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WO2016183646A1 - Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré - Google Patents

Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré Download PDF

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Publication number
WO2016183646A1
WO2016183646A1 PCT/BR2015/000073 BR2015000073W WO2016183646A1 WO 2016183646 A1 WO2016183646 A1 WO 2016183646A1 BR 2015000073 W BR2015000073 W BR 2015000073W WO 2016183646 A1 WO2016183646 A1 WO 2016183646A1
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WO
WIPO (PCT)
Prior art keywords
lens
intraocular
prosthesis
intraocular pressure
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2015/000073
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English (en)
Portuguese (pt)
Inventor
Ângela Giovanna Fiorita LAGE
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/BR2015/000073 priority Critical patent/WO2016183646A1/fr
Publication of WO2016183646A1 publication Critical patent/WO2016183646A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs

Definitions

  • the subject-matter of this patent relates to a novel type of special intraocular device - either artificial lens replacing or adding to the previously implanted natural lens or intraocular lens (IOL) - designed to allow direct measurement of the intraocular pressure at any time in the mood. in order to substantially improve the treatment and follow-up of glaucoma patients of various origins.
  • IOL intraocular lens
  • Intraocular Lenses From that time to the present day the Intraocular Lenses have been constantly improved and are produced with flexible and foldable material, which allows implantation by about 3 mm incisions and are a valuable resource for Ophthalmology. Intraocular lenses therefore allowed cataracts, the world's leading cause of blindness, to be cured by implanting this prosthesis and thus reversing the state of blindness to which these patients were condemned.
  • the second leading cause of blindness in the world is glaucoma and as it cannot be reversed, it can be said to be the leading cause of permanent blindness in the world (about 12.3% of adult blindness is caused by glaucoma) .
  • Glaucoma has no cure, but it can be controlled. Vision loss caused by glaucoma is irreversible, but may be prevented or delayed with treatment. Treatment is based on hypotensive eye drops, used to decrease intraocular pressure. Laser treatment is also used to slow the effects of the disease. Following-up with an ophthalmologist and regular use of eye drops (patient commitment is critical to successful treatment) is essential for the glaucoma sufferer to maintain the quality of his vision for as long as possible.
  • the diagnosis and treatment of glaucoma requires monitoring of the patient's intraocular pressure by the ophthalmologist, and this measurement is usually done using a Goldman tonometer, which, through the application of a force on the cornea (2 ) measures the deformation of the comeal tissue indicating a reduced intraocular pressure if the strain is greater or a high intraocular pressure if the strain caused on the cornea (2) is small.
  • a Goldman tonometer which, through the application of a force on the cornea (2 ) measures the deformation of the comeal tissue indicating a reduced intraocular pressure if the strain is greater or a high intraocular pressure if the strain caused on the cornea (2) is small.
  • this is an indirect measure of intraocuiar pressure and is imbued with several deviations.
  • Each individual has his own cornea with its own mechanical characteristics, with less or greater ability to tolerate, for example, eye pressure.
  • patients with a reduced measure of comeal hysteresis would present more marked corneal deformation as an effect of ocular pressure with consequent implications for the treatment of glaucoma, since the accuracy of applanation tonometry may be affected by corneal resistance.
  • a recent article demonstrates the effects of corneal stiffness or Young's modulus on Goldman applanation tonometry and may lead to measurements with deviations of about 15 mmHg in an eye with estimated eye pressure of 20 mmHg.
  • Such a lens is made of silicone and has an annular pressure gauge, a microprocessor and an antenna that transmits data to an external receiver.
  • This Contact Lens is to continuously monitor the shape of the cornea for 24 hours, which indicates greater or lesser intraocular pressure, based on the Goidman tonometer principle.
  • Accurate information is expected to be obtained, providing a patient profile and an appropriate strategy to control pressure throughout the day can be defined.
  • the concept applied to the present patent differs substantially from the principles used in current ophthalmology in that it seeks a direct measurement of the surrounding fluid pressure (aqueous humor), unlike the Goldman tonometer, which uses indirect intraocular pressure measurement).
  • Figure 1 represents anteroposterior section of the human eye (1), in which we see the cornea (2), the ciliary body (3), the pupil (4), the iris (5), the ligaments (6). ), the crystalline lens (7) bathed in aqueous humor, the vitreous humor (8), the sclerotic (9), the choroid (10), the retina (11), the macula (12), the fovea (13), blind spot (14), located at the intraocular emergence of the optic nerve (15), which is also called the papilla.
