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WO2016111477A1 - Composition cosmétique pour réduire ou améliorer la sécrétion de sébum stimulée par le stress, comprenant, comme ingrédient actif, un extrait de graines de carthamus tinctorious l, ou un extrait mixte de graines de carthamus tinctorious l et de graines de areca catechu l - Google Patents

Composition cosmétique pour réduire ou améliorer la sécrétion de sébum stimulée par le stress, comprenant, comme ingrédient actif, un extrait de graines de carthamus tinctorious l, ou un extrait mixte de graines de carthamus tinctorious l et de graines de areca catechu l Download PDF

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Publication number
WO2016111477A1
WO2016111477A1 PCT/KR2015/013617 KR2015013617W WO2016111477A1 WO 2016111477 A1 WO2016111477 A1 WO 2016111477A1 KR 2015013617 W KR2015013617 W KR 2015013617W WO 2016111477 A1 WO2016111477 A1 WO 2016111477A1
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WO
WIPO (PCT)
Prior art keywords
extract
seed
sebum secretion
cosmetic composition
improvement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/013617
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English (en)
Korean (ko)
Inventor
이경은
김민지
윤석균
문성준
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Cosmax Inc
Original Assignee
Cosmax Inc
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Publication date
Application filed by Cosmax Inc filed Critical Cosmax Inc
Publication of WO2016111477A1 publication Critical patent/WO2016111477A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • a cosmetic composition for alleviating or improving sebum secretion by stress stimulation containing safflower extract or a combination of safflower and betel nut extracts as an active ingredient
  • the present invention is made by the task number HN12C0061 under the support of the Ministry of Knowledge Economy of Korea, the research management professional organization of the above task is a global cosmetic research and development project group,
  • the present invention relates to a safflower extract or a safflower and betel nut combination extract, and more particularly to a sebum secretion alleviation or improvement cosmetic composition by stress stimulation containing a safflower extract or a safflower and betel nut combination extract as an active ingredient.
  • Acne which usually occurs during puberty, is a common skin disease worldwide, which is observed in more than 85% of adolescents and sometimes persists after age 30.
  • acne is a chronic inflammatory disease of the sebaceous gland of the hair follicles and is accompanied by various skin changes such as cotton cloth, papules, pus blisters, nodules, and similar cysts. In addition to problems, it can also cause interpersonal difficulties.
  • This acne mainly occurs on the face, neck, chest, etc., where the sebaceous glands are concentrated, and the pores are narrowed or blocked, preventing sebum from being discharged. It is known to be active and cause acne. There are many causes of acne, but the main cause is the excessive sebum secretion by androgen, a male hormone, hyperkeratosis of the hair follicle wall, and hair follicle stimulation due to the proliferation of propionibacteriuiti acne. It is grasped.
  • Sebaceous glands have the function of producing and metabolizing androgens. These androgens promote the lipid synthesis pathway by increasing the gene expression of enzymes involved in lipid synthesis.
  • the corresponding enzymes include fatty acid synthase (FAS), acetyl-CoA carboxylase (acetyl-CoA carboxylase). ACO), malic enzyme, ATP-citrate lyase, and sterol® regulatory element binding protein (SREBP). It has been reported that androgen regulates the above enzymes by regulating SREBP binding to SRE (Proc. Natl. Acad. Sci., 1997, 94, 12975-12980).
  • SREBPs sterol regulatory element-binding proteins
  • SREs sterol regulatory elements
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid production, including cholesterol and fatty acids.
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid production, including cholesterol and fatty acids.
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid production, including cholesterol and fatty acids.
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid production, including cholesterol and fatty acids.
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid production, including cholesterol and fatty acids.
  • SREBP-la and SREBP-lc are transcriptional regulatory regions of sterol-regulated genes, to regulate lipid
  • acne has a tendency to increase year by year as well as adolescents as well as adolescents due to hormonal abnormalities due to external or psychological stress is showing a tendency.
  • Stress is known to be a major cause of acne, which is caused by intracellular stress It is associated with increased levels of hormonal glucocorticoids and is regulated by the release of active cortisol and by the activity of ⁇ -HSDl ( ⁇ -hydroxysteroid dehydrogenasel).
  • UP-HSD1 converts inactivated cortisone to active cortisol, thereby playing an important role in regulating the concentration of cellular agents and activating corticosteroid receptors in target tissues.
  • Inhibition of the expression and activity of 11P-HSI) 1 has various physiological effects such as the treatment of skin wounds (Tiganescu A et al, 2014; JOE-13-0420) and the treatment of metabolic diseases such as antidiabetics (James S et al, 2013). Is being reported. However, research on the improvement of acne through the inhibition of sebaceous gland secretion in the skin is very little.
  • a typical attempt to improve acne skin is conventionally used to remove sebum generated by using an adsorbent powder, or to remove dead skin cells that block pores or acne by applying salicylic acid, trichloric acid and trihydroxy palmitic acid to the cosmetic composition.
