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WO2016200614A3 - Bacteria engineered to treat diseases associated with hyperammonemia - Google Patents

Bacteria engineered to treat diseases associated with hyperammonemia Download PDF

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Publication number
WO2016200614A3
WO2016200614A3 PCT/US2016/034200 US2016034200W WO2016200614A3 WO 2016200614 A3 WO2016200614 A3 WO 2016200614A3 US 2016034200 W US2016034200 W US 2016034200W WO 2016200614 A3 WO2016200614 A3 WO 2016200614A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyperammonemia
diseases associated
treat diseases
bacteria engineered
bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/034200
Other languages
French (fr)
Other versions
WO2016200614A2 (en
Inventor
Dean Falb
Vincent M. ISABELLA
Jonathan W. KOTULA
Paul F. Miller
Suman MACHINANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synlogic Inc
Original Assignee
Synlogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/960,333 external-priority patent/US9487764B2/en
Priority claimed from PCT/US2016/020530 external-priority patent/WO2016141108A1/en
Application filed by Synlogic Inc filed Critical Synlogic Inc
Priority to AU2016274311A priority Critical patent/AU2016274311A1/en
Priority to EP16731402.0A priority patent/EP3307879A2/en
Priority to JP2017564379A priority patent/JP6817966B2/en
Priority to CA2988930A priority patent/CA2988930A1/en
Publication of WO2016200614A2 publication Critical patent/WO2016200614A2/en
Priority to EP17703255.4A priority patent/EP3402498A1/en
Priority to PCT/US2017/013072 priority patent/WO2017123675A1/en
Priority to US16/069,220 priority patent/US11723932B2/en
Priority to CA3011283A priority patent/CA3011283A1/en
Publication of WO2016200614A3 publication Critical patent/WO2016200614A3/en
Priority to PCT/US2017/017552 priority patent/WO2017139697A1/en
Anticipated expiration legal-status Critical
Priority to US18/326,637 priority patent/US20240180974A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
PCT/US2016/034200 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia Ceased WO2016200614A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2016274311A AU2016274311A1 (en) 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia
EP16731402.0A EP3307879A2 (en) 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia
JP2017564379A JP6817966B2 (en) 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia
CA2988930A CA2988930A1 (en) 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia
CA3011283A CA3011283A1 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
US16/069,220 US11723932B2 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
PCT/US2017/013072 WO2017123675A1 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
EP17703255.4A EP3402498A1 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
PCT/US2017/017552 WO2017139697A1 (en) 2016-02-10 2017-02-10 Bacteria engineered to treat diseases associated with hyperammonemia
US18/326,637 US20240180974A1 (en) 2016-01-11 2023-05-31 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
US201562173706P 2015-06-10 2015-06-10
US201562173710P 2015-06-10 2015-06-10
US62/173,706 2015-06-10
US62/173,710 2015-06-10
US201562183935P 2015-06-24 2015-06-24
US62/183,935 2015-06-24
US201562184770P 2015-06-25 2015-06-25
US201562184811P 2015-06-25 2015-06-25
US62/184,811 2015-06-25
US62/184,770 2015-06-25
US201562248805P 2015-10-30 2015-10-30
US62/248,805 2015-10-30
US201562256039P 2015-11-16 2015-11-16
US201562256048P 2015-11-16 2015-11-16
US201562256041P 2015-11-16 2015-11-16
US62/256,048 2015-11-16
US62/256,041 2015-11-16
US62/256,039 2015-11-16
US201562263329P 2015-12-04 2015-12-04
US62/263,329 2015-12-04
US14/960,333 US9487764B2 (en) 2014-12-05 2015-12-04 Bacteria engineered to treat diseases associated with hyperammonemia
US14/960,333 2015-12-04
US201662277654P 2016-01-12 2016-01-12
US62/277,654 2016-01-12
US201662291468P 2016-02-04 2016-02-04
US62/291,468 2016-02-04
US201662293749P 2016-02-10 2016-02-10
US62/293,749 2016-02-10
PCT/US2016/020530 WO2016141108A1 (en) 2015-03-02 2016-03-02 Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
USPCT/US16/020530 2016-03-02

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2016/032565 Continuation-In-Part WO2016183532A1 (en) 2014-12-05 2016-05-13 Bacteria engineered to treat a disease or disorder
PCT/US2016/032556 Continuation WO2016183529A1 (en) 2015-05-13 2016-05-13 Translating machine codes to store metadata and to propagate metadata for run time checking of programming errors

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US15/164,828 Continuation-In-Part US9688967B2 (en) 2014-12-05 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia
US16/069,220 Continuation-In-Part US11723932B2 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
US16/069,220 Continuation US11723932B2 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
PCT/US2017/013072 Continuation-In-Part WO2017123675A1 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells

Publications (2)

Publication Number Publication Date
WO2016200614A2 WO2016200614A2 (en) 2016-12-15
WO2016200614A3 true WO2016200614A3 (en) 2017-01-12

Family

ID=57504262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/034200 Ceased WO2016200614A2 (en) 2015-06-10 2016-05-25 Bacteria engineered to treat diseases associated with hyperammonemia

Country Status (5)

Country Link
EP (1) EP3307879A2 (en)
JP (2) JP6817966B2 (en)
AU (1) AU2016274311A1 (en)
CA (1) CA2988930A1 (en)
WO (1) WO2016200614A2 (en)

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WO2017136795A1 (en) 2016-02-04 2017-08-10 Synlogic, Inc. Bacteria engineered to treat diseases associated with tryptophan metabolism
MX2019014027A (en) * 2017-05-24 2020-08-03 Thoeris Gmbh Use of glutamine synthetase for treating hyperammonemia.
CN119875972A (en) * 2017-12-05 2025-04-25 比奥普来克斯有限公司 Methods and compositions for preventing microbial infection
CN110446259B (en) * 2018-05-04 2022-04-15 大唐移动通信设备有限公司 Position determination method of paging opportunity and communication equipment
EP3963046A1 (en) 2019-04-29 2022-03-09 Synlogic Operating Company, Inc. Enumeration of genetically engineered microorganisms by live cell counting techniques
WO2020239882A1 (en) 2019-05-30 2020-12-03 Recordati Industria Chimica E Farmaceutica S.P.A. Pharmaceutical formulation for carglumic acid
WO2020247594A1 (en) 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
US12290540B2 (en) 2019-11-29 2025-05-06 Jinis Co., Ltd Strain having ability to lower blood ammonia levels and composition comprising same for neuronal protection
EP3839051A1 (en) * 2019-12-19 2021-06-23 Evonik Operations GmbH Method for the fermentative production of guanidinoacetic acid
CN116670269A (en) 2020-12-02 2023-08-29 同生运营公司 Engineered microorganisms
KR20230151530A (en) 2021-03-31 2023-11-01 닛폰세이테츠 가부시키가이샤 Non-oriented electrical steel sheet, punching method for non-oriented electrical steel sheet, and mold for punching non-oriented electrical steel sheet
CN120000813A (en) * 2025-02-17 2025-05-16 温州医科大学 Application of engineered probiotics in the prevention and treatment of Alzheimer's disease

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Publication number Publication date
EP3307879A2 (en) 2018-04-18
JP2018523978A (en) 2018-08-30
CA2988930A1 (en) 2016-12-15
AU2016274311A1 (en) 2018-01-18
WO2016200614A2 (en) 2016-12-15
JP6817966B2 (en) 2021-01-20
JP2021061846A (en) 2021-04-22

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