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WO2016171196A1 - Procédé de production de conteneur en verre médical pour lequel l'apparition de craquelures est réduite - Google Patents

Procédé de production de conteneur en verre médical pour lequel l'apparition de craquelures est réduite Download PDF

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Publication number
WO2016171196A1
WO2016171196A1 PCT/JP2016/062588 JP2016062588W WO2016171196A1 WO 2016171196 A1 WO2016171196 A1 WO 2016171196A1 JP 2016062588 W JP2016062588 W JP 2016062588W WO 2016171196 A1 WO2016171196 A1 WO 2016171196A1
Authority
WO
WIPO (PCT)
Prior art keywords
glass container
point burner
tip
vial
flame
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/062588
Other languages
English (en)
Japanese (ja)
Inventor
井上　淑雄
和久 森内
祥博 河合
石川　篤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nipro Corp
Original Assignee
Nipro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nipro Corp filed Critical Nipro Corp
Priority to CN201680023507.6A priority Critical patent/CN107531543B/zh
Priority to US15/567,624 priority patent/US10550027B2/en
Priority to JP2017514175A priority patent/JP6690639B2/ja
Priority to EP16783217.9A priority patent/EP3287420B1/fr
Priority to PL16783217T priority patent/PL3287420T3/pl
Publication of WO2016171196A1 publication Critical patent/WO2016171196A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B32/00—Thermal after-treatment of glass products not provided for in groups C03B19/00, C03B25/00 - C03B31/00 or C03B37/00, e.g. crystallisation, eliminating gas inclusions or other impurities; Hot-pressing vitrified, non-porous, shaped glass products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B29/00—Reheating glass products for softening or fusing their surfaces; Fire-polishing; Fusing of margins
    • C03B29/02—Reheating glass products for softening or fusing their surfaces; Fire-polishing; Fusing of margins in a discontinuous way
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C23/00—Other surface treatment of glass not in the form of fibres or filaments
    • C03C23/007—Other surface treatment of glass not in the form of fibres or filaments by thermal treatment

Definitions

  • the present invention relates to a method for manufacturing a medical glass container in which the occurrence of cracks is suppressed.
  • Borosilicate glass with excellent chemical durability is often used as a raw material for medical glass containers such as medical vials.
  • a glass tube made of borosilicate glass is heated and deformed to form the mouth and bottom of the vial.
  • the alkali component contained in the borosilicate glass is volatilized. Volatilized alkali components are condensed particularly on the inner surface in the vicinity of the bottom of the vial, resulting in a process deterioration region. Such a process-deteriorated region may elute alkali components from medicines stored in vials.
  • ISO 4802-1, ISO 4802-2, etc. elution standards for alkaline components are defined.
  • the nozzle of the point burner In fire blasting, it is preferable to insert the nozzle of the point burner into the internal space of the vial in order to place the flame ejected from the nozzle of the point burner in an optimal position.
  • the tip of the nozzle approaches the opening of the vial.
  • the vicinity of the opening of the vial is heated by the flame ejected from the nozzle of the point burner.
  • the present inventors have found that when the vicinity of the opening of the vial is heated, cracks are likely to occur near the opening of the glass container.
  • the present invention has been made in view of these circumstances, and an object thereof is to produce a crack in a medical glass container in a method for manufacturing a medical glass container formed from a borosilicate glass glass tube as a raw material. It is to provide a difficult means.
  • the tip of the ignited point burner is moved from the position where the flame ejected from the tip of the point burner does not contact the glass container to the outside of the glass container.
  • a first step of moving to a position facing the opening of the glass container a second step of inserting the tip of the ignited point burner into the internal space of the glass container through the opening, and the glass container Holding the tip of the point burner in the inner space of the glass container, a third step of causing the flame ejected from the tip of the point burner to collide with the inner surface of the glass container, and opening the tip of the point burner that has been ignited
  • the opening of the glass container And a fifth step in which the flame ejected from the tip of the point burner moves to a position where the flame does not contact the glass container, at least in the second step and the fourth step, in the third step,
  • a processing deterioration region occurs on the inner surface of the glass container.
  • the tip of a point burner is located in the interior space of a glass container, and the flame spouted from the tip of a point burner is made to collide with the inner surface of a glass container. Thereby, a process deterioration area
  • region is removed from the inner surface of a glass container.
  • a flame with a thermal power weaker than the thermal power of the point burner that collides with the inner surface of the glass container in the third step is ejected from the point burner.