  • How to prevent and treat acne by inhibiting the growth of bacteria and by using the Evening Primrose Seed Extract to inhibit sebum secretion by inhibiting the activity of 5 alpha -reductase or in the propionibacterium A method of preventing acne by applying antibacterial pine powder extract has been proposed, but still not satisfactorily satisfied.
  • Heunghwa (Carthamust inctor ius) is a seed of safflower (Carthamust inctor ius, saf f lower), also called safflower or hwanghwa is known to be effective in treating bone diseases such as fractures and osteoporosis (Korean Patent 10-1059332). .
  • safflower Carthamust inctor ius, saf f lower
  • hwanghwa is known to be effective in treating bone diseases such as fractures and osteoporosis.
  • Areca nut is the fruit of Areaca catechu belonging to the Palma family. It is distributed in warm regions such as southern South Korea, Taiwan, Malaysia, India, and Jeju Island, and is grown in tropical regions. . It is known that the betel nut is effective in dry stomach, indigestion, constipation, abdominal pain, spleen and the like (Japanese Patent Laid-Open No. 5-320037).
  • atopic dermatitis improvement ability (TS 10-1114506), elastase inhibition and free radical scavenging effect (TS 10-0457689) and 5 ⁇ -reductase activity inhibitory activity and propionibacte Antimicrobial activity to Leeum acnes (Korean Patent Registration 10—0523540) and the like are known.
  • the main object of the present invention is to reduce the sebum secretion by inhibiting the expression of ⁇ ⁇ -HSDl and SREBP-1, and as a result, the safflower extract or the safflower and betel nut combination extract as an active ingredient It is to provide a cosmetic composition for alleviating or improving sebum secretion by containing stress stimulus.
  • compositions for sebum secretion alleviation or improvement containing the extract as an active ingredient.
  • the present invention provides a cosmetic composition for sebum secretion alleviation or improvement containing the extract and the betel nut mixed extract as an active ingredient.
  • Carthamistinctoriiis seed is a seed of ⁇ Carthaimist inctor ius, saf f lower), which is also called safflower or hwanghwa, and is known to be effective in treating bone diseases such as fracture and osteoporosis (Korean Patent 10-1059332).
  • Korean Patent 10-1059332 In addition to the treatment effect for women menopausal syndrome (Korean Patent 10-1333090) is known.
  • Areca nut refers to the fruit of the areaca catechu belonging to the Palma family, and is distributed in warm regions such as southern China, Taiwan, Malaysia, India, and Jeju Island in Korea, and is grown in tropical regions. .
  • Betel nut It is known to be effective in dry stomach, indigestion, constipation, abdominal pain, and nasal passages (Japanese Patent Laid-Open No. 5-320037).
  • the ability to improve atopic dermatitis by TSLP inhibitory ability Korea Patent No. 10-1114506
  • elastase inhibition and free radical scavenging effect Korea et al. Patent No. 10-0457689
  • activity inhibition and propioni of 5 ⁇ -reductase Antibacterial activity on bacterium acnes Korean Patent No. 1 023540
  • the present inventors inhibit the expression of ⁇ ⁇ -HSDl and SREBP-1 and sebaceous gland intracellular sebum production in the safflower extract alone, and, in addition, in the safflower and betel nut combination extracts, two kinds of raw materials such as heunghwa and betel nut are synergistic.
  • SREBP1 sebum secretion alleviation or improvement effect by stress stimulation of a single extract of a fungus or a combination extract of a fungus and a betel nut.
  • stress stimulus' of the present invention means that harmful stimuli from external or psychological effects increase stress hormones (glucocorticoids) in the skin and cause sebaceous glands to induce excessive sebum. In the present invention, it means by stress stimulation by dexamethasone.
  • the extract or the combination extract is characterized in that it further exhibits an acne improving effect.
  • the extract may be extracted with any solvent conventionally used, preferably water, low-cost alcohol having 1 to 4 carbon atoms, glycerin, propylene glycol, butylene glycol or a mixed solvent thereof It is characterized by.
  • a conventional plant extraction method may be used, for example, hot water extraction, reflux cooling extraction, ultrasonic extraction, supercritical extraction, or the like. Specifically, grinding or crushing safflower and betel nuts Powder was prepared, and the mixture was immersed in the aforementioned extraction solvent and extracted at room temperature for 24 to 72 hours. Subsequently, the obtained filtrate is filtered and dried under reduced pressure to obtain a concentrated solution or lyophilized to obtain powder.
  • the mixed extract may be a mixed extract after extracting each of the single extracts, or may be an extract for the isocratic mixture of safflower and betel nut.
  • the mixed extract is characterized by extracting safflower: betel nut at a mixed weight ratio of 1-3: 1-3.
  • the mixed extract of the present invention exhibits a synergistic effect at any ratio, meaning that SREBP1 can inhibit sebum by inhibiting sebum and thus improve acne (see Experimental Example 3, FIG. 3).
  • the safflower extract or mixed extract is characterized in that it contains 0.001 to 30% by weight relative to the total weight of the composition. If it is less than 0.001 weight 3 ⁇ 4> in the above range is not preferable because there is a possibility that the acne improvement effect is weak, and inversely more than 30% by weight may be undesirable in terms of economics.
  • the safflower extract is characterized in that it exhibits an inhibitory effect of 11 beta -H-SDI 1 (11 ⁇ _hydroxysteroid dehydrogenase :!) expression.
  • 11beta-HSD1 (11 ⁇ -hydroxysteroid dehydrogenasel, 11 ⁇ -HSD1) modulates the response of glucocorticoids to act as stress hormones.
