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WO2016168400A1 - Ensemble récipient pour applicateur de médicament, et son système de surveillance - Google Patents

Ensemble récipient pour applicateur de médicament, et son système de surveillance Download PDF

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Publication number
WO2016168400A1
WO2016168400A1 PCT/US2016/027433 US2016027433W WO2016168400A1 WO 2016168400 A1 WO2016168400 A1 WO 2016168400A1 US 2016027433 W US2016027433 W US 2016027433W WO 2016168400 A1 WO2016168400 A1 WO 2016168400A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
mating portion
tracking
closed bottom
container assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/027433
Other languages
English (en)
Inventor
Serge Desjardins
Brian Fitzpatrick
Jean-Pierre Giraud
Donald L. HUBER
Robert Oringer
Claude A. PICHE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of WO2016168400A1 publication Critical patent/WO2016168400A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/02—Services making use of location information
    • H04W4/023—Services making use of location information using mutual or relative location information between multiple location based services [LBS] targets or of distance thresholds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/80—Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication

Definitions

  • the container assembly includes an interface coupler that has at least two openings for receiving the circular mating portion in a locking arrangement, and the interface coupler joins the first and second containers into the single container assembly.
  • the container assembly also includes a first plug disposed in the interior space of the first container.
  • the first plug has an external shape conforming to the interior of the wall of the first container, and a central opening for receiving an end of the nasal medicament applicator.
  • the plug includes a desiccant.
  • the container assembly includes a third container portion, which has an annular wall defining an interior space and two mating portions. One mating portion is disposed at each end of the annular wall.
  • the container assembly also includes first and second interface couplers.
  • the first interface coupler has a first opening for receiving the circular mating portion of the first container in a locking arrangement, and a second opening for receiving one of the third container mating portions in a locking arrangement.
  • the second interface coupler has a first opening for receiving the circular mating portion of the second container in a locking arrangement, and a second opening for receiving one of the third container mating portions in a locking arrangement, and the interface couplers join the first and second containers and the third container portion into a single container.
  • a first plug is disposed in the interior space of the first container, and has an external shape conforming to the interior of the annular wall, and a central opening for receiving an end of the nasal medicament applicator.
  • the plug includes a desiccant.
  • Fig. IB illustrates an exemplary container assembly having two containers, each container having a mateable connector formed integrally therewith;
  • Fig. ID illustrates an exemplary container
  • Fig. 4A illustrates a front perspective view of another exemplary interface coupler in accordance with the present disclosure including two top portions for receiving two containers;
  • Fig. 4D illustrates a cross-sectional view of the exemplary interface coupler of Fig. 4A taken along line D-D of Fig. 4C;
  • Fig. 4F illustrates the cross-sectional view of Fig. 4D further including a container end received in each top portion of the interface coupler;
  • Fig. 7 illustrates a side perspective view of another exemplary plug of Figs. 6A and 6B according to an embodiment of the present disclosure
  • Nasal medicament applicators are typically used to administer intransal formulations.
  • Exemplary applicators for administering intranasal powder formulations are disclosed in the following patents and patent applications: U.S. Patent Nos.
  • exemplary nasal medicament applicators described herein are designed for use with intranasal powder formulations, it should be appreciated that any medicament applicator, including nasal medicament applicators for liquid and gel formulations, could be used with the container, container assembly, and tracking system disclosed herein without departing from the scope of the present disclosure.
  • An exemplary nasal medicament applicator 620 compatible with the container assembly and tracking system of the present disclosure is illustrated in Fig. 6E.
  • An exemplary known nasal medicament applicator 1000 compatible with the container assembly and tracking system of the present disclosure is illustrated in Fig. 10.
  • the ball When this minimum pressure is reached, the ball is suddenly moved towards an outlet channel 1040 of the device and the flow of air 1020 created by the air blast expels the dose 1018 contained in the reservoir 1010.
  • the pre-compression created by this closing ball 1016 ensures that when it is removed from its blocking position, the energy accumulated in the hand of the user is such that the piston 1021 integral with the plunger 1025 is propelled within the chamber 1022, thereby creating a powerful air flow.
  • the air flow is suitable to finely spray the dose of product 1018 and, notably, to get rid of any product agglomerates if it is a powder product.
  • a nasal medicament applicator should not be damaged so that the plunger mechanism fails, should not be accidentally discharged in the bottom of a purse or backpack, and in the case of a powder formulation should preferably be kept dry in the event that a seal fails.
  • a container for transporting medicament applicators such as nasal medicament applicators.
  • Exemplary container assemblies 100, 100', 100" for nasal medicament applicators are illustrated in Figs. 1 A, IB, and 1C and are described herein.
  • FIG. ID An exemplary container 130 is illustrated in Fig. ID.
  • the exemplary container illustrated in Figure ID has an open top 150, an annular wall 160, and a closed bottom
  • FIGs. 6 A and 6B illustrate a container 610 configured to store a nasal medicament applicator.
  • Container 610 is an illustrative embodiment of containers 110, 130 of Fig. 1 A.
  • a plug 630 is positioned in container 610 to cradle the nasal medicament applicator 620.
  • plug 630 is removable and is friction fit inside container 610.