  • a shielding mechanism is positioned in the vicinity of the opening of the glass container, and the flame ejected from the tip of the point burner by the shielding mechanism is applied to the glass container. Shield from touching.
  • the tip of the point burner is outside the glass container, and is rotated between a position near the opening of the glass container and a position where the flame does not contact the glass container.
  • the shielding mechanism shields the flame ejected from the tip of the point burner from coming into contact with the glass container.
  • the glass container is supported so that the opening of the glass container faces upward from the horizontal direction, and at least in the second step and the fourth step, a nozzle that forms the tip of the point burner is provided. It moves with respect to the said glass container as a state along the direction parallel to the axis of the said glass container.
  • the tip of the point burner moves between the outside and inside of the glass container in parallel with the axis of the glass container.
  • the flame ejected from the tip of the point burner is ejected in a direction parallel to the axis of the glass container.
  • the glass container is supported by a pair of rollers, and the flame ejected from the tip of the point burner is collided with the inner surface of the glass container while rotating the roller. Rotate the glass container.
  • a shielding plate capable of shielding a flame ejected from the tip of the point burner is used as the shielding mechanism, and in the first step and the fifth step, an edge portion that defines the opening of the glass container is used.
  • the said shielding board is located between a part and the front-end
  • the shielding plate is positioned between the upper side of the edge of the glass container and the tip of the point burner.
  • the tip of the point burner is moved relative to the glass container by rotating the point burner.
  • the moving distance of the point burner with respect to the axial direction of the glass container is shortened, and the tip of the point burner is greatly separated from the glass container.
  • the processing deterioration region is removed using a flame of a point burner, and a crack is generated in the medical glass container. This can be suppressed.
  • FIG. 1 is a schematic view of a fire blast device 80 according to an embodiment of the present invention in a state where a point burner 30 is in a standby position.
  • FIG. 2 is a schematic view of the point burner moving device 40 in a state where the point burner 30 is along the horizontal direction (front-rear direction 103).
  • 3A and 3B are schematic views showing a state in which the vial 10 is placed on the roller pair 60 and a part of the mouth portion 13 is shielded by the shielding plate 51.
  • FIG. FIG. 4A is a diagram illustrating a state where the point burner 30 is in the standby position in the first step
  • FIG. 4B is a diagram in which the flame 31 ejected from the tip of the point burner 30 is caused by the shielding plate 51.
  • FIG. 1 is a schematic view of a fire blast device 80 according to an embodiment of the present invention in a state where a point burner 30 is in a standby position.
  • FIG. 2 is a schematic view of the point burner moving
  • FIG. 4C is a diagram showing a state where the nozzle 32 of the point burner 30 is along a direction parallel to the axis of the glass container.
  • FIG. 5 is a diagram illustrating a state where the nozzle 32 of the point burner 30 is inserted into the internal space 14 of the vial 10 in the second step.
  • FIG. 6 is a diagram illustrating the point burner 30 and the like in the third step.
  • the fire blast device 80 includes a point burner 30, a point burner moving device 40, a roller pair 60, and a shielding plate 51.
  • the fire blast device 80 is a device for performing fire blasting on the vial 10 (an example of a glass container).
  • a vertical direction 101 is defined with reference to the vertical direction in FIG. 1
  • a horizontal direction 102 is defined with reference to a direction perpendicular to the paper surface of FIG. 1.
  • a front-rear direction 103 is defined.
  • the point burner 30 has a burner body 33 and a nozzle 32, and is connected to a cylinder and a flow rate control device (not shown).
  • the burner body 33 has a generally cylindrical shape, and a flow path through which combustible gas such as liquefied natural gas and oxygen can flow, and the flow path merge to form a mixed gas, and the mixed gas can flow.
  • a simple flow path is formed in the internal space.
  • the burner body 33 is connected to a cylinder storing flammable gas and a cylinder storing oxygen in the base end side.
  • a flow rate control device (not shown) for controlling the flow rates of combustible gas and oxygen is provided.
  • the flow rate control device a known device can be used.
  • the nozzle 32 is connected to the tip end side of the burner body 33.
  • the nozzle 32 has a straw shape, and the mixed gas flowing out from the burner body 33 can flow therethrough.
  • the outer diameter of the nozzle 32 can be inserted into the internal space 14 of the vial 10 and is designed to have a thickness that allows the axial direction of the nozzle 32 to be changed in a state where the tip of the nozzle 32 is positioned in the internal space 14 of the vial 10. Has been. That is, the outer diameter of the nozzle 32 is sufficiently thinner than the inner diameter of the neck portion 18 of the vial 10.
