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WO2016108412A1 - Hematology analysis apparatus - Google Patents

Hematology analysis apparatus Download PDF

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Publication number
WO2016108412A1
WO2016108412A1 PCT/KR2015/011415 KR2015011415W WO2016108412A1 WO 2016108412 A1 WO2016108412 A1 WO 2016108412A1 KR 2015011415 W KR2015011415 W KR 2015011415W WO 2016108412 A1 WO2016108412 A1 WO 2016108412A1
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Prior art keywords
blood
sample
dilution
module
analysis
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Ceased
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PCT/KR2015/011415
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French (fr)
Korean (ko)
Inventor
한경자
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Industry Academic Cooperation Foundation of Catholic University of Korea
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Industry Academic Cooperation Foundation of Catholic University of Korea
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets

Definitions

  • the present invention relates to a blood cell analysis device, and more particularly, to a blood cell analysis device having an improved structure to improve management efficiency such as blood analysis efficiency and quality control.
  • CBC Complete Blood Cell Count
  • the CBC test is one of the most basic blood tests with various clinical indications, from diagnosis, treatment and follow-up of the disease. This test can be used to identify information on three different types of cells (blood cells) in the blood: red blood cells, white blood cells, and platelets.
  • an automatic hematology analyzer (automatic hematology analyzer) that automatically measures the number of individual blood cells in a volume after proper dilution of blood is widely used.
  • Numerical information on blood cells can also be obtained by using a hemocytometer to measure cell numbers, but automated hemocytometers are more widely used because they can measure various indicators besides numerical information. .
  • the blood cell test apparatus according to the prior art as described above has used a plurality of devices (usually 5 or more) in a large hospital because the number of samples to be processed per one device is relatively small.
  • Quality control refers to all means of managing analytical values within a certain confidence range through statistical processing to ensure accuracy and precision of analytical results.
  • This quality control requires the same reliability of the analysis results of each device, and therefore requires the inspection of each device by using separate reagents on a daily basis or by using a patient sample.
  • the present invention has been made to solve the above problems, it is to provide a blood cell analysis device that can increase the efficiency of blood analysis efficiency and quality control at the same time.
  • Another object of the present invention is to provide a blood cell analysis device that can increase the space utilization efficiency.
  • the dilution module is mixed with the blood sample and the dilution for sample analysis;
  • a plurality of optical analysis modules for dividing and introducing the same sample sample extracted from the dilution module into a predetermined amount, respectively, and dividing and analyzing the sample sample with each optical analysis device;
  • a split inlet means for dividing the sample sample into the plurality of optical analysis modules.
  • the dilution module may include dilution tanks provided in a number corresponding to the optical analysis modules; A plurality of blood side connecting pipes for fluidly connecting the respective dilution tanks and the blood extraction needles so that the blood samples can be dividedly introduced into the dilution tanks; And a plurality of vacuum modules for introducing the blood sample into the blood-side connecting tube through the respective blood extraction needles.
  • the dividing inlet means connects each dilution tank and each optical analysis module to enable fluid flow and one-to-one correspondence so that the sample sample accommodated in each dilution tank can be divided into each optical analysis module and introduced. It is preferable to include a plurality of analysis-side connecting tube.
  • the dilution module comprises: a dilution tank of the single unit; A single unit blood side connecting tube for fluidly connecting the dilution tank and a single unit of blood extraction needle so that the blood sample can be dividedly introduced into the dilution tank; And a single unit vacuum module for allowing the blood sample to enter the blood side connecting tube through the blood extraction needle.
  • the dividing inlet means fluidly connects the dilution tank of each single unit and each optical analysis module so that the sample sample contained in the dilution tank of the single unit can be divided into the optical analysis modules and introduced. It is also possible to include a; a plurality of analysis side connecting pipe to be made.
  • the split inlet means is one connecting tube and the connecting tube connected to the dilution tank of the single unit so that the sample sample contained in the dilution tank of the single unit can be divided into each optical analysis module and introduced.
  • it may include a plurality of branch pipes branched from and connected to each optical analysis module.
  • the dilution module includes a plurality of dilution tanks; A plurality of blood side connecting pipes for fluidly connecting the dilution tank and the blood extraction needle of the single unit so that the blood sample can be divided into the dilution tank; A single unit vacuum module for introducing the blood sample into the blood side connecting tube through the blood extraction needle; And selective connection means for allowing the blood extraction needle of the single unit to be selectively connected to the plurality of blood side connection tubes.
  • the selective connecting means includes a solenoid valve configured to selectively communicate any one of the vacuum module of the single unit and the blood-side connecting tubes.
  • the optical analysis modules include an analysis tank radially arranged along the circumferential direction and the sample sample is introduced therein, and each optical analysis device includes light sources disposed on a central axis of the array of the analysis tanks. It is preferable to make.
  • each sample sample is introduced into the optical analysis module in the state divided by the split inflow means.
  • the analysis of blood can be performed by dividing the analysis time, thereby reducing the analysis time, thereby improving the efficiency of blood analysis, and by using a single device to test the use of multiple devices, quality control The benefits of improving the efficiency of the product are derived.
  • FIG. 1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention.
  • FIG. 2 is a view for explaining the configuration and operation principle of an embodiment of the present invention.
  • FIG. 3 is a view for explaining an example of the arrangement structure of an embodiment of the present invention.
  • FIG. 4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 5 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 6 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention
  • Figure 2 is a view for explaining the configuration and operation principle of an embodiment of the present invention
  • Figure 3 is an example of a layout structure of an embodiment of the present invention A diagram for explaining.
  • the blood cell analysis apparatus is used for the Complete Blood Cell Count (CBC) test, which is one of the methods for testing blood, and includes a dilution module 1 and an optical analysis module 2. And split inlet means.
  • CBC Complete Blood Cell Count
  • a specific diluent is used together for reasons of smoothness of analysis or efficiency of analysis, depending on a subject required for the analysis, ie, red blood cells, white blood cells, platelets, and the like.
  • a subject required for the analysis ie, red blood cells, white blood cells, platelets, and the like.
  • the specific diluent corresponds to a well-known material, further description thereof will be omitted.