  • 11 ⁇ -HSD1 expression is high in acne skin (Br iti sh Journal of Dermatology, 2013, 168, 47-55).
  • 11 ⁇ —HSD1 expression and activity inhibition has been reported in various physiological effects such as the treatment of skin wounds (Tiganescu A et al, 2014; JOE- 13-0420) and the treatment of metabolic diseases such as antidiabetics (James S et al, 2013). have.
  • the results of studies showing the skin sebum-releasing effect and consequently the acne suppression effect are insignificant.
  • the extract inhibits the expression of ⁇ -HSDl increased by dexamethasone, resulting in sebum secretion or amelioration effect. It means that the symptoms can be ameliorated or treated (see Example 1).
  • the safflower extract or mixed extract is characterized in that it exhibits an inhibitory effect on the sterol regulator factor binding protein (stero l regu latory element binding protein) expression.
  • SREBP Sterol regulatory element -binding protein
  • SRE sterol respiratory element
  • the extract of Hwahwaja showed an excellent SREBP inhibitory effect, and the safflower and betel nut mixed extracts exhibited a synergistic effect, which was more excellent than the safflower extract alone.
  • the Hwahwaja extract of the present invention or the Hwajaja and Betelza mixed extract, can inhibit sebum production by inhibiting SREBP and thus improve acne (see Experimental Example 2).
  • the extract or mixed extract may be prepared in any formulation commonly prepared in the art, preferably, a group consisting of softening lotion, nourishing lotion, nourishing cream, moisture cream, spot, gel lotion and ointment It is characterized by having the formulation selected from.
  • the cosmetic composition of the present invention may include other auxiliaries in addition to the carrier, and may include, for example, preservatives, antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings.
  • the cosmetic composition containing the Hwahwaja extract or Hwajaja and Betelza extract according to the present invention as an active ingredient effectively inhibits the expression of ⁇ ⁇ -HSDl and SREBP-1 overexpressed by stress. As it leads to a reduction in sebum secretion, the result is an excellent skin trouble prevention, acne prevention and improvement effect.
  • Figure 1 is a graph of the results of Experiment 1 measuring the effect on the gene expression of ⁇ ⁇ -HSDl when treated with safflower extract in Texametason treated human sebaceous gland cells.
  • Figure 2 is a graph of the results of Experimental Example 2 measuring the effect on the gene expression of SREBP-la and SREBP-lc upon treatment of extract from hepatic sebaceous gland cells with excessive lipid synthesis by dexamethasone.
  • Figure 3 measures the effect on the gene expression of SREBP-la and SREBP-lc during treatment of safflower extract, betel nut extract, and extract mixture for each combination of hepater and betel nut in sebaceous gland cells in which lipid synthesis was excessively produced by dexamethasone It is a graph of the results of Experimental Example 3.
  • Figure 4 shows the results of Experiment 4 showing the degree of inhibition of intracellular lipid synthesis during the treatment of safflower extract, betel nut extract, and extract combination for each combination of safflower and betel nut in sebaceous gland cells in which lipid synthesis by dexamethasone was excessively produced It is a graph.
  • Heunghwa Light Gwang-Nangja was purchased from Gyeongdong Market (Seo, Korea), powdered, 100g each, put in separate containers, immersed in 1L of 70% ethanol solution as an extraction solvent, and left at room temperature for 24 hours. Got. The obtained extract was filtered using filter paper, and the filtrate was concentrated under reduced pressure with a rotary evaporator to obtain 7.5 g of Hwahwaja and 13.2g of Betelza.
  • Example 2 Preparation of safflower and betel nut mixed extracts
  • Example 1 The safflower and betel nut extracts obtained in Example 1 are shown in Table 1 below. As indicated, the mixtures were obtained to obtain an extraction mixture.
  • the obtained extract mixture was dissolved in lMSG / ml and concentration in DMSOWimethyl sulfoxide) as a solvent, and used in Experimental Examples 1 to 3 below.
  • cDNA was synthesized by extracting intracellular mRNA.
  • the synthesized cDNA was prepared in real-time using a target primer and a cyanine dye, a SYBR green master mix.
  • t ime) polymerase chain reaction (PCR) was performed to evaluate the gene expression of 11 ⁇ -HSD1.
  • Table 2 and Figure 1 it was confirmed that the ⁇ ⁇ -HSm overexpressed by Texamethason is significantly suppressed by the safflower extract 1, 10 g / mi treatment.
  • human sebaceous gland cells were cultured in the same manner as described in Experimental Example 1 above, followed by the addition of dexamethasone and Example 1, followed by additional culture for 24 hours to measure the expression level of SREBP-1. .
  • the cells were dispensed into four-chamber slides (chamber slides) for the experiment, incubated in the medium described in Experimental Example 1 for 2 days, and then dexamethasone Heunghwa extract 10 g / m «obtained in Example 1, safflower and betel nut extract 10 / ⁇ and PF-915275 1 ⁇ obtained in Example 2, respectively, and further incubated for 24 hours.
  • the cells were fixed with 10% formalin for 1 hour, washed with 60% isopropanol for 5 minutes, and an oil red 0 solution was added to each well.
  • hematoxylin hematoxylin
  • the lotion containing the mixed extract obtained in Example 2 was prepared according to a conventional method according to the composition components and composition ratios shown in Table 7 below.
  • a moisture cream containing the extract mixture obtained in Example 2 was prepared in a conventional manner according to the composition ingredients and composition ratios as shown in Table 8 below.