  • the length along the axial direction of the nozzle 32 is sufficiently longer than the length along the axial direction of the vial 10.
  • a material having high heat resistance such as ceramic is preferable.
  • the mixed gas flows out from the inner space of the burner body 33 through the inner space of the nozzle 32 to the outside from the tip of the nozzle 32 which is the tip of the point burner 30.
  • flame is ejected from the tip of the point burner 30.
  • the thermal power of the flame 31 ejected from the tip of the point burner 30 can be controlled by diffling the flow rates of gas and oxygen by the flow rate control device.
  • the strength of the thermal power is generally defined by the amount of heat per hour (kcal / h).
  • the point burner moving device 40 is for moving the point burner 30 relative to the vial 10. As shown in FIG. 1, the point burner moving device 40 includes a rotation device 41, a slide device 42, and a burner support portion 43.
  • the rotation device 41 has a rotation shaft 44, a rotation shaft support portion 45, and a rotation drive device (not shown).
  • the rotation shaft 44 is rotatably supported by the rotation shaft support portion 45 in a state where the axial direction is along the left-right direction 102.
  • a burner support portion 43 is fixed to the rotation shaft 44.
  • the point burner 30 is connected to the rotating shaft 44 through the burner support portion 43. By rotating the rotation shaft 44, the point burner 30 rotates around the rotation shaft 44 together with the burner support portion 43.
  • a driving force is input to the rotating shaft 44 from a driving source such as a stepping motor.
  • the point burner 30 is rotated to a desired rotation position by controlling the rotation direction and the rotation amount of the drive source.
  • the slide device 42 includes a slide portion 46, a slide portion support 47, and a slide drive device (not shown).
  • the slide portion 46 is stacked on the upper surface of the slide portion support base 47 so as to be slidable in the front-rear direction 103.
  • a guide along the front-rear direction 103 is provided on the upper surface of the slide support base 47, and the slide unit 46 is guided in the front-rear direction 103 by this guide.
  • a driving force is input to the slide unit 46 from a driving source such as a stepping motor.
  • the slide unit 46 By controlling the direction and driving amount of the driving force supplied from the driving source with respect to the front-rear direction 103, the slide unit 46 is slid to an arbitrary position with respect to the front-rear direction 103. As the slide portion 46 slides, the rotation shaft support portion 45 and the point burner 30 move.
  • the position of the point burner 30 shown in FIG. 1 is a standby position. In the standby position, the point burner 30 is located in the right-hand direction in FIG. Further, the flame 31 ejected from the tip of the nozzle 32 of the point burner 30 is generally directed upward, and is a position that does not contact the vial 10.
  • the point burner 30 can be moved to a slide position as shown in FIG. 2 by rotating the rotating shaft 44 counterclockwise. In the slide position, the axial direction of the point burner 30 may be slightly inclined with respect to the horizontal direction (front-rear direction 103). The axial direction of the point burner 30 is parallel to the axial lines of a roller pair 60 and a vial 10 described later.
  • the tip of the nozzle 32 of the point burner 30 is inclined with respect to the horizontal direction (front-rear direction 103) so that the tip of the nozzle 32 is below the base end side.
  • the axis of the nozzle 32 is inclined from 0 to 10 degrees with respect to the horizontal direction (front-rear direction 103). Further, the tip of the nozzle 32 of the point burner 30 is at a position facing the opening 16 of the vial 10 outside the vial 10. When the rotation shaft 44 is rotated clockwise from the slide position, the point burner 30 can be moved from the slide position to the standby position.
  • roller pair 60 As shown in FIGS. 3A and 3B, the roller pair 60 is a pair of a first roller 61 and a second roller 62.
  • the first roller 61 and the second roller 62 are juxtaposed along the left-right direction 102 with the rotation axis slightly inclined with respect to the front-rear direction 103.
  • the axis line inclines with respect to a horizontal direction (front-back direction 103) so that the surface which opposes the point burner 30 may become above from the other side.
  • the axis of the roller pair 60 is inclined from 0 to 10 degrees with respect to the horizontal direction (front-rear direction 103).
  • the interval between the first roller 61 and the second roller 62 is sufficiently narrow with respect to the outer diameter of the vial 10.
  • the vial 10 is placed on the roller pair 60 so that the outer peripheral surface of the vial 10 is in contact with the outer peripheral surfaces of both the first roller 61 and the second roller 62.
  • the axis of the vial 10 placed on the roller pair 60 is parallel to the axes of the first roller 61 and the second roller 62.
