation d'un matériau en polyéthylène dans des récipients de liquide qui sont stérilisables à une température de ≥ 100°C durant une période de > 15 minutes, le matériau de polyéthylène ayant une densité > 928 kg/m3 telle que déterminée selon la norme ISO 1183-1, procédé A, et un débit de la masse fondue de ≥ 0,50 et 51,00 g/10 min tel que déterminé selon la norme ISO 1133-1 à une température de 190°C et une charge de 2,16 kg ; le matériau de polyéthylène étant produit dans un procédé de polymérisation radicalaire sous haute pression à une pression de ≥ 1 600 bars.
PCT/EP2016/064081 2015-06-18 2016-06-17 Utilisation de matériaux en polyéthylène dans la production de récipients de liquide stérilisables Ceased WO2016203016A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/736,591 US10828860B2 (en) 2015-06-18 2016-06-17 Use of polyethylene materials in the production of sterilisable liquid containers
CN201680035446.5A CN107750258A (zh) 2015-06-18 2016-06-17 聚乙烯材料在生产可灭菌的液体容器中的用途
EP16733344.2A EP3310550B1 (fr) 2015-06-18 2016-06-17 Utilisation de matériaux de type polyéthylène dans la fabrication de récipients de liquide stérilisables

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15172647 2015-06-18
EP15172647.8 2015-06-18

Publications (1)

Publication Number Publication Date
WO2016203016A1 true WO2016203016A1 (fr) 2016-12-22

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Application Number Title Priority Date Filing Date
PCT/EP2016/064081 Ceased WO2016203016A1 (fr) 2015-06-18 2016-06-17 Utilisation de matériaux en polyéthylène dans la production de récipients de liquide stérilisables

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EP3310550B1 (fr) 2025-04-23

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