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WO2016126006A8 - Microorganism capable of producing quinolinic acid, and method for producing quinolinic acid utilizing the microorganism - Google Patents

Microorganism capable of producing quinolinic acid, and method for producing quinolinic acid utilizing the microorganism Download PDF

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Publication number
WO2016126006A8
WO2016126006A8 PCT/KR2015/014344 KR2015014344W WO2016126006A8 WO 2016126006 A8 WO2016126006 A8 WO 2016126006A8 KR 2015014344 W KR2015014344 W KR 2015014344W WO 2016126006 A8 WO2016126006 A8 WO 2016126006A8
Authority
WO
WIPO (PCT)
Prior art keywords
microorganism
quinolinic acid
producing quinolinic
producing
utilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/014344
Other languages
French (fr)
Korean (ko)
Other versions
WO2016126006A1 (en
Inventor
이재민
김주은
이재희
장진숙
김소영
신용욱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Priority to BR112017016626A priority Critical patent/BR112017016626A2/en
Priority to CN201580075334.8A priority patent/CN107278225A/en
Priority to EP15881324.6A priority patent/EP3255150A4/en
Priority to US15/546,467 priority patent/US20180163186A1/en
Priority to JP2017540829A priority patent/JP6502515B2/en
Publication of WO2016126006A1 publication Critical patent/WO2016126006A1/en
Publication of WO2016126006A8 publication Critical patent/WO2016126006A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03016—L-Aspartate oxidase (1.4.3.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01072—Quinolinate synthase (2.5.1.72)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a microorganism capable of producing quinolinic acid, and to a method for producing same utilizing the microorganism.
PCT/KR2015/014344 2015-02-03 2015-12-28 Microorganism having quinolinic acid production ability, and method for producing quinolinic acid by using same Ceased WO2016126006A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BR112017016626A BR112017016626A2 (en) 2015-02-03 2015-12-28 microorganism capable of producing quinolic acid and method for producing quinolic acid using microorganism
CN201580075334.8A CN107278225A (en) 2015-02-03 2015-12-28 The method that the microorganism of quinolinic acid can be produced and quinolinic acid is produced using the microorganism
EP15881324.6A EP3255150A4 (en) 2015-02-03 2015-12-28 Microorganism capable of producing quinolinic acid, and method for producing quinolinic acid utilizing the microorganism
US15/546,467 US20180163186A1 (en) 2015-02-03 2015-12-28 Microorganism having quinolinic acid production ability, and method for producing quinolinic acid by using same
JP2017540829A JP6502515B2 (en) 2015-02-03 2015-12-28 Microorganism having ability to produce quinolinic acid and method for producing quinolinic acid using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0016971 2015-02-03
KR1020150016971A KR101758446B1 (en) 2015-02-03 2015-02-03 A microorganism having an ability to produce quinolinic acid and a method for producing a quinolinic acid using the same

Publications (2)

Publication Number Publication Date
WO2016126006A1 WO2016126006A1 (en) 2016-08-11
WO2016126006A8 true WO2016126006A8 (en) 2016-11-10

Family

ID=56564304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/014344 Ceased WO2016126006A1 (en) 2015-02-03 2015-12-28 Microorganism having quinolinic acid production ability, and method for producing quinolinic acid by using same

Country Status (8)

Country Link
US (1) US20180163186A1 (en)
EP (1) EP3255150A4 (en)
JP (1) JP6502515B2 (en)
KR (1) KR101758446B1 (en)
CN (1) CN107278225A (en)
BR (1) BR112017016626A2 (en)
MY (1) MY173051A (en)
WO (1) WO2016126006A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113512540B (en) * 2021-05-31 2022-07-19 廊坊梅花生物技术开发有限公司 A kind of quinolinic acid synthase mutant and its application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101223904B1 (en) * 2011-01-14 2013-01-21 씨제이제일제당 (주) Method for the preparation of nicotinic acid
KR101359844B1 (en) * 2012-01-06 2014-02-25 씨제이제일제당 (주) Recombinant microorganism producing quinolinic acid and method of producing quinolinic acid using the same
KR101634582B1 (en) * 2013-07-25 2016-06-30 씨제이제일제당 주식회사 L-aspartate oxidase variant resistant to nicotinic acid or NAD and a method for producing quinolinate or nicotinic acid

Also Published As

Publication number Publication date
WO2016126006A1 (en) 2016-08-11
MY173051A (en) 2019-12-23
KR101758446B1 (en) 2017-07-17
KR20160095715A (en) 2016-08-12
CN107278225A (en) 2017-10-20
JP2018504914A (en) 2018-02-22
BR112017016626A2 (en) 2018-04-03
EP3255150A1 (en) 2017-12-13
JP6502515B2 (en) 2019-04-17
EP3255150A4 (en) 2018-11-14
US20180163186A1 (en) 2018-06-14

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