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WO2016165634A1 - Dispositif de traitement froid et chaud du mélanome - Google Patents

Dispositif de traitement froid et chaud du mélanome Download PDF

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Publication number
WO2016165634A1
WO2016165634A1 PCT/CN2016/079334 CN2016079334W WO2016165634A1 WO 2016165634 A1 WO2016165634 A1 WO 2016165634A1 CN 2016079334 W CN2016079334 W CN 2016079334W WO 2016165634 A1 WO2016165634 A1 WO 2016165634A1
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WO
WIPO (PCT)
Prior art keywords
treatment
cold
melanoma
tumor
temperature
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Ceased
Application number
PCT/CN2016/079334
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English (en)
Chinese (zh)
Inventor
徐学敏
张爱丽
刘苹
白景峰
孙建奇
邹金成
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Shanghai Jiao Tong University
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Shanghai Jiao Tong University
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Filing date
Publication date
Application filed by Shanghai Jiao Tong University filed Critical Shanghai Jiao Tong University
Publication of WO2016165634A1 publication Critical patent/WO2016165634A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating

Definitions

  • the heat source in the tumor treatment unit is preferably one of radio frequency, microwave or infrared.
  • the control circuit controls the power of the hyperthermia through the thermotherapy control circuit to achieve the function of controlling the heating process and the thermotherapy maintenance of the hyperthermia.
  • the conformal probe has a medium flow channel inside, the channel is provided with a medium inlet and a medium outlet, and the liquid refrigerant flows through the medium inlet and the medium outlet in the probe to the tumor tissue.
  • the cold source joint is connected.
  • the heat source heats the tumor tissue by being connected to a heat source connection port.
  • FIG. 2 is a schematic structural view of a conformal probe according to a preferred embodiment of the present invention.
  • Figure 3 is a photograph of the state of the mice after alternating hot and cold treatment
  • Figure 4 is a comparison of overall survival and survival time in different groups of mice
  • the device mainly utilizes the therapeutic control system to control the alternate use of the cold source and the heat source, thereby achieving tumor ablation and distal metastasis inhibition.
  • the device comprises a treatment control system A and a tumor treatment unit B, wherein the treatment control system A is composed of a small chemical control machine 1 and a display monitoring module 2, wherein a small industrial computer integrates a high-speed data acquisition board for Real-time collection of tissue temperature data during treatment, related treatment parameter data, and control by the industrial computer program, the occurrence of numerical control signals, control of the operation of the tumor treatment device; the tumor treatment unit B includes control circuit 3, cold source 4, heat source 5 Temperature sensor 6, conformal probe 7.
  • the cold and heat treatment device of the invention can effectively treat melanoma, and the present embodiment obtains a good therapeutic effect by treating the mouse melanoma with the invention.
  • the specific experimental process is as follows:
  • mice 6-8 weeks old SPF C57BL/6 female mice (Shanghai Slack Animal Center) were housed in independent ventilation cages and manually controlled for 12 hours to change light. Mice are free to ingest 60Co radiation-sterilized feed And high temperature sterilized water.
  • Mouse B16F10 melanoma cells (ATCC) were cultured with 10% newborn fetal bovine serum (Hangzhou Sijiqing Co., Ltd.) and double antibody (100 U/mL penicillin, 100 g/mL streptomycin) (Shanghai Bioengineering Bioengineering) Technical Services Ltd.) in RPMI1640 medium (Hyclone, USA).
  • Control group Alternate cooling and heating treatment.
  • the study contents were as follows: After 12 days of inoculation, the mice were randomly divided into 2 groups and treated differently: control group and cold-heat combined treatment group. After treatment, 10 mice in each group were observed for long-term treatment; in addition, 4 mice in each group were given a secondary tumor challenge 45 days after treatment to detect tumor growth and survival rate. Tumor mice were used as controls.