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Abstract

La présente invention concerne une composition cosmétique pour réduire ou améliorer la sécrétion de sébum stimulée par le stress, comprenant, en tant qu'ingrédient actif, un extrait de graines de Carthamus tinctorious L ou un extrait mixte de graines de Carthamus tinctorious L et de graines de Areca catechu L. Selon la présente invention, l'extrait de graines de Carthamus tinctorious L, ou l'extrait mixte de graines de Carthamus tinctorious L et de graines de Areca catechu L peut par conséquent présenter un effet d'amélioration des symptômes de l'acné par réduction de la sécrétion de sébum par l'inhibition de l'expression de 11β-HSD1 et SREBP-1 stimulée par le stress.
PCT/KR2015/013617 2015-01-07 2015-12-11 Composition cosmétique pour réduire ou améliorer la sécrétion de sébum stimulée par le stress, comprenant, comme ingrédient actif, un extrait de graines de carthamus tinctorious l, ou un extrait mixte de graines de carthamus tinctorious l et de graines de areca catechu l Ceased WO2016111477A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0001826 2015-01-07
KR1020150001826A KR102272771B1 (ko) 2015-01-07 2015-01-07 홍화자 추출물 또는, 홍화자 및 빈랑자 혼합추출물을 유효성분으로 함유하는 스트레스 자극에 의한 피지분비완화 또는 개선용 화장료 조성물

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110711158A (zh) * 2018-07-12 2020-01-21 科丝美诗株式会社 用于减少皮脂分泌和收缩毛孔大小的含有冬青提取物的化妆材料组合物

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* Cited by examiner, † Cited by third party
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KR102068194B1 (ko) * 2017-08-22 2020-01-20 유한킴벌리 주식회사 식물 추출물을 포함하는 피부 항염, 피지 분비 억제용, 또는 여드름 개선용 조성물
KR102192928B1 (ko) * 2019-06-17 2020-12-18 국민대학교산학협력단 복합 식물 추출물을 포함하는 피부 개선 및 미세먼지 흡착 방지용 화장료 조성물

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110711158A (zh) * 2018-07-12 2020-01-21 科丝美诗株式会社 用于减少皮脂分泌和收缩毛孔大小的含有冬青提取物的化妆材料组合物

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