  • the dilution module 1 is a portion in which a blood sample to be analyzed and a sample analysis diluent are mixed with each other, and as shown in FIG. 2, includes a dilution tank 11.
  • the dilution module 1 may be implemented in various ways, but in this embodiment, a plurality of dilution tanks 11 and blood-side connecting tubes 12 provided in a number corresponding to the optical analysis modules 2. And vacuum modules 14.
  • each of the dilution tanks 11 the same blood sample is divided into and flows through the plurality of blood extraction needles 13 and the blood side connection pipes 12 by the action of the respective vacuum modules 14, and the divided flows in this way.
  • the prepared blood sample, the sample sample (S) formed by mixing with the diluent of the dilution tank (11) is introduced into the plurality of optical analysis module (2).
  • the dilution module 1 employed in this embodiment includes dilution tanks 11 provided in a number corresponding to the optical analysis modules 2.
  • the same blood sample is divided into each of the dilution tanks 11, and the present embodiment includes a plurality of blood side connecting pipes 12 and a plurality of vacuum modules 14 to implement such a split inflow. Is done.
  • Each blood-side connection tube 12 connects each of the dilution tanks 11 and the blood extraction needles 13 so that fluid flow is possible, so that blood samples may be divided into each of the dilution tanks 11 and flow into the dilution tanks 11. do.
  • Each vacuum module 14 for example, by the selective opening and closing of the flow path by the solenoid valve, the blood sample can be introduced into each blood side connecting tube 12 through the blood extraction needle (13).
  • a blood sample that is analyzed is divided into a plurality of dilution modules 1 and flows into a plurality of sample samples (S). ) Are each introduced.
  • Each optical analysis module 2 includes an analysis tank 20 for analyzing the sample sample S.
  • the analysis tank 20 includes a sheath fluid in which the sample sample S is surrounded. It may be made to include a rapid forming portion 22 for forming the rapids 23 to be placed in the center of the "rapid") so that the cells are optically analyzed one by one.
  • the sample sample (S) is introduced into the analysis tank 20 in the course of the flow of the rapids 23, the sample sample (S) is sucked up with the rapids 23, and elongate thinly. As the blood cells of the sample sample S are aligned along the elongated direction, targeting of the blood cells by the optical analyzer 24 to be described later is smoothly performed.
  • the rapid flow 23 and the sample sample S are illustrated as being divided by the main body 21 to facilitate understanding, but the rapid flow 23 is in contact with the sample sample S. It will be said to be formed to surround the sample sample S in a state.
  • the sample sample S is irradiated by an optical analysis device such as a laser 24 after passing through the main body 21.
  • the optical analysis device employed in the optical analysis module 2 can be implemented in various ways, but the laser 24 is employed in this embodiment. As the sample sample S is irradiated with the laser 24, the analysis and counting of blood, particularly white blood cells, may be performed.
  • an optical analyzer 25 is provided on the opposite side of the laser 24 centering on the analysis tank.
  • the trajectory that reaches the optical analyzer 25 by refraction or the like after the laser 24 is irradiated to the sample sample S is illustrated as a straight line for convenience, but it is generally bent by about 15 degrees.
  • the plurality of optical analysis modules 2 are preferably arranged radially along the circumferential direction in order to increase the efficiency of space utilization.
  • the light source of each optical analysis device is arranged on the center axis of the arrangement of the analysis tanks 20 to enable optimization of space utilization.
  • the split inlet means for dividing the sample sample into each optical analysis module 2 can be implemented in various ways, as will be described later.
  • the respective dilution tanks 11 and each It is configured to include a plurality of analysis side connectors (3) connecting the analysis tank (20) fluidly and one-to-one correspondence.
  • the analysis side connecting pipe (3) is a method for implementing a hydraulic device such as a known fluid circuit, and the like, each sample sample (S) accommodated in each dilution tank (11) the optical analysis module (2) It acts as a mediator by dividing into.
  • the blood cell analysis apparatus having the above-described configuration divides and analyzes a specific blood sample into one piece of equipment and then collects the analysis values to complete analysis of the specific blood sample, and then re-creates another specific blood sample. By having a mechanism to analyze with the instrument, it is possible to further increase the analysis efficiency.
  • the blood cell analysis device comprising a dilution module 1, a plurality of optical analysis modules 2 and a split inlet means, the sample to be analyzed is divided into the dilution module 1 After being introduced, each sample sample (S) is separated by the split inlet means and then separately analyzed after entering the optical analysis module (2), so that the analysis of blood can be divided and performed.
  • the efficiency of quality control can be derived.
  • reference numeral 4 is a known resistance measuring means for measuring the size and number of blood cells in a manner using an electrical impedence, that is, an electrical resistance principle. It is common to use with the device.
  • FIG. 4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • the configuration of the dilution module 100 and the split inlet means is different from the above-described embodiment and thus has a difference in function.
  • the configuration for supplying and diluting blood is used as a single unit, and the structure in which the diluted sample sample is divided into the optical analysis module and adopted is adopted, and thus the configuration is simpler than that of the embodiment described above.
  • the dilution module 100 employed in the present embodiment includes a dilution tank of a single unit, a blood side connection pipe 120 of a single unit, and a vacuum module 140 of a single unit.
  • the plurality of analysis side connectors are formed.
  • a blood sample is extracted from one blood extraction needle 130 connected to a blood sample and mixed with the diluent through one dilution module 100, and then the mixed sample sample is mixed with each optical.
  • connection tube 301 is connected to the dilution tank of the single unit, and a plurality of branch tubes 302 are branched from the connection tube 301 and connected to each optical analysis module, thereby providing a sample. Allow the sample to be split and analyzed.
  • FIG. 6 is a view for explaining the configuration and operation principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • the embodiment shown in this figure has a structure in which the dilution module includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402, while the vacuum module 403 has a single unit adopted. .
  • the present embodiment includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402 to enable quick and accurate analysis of the sample sample, while simplifying the configuration of the blood sample supply side. While at the same time enabling rapid supply of blood samples.
  • the present embodiment includes a single unit of the vacuum module 403 for introducing a blood sample into the blood-side connecting tubes 402 through the blood extraction needle 405,
  • the blood extraction needle 405 of a single unit comprises an optional connecting means 406 for selectively connecting to the plurality of blood side connecting tubes 402.
  • the selective contact means for example, can be implemented in the same configuration as the solenoid valve 406, to enable a vacuum action by the vacuum module 403 on any one side of the plurality of blood side connection pipe 402. .
  • This selective connection means can further increase the supply efficiency of the blood sample to the dilution module side, thereby further increasing the blood analysis efficiency according to the present embodiment.

