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WO2016193743A1 - Dispositif de distribution d'aérosol - Google Patents

Dispositif de distribution d'aérosol Download PDF

Info

Publication number
WO2016193743A1
WO2016193743A1 PCT/GB2016/051636 GB2016051636W WO2016193743A1 WO 2016193743 A1 WO2016193743 A1 WO 2016193743A1 GB 2016051636 W GB2016051636 W GB 2016051636W WO 2016193743 A1 WO2016193743 A1 WO 2016193743A1
Authority
WO
WIPO (PCT)
Prior art keywords
delivery device
aerosol delivery
liquid
electrohydrodynamic aerosol
electrohydrodynamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2016/051636
Other languages
English (en)
Inventor
Elizabeth CROSSLEY
Alfred Vincent SPENCER
Caner Yurteri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicoventures Holdings Ltd
Original Assignee
Nicoventures Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicoventures Holdings Ltd filed Critical Nicoventures Holdings Ltd
Publication of WO2016193743A1 publication Critical patent/WO2016193743A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles

Definitions

  • Electronic cigarettes (e-cigarettes) and other similar devices have been used to produce a nicotine containing aerosol without the need to burn tobacco.
  • e-cigarettes Electronic cigarettes
  • providing an aerosol which is both physiologically and sensorially acceptable to consumers has been a challenge for many e-cigarette devices publically available.
  • the consumer may be satisfied with the olfactory experience provided by the aerosol; however, they may perceive the physiological experience to be unsatisfactory.
  • the present invention is aimed at providing an aerosol delivery device which is capable of providing an aerosol which is acceptable from both a sensorial and physiological standpoint.
  • particles which have a median mass aerodynamic diameter (MMAD) of less than 10 ⁇ are able to bypass the buccal cavity and deposit in the lung, with sizes less than 5 ⁇ able to enter the deep lung.
  • MMAD median mass aerodynamic diameter
  • the sensorial qualities of the aerosol may be compromised since the user is less able to perceive the presence of the aerosol in the buccal cavity.
  • particles which have a median mass aerodynamic diameter (MMAD) of greater than 5 ⁇ are generally more susceptible to deposition in the buccal cavity and as a result are more perceptible to a user from a sensorial (olfactory) perspective.
  • the electrohydrodynamic aerosol delivery device may comprise
  • the nozzle may comprise an outlet orifice and a ground electrode, the outlet orifice and ground electrode being spaced apart from one another.
  • the nozzle may comprise multiple outlet orifices.
  • the power source may be electrically connected to the nozzle such that when activated an electrical potential is applied across the outlet orifice and the ground electrode.
  • the power source may be activated in response to the user inhaling through the device or actuating a button on the device.
  • the one or more parameters which affect the particle size of the produced aerosol may be varied within 2 seconds of the commencement of the inhalation event.
  • the flow of liquid to the nozzle may be controlled through the liquid delivery mechanism.
  • the liquid delivery mechanism may be powered or non-powered.
  • the control unit may be configured to increase or decrease the flow of liquid to the nozzle during an inhalation event.
  • the variation of the potential difference applied between the orifice and the ground electrode may be increased, decreased or pulsed during an inhalation event.
  • the potential difference applied between the orifice and the ground electrode may be pulsed during an inhalation event.
  • the pulsed potential difference may be delivered at a frequency linked to one or more of:
  • the parameters which are varied during the inhalation event may be potential difference applied between the orifice and the ground electrode and flow of liquid to the nozzle.
  • the variation of the one or more of the parameters which are to be varied may lead to an aerosol having a particle size distribution with a maxima at less than 5 microns and a maxima at greater than 5 microns.
  • the variation of the one or more of the parameters which are to be varied may lead to an aerosol having a particle size distribution with a maxima at less than 3 microns and a maxima at greater than 8 microns.
  • the electrohydrodynamic aerosol delivery device may further comprise a liquid store in fluid communication with the liquid delivery mechanism.
  • the liquid store may be replaceable or re-fillable.
  • the electrohydrodynamic aerosol delivery device may further comprise a mouthpiece arranged over the nozzle.
  • the mouthpiece has an air channel which communicates the orifice of the nozzle with the buccal cavity of the user.
  • the aerosol is one where the particle size distribution has one peak equal to or below 5 ⁇ , and a second peak greater than 5 ⁇ , preferably greater than 7 ⁇ preferably greater than 10 ⁇ . In one embodiment, the aerosol is one where the particle size distribution has one peak falling in the range of about 0.1 to 5 ⁇ , and a second peak falling in the range of about 10 to 100 pm.