  • Plug 630 may optionally include a desiccant to reduce moisture in the container 610.
  • Plug 630 is disposed in the interior space of container 610 formed by annular wall 612 and illustratively has a cylindrical external shape conforming to the interior of the annular wall 612.
  • Plug 630 When plug 630 is positioned in container 610, an annular ledge 640 of plug 630 abuts an annular seat 642 located at the closed end of container 610. Plug 630 also has a central opening 632 for receiving an end 622, 624 of the nasal medicament applicator 620.
  • nasal medicament applicator 620 is oriented such that the product outlet 626 is directed towards the bottom or closed end of container 610.
  • An annular flange 646 of applicator 620 is supported by an annular end wall 650 of plug 630 and is retained via an annular ridge 638 formed on the interior surface of container wall 612. In this embodiment, applicator 620 will not fall out of container 610 unless it is pulled out with a force sufficient to slide flange 646 past ridge 638.
  • nasal medicament applicator 620 is oriented such that the product outlet 626 is directed outwards from the open end of container 610, and an annular shoulder 648 of applicator 620 is supported by annular end wall 650 of plug 630. In the orientation of Fig. 6B, applicator 620 is not retained within container 610 via ridge 638.
  • Fig. 1 A illustrates a container assembly 100 having two containers: container 110 and container 130.
  • Each container 110, 130 has a respective body portion 112, 132 each having an open top, a closed bottom, and an annular wall defining an interior space (see container 610 of FIGS. 6 A and 6B, for example).
  • the open tops of containers 110, 130 face away from each other and the closed ends of containers 110, 130 face towards each other and are coupled together via an interface coupler 120.
  • Each of containers 110, 130 includes a cap 105, 125, respectively, for sealing the open end of the respective container 110, 130.
  • a cap 105, 125 respectively, for sealing the open end of the respective container 110, 130.
  • Container 130 is intended for the storage of any item that fits within the interior space of the container 130, such as glucose tablets, candy, test strips, or other fast-acting carbohydrates, and in the illustrated embodiment is not intended for the storage of another nasal medicament applicator, although in other embodiments container 130 may store another nasal medicament applicator.
  • Caps 105 and 125 may be secured to their respective containers 110, 130 by a snap fit, a compression fit, threads, or any other closure mechanism suitable for securing a cap or lid on a container 110 130.
  • the closed bottoms of containers 110 and 130 include circular mating portions (see mating portion 634 of Fig. 6 A) which are connected together via interface coupler 120, such as via threads, snap fit, compression fit, or other suitable coupling mechanism.
  • any portion of the containers 110, 130 and/or interface coupler 120 may also include a tracking device (see, for example, tracking device 808 of Fig. 8 described herein).
  • the tracking device may be embedded in the container(s) 110 ,130 and/or interface coupler 120 at the time of manufacture, or affixed to the container(s) 110, 130 and/or interface coupler 120 after manufacture.
  • Figure IB illustrates another embodiment of a container assembly 100' that includes containers 110' and 130' having respective body portions 112', 132' each having an open end, a closed end, and an annular wall defining an interior space.
  • Caps 105', 125' are coupled at the open ends of respective containers 110', 130'.
  • Containers 110', 130' are connected directly together at their respective closed ends via their respective integrated mating portions 114', 134', which are configured to mate with each other via threads, snap fit, compression fit, or other suitable coupling mechanism.
  • mating portions 114', 134' cooperate to serve as the interface coupler, and a separate interface coupler is not required.
  • Figure 5 also illustrates an exemplary circular mating portion 634 of container 610.
  • Circular mating portion 634 is integral with and extends from the closed bottom of container 610.
  • Mating portion 634 includes a threaded annular outer portion 654 extending from the bottom of container 610 having a smaller external diameter than annular wall 612, and an annular shoulder 655 extends between the bottom end of wall 612 and annular outer portion 654.
  • An annular space or valley 656 extends between annular outer portion 654 and an inner end portion 657, as illustrated in Figs. 5, 6A, and 6B.
  • Inner end portion 657 has a circular flat outer surface 652 and forms the bottom of the container 610.
  • the external diameter of the circular mating portion 634 is illustratively smaller than the external diameter of the annular wall 612 of the container 610.
  • FIGS. 2 A through 2D illustrate an exemplary interface coupler 120 in
  • Coupler 120 includes opposite first and second openings 210, 220 formed by an outer cylindrical wall 222.
  • Each of the openings 210, 220 is designed to receive an end of a container (e.g., closed ends of containers 110, 130, 610 or open ends of container 135).
  • first and second openings 210, 220 are each designed to receive a circular mating portion 634 of container 610 (see Figs. 5-6B).
  • interface coupler 120 includes a circular interior wall 228 extending perpendicular to outer cylindrical wall 222.
  • An annular ridge 226 is formed on both surfaces of the interior wall 228, and each annular ridge 226 has a smaller diameter than the inner surface of outer wall 222.
  • Figures 3A through 3D illustrate another exemplary interface coupler 300 having a first opening 310 formed by a first cylindrical wall 304 and configured to receive a circular mating portion 634 (Figs. 5-6B).
  • a second opposite opening 320 formed by a second cylindrical wall 302 serves as an adaptor opening and is configured to receive an end of a container that does not have a circular mating portion 634.
  • the adaptor opening 320 may be configured to receive an end of a commercially available tube of glucose tablets.
  • protrusions 308 extend into adaptor opening 320 and are configured to secure the end of the received tube or container via a snap fit or compression fit.
  • the adaptor opening 320 may be threaded to receive the threaded end of the container.
  • a "side by side” interface coupler 400 is illustrated in Figs. 4A through 4F.
  • a system and method for tracking a user's proximity to a medicament container assembly are also provided herein in Figs. 8 and 9.