  • the first roller 61 and the second roller 62 rotate in the same direction, the vial 10 placed on the roller pair 60 is rotated around the axis of the vial 10.
  • the first roller 61 and the second roller 62 receive a driving force from a driving source such as a motor.
  • a support mechanism for rotatably supporting the roller pair 60 is omitted.
  • a counter plate 20 is provided opposite to the point burner 30 in the front-rear direction 103 with respect to the roller pair 60.
  • the contact plate 20 is a flat plate having a flat surface on the roller pair 60 side, and is disposed so as to protrude upward from the roller pair 60.
  • the contact plate 20 can contact the bottom 11 of the vial 10 placed on the roller pair 60.
  • the bottom of the vial 10 placed on the roller pair 60 is positioned with respect to the front-rear direction 103 by the contact plate 20.
  • the shielding plate 51 is an example of a shielding mechanism. As shown in FIG. 3A and FIG. 3B, the shielding plate 51 is a thin flat plate in the front-rear direction 103. The shielding plate 51 has a trapezoidal shape that narrows downward in the left-right direction 102. The width of the shielding plate 51 in the left-right direction 102 is designed to be wider than the outer diameter of the mouth portion 13 of the vial 10. The shielding plate 51 is positioned between the roller pair 60 and the point burner 30 in the front-rear direction 103 so that one of the front and back surfaces extends in the up-down direction 101 and the left-right direction 102. As shown in FIG.
  • the shielding plate 51 is tilted in the front-rear direction 103 so as to be parallel to the edge 17 that defines the opening 16 of the vial 10.
  • the shielding plate 51 is disposed slightly above the roller pair 60.
  • the lower end of the shielding plate 51 is located slightly above the center of the opening 16 of the vial 10 in the vertical direction 101.
  • the surface of the shielding plate 51 on the side of the vial 10 faces while being close to a part on the upper side of the end surface having the edge 17 in the mouth portion 13.
  • the position of the shielding plate 51 is movable in accordance with the size of the vial 10 placed on the roller pair 60. Although not shown in detail in each drawing, it is preferable that the shielding plate 51 is movable with respect to the vertical direction 101. As will be described later, the position of the shielding plate 51 is adjusted so as to be between a part of the upper side of the edge portion 17 that defines the opening 16 of the vial 10 and the point burner 30. The flame 31 ejected from the tip of the point burner 30 can move in the vertical direction 101 while contacting the central portion of the shielding plate 51 in the left-right direction 102 from above to below.
  • the material of the shielding plate 51 may be any material that blocks the flame 31 ejected from the tip of the point burner 30, and examples thereof include metals such as stainless steel and graphite having good thermal conductivity.
  • the vial 10 is an example of a medical glass container. As shown in FIGS. 3 and 4, the vial 10 is a container having a substantially cylindrical outer shape with a sealed bottom, and has a bottom part 11, a side part 12, a neck part 18 and a mouth part 13 in order from the left side.
  • the vial 10 has an internal space 14 and opens at one end of the mouth portion 13.
  • the bottom portion 11 has a flat disk shape and is continuous with the side surface portion 12 at the edge of the bottom portion 11.
  • the side surface portion 12 has a cylindrical shape.
  • the side surface portion 12 is formed with a constant outer diameter and inner diameter in the axial direction.
  • the neck portion 18 is continuous with the side surface portion 12 and narrows in a tapered shape from the side surface portion 12.
  • the inner diameter and outer diameter of the neck portion 18 are formed to be narrower than the side surface portion 12.
  • the mouth portion 13 is continuous with the neck portion 18 and has an opening 16 defined by the edge portion 17.
  • the inner diameter and outer diameter of the mouth portion 13 are formed narrower than the side surface portion 12.
  • the outer diameter of the mouth portion 13 is formed wider than the narrowest portion of the outer diameter of the neck portion 18.
  • the manufacturing method of the vial 10 mainly includes a container forming process and a fire blast process.
  • the container forming step is a step of forming the vial 10 from a glass tube.
  • the fire blasting process is a process of causing the flame 31 ejected from the tip of the point burner 30 to collide with a work deterioration region on the inner surface 15 of the vial 10.
  • the vial 10 is formed by heating a glass tube that is held vertically and rotates using a general vertical molding machine.
  • the glass tube is softened by being heated by a burner flame.
  • the bottom portion 11 and the mouth portion 13 of the vial 10 are formed from the glass tube.
  • alkali borate or the like is volatilized from the borosilicate glass that is the raw material of the glass tube.