  • the lens 7 is shown in side view in Figure 1 with approximately elliptical shape and, if viewed frontally, has approximately circular shape.
  • Both the intraocular lens usually used in the treatment of cataract and the intraocular lens - prosthesis - with embedded vessel pressure meter, object of this patent, are surgically implanted to replace the lens (7) and both also replace the optical function of the lens for convergence of the lens. light and images on the retina (1 1).
  • the innovation core of the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER" refers to the use of an intraocular optic device, surgically implanted in the region of the lens of the lens or preferably to replace it, to fulfill the optical function of the lens and additionally serve as an instrument for measuring intraocular pressure existing directly in aqueous humor.
  • FIG. 2 is a schematic representation of the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER" in front view (16 to 20) and external pressure reading receiver (21).
  • element 16 is the optical material substrate of the lens itself.
  • Elements 17 through 20 represent the electronic components of the lens involved in intraocular pressure measurement.
  • External electromagnetic excitation (22) is generated by external emitter / receiver equipment (21), triggered by the physician or patient near the eye at the time the measurements are taken.
  • the energy captured by the antenna (17) is used in the electronic circuit (19) and the pressure sensor (20) mounted on the lens (16) for reading intraocular pressure.
  • the energy is also used for the electronic circuit (19) to send, via antenna (18), a return signal (23) with the value of the pressure read to be captured by the external transmitter / receiver equipment (21).
  • the intraocular pressure value is recorded and displayed on the external equipment (21).
  • External equipment (21) can download saved data from various intraocular pressure readings into a computer for physician and patient use.
  • the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER" object of this patent, can assume several configurations and the one adopted in illustration 2 is very convenient in its simplicity of operation and construction.
  • a single antenna may be used to perform the functions of the antenna (17) used to receive the power-up signal and the antenna (18) to send the signal with the pressure reading.
  • the "INTRAOCULAR LENS - PROSTHESIS - WITH BOARDING INTRAOCULAR PRESSURE METER” may be provided with a micro battery and photocells for loading with consequent increased complexity of the prosthesis.
  • the external unit (21) can assume various configurations, such as a wristwatch with an additional intraocular pressure gauge function, or as a spectacle frame with an additional intraocular pressure gauge function and can display pressure values. collected on a display or may even have the ability to download them on a microcomputer for automatic sending to the attending physician.
  • the configuration of the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER” shown in figure 2 and powered and powered by electromagnetic induction presents a simple concept as it does not require the use of batteries and photocells.
  • the induction used to excite and energize electronic circuits is a widely used technology and has application ranging from charging pacemakers batteries in the field of cardiology to commercial applications such as "safety labels" affixed to clothing (which do not have which only consist of an internal antenna and passive electronic circuit) and can be excited / energized by external emission antennas affixed to the outlet of the oven to emit a return electromagnetic signal which, in turn, captured by external antennas, makes sound the shop alarm.
  • the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER" (16) may or may not replace the lens and may only be implanted in addition to the natural lens or a previously implanted Intraocular Lens.
  • the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER” (16) is transparent and has carefully controlled geometric shape and internal refractive index to ensure correct optical convergence of the patient's eye in the same way as a lens. traditional intraocular.
  • the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER” (16) has a sensor for pressure measurement for the surrounding fluid (aqueous humor), electronic circuitry for reading the pressure signal and its wireless transmission to the outdoor environment, energization circuit from external or internal rechargeable source.
  • the "INTRAOCULAR LENS - PROSTHESIS WITH BOARDING INTRAOCULAR PRESSURE METER” (16) can be manufactured on a robotic industrial scale in short. time frames and at affordable costs.
  • This additional device may take the form of a valve or a micro pump and may act directly on the intraocular pressure, being controlled and actuated from the INTRAOCULAR LENS, object of the present invention.
  • the doctor or the user of the Intraocular Lens could, in specific cases, activate the device (valve or micro-pump) by actuation via the external unit (21).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Prostheses (AREA)