  • An inhalation event refers to a discrete period of inhalation wherein the air flow through the device increases from zero to a maximum and then reduces back to zero. There may be one or more flow maxima occurring throughout the inhalation event, with the proviso that the inhalation event is deemed to have finished when the flow through the device has dropped to substantially zero.
  • flow through a device can be measured, such as via pressure change, rate of airflow etc.
  • the present disclosure is not limited to an inhalation being determined in one particular manner.
  • the inhalation event will typically last for a number of seconds, for example for around 3 seconds.
  • an inhalation event has a duration of up to 1 second.
  • an inhalation event has a duration of up to 2 seconds.
  • an inhalation event has a duration of up to 3 seconds.
  • an inhalation event has a duration of up to 4 seconds.
  • an inhalation event has a duration of up to 5 seconds.
  • an inhalation event has a duration of 1 second or more, 2 seconds or more, 3 seconds or more, 4 seconds or more, 5 seconds or more.
  • the aerosol delivery device is activated for all or part of the inhalation event.
  • activation refers to the application of an electrical potential across a nozzle of the device which expels the formulation into an aerosol, and a ground electrode spaced apart from the nozzle.
  • the electrical potential applied can either be constant for the duration of the inhalation event, or can vary.
  • Other aspects of the device may also be activated during an inhalation event.
  • the device comprises a liquid delivery mechanism
  • the liquid delivery mechanism need not require power, as it may rely on physical forces to deliver liquid to the nozzle, for example via capillary action or gravity.
  • Electrohydrodynamics involves the study of the dynamics of electrically charged fluids.
  • electrohydrodynamics can refer to the generation of an aerosol as a result of imparting an electrically conductive liquid with electrical charge.
  • the electrical charge increases within the liquid, repulsive forces drive the liquid apart to form a jet which breaks into droplets.
  • the ability of the liquid to form droplets depends on a number of factors, including the surface tension of the liquid, its electrical properties, the magnitude of the electric field and the flow rate of the liquid to the nozzle at which the electric field is applied.
  • an electrohydrodynamic aerosol delivery device for delivering an aerosol to a user via inhalation, wherein the device is configured to vary one or more parameters which affect the particle size of the produced aerosol during a discrete inhalation event.
  • the produced jet can be characterised into two further sub-categories: the varicose mode and the whipping jet mode.
  • the applied electric potential is the primary factor affecting the sub-operating mode (see Yurteri et al, Kona Powder and Particle Journal No. 28 (2010), 91-115, Fig. 6 a) and b)).
  • the flow rate need not be the same for all inhalation events.
  • the liquid delivery mechanism may be controlled such that the flow rate can be varied between inhalation events. This has the advantage that the particle size distribution of the produced aerosol can be shifted up or down in mean size depending on the flow rate set by the user.
  • the liquid delivery mechanism may be controlled by a control unit (such as a control microchip) which modulates the flow rate.
  • the liquid delivery mechanism may comprise a pump, such as a micro pump, and the control unit is able to control the pump to increase or decrease the flow rate.
  • the particle sizes of the aerosols derived from Sample 2 vary according to increasing flow rate, regardless of whether a varicose sub-mode or a whipping sub-mode is utilised. Accordingly, by varying the flow rate (Q.) of the liquid during an inhalation event it is possible to prepare a single aerosol with a range of particle sizes. In essence, the user can tune the particle size of the device by varying the flow rate. However, it is particularly advantageous that the particle size can be varied across the threshold at which on the one hand particles are more likely to deposit in the deep lung (5 micron and below) and on the other hand particles are more likely to deposit in the buccal cavity (above 5 micron).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un dispositif de distribution d'aérosol électro-hydrodynamique (100) pour distribuer un aérosol à un utilisateur par inhalation, le dispositif étant configuré pour faire varier un ou plusieurs paramètres qui modifient la taille des particules de l'aérosol produit lors d'un événement d'inhalation individuel.
PCT/GB2016/051636 2015-05-06 2016-06-03 Dispositif de distribution d'aérosol Ceased WO2016193743A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1509820.5A GB201509820D0 (en) 2015-05-06 2015-05-06 Aerosol delivery device
GB1509820.5 2015-06-05

Publications (1)

Publication Number Publication Date
WO2016193743A1 true WO2016193743A1 (fr) 2016-12-08