  • Alkaline components such as volatilized alkali borate adhere to the vicinity of the bottom 11 on the inner surface 15 of the vial 10 and cause a work deterioration region. In order to remove the processing deterioration region, a fire blast process described in detail below is performed.
  • a fire blasting device 80 In the fire blasting process, a fire blasting device 80 is used.
  • the fire blast process mainly includes the following five processes. (1) From the position where the flame 31 ejected from the tip of the point burner 30 does not contact the vial 10 to the position outside the vial 10 and facing the opening 16 of the vial 10 1st process to move. (2) Second step of inserting the tip of the ignited point burner 30 into the internal space 14 of the vial 10 through the opening 16. (3) A third step of causing the flame 31 ejected from the tip of the point burner 30 to collide with the inner surface 15 of the vial 10 while holding the tip of the point burner 30 in the internal space 14 of the vial 10.
  • the vial 10 is placed on a rotating roller pair 60.
  • the vial 10 is rotated about the axis of the vial 10 while the bottom 11 of the vial 10 abuts against the plate 20.
  • the shielding plate 51 is moved to a position corresponding to the size of the vial 10 in the first step. That is, the shielding plate 51 is adjusted so as to be between the point burner 30 and a part on the upper side of the edge 17 that defines the opening 16 of the vial 10 in the front-rear direction 103 and the vertical direction 101.
  • the shielding plate 51 is positioned near the opening 16 of the vial 10.
  • the point burner 30 is positioned at the standby position.
  • the axis of the nozzle 32 of the point burner 30 is inclined with respect to the horizontal direction (the front-rear direction 103) so that the tip is located above the vial 10 placed on the roller pair 60.
  • the angle at which the axis of the nozzle 32 is inclined with respect to the horizontal direction (the front-rear direction 103) is set according to the outer shape of the vial 10 and the length of the nozzle 32. For example, as shown in FIG. In addition, it is about 70 degrees.
  • the point burner 30 is ignited before the first step is performed, but the flame 31 ejected from the tip of the nozzle 32 of the point burner 30 does not contact the vial 10 in the standby position.
  • the thermal power of the flame 31 ejected from the tip of the point burner 30 can be controlled by a flow control device.
  • the heating power of the flame 31 ejected from the tip of the point burner 30 is adjusted to be weaker than the heating power of the flame 31 that collides with the inner surface 15 of the vial 10 in the third step.
  • the flame 31 ejected from the tip of the point burner 30 does not need to be strong enough to perform fire blasting on the vial 10, and is caused to collide with the inner surface 15 of the vial 10 in the third step. It is preferable that the heating power of the flame 31 is weaker.
  • the point burner 30 at the standby position is rotated by the rotation device 41 to a position where the axis of the nozzle 32 is parallel to the axis of the vial 10. .
  • the flame 31 ejected from the tip of the point burner 30 also descends while drawing an arc.
  • the flame 31 ejected from the tip of the point burner 30 moves while contacting the central portion of the shielding plate 51 in the left-right direction 102 from above to below.
  • the shielding plate 51 does not exist, the rotation trajectory of the flame 31 overlaps with the mouth portion 13 of the vial 10 placed on the roller pair 60, but from the tip of the point burner 30.
  • the jetted flame 31 Since the jetted flame 31 is shielded by the shielding plate 51, it does not contact the mouth 13 of the vial 10.
  • the point burner 30 When the point burner 30 is rotated to the position shown in FIG. 4C, the axis of the nozzle 32 becomes parallel to the axis of the vial 10 and the tip of the nozzle 32 substantially coincides with the center of the opening 16 of the vial 10. To do.
  • the tip of the point burner 30 is positioned below the lower end of the shielding plate 51, and a part of the flame 31 ejected from the tip of the point burner 30 passes through the mouth portion 13 to the internal space 14 of the vial 10. enter in.
  • the thermal power of the flame 31 ejected from the tip of the point burner 30 is adjusted to be weaker than the thermal power of the flame 31 that collides with the inner surface 15 of the vial 10 in the third step.
  • the point burner 30 is ignited in the second step by the slide device 42.
  • the nozzle 32 is slid along the horizontal direction (front-rear direction 103) in a direction in which the nozzle 32 enters the internal space 14 of the vial 10 in a state where the nozzle 32 is aligned in a direction parallel to the axis of the vial 10.
  • FIG. 5 the tip portion of the nozzle 32 enters the internal space 14 through the opening 16 of the vial 10.