  • any wireless communication protocol may be used to implement the tracking system 800 described herein, so long as the wireless communication protocol enables a tracking device 808 and a monitoring device 802 (and/or proxy device 806) to communicate with each other over a wireless network 804.
  • Exemplary wireless communication protocols include, but are not limited to, Bluetooth, Rubee, RFID, Zigbee, Wi-Fi, cellular communication protocols, and near field communication protocols such as those used to implement Apple Pay, Samsung Pay, and Google Wallet.
  • the tracking device 808 is a low power or ultra lower power device that draws little power, so that the battery life of the tracking device meets or exceeds the shelf life of the medicine contained within the container assembly.
  • a tracking device 808 is securely affixed to or embedded in a medicament container(s) and/or one or more interface couplers in a container assembly as described above.
  • a monitoring device 802 is configured to communicate with the tracking device 808.
  • the tracking device 808 is a Bluetooth device
  • a smartphone such as an Apple iPhone® or Samsung Galaxy S® may serve as the monitoring device 802.
  • the monitoring device 802 may be any computing device including, but not limited to, a smartphone, tablet computer, laptop computer, wearable computer (Google Glass or the like), smart watch, or the like.
  • monitoring device 802 includes a tracking device interface 824 for communicating via network 804 with tracking device 808, a network interface 826 for communicating via network 810 with a remote computing device 812, a display adapter and display 828, audio
  • input/output 830 an input device 832 (e.g., keyboard, mouse, touchscreen, voice command, etc.), and system memory 834.
  • input device 832 e.g., keyboard, mouse, touchscreen, voice command, etc.
  • system memory 834 e.g., random access memory
  • the non-transitory computer-readable storage medium 820 may be co- located with the transmitting device or be physically within the monitoring device 802. In other implementations, the non-transitory computer-readable storage medium 820 may be located at a remote location and accessed remotely via a network connection, such as via network 810.
  • the tracking program is configured with instructions that cause the processor 822 of monitoring device 802 to perform the functions described herein.
  • a flow diagram 900 of an exemplary method of operation of monitoring device 802 is illustrated in Fig. 9.
  • monitoring device 802 sends a query to (e.g., pings) the tracking device 808 via the tracking network 804 to determine whether or not the tracking device 808 is within communication range of the monitoring device 802.
  • the monitoring device 802 receives a response from the tracking device 808 (and/or other configured devices on the tracking network 804) or determines that a response has not been received.
  • monitoring device 802 stores the response (or no response event) and compares the tracking device response history to predefined conditions such as status and/or alarm conditions to determine the status of the tracking device 808.
  • monitoring device 802 communicates the status or alarm to a user, such as by displaying the status/alarm on a display of monitoring device 802 or by communicating the status/alarm to a remote computing device 812 via network 810.
  • the frequency of queries to the tracking device 808 may be increased to assist the user in locating the medicament container quickly (by narrowing the search area) in the event that the medicament container becomes separated from the user.
  • the tracking device 808 should respond to each received query via an appropriate protocol to confirm that the tracking device 808 is still within range of the transmitting device 802.
  • Bluetooth for example, has a range of approximately 32 feet (10 meters).
  • the tracking device 808 will not respond to queries from the transmitting device 802.
  • the number of unsuccessful queries (no response) is stored and the percentage of time a user is "compliant" in keeping his or her container assembly in close proximity can be computed.
  • successful responses may also be stored, along with timestamps, the GPS location of the monitoring device 802 (if the device is configured with GPS) and other data related to queries sent and responses received may also be stored, either locally in the monitoring device 802 or remotely, for example, in a remotely hosted database residing on a non- transitory computer-readable storage device and communicated via a network connection 810. It should also be appreciated that all query/response-related data stored, either locally or remotely, may be exported so that it can be viewed by a third party.
  • the tracking device 808 may include GPS capabilities. When the tracking device 808 is GPS-enabled, responses to queries will include GPS coordinates for the tracking device 808. Preferably, these coordinates are received and at least recent responses are stored by the transmitting device 802 in a non- transitory computer-readable storage medium 820, so that the last known position of the tracking device 808 can be relayed (displayed, emailed, sent to a third party via SMS, iMessage, or the like) to a user when the tracking device 808 fails to return a response to a query.
  • the number and/or frequency of alarm conditions may be tracked by the software so that compliance with carrying the medicament container can be determined.
  • GPS coordinates of the monitoring device 802 may be associated with successful query responses so that, when the tracking device 808 fails to respond to a query, a user may be able to determine an area in which to search for his or her container assembly.
  • a wearable transmitting device 806 may be programmed using a computer or smart phone.
  • the wearable transmitting device 806 acts as a proxy for a smart phone or more complex computing device 802 and is referred to herein as a "proxy device" 806.
  • the proxy device 806 may have a simplified interface that provides feedback, such as audible or visual feedback, when an alarm condition occurs.
  • the monitoring device 802 provides feedback to the user to incentivize the user for compliance. Incentives are preferably programmable, for example, by a parent. Milestones in compliance may be communicated to a third party (parent, physician, insurance agent) via a communications protocol (SMS, iMessage, email), to encourage or reward compliance.
  • SMS communications protocol

