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WO2016108206A3 - Procédés de préparation d'idélalisib et de ses intermédiaires - Google Patents

Procédés de préparation d'idélalisib et de ses intermédiaires Download PDF

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Publication number
WO2016108206A3
WO2016108206A3 PCT/IB2015/060069 IB2015060069W WO2016108206A3 WO 2016108206 A3 WO2016108206 A3 WO 2016108206A3 IB 2015060069 W IB2015060069 W IB 2015060069W WO 2016108206 A3 WO2016108206 A3 WO 2016108206A3
Authority
WO
WIPO (PCT)
Prior art keywords
idelalisib
intermediates
preparation
processes
present application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/060069
Other languages
English (en)
Other versions
WO2016108206A2 (fr
Inventor
Srinivas ORUGANTI
Saikat Sen
Vilas Hareshwar Dahanukar
Rakesh GANORKAR
Ramesh Chakka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of WO2016108206A2 publication Critical patent/WO2016108206A2/fr
Publication of WO2016108206A3 publication Critical patent/WO2016108206A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Laser Beam Processing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés pour la préparation d'idélalisib et de ses intermédiaires. La présente invention concerne également un procédé de purification d'idélalisib.
PCT/IB2015/060069 2014-12-31 2015-12-31 Procédés de préparation d'idélalisib et de ses intermédiaires Ceased WO2016108206A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN6844CH2014 2014-12-31
IN6844/CHE/2014 2014-12-31
IN2493CH2015 2015-05-18
IN2493/CHE/2015 2015-05-18

Publications (2)

Publication Number Publication Date
WO2016108206A2 WO2016108206A2 (fr) 2016-07-07
WO2016108206A3 true WO2016108206A3 (fr) 2016-08-18

Family

ID=56285111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/060069 Ceased WO2016108206A2 (fr) 2014-12-31 2015-12-31 Procédés de préparation d'idélalisib et de ses intermédiaires

Country Status (1)

Country Link
WO (1) WO2016108206A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017009333A1 (fr) * 2015-07-13 2017-01-19 Synthon B.V. Procédé de purification de l'idélalisib
WO2018198131A1 (fr) * 2017-04-24 2018-11-01 Natco Pharma Limited Procédé de préparation d'idélalisib amorphe
WO2019092253A1 (fr) 2017-11-10 2019-05-16 Synthon B.V. Procédé de préparation d'idélalisib
CN108409740B (zh) * 2018-03-14 2020-05-08 盐城师范学院 一种艾代拉里斯制备方法
WO2019178596A1 (fr) 2018-03-16 2019-09-19 Johnson Matthey Public Limited Company Formes à l'état solide solvatées de pyridine ou de n,n-diméthylacétamide d'idélalisib solvaté, leur utilisation et leur préparation
CN109503430B (zh) * 2018-12-29 2021-01-29 浙江东亚药业股份有限公司 一种邻氟邻亚胺基苯甲酸中间体化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113554A2 (fr) * 2004-05-13 2005-12-01 Icos Corporation Méthode de préparation du 3-phényle-2-[9h-purine-6-ylamino)-méthyle]-3h-quinazoline-4-un et composés substitués et associés

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113554A2 (fr) * 2004-05-13 2005-12-01 Icos Corporation Méthode de préparation du 3-phényle-2-[9h-purine-6-ylamino)-méthyle]-3h-quinazoline-4-un et composés substitués et associés
WO2005113556A1 (fr) * 2004-05-13 2005-12-01 Icos Corporation Quinazolinones utilisees en tant qu'inhibiteurs de la phosphatidylinositol 3-kinase delta humaine

Also Published As

Publication number Publication date
WO2016108206A2 (fr) 2016-07-07

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