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WO2016126122A3 - Composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing exosomes extracted from stem cells differentiating into chondrocytes - Google Patents

Composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing exosomes extracted from stem cells differentiating into chondrocytes Download PDF

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Publication number
WO2016126122A3
WO2016126122A3 PCT/KR2016/001230 KR2016001230W WO2016126122A3 WO 2016126122 A3 WO2016126122 A3 WO 2016126122A3 KR 2016001230 W KR2016001230 W KR 2016001230W WO 2016126122 A3 WO2016126122 A3 WO 2016126122A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
chondrocyte differentiation
tissue regeneration
cartilage
chondrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2016/001230
Other languages
French (fr)
Korean (ko)
Other versions
WO2016126122A2 (en
Inventor
조용우
최지숙
우창희
최영찬
조동규
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry University Cooperation Foundation IUCF HYU
Original Assignee
Industry University Cooperation Foundation IUCF HYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160013293A external-priority patent/KR101706642B1/en
Application filed by Industry University Cooperation Foundation IUCF HYU filed Critical Industry University Cooperation Foundation IUCF HYU
Priority to EP16746863.6A priority Critical patent/EP3235500B1/en
Priority to JP2017538397A priority patent/JP6577038B2/en
Priority to CN201680008522.3A priority patent/CN107223153B/en
Publication of WO2016126122A2 publication Critical patent/WO2016126122A2/en
Publication of WO2016126122A3 publication Critical patent/WO2016126122A3/en
Priority to US15/642,156 priority patent/US20170296590A1/en
Anticipated expiration legal-status Critical
Priority to US17/894,936 priority patent/US20230047434A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to: a composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing, as active ingredients, exosomes extracted from stem cells differentiating into chondrocytes; a medium composition for chondrocyte differentiation induction, an injection for cartilage tissue regeneration, and a pharmaceutical composition for treating cartilage disorders, all of which contain the composition; and a method for treating cartilage disorders. According to one specific embodiment of the present invention, the composition for chondrocyte differentiation induction or cartilage regeneration contains, as active factors, exosomes extracted from stem cells differentiating into chondrocytes. Exosomes to be secreted during stem cell differentiation contain growth factors associated with chondrocyte differentiation, and genes and proteins associated with stem cell proliferation and regeneration, and thus the induction of damaged cartilage tissue regeneration is excellent. In addition, an active material can be stably and rapidly delivered as a cell-derived vehicle into cells while side effects on a conventional cell therapeutic agent are minimized. Therefore, a patient's pain can be reduced through a simple operation by means of an injection composition for preventing and treating cartilage disorders, and cartilage disorders can be continuously and effectively treated after an operation.
PCT/KR2016/001230 2015-02-04 2016-02-04 Composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing exosomes extracted from stem cells differentiating into chondrocytes Ceased WO2016126122A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP16746863.6A EP3235500B1 (en) 2015-02-04 2016-02-04 Composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing exosomes extracted from stem cells differentiating into chondrocytes
JP2017538397A JP6577038B2 (en) 2015-02-04 2016-02-04 Composition for inducing differentiation into chondrocytes containing exosomes derived from stem cells differentiated into chondrocytes or for regeneration of cartilage tissue
CN201680008522.3A CN107223153B (en) 2015-02-04 2016-02-04 Composition for chondrocyte differentiation induction or cartilage tissue regeneration comprising exosomes derived from stem cells that are differentiating into chondrocytes
US15/642,156 US20170296590A1 (en) 2015-02-04 2017-07-05 Composition for inducing chondrocyte differentiation and regenerating cartilage tissue
US17/894,936 US20230047434A1 (en) 2015-02-04 2022-08-24 Composition for inducing chondrocyte differentiation and regenerating cartilage tissue

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2015-0017349 2015-02-04
KR20150017349 2015-02-04
KR1020160013293A KR101706642B1 (en) 2015-02-04 2016-02-03 Composition comprising exosomes extracted from stem cells which differentiate into chondrocytes for inducing chondrogenic differentiation or regenerating cartilage tissue
KR10-2016-0013293 2016-02-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/642,156 Continuation US20170296590A1 (en) 2015-02-04 2017-07-05 Composition for inducing chondrocyte differentiation and regenerating cartilage tissue

Publications (2)

Publication Number Publication Date
WO2016126122A2 WO2016126122A2 (en) 2016-08-11
WO2016126122A3 true WO2016126122A3 (en) 2016-10-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/001230 Ceased WO2016126122A2 (en) 2015-02-04 2016-02-04 Composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing exosomes extracted from stem cells differentiating into chondrocytes

Country Status (1)

Country Link
WO (1) WO2016126122A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102056172B1 (en) * 2017-12-06 2019-12-16 주식회사 디자인셀 Composition for treating or preventing arthritis comprising culture solution of stem cell-derived exosome
US20220062348A1 (en) * 2018-09-19 2022-03-03 Yeditepe Universitesi Isolated septal cartilage exosome used for generating cartilage tissue
CN115487208A (en) * 2022-10-24 2022-12-20 格莱康美生物医学技术(北京)有限公司 A composition for treating osteoarthritis/cartilage damage and its preparation method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528706A (en) * 2003-06-27 2007-10-18 エチコン、インコーポレイテッド Repair and regeneration of cartilage and bone using postpartum cells
US20110014251A1 (en) * 2008-01-04 2011-01-20 Lydac Neuroscience Limited Microvesicles
WO2014013258A1 (en) * 2012-07-19 2014-01-23 Reneuron Limited Stem cell microparticles
CN103767985A (en) * 2012-10-22 2014-05-07 吉林省霍普金斯药物研究院有限责任公司 Preparation and application of exosome secreted by human derived blood or mesenchymal stem cell

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528706A (en) * 2003-06-27 2007-10-18 エチコン、インコーポレイテッド Repair and regeneration of cartilage and bone using postpartum cells
US20110014251A1 (en) * 2008-01-04 2011-01-20 Lydac Neuroscience Limited Microvesicles
WO2014013258A1 (en) * 2012-07-19 2014-01-23 Reneuron Limited Stem cell microparticles
CN103767985A (en) * 2012-10-22 2014-05-07 吉林省霍普金斯药物研究院有限责任公司 Preparation and application of exosome secreted by human derived blood or mesenchymal stem cell

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAUMUS, M. ET AL.: "Mesenchymal Stem Cells in Regenerative Medicine applied to Rheumatic Diseases: Role of Secretome and Exosomes", BIOCHIMIE, vol. 95, 2013, pages 2229 - 2234, XP028768026 *

Also Published As

Publication number Publication date
WO2016126122A2 (en) 2016-08-11

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