Family

ID=53785044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2016/051636 Ceased WO2016193743A1 (fr) 2015-05-06 2016-06-03 Dispositif de distribution d'aérosol

Country Status (2)

Country Link
GB (1) GB201509820D0 (fr)
WO (1) WO2016193743A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US11553734B2 (en) 2018-11-08 2023-01-17 Juul Labs, Inc. Cartridges for vaporizer devices
US11564287B2 (en) 2018-11-05 2023-01-24 Juul Labs, Inc. Cartridges with vaporizable material including at least one ionic component

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064590A1 (fr) * 1999-04-23 2000-11-02 Battelle Memorial Institute Pulverisateur aerosol electrohydrodynamique (ehd) a commande directionnelle
WO2000066206A2 (fr) * 1999-05-03 2000-11-09 Battelle Memorial Institute Compositions destinees a la dispersion par aerosol et a l'inhalation
WO2003053502A1 (fr) * 2001-12-20 2003-07-03 Chrysalis Technologies Incorporated Regulation de l'ecoulement d'air d'entrainment d'une embouchure d'atomiseur
EP1365827A2 (fr) * 2001-02-26 2003-12-03 Optinose AS Dispositifs nasaux
WO2004022243A1 (fr) * 2002-09-06 2004-03-18 Chrysalis Technologies Incorporated Dispositifs de production d'aerosol et procedes de production d'aerosols a dimensions granulometriques regulees
WO2010129994A1 (fr) * 2009-05-11 2010-11-18 Monash University Appareil microfluidique pour l'atomisation d'un liquide
WO2012158033A1 (fr) * 2011-05-17 2012-11-22 Gilbert Technologies B.V. Système d'atomisation électro-hydrodynamique
WO2014183073A1 (fr) * 2013-05-10 2014-11-13 Loec, Inc. Dispositif à tourbillon d'arôme

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064590A1 (fr) * 1999-04-23 2000-11-02 Battelle Memorial Institute Pulverisateur aerosol electrohydrodynamique (ehd) a commande directionnelle
WO2000066206A2 (fr) * 1999-05-03 2000-11-09 Battelle Memorial Institute Compositions destinees a la dispersion par aerosol et a l'inhalation
EP1365827A2 (fr) * 2001-02-26 2003-12-03 Optinose AS Dispositifs nasaux
WO2003053502A1 (fr) * 2001-12-20 2003-07-03 Chrysalis Technologies Incorporated Regulation de l'ecoulement d'air d'entrainment d'une embouchure d'atomiseur
WO2004022243A1 (fr) * 2002-09-06 2004-03-18 Chrysalis Technologies Incorporated Dispositifs de production d'aerosol et procedes de production d'aerosols a dimensions granulometriques regulees
WO2010129994A1 (fr) * 2009-05-11 2010-11-18 Monash University Appareil microfluidique pour l'atomisation d'un liquide
WO2012158033A1 (fr) * 2011-05-17 2012-11-22 Gilbert Technologies B.V. Système d'atomisation électro-hydrodynamique
WO2014183073A1 (fr) * 2013-05-10 2014-11-13 Loec, Inc. Dispositif à tourbillon d'arôme

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US10638792B2 (en) 2013-03-15 2020-05-05 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10201190B2 (en) 2013-12-23 2019-02-12 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10058124B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10070669B2 (en) 2013-12-23 2018-09-11 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US11752283B2 (en) 2013-12-23 2023-09-12 Juul Labs, Inc. Vaporization device systems and methods
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
US10117465B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10117466B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10912331B2 (en) 2013-12-23 2021-02-09 Juul Labs, Inc. Vaporization device systems and methods
US10667560B2 (en) 2013-12-23 2020-06-02 Juul Labs, Inc. Vaporizer apparatus
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10264823B2 (en) 2013-12-23 2019-04-23 Juul Labs, Inc. Vaporization device systems and methods
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10701975B2 (en) 2013-12-23 2020-07-07 Juul Labs, Inc. Vaporization device systems and methods
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD913583S1 (en) 2016-06-16 2021-03-16 Pax Labs, Inc. Vaporizer device
USD929036S1 (en) 2016-06-16 2021-08-24 Pax Labs, Inc. Vaporizer cartridge and device assembly
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US11564287B2 (en) 2018-11-05 2023-01-24 Juul Labs, Inc. Cartridges with vaporizable material including at least one ionic component
US11553734B2 (en) 2018-11-08 2023-01-17 Juul Labs, Inc. Cartridges for vaporizer devices

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