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Abstract

The present invention relates to a hematology analysis apparatus. According to the present invention, the hematology analysis apparatus comprises: a dilution module in which a blood sample and a dilution solution for sample analysis are mixed with each other; a plurality of optical analysis modules into which each of the same samples extracted from the dilution module dividedly flow at a predetermined amount, and which dividedly analyze the samples with respective optical analysis devices; and a division and inflow means for making the samples dividedly flow into a plurality of the optical analysis modules.

Description

혈구 분석 장치Blood cell analysis device

본 발명은 혈구 분석 장치에 관한 것으로, 더욱 상게하게는 혈액 분석 효율 및 정도관리 등의 관리 효율을 높일 수 있도록, 구조가 개선된 혈구 분석 장치에 관한 것이다. The present invention relates to a blood cell analysis device, and more particularly, to a blood cell analysis device having an improved structure to improve management efficiency such as blood analysis efficiency and quality control.

혈액을 검사하는 방법 중의 하나로 CBC(Complete Blood Cell Count)검사가 널리 사용되고 있다. As one of the blood test methods, the Complete Blood Cell Count (CBC) test is widely used.

즉, CBC 검사는, 질환의 진단, 치료 및 추적 관찰에 이르기까지 다양한 임상 적응증을 갖는 가장 기본적인 혈액 검사의 하나이다. 이 검사를 통해 혈액 내 존재하는 세 가지 종류의 세포(혈구), 즉 적혈구, 백혈구, 그리고 혈소판에 대한 정보를 다양한 지표(parameter)를 이용해 파악할 수 있다.That is, the CBC test is one of the most basic blood tests with various clinical indications, from diagnosis, treatment and follow-up of the disease. This test can be used to identify information on three different types of cells (blood cells) in the blood: red blood cells, white blood cells, and platelets.

혈구의 수적인 정보를 얻기 위해서 혈액을 적절하게 희석한 후에 일정 용적 내의 각각의 혈구 세포수를 자동으로 측정하는 자동 혈구 분석기(automatic hematology analyzer)가 널리 쓰이고 있다. 혈구계(hemocytometer)를 이용하여 현미경을 통해 세포수를 측정하는 수기법으로도 혈구의 수적인 정보를 얻을 수 있으나 자동 혈구 분석기는 수적인 정보 이외의 다양한 지표를 측정할 수 있기 때문에 더 널리 쓰이고 있다.In order to obtain a numerical information of the blood cells, an automatic hematology analyzer (automatic hematology analyzer) that automatically measures the number of individual blood cells in a volume after proper dilution of blood is widely used. Numerical information on blood cells can also be obtained by using a hemocytometer to measure cell numbers, but automated hemocytometers are more widely used because they can measure various indicators besides numerical information. .

그러나, 상술한 바와 같은 종래기술에 의한 혈구 검사 장치는, 장비 하나당 처리하는 검체 수가 상대적으로 적어서 큰 병원의 경우 여러 대(보통 5대 이상)의 장비를 사용하여 왔다. However, the blood cell test apparatus according to the prior art as described above has used a plurality of devices (usually 5 or more) in a large hospital because the number of samples to be processed per one device is relatively small.

이와 같이, 여러 대의 장비를 사용하여 혈액 검사의 효율을 높일 수 있음은 주지의 사실이나, 이 경우 고가의 장비를 여러 대를 구입하여야 하는 단점이 있음은 물론, 무엇보다도 정도관리(精度管理, quality control)의 비효율성 때문에 인력 및 시간적인 낭비가 초래되는 단점이 있다.As such, it is well known that the efficiency of blood tests can be improved by using a plurality of equipments, but in this case, there are disadvantages of purchasing expensive equipments, and above all, quality control (quality control) The inefficiency of the control) has the disadvantage of causing manpower and time waste.

정도관리는, 분석결과에 대한 정확도와 정밀도를 확보하기 위하여 통계적 처리를 통한 일정한 신뢰범위 내에서 분석치를 관리하는 모든 수단을 말한다.Quality control refers to all means of managing analytical values within a certain confidence range through statistical processing to ensure accuracy and precision of analytical results.

이러한 정도관리는, 각 장비의 분석결과에 대한 동일한 신뢰도가 요구되기 때문에, 일단위로 별도의 시약을 사용하거나 환자 검체를 사용하여 각 장비의 점검이 요구된다.This quality control requires the same reliability of the analysis results of each device, and therefore requires the inspection of each device by using separate reagents on a daily basis or by using a patient sample.

따라서, 정도관리를 위한 관리자의 노동력 및 시간이 각 장비의 개수에 비례하고 소모 시약 등 비용이 발생하기 때문에, 여러 대의 혈구분석 장비를 사용하는 경우 정도관리의 비효율성이 지적되어 왔다.Therefore, inefficiency of quality control has been pointed out when using several hemocytometers because the labor force and time of the quality control for the quality control is proportional to the number of each equipment and the cost of consumption reagents is generated.

본 발명은 상기와 같은 문제점을 해결하기 위해 안출된 것으로, 혈액 분석 효율 및 정도 관리의 효율을 동시에 높일 수 있는 혈구 분석 장치를 제공하고자 하는 것이다. The present invention has been made to solve the above problems, it is to provide a blood cell analysis device that can increase the efficiency of blood analysis efficiency and quality control at the same time.

본 발명의 다른 목적은 공간 활용 효율을 높일 수 있는 혈구 분석 장치를 제공하고자 하는 것이다. Another object of the present invention is to provide a blood cell analysis device that can increase the space utilization efficiency.

상기 목적을 달성하기 위한 본 발명에 의한 혈구 분석 장치는, 혈액 샘플과 샘플 분석용 희석액이 서로 혼합되는 희석 모듈; 상기 희석 모듈로부터 추출된 동일한 샘플 시료가 각각 일정한 양으로 분할 유입되고, 각각의 광학 분석 장치로 상기 샘플 시료를 분할 분석하는 복수의 광학분석모듈들; 및 상기 샘플 시료를 상기 복수의 광학분석모듈들에 분할하여 유입시켜 주기 위한 분할 유입 수단;을 포함하여 이루어지는 것을 특징으로 한다. Blood cell analysis apparatus according to the present invention for achieving the above object, the dilution module is mixed with the blood sample and the dilution for sample analysis; A plurality of optical analysis modules for dividing and introducing the same sample sample extracted from the dilution module into a predetermined amount, respectively, and dividing and analyzing the sample sample with each optical analysis device; And a split inlet means for dividing the sample sample into the plurality of optical analysis modules.

상기 희석 모듈은, 상기 광학분석모듈들에 대응되는 개수로 마련되는 희석탱크들; 상기 각 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 각 희석탱크와 혈액 추출용 니들을 유체유동 가능하게 연결시키는 복수의 혈액측 연결관; 및 상기 혈액 샘플이 상기 각 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 복수의 진공모듈들;을 포함하여 이루어지는 것이 바람직하다. The dilution module may include dilution tanks provided in a number corresponding to the optical analysis modules; A plurality of blood side connecting pipes for fluidly connecting the respective dilution tanks and the blood extraction needles so that the blood samples can be dividedly introduced into the dilution tanks; And a plurality of vacuum modules for introducing the blood sample into the blood-side connecting tube through the respective blood extraction needles.

상기 분할 유입 수단은, 상기 각 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 각 희석탱크와 각 광학분석모듈을 유체유동 가능 및 일대일 대응되게 연결시키는 복수의 분석측 연결관;을 포함하여 이루어지는 것이 바람직하다. The dividing inlet means connects each dilution tank and each optical analysis module to enable fluid flow and one-to-one correspondence so that the sample sample accommodated in each dilution tank can be divided into each optical analysis module and introduced. It is preferable to include a plurality of analysis-side connecting tube.

상기 희석 모듈은, 상기 단일 유닛의 희석탱크; 상기 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 희석탱크와 단일 유닛의 혈액 추출용 니들을 유체유동 가능하게 연결시키는 단일 유닛의 혈액측 연결관; 및 상기 혈액 샘플이 상기 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 단일 유닛의 진공모듈;을 포함하여 이루어질 수 있다. The dilution module comprises: a dilution tank of the single unit; A single unit blood side connecting tube for fluidly connecting the dilution tank and a single unit of blood extraction needle so that the blood sample can be dividedly introduced into the dilution tank; And a single unit vacuum module for allowing the blood sample to enter the blood side connecting tube through the blood extraction needle.