  • the point burner 30 is rotated by the rotation device 41 so that the tip of the nozzle 32 faces the vicinity of the upper end of the bottom 11 of the inner surface 15 of the vial 10.
  • the axis of the nozzle 32 of the point burner 30 is inclined with respect to the horizontal direction (front-rear direction 103) so that the tip end is above the base end.
  • the fire power of the flame 31 ejected from the tip of the point burner 30 is adjusted to a sufficient strength to perform fire blasting on the vial 10.
  • the heating power of the flame 31 ejected from the tip of the point burner 30 needs to be strong enough to remove alkali components and the like contained in the processing deterioration region to the outside of the vial 10.
  • the flame 31 ejected from the tip of the point burner 30 collides with the inner surface 15 of the vial 10. Further, when the roller pair 60 is rotated, the vial 10 rotates around the axis while keeping the axis line along the horizontal direction (front-rear direction 103). Thereby, the flame 31 ejected from the tip of the point burner 30 sequentially collides in the circumferential direction of the inner surface 15 of the vial 10. Thereby, the process deterioration area which arose in the inner surface 15 of the vial 10 is removed.
  • the process in which the processing deterioration region is removed by the flame 31 ejected from the tip of the point burner 30 is called fire blast.
  • the heating power of the flame 31 ejected from the tip of the point burner 30 is adjusted to be weaker than the heating power of the flame 31 that collides with the inner surface 15 of the vial 10 in the third step.
  • the point burner 30 is rotated by the rotating device 41 until the axis of the nozzle 32 is parallel to the axis of the vial 10.
  • the point burner 30 is slid by the slide device 42 in the opposite direction to the second step, that is, away from the vial 10, so that the nozzle 32 moves from the internal space 14 to the outside through the opening 16 of the vial 10. (The state shown in FIG. 4C).
  • the thermal power of the flame 31 ejected from the tip of the point burner 30 is adjusted to be weaker than the thermal power of the flame 31 that collides with the inner surface 15 of the vial 10 in the third step.
  • the point burner 30 is rotated from the position shown in FIG. 4C to the standby position shown in FIG. In the process in which the point burner 30 is rotated, the flame 31 ejected from the tip of the point burner 30 is shielded by the shielding plate 51 as shown in FIG. Therefore, in this rotation, the flame 31 ejected from the tip of the point burner 30 does not contact the vial 10.
  • the process deterioration region is removed from the inner surface 15 of the vial 10 by causing the flame 31 ejected from the tip of the point burner 30 to collide with the process deterioration region on the inner surface 15 of the vial 10. Is done.
  • the flame 31 having a thermal power that is weaker than the thermal power of the flame 31 of the point burner 30 that collides with the inner surface of the vial 10 in the third step is ejected from the tip of the point burner 30.
  • the shielding plate 51 prevents the flame 31 from coming into direct contact with the periphery of the opening 16 of the vial 10. Thereby, the occurrence of cracks in the vial 10 is suppressed.
  • the vial 10 is supported so that the opening of the vial 10 faces upward in the horizontal direction (front-rear direction 103).
  • the nozzle 32 constituting the tip of the point burner 30 is attached to the vial 10. It moves with respect to the vial 10 as a state along the direction parallel to the axis of. For this reason, the tip of the point burner 30 is moved between the outside of the vial 10 and the internal space 14 in parallel to the axial direction of the vial 10.
  • the flame 31 ejected from the tip of the point burner 30 is ejected in parallel to the axial direction of the vial 10.
  • the tip of the point burner 30 passes near the neck 18 of the vial 10, the flame 31 is jetted in parallel to the axial direction of the vial 10. It is suppressed that 31 contacts.
  • the vial 10 is supported by the pair of rollers 60, and the vial 10 is rotated by the rotation of the roller pair 60 while the flame 31 ejected from the tip of the point burner 30 collides with the inner surface 15 of the vial 10. It is rotated around the axis of the vial 10. For this reason, the flame 31 ejected from the tip of the point burner 30 collides uniformly in the circumferential direction on the inner surface 15 of the vial 10.
  • the shielding plate 51 that can shield the flame 31 ejected from the tip of the point burner 30 is used as the shielding plate 51, and a part of the edge 17 that defines the opening 16 of the vial 10 in the first step and the fifth step Since the shielding plate 51 is positioned between the tip of the point burner 30, a simple structure shielding mechanism is realized.
  • the horizontal direction of the point burner 30 in the first step and the fifth step is shortened. That is, in the first step and the fifth step, the moving distance of the point burner 30 with respect to the axial direction of the vial 10 is designed to be short.
