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WO2016195526A1 - Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur - Google Patents

Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur Download PDF

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Publication number
WO2016195526A1
WO2016195526A1 PCT/RU2015/000349 RU2015000349W WO2016195526A1 WO 2016195526 A1 WO2016195526 A1 WO 2016195526A1 RU 2015000349 W RU2015000349 W RU 2015000349W WO 2016195526 A1 WO2016195526 A1 WO 2016195526A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
theanine
dogs
cats
tryptophan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2015/000349
Other languages
English (en)
Russian (ru)
Inventor
Людмила Борисовна ТИМИРОВА
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denisov Dmitry Evgenievich
Original Assignee
Denisov Dmitry Evgenievich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denisov Dmitry Evgenievich filed Critical Denisov Dmitry Evgenievich
Priority to PCT/RU2015/000349 priority Critical patent/WO2016195526A1/fr
Publication of WO2016195526A1 publication Critical patent/WO2016195526A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia

Definitions

  • the invention relates to veterinary medicine and animal feeding, namely the production of sedatives for cats and dogs.
  • State of the art relates to veterinary medicine and animal feeding, namely the production of sedatives for cats and dogs.
  • Veterinary preparations, feed additives and other products for animals are known that have a calming and anti-stress effect that are used, including when excited by sexual hunting (Stop-stress, Cot-Bayun, etc.). They contain as active substances various groups of compounds (plant extracts, pheromone-like substances). However, these funds do not have a fast enough effect and during sexual arousal are used mainly as an additional tool.
  • the closest analogue of the invention are chewing tablets for dogs and cats "Anxitane®" (manufactured by Virbac Corporation, France), containing the active ingredient amino acid L-theanine. Tablets promote relaxation, relieve nervousness, anxiety, stress (L. Kern. La transmission de la dairy. In: La Communication. Collection Zoopsychiatrie, Beata C. ed. Marseille, Solal Editeurs, 2005).
  • L-Theanine an amino acid that is part of Anxitane®, has a calming and neuroprotective effect on laboratory animals (Vlasov TD, Barkovskaya A.A., Zukhurova M.A., Tsverina V.M. Mechanisms of the neuroprotective effect of green tea component - L-theanine / Regional blood circulation and microcirculation. - 2010.-N 4.- ⁇ .67-71.).
  • L-theanine as a sedative in the composition of feed additives, dietary supplements, in sports nutrition, as well as food products.
  • Anxitane® does not reduce arousal during sexual hunting in cats and dogs and has a long course of use to achieve a calming effect. Disclosure of invention
  • the objective of the invention was the creation on the basis of the amino acid L-theanine sedative for cats and dogs, which, unlike the analogue, has a quick action and effective, including during sexual hunting.
  • compositions based on the amino acid L-theanine and additional soothing components in particular glycine, tryptophan, ginger and valerian root, were studied.
  • Tests were carried out for each composition on 10 cats and 10 dogs of different ages, sex and different breeds in stressful situations (exhibitions, visits to a veterinarian, etc.), as well as those in arousal caused by sexual hunting. The results are presented in the examples below.
  • Excipients lactose, starch, dry whey, talc
  • flavor additives up to 0.3 g.
  • Tests have shown the calming effect of the composition only in cases where the arousal is not caused by the presence of sexual hunting or sexual arousal.
  • the composition did not have a calming effect in 4 cats that were in the period of sexual hunting and in 2 dogs in a state of sexual arousal.
  • This composition had a sedative effect in 36% of animals after application for 3 times a day. Almost had no effect on animals that are sexually aroused.
  • the composition had a long lasting soothing effect.
  • L-Tryptophan is an essential amino acid that, along with other amino acids, is widely used as a feed additive to balance the diets of farm and domestic animals.
  • a calming feed additive containing tryptophan (Equilizer (France)) is also known. horses with a pronounced reaction to stress and with increased nervousness.
  • tryptophan reduces sexual arousal during sexual hunting in animals.
  • the term “Theanine” (L-theanine, 1-thianine, 1-Theanine, 1-teanin) of the present invention is an amino acid derived from glutamic acid ( ⁇ -glutamyl ethylamide), obtained primarily from tea leaves, as well as synthetic and microbiological . Any form of the amino acid L-theanine, D-theanine and DL-theanine can be used, but it is preferable to use the L-form.
  • Theanine of the present invention can be used both as an amino acid and as an extract of green tea.
  • the tryptophan of the present invention can be 1-tryptophan, 5-hydroxytryptophan, plant extracts containing tryptophan and its derivatives and other biologically active forms of tryptophan and its derivatives obtained by various methods.
  • This composition had a calming effect on all animals, but the effect was less pronounced and not long.
  • the solution was used in a dose of 5 ml per 10 kg of body weight. Tests have shown that in the form of a solution, the composition is no less effective than the solid form and has a calming effect on all animals.
  • the optimal composition is the one containing theanine - 50 mg and tryptophan - 8 mg per 10 kg of animal body weight.
  • composition can be incorporated into feed additives, feed, treats and other feed products for cats and dogs. It can be used in combination with well-known auxiliary substances and excipients (lactose, starch, whey, cheese powder, milk flour, vegetable flour, meat flour, sugar syrup, broth and other feed and pharmaceutical ingredients).
  • the composition is effective both in the form of solid forms (for example, tablets), and in the composition of liquid feed products.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention se rapporte à la médecine vétérinaire. L'invention concerne une composition apaisante ayant une action de diminution de l'excitation sexuelle chez les chiens et les chats qui contient dans une dose pour 10 kg en poids du corps de l'animal, de 5 à 100 mg de théanine et de 2 à 16 mg de tryptophane. Cette composition normalise le comportement des animaux dans les 30 à 60 minutes suivant l'absorption.
PCT/RU2015/000349 2015-06-03 2015-06-03 Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur Ceased WO2016195526A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2015/000349 WO2016195526A1 (fr) 2015-06-03 2015-06-03 Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2015/000349 WO2016195526A1 (fr) 2015-06-03 2015-06-03 Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur

Publications (1)

Publication Number Publication Date
WO2016195526A1 true WO2016195526A1 (fr) 2016-12-08

Family

ID=57441297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2015/000349 Ceased WO2016195526A1 (fr) 2015-06-03 2015-06-03 Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur

Country Status (1)

Country Link
WO (1) WO2016195526A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080044499A1 (en) * 2004-04-06 2008-02-21 Taiyokagaku Co., Ltd. Sleep Improvement Composition
RU2479316C2 (ru) * 2007-09-04 2013-04-20 Дзе Проктер Энд Гэмбл Компани Пероральные композиции, продукты и способы применения

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080044499A1 (en) * 2004-04-06 2008-02-21 Taiyokagaku Co., Ltd. Sleep Improvement Composition
RU2479316C2 (ru) * 2007-09-04 2013-04-20 Дзе Проктер Энд Гэмбл Компани Пероральные композиции, продукты и способы применения

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