상기 분할 유입 수단은, 상기 단일 유닛의 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 단일 유닛의 희석탱크와 각 광학분석모듈을 유체유동 가능하게 연결시키는 복수의 분석측 연결관;을 포함하여 이루어지는 것도 가능하다. The dividing inlet means fluidly connects the dilution tank of each single unit and each optical analysis module so that the sample sample contained in the dilution tank of the single unit can be divided into the optical analysis modules and introduced. It is also possible to include a; a plurality of analysis side connecting pipe to be made.

상기 분할 유입 수단은, 상기 단일 유닛의 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 단일 유닛의 희석탱크에 접속되는 하나의 접속관과 상기 접속관으로부터 분기되어 상기 각 광학분석모듈에 접속되는 복수의 분기관들을 포함하여 이루어질 수 있음은 물론이다. The split inlet means is one connecting tube and the connecting tube connected to the dilution tank of the single unit so that the sample sample contained in the dilution tank of the single unit can be divided into each optical analysis module and introduced. Of course, it may include a plurality of branch pipes branched from and connected to each optical analysis module.

상기 희석 모듈은, 복수의 희석탱크들; 상기 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 희석탱크와 단일 유닛의 혈액 추출용 니들을 유체유동 가능하게 연결시키는 복수의 혈액측 연결관들; 상기 혈액 샘플이 상기 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 단일 유닛의 진공모듈; 및 상기 단일 유닛의 혈액 추출용 니들이 상기 복수의 혈액측 연결관들에 선택적으로 접속되게 하는 선택적 접속수단;을 포함하여 이루어지는 것도 가능하다. The dilution module includes a plurality of dilution tanks; A plurality of blood side connecting pipes for fluidly connecting the dilution tank and the blood extraction needle of the single unit so that the blood sample can be divided into the dilution tank; A single unit vacuum module for introducing the blood sample into the blood side connecting tube through the blood extraction needle; And selective connection means for allowing the blood extraction needle of the single unit to be selectively connected to the plurality of blood side connection tubes.

상기 선택적 접속수단은, 상기 단일 유닛의 진공모듈과 상기 혈액측 연결관들 중 어느 하나를 선택적으로 소통되게 하는 솔레노이드 밸브;를 포함하여 이루어지는 것이 바람직하다. Preferably, the selective connecting means includes a solenoid valve configured to selectively communicate any one of the vacuum module of the single unit and the blood-side connecting tubes.

*상기 광학분석모듈들은, 원주방향을 따라 방사형으로 배열되고 상기 샘플시료가 유입되는 분석탱크들을 포함하여 이루어지고, 상기 각 광학 분석 장치는, 상기 분석탱크들의 배열 중심축에 배치되는 광원들을 포함하여 이루어지는 것이 바람직하다. The optical analysis modules include an analysis tank radially arranged along the circumferential direction and the sample sample is introduced therein, and each optical analysis device includes light sources disposed on a central axis of the array of the analysis tanks. It is preferable to make.

상술한 바와 같은 구성을 가지는 본 발명에 의한 혈구 분석 장치는, 분석 대상 샘플이 희석 모듈에 분할하여 유입된 이후, 각각의 샘플시료가 분할 유입 수단에 의해 분할된 상태로 광학분석모듈에 유입된 이후 개별적으로 분석됨에 따라, 혈액의 분석을 분할하여 수행할 수 있게 하여 분석시간을 단축시킴으로써 혈액 분석 효율을 높일 수 있음은 물론, 여러 대의 장비를 사용할 것을 한 대의 장비로 검사할 수 있게 함으로써, 정도관리의 효율을 높일 수 있는 장점을 도출한다. In the apparatus for analyzing blood cells according to the present invention having the configuration as described above, after the sample to be analyzed is divided into the dilution module and introduced, each sample sample is introduced into the optical analysis module in the state divided by the split inflow means. As it is analyzed separately, the analysis of blood can be performed by dividing the analysis time, thereby reducing the analysis time, thereby improving the efficiency of blood analysis, and by using a single device to test the use of multiple devices, quality control The benefits of improving the efficiency of the product are derived.

그리고, 본 발명에 의하면, 여러 대의 장비를 사용하지 않고 한 대의 장비로도 혈구 분석을 효율적으로 수행할 수 있게 됨에 따라, 설치 공간의 확보가 용이하여 공간 활용의 효율을 높일 수 있게 하는 장점이 기대된다. In addition, according to the present invention, as it is possible to efficiently perform blood cell analysis even with a single device without using a plurality of devices, it is expected that the installation space can be easily secured, thereby increasing the efficiency of space utilization. do.

도 1은 본 발명의 일실시예에 따른 혈구 분석 장치의 블럭도.1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention.

도 2는 본 발명 일실시예의 구성 및 동작원리를 설명하기 위한 도면.2 is a view for explaining the configuration and operation principle of an embodiment of the present invention.

도 3은 본 발명 일실시예의 배치구조의 일례를 설명하기 위한 도면.3 is a view for explaining an example of the arrangement structure of an embodiment of the present invention.

도 4는 본 발명의 다른 실시예에 따른 혈구 분석 장치의 구성 및 작동 원리를 설명하기 위한 도면.4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.

도 5는 본 발명의 또 다른 실시예에 따른 혈구 분석 장치의 구성 및 작동 원리를 설명하기 위한 도면.5 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.

도 6은 본 발명의 또 다른 실시예에 따른 혈구 분석 장치의 구성 및 작동 원리를 설명하기 위한 도면.6 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.

이하에서는 본 발명의 일실시예에 따른 혈구 분석 장치를 첨부된 도면을 참조하여 상세히 설명하기로 한다.Hereinafter, a blood cell analysis apparatus according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

도 1은 본 발명의 일실시예에 따른 혈구 분석 장치의 블럭도이고, 도 2는 본 발명 일실시예의 구성 및 동작원리를 설명하기 위한 도면이며, 도 3은 본 발명 일실시예의 배치구조의 일례를 설명하기 위한 도면이다. 1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention, Figure 2 is a view for explaining the configuration and operation principle of an embodiment of the present invention, Figure 3 is an example of a layout structure of an embodiment of the present invention A diagram for explaining.

이들 도면에 도시된 바와 같이, 본 발명에 의한 혈구 분석 장치는, 혈액을 검사하는 방법 중의 하나인 CBC(Complete Blood Cell Count)검사에 사용되는 것으로, 희석 모듈(1)과 광학분석모듈(2)과 분할 유입 수단을 포함하여 이루어진다.As shown in these figures, the blood cell analysis apparatus according to the present invention is used for the Complete Blood Cell Count (CBC) test, which is one of the methods for testing blood, and includes a dilution module 1 and an optical analysis module 2. And split inlet means.