  • the shielding plate 51 is employed as the shielding mechanism, but the effects of the present invention can be achieved even in a form in which the shielding mechanism is not employed.
  • the thermal power of the flame 31 ejected from the tip of the point burner 30 is caused by the thermal power of the flame 31 that collides with the inner surface 15 of the vial 10 in the third step.
  • the point burner 30 is rotated in the first step and the fifth step, the amount of heat applied to the vicinity of the mouth portion 13 is reduced by the flame 31 coming into contact with the vicinity of the mouth portion 13 of the vial 10. be able to.
  • the shielding mechanism is not limited to the shielding plate 51, and any mechanism that prevents the flame 31 ejected from the point burner 30 from coming into contact with the vial 10 may be used.
  • the shielding plate 51 instead of the shielding plate 51, an airflow flowing in the direction intersecting the axis of the vial 10 is formed near the mouth portion 13 of the vial 10 and ejected from the tip of the point burner 30. You may make it not reach the vial 10 without extinguishing the flame 31 made.
  • the shape of the shielding plate 51 is not particularly limited, and any other shape can be used as long as the flame 31 ejected from the tip of the point burner 30 is prevented from contacting the vicinity of the opening 16 of the vial 10. Also good. Further, the shielding plate 51 is not limited to a flat plate shape, and may be a shape having a curved surface along the rotation locus of the tip of the nozzle 32, for example.
  • the vial 10 is formed using a general vertical molding machine, but other forming methods may be adopted.
  • the vial 10 may be formed by forming a glass container from a glass tube held with the axis of the glass tube along the horizontal direction (using a so-called horizontal molding machine).
  • the glass container is not limited to the vial 10 and may be a glass container having another shape.
  • an ampoule-shaped glass container may be used, or an intermediate product in which the vial 10 is not completely formed, for example, a bottom portion 11 but a mouth portion 13 may not be formed.
  • the movement of the point burner 30 to the standby position is not limited to rotation.
  • the point burner 30 with the nozzle 32 in the horizontal direction is moved in the up and down direction 101, so that the point is set to the standby position and the position shown in FIG.
  • the burner 30 may be moved.
  • the point burner 30 with the nozzle 32 in the horizontal direction may be slid only in the front-rear direction 103.
  • the point burner 30 is located between the position shown in FIG. 4C and a standby position which is on the right side of this position and where the flame 31 ejected from the tip of the point burner 30 does not contact the vial 10. Is moved along the front-rear direction 103.
  • the nozzle 32 of the point burner 30 is moved by the rotating device 41.
  • the point burner 30 is rotated so that the direction is inclined with respect to the horizontal direction, but the vial 10 is further inclined with respect to the horizontal direction in the axial direction while the point burner 30 is fixed.
  • the flame 31 ejected from the tip of the point burner 30 may collide with the processing deterioration region in the inner surface 15 of the vial 10.
  • the inner surface 15 of the vial 10 that collides with the flame 31 ejected from the tip of the point burner 30 does not necessarily have to be the entire inner surface 15.
  • the flame 31 may collide with only the vicinity of the bottom 11 of the inner surface 15.
  • the roller pair 60 is inclined with respect to the horizontal direction (front-rear direction 103) so that the surface facing the point burner 30 is above the opposite side.
  • the roller pair 60 may be positioned such that the axis thereof is in the horizontal direction (front-rear direction 103). Accordingly, in the second step and the fourth step, the point burner 30 may be moved in the horizontal direction (front-rear direction 103) while being fixed so that the axis of the point burner 30 is in the horizontal direction (front-rear direction 103).
  • roller pair 60 is used to rotate the vial 10 around the axial direction
  • the apparatus for rotating the vial 10 is not limited to the roller pair 60.
  • a chuck device that holds and rotates the vial 10 may be used.
  • the vial 10 was formed by the container forming step shown in the above embodiment.
  • a vial 10 was formed by processing a glass tube using a standard vertical molding machine.
  • the size of the vial formed in the examples is 18 mm in outer diameter, 33 mm in total length, and 3 mL in volume.
  • Example 1 The 20 blasted vials 10 were subjected to the fire blast process shown in the above-described embodiment.
  • the vial 10 was rotated by the roller pair 60.
  • the flow rate of gas and oxygen introduced into the point burner 30 was adjusted by a flow rate control device.
  • the gas flow rate was adjusted to 0.3 L / min, and the oxygen flow rate was adjusted to 0.7 L / min.
  • the gas flow rate was adjusted to 0.4 L / min, and the oxygen flow rate was adjusted to 0.9 L / min.