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Primary Health Care (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Food Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Signal Processing (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un récipient destiné à accueillir un médicament contenu dans un applicateur, tels que des médicaments administrés par voie intranasale, le récipient et applicateur étant sous la forme d'une combinaison. L'invention concerne en outre un adaptateur ou une interface conçu(e) pour connecter le récipient à d'autres récipients, ainsi que des dispositifs, des systèmes et des procédés conçus pour suivre l'emplacement d'un ou plusieurs récipients.
PCT/US2016/027433 2015-04-16 2016-04-14 Ensemble récipient pour applicateur de médicament, et son système de surveillance Ceased WO2016168400A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562148684P 2015-04-16 2015-04-16
US62/148,684 2015-04-16

Publications (1)

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WO2016168400A1 true WO2016168400A1 (fr) 2016-10-20

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD856798S1 (en) 2017-11-03 2019-08-20 Eli Lilly & Company Container assembly
US10765602B1 (en) 2019-03-29 2020-09-08 Eli Lilly And Company Medication delivery systems and methods
EP3727053B1 (fr) 2017-12-18 2022-10-19 JT International SA Appareil de localisation d'un dispositif de génération d'aérosol
US20230051213A1 (en) * 2020-02-06 2023-02-16 Eli Lilly And Company Drug container systems including lock-out mechanisms

Citations (1)

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US20140334804A1 (en) * 2012-03-26 2014-11-13 Enbright Co., Ltd. Atomization control unit and a portable atomizing apparatus having the same

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HAMILTON, J.G.: "Needle phobia: a neglected diagnosis", J 1-7AM PRACT., vol. 41, no. 2, 1995, pages 169 - 175

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD856798S1 (en) 2017-11-03 2019-08-20 Eli Lilly & Company Container assembly
USD881004S1 (en) 2017-11-03 2020-04-14 Eli Lilly And Company Container assembly
EP3727053B1 (fr) 2017-12-18 2022-10-19 JT International SA Appareil de localisation d'un dispositif de génération d'aérosol
US11785437B2 (en) 2017-12-18 2023-10-10 Jt International S.A. Apparatus for locating an aerosol generation device
EP4136994B1 (fr) 2017-12-18 2023-11-01 JT International SA Appareil de localisation d'un dispositif de génération d'aérosol
US12200590B2 (en) 2017-12-18 2025-01-14 Jt International S.A. Apparatus for locating an aerosol generation device
US10765602B1 (en) 2019-03-29 2020-09-08 Eli Lilly And Company Medication delivery systems and methods
US11938089B2 (en) 2019-03-29 2024-03-26 Amphastar Pharmaceuticals, Inc. Medication delivery systems and methods
US20230051213A1 (en) * 2020-02-06 2023-02-16 Eli Lilly And Company Drug container systems including lock-out mechanisms

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