혈액을 분석하기 위해서는 그 분석에 요구되는 대상, 즉 적혈구, 백혈구, 혈소판 등의 대상에 따라, 분석의 원활함 또는 분석의 효율성의 이유로 특정 희석액이 함께 사용된다. 여기서, 상기 특정 희석액은 널리 알려진 물질에 해당하므로 추가적인 설명은 생략하기로 한다. In order to analyze blood, a specific diluent is used together for reasons of smoothness of analysis or efficiency of analysis, depending on a subject required for the analysis, ie, red blood cells, white blood cells, platelets, and the like. Here, since the specific diluent corresponds to a well-known material, further description thereof will be omitted.

상기 희석 모듈(1)은, 분석이 요구되는 혈액 샘플과 샘플 분석용 희석액이 서로 혼합되는 부분으로, 도 2에 잘 도시된 바와 같이, 희석탱크(11)를 포함하여 이루어진다.The dilution module 1 is a portion in which a blood sample to be analyzed and a sample analysis diluent are mixed with each other, and as shown in FIG. 2, includes a dilution tank 11.

상기 희석 모듈(1)은, 다양하게 구현이 가능하나, 본 실시예에서는 상기 광학분석모듈(2)들에 대응되는 개수로 마련되는 복수의 희석탱크(11)들과 혈액측 연결관(12)들과 진공모듈(14)들을 포함하여 이루어진다.The dilution module 1 may be implemented in various ways, but in this embodiment, a plurality of dilution tanks 11 and blood-side connecting tubes 12 provided in a number corresponding to the optical analysis modules 2. And vacuum modules 14.

상기 각 희석탱크(11)에서는, 동일한 혈액 샘플이 상기 각 진공모듈(14)의 작용으로 복수의 혈액 추출용 니들(13) 및 혈액측 연결관(12)을 통해 분할 유입되고, 이와 같이 분할 유입된 혈액 샘플은, 상기 희석탱크(11)의 희석액과 혼합되어 형성된 샘플 시료(S)는 상기 복수의 광학분석모듈(2)들에 분할하여 유입된다. In each of the dilution tanks 11, the same blood sample is divided into and flows through the plurality of blood extraction needles 13 and the blood side connection pipes 12 by the action of the respective vacuum modules 14, and the divided flows in this way. The prepared blood sample, the sample sample (S) formed by mixing with the diluent of the dilution tank (11) is introduced into the plurality of optical analysis module (2).

분석대상인 혈액샘플이 상기 각 희석 모듈(1)에서 광학분석모듈(2)에 이르기까지 작용하는 구체적인 구성에 대한 설명은 아래와 같다.Description of the specific configuration of the blood sample to be analyzed from each of the dilution module (1) to the optical analysis module (2) is as follows.

1)희석 모듈1) dilution module

도 2에 잘 도시된 바와 같이, 본 실시예에 채용된 희석 모듈(1)은, 상기 광학분석모듈(2)들에 대응되는 개수로 마련되는 희석탱크(11)들을 포함한다. 상기 각 희석탱크(11)에는 동일한 혈액샘플이 분할하여 유입되는데, 이러한 분할유입의 구현을 위해 본 실시예는, 복수의 혈액측 연결관(12)들과 복수의 진공모듈(14)들을 포함하여 이루어진다.As shown in FIG. 2, the dilution module 1 employed in this embodiment includes dilution tanks 11 provided in a number corresponding to the optical analysis modules 2. The same blood sample is divided into each of the dilution tanks 11, and the present embodiment includes a plurality of blood side connecting pipes 12 and a plurality of vacuum modules 14 to implement such a split inflow. Is done.

각 혈액측 연결관(12)은, 상기 각 희석탱크(11)와 혈액 추출용 니들(13)을 유체유동 가능하게 연결시킴으로써, 상기 각 희석탱크(11)에 혈액 샘플이 분할하여 유입될 수 있게 한다. Each blood-side connection tube 12 connects each of the dilution tanks 11 and the blood extraction needles 13 so that fluid flow is possible, so that blood samples may be divided into each of the dilution tanks 11 and flow into the dilution tanks 11. do.

각 진공모듈(14)은, 예컨대 솔레노이드 밸브에 의한 유로의 선택적 개방 및 폐쇄 동작으로, 혈액 샘플이 상기 혈액 추출용 니들(13)을 통해 각 혈액측 연결관(12)으로 유입될 수 있도록 한다. Each vacuum module 14, for example, by the selective opening and closing of the flow path by the solenoid valve, the blood sample can be introduced into each blood side connecting tube 12 through the blood extraction needle (13).

2)광학분석모듈2) optical analysis module

도 2를 참조하면, 본 실시예에 채용된 복수의 광학분석모듈(2)들에는, 분석대상인 혈액샘플이 복수의 희석 모듈(1)들에 분할하여 유입됨에 따라 일정량으로 분할된 샘플시료(S)가 각각 유입된다. Referring to FIG. 2, in the plurality of optical analysis modules 2 employed in the present embodiment, a blood sample that is analyzed is divided into a plurality of dilution modules 1 and flows into a plurality of sample samples (S). ) Are each introduced.

각 광학분석모듈(2)은, 상기 샘플시료(S)의 분석을 위한 분석탱크(20)를 포함하고, 상기 분석탱크(20)는, 상기 샘플시료(S)가 주변의 외장액(sheath fluid; 이하 '급류'라 함)의 중앙에 놓이도록 배치됨으로써 세포가 하나씩 광학분석되도록 하는 급류(23)를 형성시키기 위한 급류 형성부(22)를 포함하여 이루어질 수 있다.Each optical analysis module 2 includes an analysis tank 20 for analyzing the sample sample S. The analysis tank 20 includes a sheath fluid in which the sample sample S is surrounded. It may be made to include a rapid forming portion 22 for forming the rapids 23 to be placed in the center of the "rapid") so that the cells are optically analyzed one by one.

즉, 상기 급류(23)가 유동하는 과정에서 상기 샘플시료(S)가 상기 분석탱크(20) 내로 유입되면, 상기 샘플시료(S)가 급류(23)와 함께 빨려 올라가면서 가늘고 길게 늘어지게 되고, 샘플시료(S)의 혈구들이 각각 길게 늘어진 방향을 따라 정렬되면서 후술할 광학 분석 장치(24)에 의한 혈구의 타겟팅이 원할하게 이루어지게 된다.That is, when the sample sample (S) is introduced into the analysis tank 20 in the course of the flow of the rapids 23, the sample sample (S) is sucked up with the rapids 23, and elongate thinly. As the blood cells of the sample sample S are aligned along the elongated direction, targeting of the blood cells by the optical analyzer 24 to be described later is smoothly performed.

*따라서, 본 실시예에서는 이해를 돕기 위해 본체부(21)에 의해 급류(23)와 샘플시료(S)가 구획되는 것처럼 도시되어 있으나, 상기 급류(23)가 샘플시료(S)와 닿아 있는 상태로 그 샘플시료(S)의 주변을 둘러서 형성되는 것이 일반적이라 할 것이다. Therefore, in the present embodiment, the rapid flow 23 and the sample sample S are illustrated as being divided by the main body 21 to facilitate understanding, but the rapid flow 23 is in contact with the sample sample S. It will be said to be formed to surround the sample sample S in a state.