  • the fire blasting in the third step was performed for 10 to 30 seconds.
  • the gas flow rate was adjusted to 0.4 L / min or more, and the oxygen flow rate was adjusted to 0.9 L / min or more.
  • Example 2 A fire blasting process was performed on the 20 vials 10 formed in the same manner as in Example 1 except that the shielding plate 51 was not used.

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  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Geochemistry & Mineralogy (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Re-Forming, After-Treatment, Cutting And Transporting Of Glass Products (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Surface Treatment Of Glass (AREA)

Abstract

[Problème] Fournir un moyen de production d'un conteneur en verre médical pour lequel l'apparition de craquelures est réduite. [Solution] L'invention concerne un procédé de fabrication d'un conteneur en verre médical comprenant : une première étape dans laquelle l'extrémité distale d'un brûleur à pointe allumée 30 est déplacée d'une position où une flamme 31 n'est pas en contact avec un flacon 10 vers une position faisant face à une ouverture extérieure 16 du flacon 10 ; une deuxième étape dans laquelle l'extrémité distale du brûleur à pointe 30 est insérée dans un espace intérieur 14 du flacon 10 ; une troisième étape dans laquelle la flamme 31 est amenée à entrer en collision avec une surface interne 15 du flacon 10 tandis que l'extrémité distale du brûleur à pointe 30 est retenue dans l'espace intérieur 14 ; une quatrième étape dans laquelle l'extrémité distale du brûleur à pointe 30 est déplacée de l'espace intérieur 14 vers l'extérieur de celui-ci ; et une cinquième étape dans laquelle l'extrémité distale du brûleur à pointe 30 est déplacée de la position faisant face à l'ouverture 16 vers une position d'attente. Dans au moins la deuxième étape et la quatrième étape, le brûleur à pointe 30 émet une flamme 31 ayant une intensité de flamme inférieure à l'intensité de flamme de la flamme 31 du brûleur à pointe 30, ladite flamme entrant en collision avec la surface intérieure du flacon 10 dans la troisième étape.
PCT/JP2016/062588 2015-04-24 2016-04-21 Procédé de production de conteneur en verre médical pour lequel l'apparition de craquelures est réduite Ceased WO2016171196A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201680023507.6A CN107531543B (zh) 2015-04-24 2016-04-21 抑制裂纹产生的医用玻璃容器的制造方法
US15/567,624 US10550027B2 (en) 2015-04-24 2016-04-21 Method for producing medical glass container in which occurrence of cracking is reduced
JP2017514175A JP6690639B2 (ja) 2015-04-24 2016-04-21 クラックの発生が抑制された医療用ガラス容器の製造方法
EP16783217.9A EP3287420B1 (fr) 2015-04-24 2016-04-21 Procédé de production de conteneur en verre médical pour lequel l'apparition de craquelures est réduite
PL16783217T PL3287420T3 (pl) 2015-04-24 2016-04-21 Sposób wytwarzania medycznego pojemnika szklanego, w którym zmniejszone jest występowanie pęknięć

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JP2015-089622 2015-04-24
JP2015089622 2015-04-24

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EP3287421B1 (fr) * 2015-04-24 2020-10-21 Nipro Corporation Procédé de production de récipient en verre médical, et dispositif de soufflage par feu pourvu d'un rotateur
DE102016123865A1 (de) * 2016-12-08 2018-06-14 Schott Ag Verfahren zum Weiterverarbeiten eines Glasrohr-Halbzeugs einschließlich einer thermischen Umformung
DE102016124833A1 (de) 2016-12-19 2018-06-21 Schott Ag Verfahren zum Herstellen eines Hohlglasprodukts aus einem Glasrohr-Halbzeug mit Markierungen, sowie Verwendungen hiervon
US20180346368A1 (en) * 2017-05-31 2018-12-06 Nipro Corporation Method of manufacturing glass vessel, and apparatus for manufacturing glass vessel

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US10550027B2 (en) 2020-02-04
PL3287420T3 (pl) 2021-06-14
JP6690639B2 (ja) 2020-04-28
HUE052984T2 (hu) 2021-05-28
EP3287420A1 (fr) 2018-02-28
EP3287420B1 (fr) 2020-10-21
CN107531543A (zh) 2018-01-02
US20180111867A1 (en) 2018-04-26
EP3287420A4 (fr) 2018-12-19
CN107531543B (zh) 2021-04-09
JPWO2016171196A1 (ja) 2018-03-08

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