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WO2016100349A3 - Composés azahétérocycliques bicycliques utilisés comme antagonistes des récepteurs nmda nr2b - Google Patents

Composés azahétérocycliques bicycliques utilisés comme antagonistes des récepteurs nmda nr2b Download PDF

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Publication number
WO2016100349A3
WO2016100349A3 PCT/US2015/065829 US2015065829W WO2016100349A3 WO 2016100349 A3 WO2016100349 A3 WO 2016100349A3 US 2015065829 W US2015065829 W US 2015065829W WO 2016100349 A3 WO2016100349 A3 WO 2016100349A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
nmda receptor
nr2b
formula
azaheterocyclic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/065829
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English (en)
Other versions
WO2016100349A2 (fr
Inventor
Gideon Shapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rugen Holdings (cayman) Ltd
Original Assignee
Rugen Holdings (cayman) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rugen Holdings (cayman) Ltd filed Critical Rugen Holdings (cayman) Ltd
Publication of WO2016100349A2 publication Critical patent/WO2016100349A2/fr
Publication of WO2016100349A3 publication Critical patent/WO2016100349A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des entités chimiques de formule (I), dans laquelle R1 et Z sont tels que définis dans la description, utilisées comme antagonistes sélectifs du sous-type NR2B des récepteurs. L'invention concerne également des compositions pharmaceutiques comprenant une entité chimique de formule (I), et des méthodes de traitement de diverses maladies et divers troubles associés à l'antagonisme NR2B, par ex., de maladies et troubles du système nerveux central, tels que la dépression, par l'administration d'une entité chimique de formule I.
PCT/US2015/065829 2014-12-16 2015-12-15 Composés azahétérocycliques bicycliques utilisés comme antagonistes des récepteurs nmda nr2b Ceased WO2016100349A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462092791P 2014-12-16 2014-12-16
US62/092,791 2014-12-16

Publications (2)

Publication Number Publication Date
WO2016100349A2 WO2016100349A2 (fr) 2016-06-23
WO2016100349A3 true WO2016100349A3 (fr) 2016-08-18

Family

ID=56127835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/065829 Ceased WO2016100349A2 (fr) 2014-12-16 2015-12-15 Composés azahétérocycliques bicycliques utilisés comme antagonistes des récepteurs nmda nr2b

Country Status (1)

Country Link
WO (1) WO2016100349A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044323A1 (fr) 2014-09-15 2016-03-24 Rugen Holdings (Cayman) Limited Dérivés de pyrrolopyrimidine à titre d'antagonistes des récepteurs nmda nr2b
WO2016126869A1 (fr) 2015-02-04 2016-08-11 Rugen Holdings (Cayman) Limited Dérivés 3,3-difluoro-pipéridine en tant qu'antagonistes des récepteurs nmda nr2b
US10584127B2 (en) 2015-06-01 2020-03-10 Rugen Holdings (Cayman) Limited 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN113950478B (zh) 2019-06-04 2024-02-02 勃林格殷格翰国际有限公司 作为nr2b负向调节剂的嘌呤衍生物及其作为药物的用途，特别是用于治疗抑郁病症
CN113906033B (zh) 2019-06-04 2024-04-02 勃林格殷格翰国际有限公司 咪唑并吡嗪衍生物及其作为药剂的用途
CN114213424B (zh) * 2021-12-30 2023-05-26 杭州高光制药有限公司 一种呋喃[3，2-b]并吡啶衍生物的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020165241A1 (en) * 2001-02-23 2002-11-07 Claiborne Christopher F. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
US20030018038A1 (en) * 1999-10-29 2003-01-23 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US20070149568A1 (en) * 2003-06-04 2007-06-28 Liverton Nigel J N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
US20110172415A1 (en) * 2006-02-23 2011-07-14 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030018038A1 (en) * 1999-10-29 2003-01-23 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US20020165241A1 (en) * 2001-02-23 2002-11-07 Claiborne Christopher F. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
US20070149568A1 (en) * 2003-06-04 2007-06-28 Liverton Nigel J N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
US20110172415A1 (en) * 2006-02-23 2011-07-14 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group

Also Published As

Publication number Publication date
WO2016100349A2 (fr) 2016-06-23

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