상기 샘플시료(S)는, 상기 본체부(21)를 통과한 이후 레이저(24)와 같은 광학 분석 장치에 의해 조사(irradiation)된다. The sample sample S is irradiated by an optical analysis device such as a laser 24 after passing through the main body 21.

상기 광학분석모듈(2)에 채용된 광학 분석 장치는, 다양하게 구현이 가능하나, 본 실시예에서는 레이저(24)가 채용되었다. 상기 샘플시료(S)는 상기 레이저(24)가 조사됨에 따라 혈액, 특히 백혈구에 대한 분석 및 카운팅이 이루어질 수 있게 된다. The optical analysis device employed in the optical analysis module 2 can be implemented in various ways, but the laser 24 is employed in this embodiment. As the sample sample S is irradiated with the laser 24, the analysis and counting of blood, particularly white blood cells, may be performed.

한편, 상기 분석탱크를 중심으로 하여 상기 레이저(24)의 반대측에는 광분석기(25)가 마련되어 있다. 본 실시예에서는 상기 레이저(24)가 샘플시료(S)에 조사된 이후 굴절 등에 의해 상기 광분석기(25)에 도달하는 궤도가 편의성 직선으로 도시되어 있으나, 15도 정도 휘어지는 것이 일반적이다. On the other hand, an optical analyzer 25 is provided on the opposite side of the laser 24 centering on the analysis tank. In this embodiment, the trajectory that reaches the optical analyzer 25 by refraction or the like after the laser 24 is irradiated to the sample sample S is illustrated as a straight line for convenience, but it is generally bent by about 15 degrees.

도 3에 잘 도시된 바와 같이, 복수의 광학분석모듈(2)들은, 공간 활용의 효율성을 높이기 위해 원주방향을 따라 방사형으로 배열되는 것이 바람직하다. 이러한 배열구조에 의하면, 각 광학 분석 장치의 광원이, 상기 분석탱크(20)들의 배열 중심축에 배치됨으로써 공간 활용의 최적화를 가능하게 한다. As shown in FIG. 3, the plurality of optical analysis modules 2 are preferably arranged radially along the circumferential direction in order to increase the efficiency of space utilization. According to such an arrangement structure, the light source of each optical analysis device is arranged on the center axis of the arrangement of the analysis tanks 20 to enable optimization of space utilization.

3)분할 유입 수단3) Split inflow means

상기 샘플 시료를 각 광학분석모듈(2)에 분할하여 유입시키기 위한 분할 유입 수단은, 후술하는 바와 같이, 여러 가지의 방법으로 구현이 가능하나, 본 실시예에서는 상기 각 희석탱크(11)와 각 분석탱크(20)를 유체유동 가능 및 일대일 대응되게 연결시키는 복수의 분석측 연결관(3)들을 포함하도록 구성되었다.The split inlet means for dividing the sample sample into each optical analysis module 2 can be implemented in various ways, as will be described later. In this embodiment, the respective dilution tanks 11 and each It is configured to include a plurality of analysis side connectors (3) connecting the analysis tank (20) fluidly and one-to-one correspondence.

상기 각 분석측 연결관(3)은, 공지의 유체회로와 같은 유압장치 등의 구현 방법으로, 상기 각 희석탱크(11)에 수용되어 있는 샘플 시료(S)를 상기 각 광학분석모듈(2)에 분할하여 유입시켜 주는 매개체 역할을 한다. The analysis side connecting pipe (3) is a method for implementing a hydraulic device such as a known fluid circuit, and the like, each sample sample (S) accommodated in each dilution tank (11) the optical analysis module (2) It acts as a mediator by dividing into.

상술한 구성을 가지는 본 발명에 의한 혈구 분석 장치는, 특정 혈액샘플을 한 대의 장비로 분할하여 분석한 후 그 분석치를 취합함으로써 특정 혈액샘플의 분석을 완료하고, 이후 다른 특정 혈액샘플을 다시 한 대의 장비로 분석하는 메카니즘을 가짐으로써, 분석효율을 더욱 높일 수 있게 한다. The blood cell analysis apparatus according to the present invention having the above-described configuration divides and analyzes a specific blood sample into one piece of equipment and then collects the analysis values to complete analysis of the specific blood sample, and then re-creates another specific blood sample. By having a mechanism to analyze with the instrument, it is possible to further increase the analysis efficiency.

이상, 본 발명의 일실시예에 따른 혈구 분석 장치에 대해 설명하였다. In the above, the blood cell analysis apparatus according to an embodiment of the present invention has been described.

상술한 바와 같이, 희석 모듈(1)과 복수의 광학분석모듈(2)들과 분할 유입 수단을 포함하여 이루어지는 본 발명에 의한 혈구 분석 장치는, 분석 대상 샘플이 상기 희석 모듈(1)에 분할하여 유입된 이후, 각각의 샘플시료(S)가 상기 분할 유입 수단에 의해 분할된 상태로 상기 광학분석모듈(2)에 유입된 이후 개별적으로 분석됨에 따라, 혈액의 분석을 분할하여 수행할 수 있게 하여 혈액 분석 효율을 높일 수 있음은 물론, 여러 대의 장비를 사용할 것을 한 대의 장비로 검사할 수 있게 함으로써, 정도관리의 효율을 높일 수 있는 장점을 도출한다. As described above, the blood cell analysis device according to the present invention comprising a dilution module 1, a plurality of optical analysis modules 2 and a split inlet means, the sample to be analyzed is divided into the dilution module 1 After being introduced, each sample sample (S) is separated by the split inlet means and then separately analyzed after entering the optical analysis module (2), so that the analysis of blood can be divided and performed. In addition to improving the efficiency of blood analysis, by using a single device to test the use of multiple devices, the efficiency of quality control can be derived.

그리고, 본 발명에 의하면, 여러 대의 장비를 사용하지 않고 한 대의 장비로도 혈구 분석을 효율적으로 수행할 수 있게 됨에 따라, 설치 공간의 확보가 용이하여 공간 활용의 효율을 높일 수 있게 하는 장점이 기대된다. In addition, according to the present invention, as it is possible to efficiently perform blood cell analysis even with a single device without using a plurality of devices, it is expected that the installation space can be easily secured, thereby increasing the efficiency of space utilization. do.

한편, 도면 중 미설명부호 4(도 1 참조)는 전기 저항(electrical impedence) 즉, 전기 저항 원리를 이용한 방식으로 혈구의 크기와 수를 측정하는 공지의 저항성 측정 수단으로, 본 발명에 의한 혈구 분석 장치와 함께 사용되는 것이 일반적이다.In the drawing, reference numeral 4 (see FIG. 1) is a known resistance measuring means for measuring the size and number of blood cells in a manner using an electrical impedence, that is, an electrical resistance principle. It is common to use with the device.