Abstract

Domaines de l'invention : - Amélioration considérable de la qualité de traitement de personnes souffrant de glaucome d'origines diverses. - Ophtalmologie. Le présent brevet a pour objet un nouveau type de dispositif intraoculaire spécial - ou cristallin artificiel en remplacement ou en complément du cristallin naturel ou de la lentille oculaire préalablement implantée - destiné à permettre la mesure directe de la pression intraoculaire en cours à n'importe quel moment dans l'humeur aqueuse de façon à améliorer sensiblement le traitement et l'accompagnement de patients souffrant de glaucome d'origines diverses. La présente "Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré", est transparente et possède une forme géométrique et un indice de réfraction interne soigneusement contrôlés, de manière à assurer une bonne convergence optique de l'oeil et à disposer d'un capteur de mesure de pression pour le fluide environnant (humeur aqueuse), un circuit électronique permettant la lecture du signal de pression et sa transmission sans fil vers l'environnement extérieur, un circuit assurant l'alimentation en énergie à partir d'une source externe ou interne rechargeable. La présente "Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré" peut être combinée à un dispositif valve ou micro-pompe. Ce dispositif peut agir directement sur la pression intraoculaire et est commandé et actionné à partir de la lentille intraoculaire objet du présent brevet.
PCT/BR2015/000073 2015-05-15 2015-05-15 Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré Ceased WO2016183646A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/BR2015/000073 WO2016183646A1 (fr) 2015-05-15 2015-05-15 Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2015/000073 WO2016183646A1 (fr) 2015-05-15 2015-05-15 Lentille intraoculaire - prothèse - avec dispositif de mesure de pression intraoculaire intégré

Publications (1)

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WO2016183646A1 true WO2016183646A1 (fr) 2016-11-24

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179953A (en) * 1991-08-27 1993-01-19 Jermik Systems, Ltd. Portable diurnal intraocular pressure recording system
GB2464981A (en) * 2008-11-01 2010-05-05 Univ Dundee Pressure sensor for measuring intraocular pressure that can be worn on the eye.
US20110071505A1 (en) * 2009-09-21 2011-03-24 Matthew Rickard Intraocular Pressure Sensor with External Pressure Compensation
DE102009046823A1 (de) * 2009-11-18 2011-05-19 Robert Bosch Gmbh System zum Einstellen des Augeninnendrucks
WO2011083105A1 (fr) * 2010-01-05 2011-07-14 Sensimed Sa Dispositif de surveillance de la pression intraoculaire
WO2012037455A1 (fr) * 2010-09-16 2012-03-22 Orthomems, Inc. Capteur de pression implantable expansible pour chirurgie intraoculaire
WO2012052765A2 (fr) * 2010-10-20 2012-04-26 University Of Dundee Dispositif de surveillance de pression intra-oculaire
WO2013050073A1 (fr) * 2011-10-05 2013-04-11 Sensimed Sa Dispositif de mesure et/ou de surveillance de la pression intraoculaire

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179953A (en) * 1991-08-27 1993-01-19 Jermik Systems, Ltd. Portable diurnal intraocular pressure recording system
GB2464981A (en) * 2008-11-01 2010-05-05 Univ Dundee Pressure sensor for measuring intraocular pressure that can be worn on the eye.
US20110071505A1 (en) * 2009-09-21 2011-03-24 Matthew Rickard Intraocular Pressure Sensor with External Pressure Compensation
DE102009046823A1 (de) * 2009-11-18 2011-05-19 Robert Bosch Gmbh System zum Einstellen des Augeninnendrucks
WO2011083105A1 (fr) * 2010-01-05 2011-07-14 Sensimed Sa Dispositif de surveillance de la pression intraoculaire
WO2012037455A1 (fr) * 2010-09-16 2012-03-22 Orthomems, Inc. Capteur de pression implantable expansible pour chirurgie intraoculaire
WO2012052765A2 (fr) * 2010-10-20 2012-04-26 University Of Dundee Dispositif de surveillance de pression intra-oculaire
WO2013050073A1 (fr) * 2011-10-05 2013-04-11 Sensimed Sa Dispositif de mesure et/ou de surveillance de la pression intraoculaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTEO LEONARDI ET AL.: "Wireless contact lens sensor for intraocular pressure monitoring: assessment on enucleated pig eyes", ACTA OPHTHALMOLOGICA, June 2009 (2009-06-01), pages 433 - 437, XP055330422 *

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