이하에서 설명할 본 발명의 다양한 실시예들은, 본 발명의 기술사상이 채용될 수 있는 다양한 구현예들에 대한 것이다. Various embodiments of the present invention to be described below are directed to various embodiments in which the technical idea of the present invention may be employed.

도 4를 참조하여 본 발명의 다른 실시예에 따른 혈구 분석 장치를 상세히 설명하기로 한다.Referring to Figure 4 will be described in detail the blood cell analysis apparatus according to another embodiment of the present invention.

도 4는 본 발명의 다른 실시예에 따른 혈구 분석 장치의 구성 및 작동 원리를 설명하기 위한 도면이다.4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.

이 도면에 도시된 실시예는, 희석 모듈(100)과 분할 유입 수단에 관한 구성이 앞에서 설명한 실시예와 다르고 이로 인한 기능의 차이를 가진다. In the embodiment shown in this figure, the configuration of the dilution module 100 and the split inlet means is different from the above-described embodiment and thus has a difference in function.

본 실시예는, 혈액 공급 및 희석을 위한 구성을 단일 유닛으로 하고, 그 희석된 샘플 시료를 광학분석모듈에 분할하여 유입시키는 구성이 채택됨으로써, 앞에서 설명한 실시예의 구성에 비해 간소한 구성을 가진다. In this embodiment, the configuration for supplying and diluting blood is used as a single unit, and the structure in which the diluted sample sample is divided into the optical analysis module and adopted is adopted, and thus the configuration is simpler than that of the embodiment described above.

즉, 본 실시예에 채용된 희석 모듈(100)은, 단일 유닛의 희석탱크와 단일 유닛의 혈액측 연결관(120)과 단일 유닛의 진공모듈(140)을 포함하여 이루어지고, 분할 유입 수단은, 앞에서 설명한 실시예와 마찬가지로 복수의 분석측 연결관들로 이루어진다.That is, the dilution module 100 employed in the present embodiment includes a dilution tank of a single unit, a blood side connection pipe 120 of a single unit, and a vacuum module 140 of a single unit. As in the above-described embodiment, the plurality of analysis side connectors are formed.

이러한 실시예에 의하면, 혈액샘플에 접속되어 있는 하나의 혈액 추출용 니들(130)로부터 혈액 샘플을 추출하여 하나의 희석모듈(100)을 통해 희석액과 혼합한 이후, 그 혼합된 샘플시료를 각 광학분석모듈에 분할 유입되게 함으로써, 혈액 분석 효율 및 정도관리 효율을 높일 수 있음은 물론, 상대적으로 간소한 구성을 가지는 장점을 가진다. According to this embodiment, a blood sample is extracted from one blood extraction needle 130 connected to a blood sample and mixed with the diluent through one dilution module 100, and then the mixed sample sample is mixed with each optical. By splitting the flow into the analysis module, blood analysis efficiency and quality control efficiency can be increased, as well as having a relatively simple configuration.

물론, 도 5에 도시된 바와 같이, 단일 유닛의 희석탱크와 단일 유닛의 혈액측 연결관과 단일 유닛의 진공 모듈로 이루어진 희석 모듈과 함께, 하나의 접속관(301)과 복수의 분기관(302)들로 구성되는 분할 유입 수단의 구현도 가능하다. Of course, as shown in FIG. 5, one connecting tube 301 and a plurality of branch pipes 302, together with a dilution module consisting of a single unit dilution tank, a single unit blood side connection tube, and a single unit vacuum module. It is also possible to implement a split inlet means consisting of

이러한 실시예에 의하면, 하나의 접속관(301)이 상기 단일 유닛의 희석탱크에 접속되고, 복수의 분기관(302)들이 상기 접속관(301)으로부터 분기되어 각 광학분석모듈에 접속됨으로써, 샘플시료를 분할하여 분석할 수 있도록 한다. According to this embodiment, one connection tube 301 is connected to the dilution tank of the single unit, and a plurality of branch tubes 302 are branched from the connection tube 301 and connected to each optical analysis module, thereby providing a sample. Allow the sample to be split and analyzed.

이 실시예는, 샘플시료가 각 분기관(302)을 통해 동일하게 유입될 수 있게 하는 정량 분할 밸브(303)가 채용되어야 하는 번거로움은 있으나, 정도관리시 오차에 대한 각 장비별 신뢰도 개선시에 점검해야 하는 체크리스트의 항목이 줄어, 정도관리 효율을 더욱 높일 수 있게 한다. In this embodiment, there is a hassle to employ a quantitative split valve 303 to allow the sample sample to be equally introduced through each branch pipe 302, but when improving the reliability of each equipment for the error in quality control The number of items in the checklist that need to be checked is reduced, making the quality control even more efficient.

도 6은 본 발명의 또 다른 실시예에 따른 혈구 분석 장치의 구성 및 작동원리를 설명하기 위한 도면이다.6 is a view for explaining the configuration and operation principle of the blood cell analysis apparatus according to another embodiment of the present invention.

이 도면에 도시된 실시예는, 희석 모듈을 복수의 희석탱크(401)들과 복수의 혈액측 연결관(402)들을 포함하는 한편, 진공모듈(403)의 경우 단일 유닛이 채택된 구조를 가진다.The embodiment shown in this figure has a structure in which the dilution module includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402, while the vacuum module 403 has a single unit adopted. .

즉, 본 실시예는, 복수의 희석탱크(401)와 복수의 혈액측 연결관(402)들을 포함함으로써, 샘플시료의 신속하고 정밀한 분석을 가능하게 하는 한편, 혈액 샘플 공급 측의 구성을 간소하게 함과 동시에 신속한 혈액 샘플의 공급을 가능하게 한다.That is, the present embodiment includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402 to enable quick and accurate analysis of the sample sample, while simplifying the configuration of the blood sample supply side. While at the same time enabling rapid supply of blood samples.

이러한 기능의 발휘를 위해 본 실시예는, 혈액 샘플이 혈액 추출용 니들(405)을 통해 상기 혈액측 연결관(402)들에 유입되게 하기 위한 단일 유닛의 진공모듈(403)을 포함하고, 상기 단일 유닛의 혈액 추출용 니들(405)이 상기 복수의 혈액측 연결관(402)들에 선택적으로 접속되게 하는 선택적 접속수단(406)을 포함하여 이루어진다.In order to achieve this function, the present embodiment includes a single unit of the vacuum module 403 for introducing a blood sample into the blood-side connecting tubes 402 through the blood extraction needle 405, The blood extraction needle 405 of a single unit comprises an optional connecting means 406 for selectively connecting to the plurality of blood side connecting tubes 402.

상기 선택적 접촉수단은, 예컨대 솔레노이드 밸브(406)와 같은 구성으로 구현이 가능하여, 상기 복수의 혈액측 연결관(402)들 중 어느 일측에 상기 진공모듈(403)에 의한 진공 작용을 가능하게 한다.The selective contact means, for example, can be implemented in the same configuration as the solenoid valve 406, to enable a vacuum action by the vacuum module 403 on any one side of the plurality of blood side connection pipe 402. .

이러한 선택적 접속수단은, 혈액샘플의 희석 모듈 측으로의 공급 효율을 더욱 높일 수 있게 함에 따라, 본 실시예에 의한 혈액 분석 효율을 더욱 높일 수 있게 한다. This selective connection means can further increase the supply efficiency of the blood sample to the dilution module side, thereby further increasing the blood analysis efficiency according to the present embodiment.

이상, 본 발명에 대한 바람직한 실시예들을 설명하였으나, 본 발명은 위에서 설명된 실시예들에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며 본 발명 속하는 기술분야에서 다양한 변형과 개작을 할 수 있음은 자명하다. As mentioned above, although preferred embodiments of the present invention have been described, the present invention is not limited to the above-described embodiments but is defined by the claims, and it is obvious that various modifications and adaptations can be made in the technical field to which the present invention pertains. Do.

Claims (9)

혈액 샘플과 샘플 분석용 희석액이 서로 혼합되는 희석 모듈;A dilution module in which a blood sample and a diluent for sample analysis are mixed with each other; 상기 희석 모듈로부터 추출된 동일한 샘플 시료가 각각 일정한 양으로 분할 유입되고, 각각의 광학 분석 장치로 상기 샘플 시료를 분할 분석하는 복수의 광학분석모듈들; 및A plurality of optical analysis modules for dividing and introducing the same sample sample extracted from the dilution module into a predetermined amount, respectively, and dividing and analyzing the sample sample with each optical analysis device; And 상기 샘플 시료를 상기 복수의 광학분석모듈들에 분할하여 유입시켜 주기 위한 분할 유입 수단;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.And a split inlet means for dividing and introducing the sample sample into the plurality of optical analysis modules. 제1항에 있어서,The method of claim 1, 상기 희석 모듈은,The dilution module, 상기 광학분석모듈들에 대응되는 개수로 마련되는 희석탱크들;Dilution tanks provided in a number corresponding to the optical analysis modules; 상기 각 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 각 희석탱크와 혈액 추출용 니들을 유체유동 가능하게 연결시키는 복수의 혈액측 연결관; 및A plurality of blood side connecting pipes for fluidly connecting the respective dilution tanks and the blood extraction needles so that the blood samples can be dividedly introduced into the dilution tanks; And 상기 혈액 샘플이 상기 각 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 복수의 진공모듈들;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.And a plurality of vacuum modules for allowing the blood sample to flow into the blood-side connecting tube through the respective blood extraction needles. 제2항에 있어서, The method of claim 2, 상기 분할 유입 수단은, The split inflow means, 상기 각 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 각 희석탱크와 각 광학분석모듈을 유체유동 가능 및 일대일 대응되게 연결시키는 복수의 분석측 연결관;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.A plurality of analysis side connectors for fluid flow and one-to-one correspondence between the dilution tank and each optical analysis module so that the sample sample contained in each dilution tank can be divided into each optical analysis module and introduced. Blood cell analysis device comprising a. 제1항에 있어서,The method of claim 1, 상기 희석 모듈은,The dilution module, 상기 단일 유닛의 희석탱크;The dilution tank of the single unit; 상기 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 희석탱크와 단일 유닛의 혈액 추출용 니들을 유체유동 가능하게 연결시키는 단일 유닛의 혈액측 연결관; 및A single unit blood side connecting tube for fluidly connecting the dilution tank and a single unit of blood extraction needle so that the blood sample can be dividedly introduced into the dilution tank; And 상기 혈액 샘플이 상기 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 단일 유닛의 진공모듈;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.And a single unit vacuum module for allowing the blood sample to flow into the blood side connection tube through the blood extraction needle. 제4항에 있어서,The method of claim 4, wherein 상기 분할 유입 수단은,The split inflow means, 상기 단일 유닛의 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 단일 유닛의 희석탱크와 각 광학분석모듈을 유체유동 가능하게 연결시키는 복수의 분석측 연결관;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.A plurality of analysis side connections for fluidly connecting the dilution tank and each optical analysis module of the single unit so that the sample sample contained in the dilution tank of the single unit can be divided into each of the optical analysis module to flow in Blood cell analysis device comprising a tube; 제4항에 있어서,The method of claim 4, wherein 상기 분할 유입 수단은,The split inflow means, 상기 단일 유닛의 희석탱크에 수용되어 있는 샘플 시료를 상기 각 광학분석모듈에 분할하여 유입시켜 줄 수 있도록, 상기 단일 유닛의 희석탱크에 접속되는 하나의 접속관과 상기 접속관으로부터 분기되어 상기 각 광학분석모듈에 접속되는 복수의 분기관들을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.One connection tube connected to the dilution tank of the single unit and branched from the connection tube to divide the sample sample contained in the dilution tank of the single unit into each optical analysis module Blood cell analysis device comprising a plurality of branch pipes connected to the analysis module. 제1항에 있어서, The method of claim 1, 상기 희석 모듈은,The dilution module, 복수의 희석탱크들;A plurality of dilution tanks; 상기 희석탱크에 상기 혈액 샘플이 분할하여 유입될 수 있도록, 상기 희석탱크와 단일 유닛의 혈액 추출용 니들을 유체유동 가능하게 연결시키는 복수의 혈액측 연결관들; A plurality of blood side connecting pipes for fluidly connecting the dilution tank and the blood extraction needle of the single unit so that the blood sample can be divided into the dilution tank; 상기 혈액 샘플이 상기 혈액 추출용 니들을 통해 상기 혈액측 연결관에 유입되게 하기 위한 단일 유닛의 진공모듈; 및A single unit vacuum module for introducing the blood sample into the blood side connecting tube through the blood extraction needle; And 상기 단일 유닛의 혈액 추출용 니들이 상기 복수의 혈액측 연결관들에 선택적으로 접속되게 하는 선택적 접속수단;을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.And a selective connection means for selectively connecting the blood extraction needle of the single unit to the plurality of blood side connection tubes. 제7항에 있어서,The method of claim 7, wherein 상기 선택적 접속수단은,The selective connection means, 상기 단일 유닛의 진공모듈과 상기 혈액측 연결관들 중 어느 하나를 선택적으로 소통되게 하는 솔레노이드 밸브;를 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치.And a solenoid valve configured to selectively communicate any one of the vacuum module of the single unit and the blood side connecting tubes. 제1항에 있어서,The method of claim 1, 상기 광학분석모듈들은, 원주방향을 따라 방사형으로 배열되고 상기 샘플시료가 유입되는 분석탱크들을 포함하여 이루어지고,The optical analysis modules, including the analysis tank is arranged radially along the circumferential direction and the sample sample is introduced, 상기 각 광학 분석 장치는, 상기 분석탱크들의 배열 중심축에 배치되는 광원들을 포함하여 이루어지는 것을 특징으로 하는 혈구 분석 장치. Each optical analysis device, the blood cell analysis device comprises a light source disposed on the central axis of the array of the analysis tank.
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