  • the treatment device for melanoma in the present embodiment mainly includes cold treatment for cooling the tumor tissue; heat treatment is used for the given Tumor tissue warming; and real-time monitoring and control of the tumor treatment system for real-time control of the operation of the tumor treatment device and monitoring of the working state of the system.
  • a conformal probe of the device is used to adhere to the tumor tissue, and a cold source is used to cool the tumor tissue by a conformal probe, and the heat source is contacted with the conformal probe to the tumor.
  • the organization warms up.
  • Tumors were treated 12 days after tumor inoculation and tumor volume was measured before treatment. Before treatment, tumor-bearing mice were randomly divided into two groups: control group and cold-heat combined treatment group. The mice in need of treatment were first anesthetized, and then the tumor site was disinfected with alcohol and iodine. The following treatment process is then performed.
  • Step S2 after the end of the therapeutic preparation work, heating the tumor to a set temperature T1 required for the tumor treatment, and after heating the tumor to the set temperature T1, the system will automatically maintain a period of time t1,
  • the maintenance time is the optimal time determined by the laboratory after the study and treatment of the tumor.
  • Step S6 Repeat steps S2 to S5 one or more times.
  • This section mainly includes: observation of the growth of orthotopic tumors in the control group, ablation and recurrence of orthotopic tumors in the treatment group, and metastasis of each group of mice (daily), and recording changes in body weight before and after treatment (twice a week) ), statistics on long-term survival and survival time of mice, etc. These indicators can effectively reflect the survival of mice, and the statistics of survival rate and survival time are the most important indicators for evaluating the therapeutic effect.
  • mice in each group were observed for 2 months, and the time of death was recorded (Fig. 4).
  • Cold and heat alternate treatment After treatment, 8 of the mice were in good condition, and only 2 mice died 15 days after treatment (27 days after inoculation) and 25 days (37 days after inoculation), and the remaining 8 were observed in two months. No recurrence of the in situ was found. The control mice died all within 2 months after inoculation. Therefore, alternating hot and cold treatment of tumors can greatly improve the survival rate of mice and achieve a good therapeutic effect.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un dispositif de traitement froid et chaud du mélanome comprenant un système de commande de traitement (A) et une unité de traitement de tumeur (B). Le système de commande de traitement (A) comprend un petit ordinateur personnel industriel (1) et un module d'affichage et de surveillance (2), et est utilisé pour commander le travail coopératif des dispositifs de traitement de tumeur, de sorte que le traitement à commande de programme automatique du mélanome est obtenu, et le processus de traitement est affiché et surveillé en temps réel. L'unité de traitement de tumeur (B) comprend une source froide (4), une source chaude (5), une sonde conforme (7), un circuit de commande de dispositif (3) et analogue, et est principalement destinée au traitement d'un tissu de mélanome. En outre, l'unité de traitement de tumeur (B) peut renvoyer la température d'un tissu tumoral au moyen d'un capteur de température (6), de manière à mieux régler la température de traitement. Le dispositif de traitement froid et chaud du mélanome est simple de fonctionnement, peut faire entièrement fondre un tissu au sein d'une tumeur et peut améliorer la réponse immunitaire d'un corps vivant, et présente un effet d'application remarquable.
PCT/CN2016/079334 2015-04-14 2016-04-14 Dispositif de traitement froid et chaud du mélanome Ceased WO2016165634A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510176857.3 2015-04-14
CN201510176857.3A CN104783890B (zh) 2015-04-14 2015-04-14 一种黑色素瘤冷热治疗装置

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643178A (zh) * 2019-05-20 2020-09-11 上海申赞科贸有限公司 肿瘤消融冷热交替治疗设备

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104783890B (zh) * 2015-04-14 2018-05-01 上海交通大学 一种黑色素瘤冷热治疗装置
CN105615998B (zh) * 2016-02-29 2018-04-06 上海交通大学 一种动脉粥样硬化靶向治疗装置
CN106137378A (zh) * 2016-06-21 2016-11-23 上海交通大学 一种小型数字化冷热交替治疗仪
CN109512503B (zh) * 2017-09-18 2020-03-31 四川锦江电子科技有限公司 一种可进行刺激输出的低温等离子消融系统
CN110151309B (zh) * 2018-02-14 2022-02-15 上海美杰医疗科技有限公司 多模态消融治疗术前规划方法及其设备
CN111012474A (zh) * 2019-09-17 2020-04-17 日照天一生物医疗科技有限公司 一种冷冻消融针及其消融系统
CN110681060A (zh) * 2019-09-28 2020-01-14 复旦大学 一种黑色素瘤光疗装置
CN112869865B (zh) * 2021-01-11 2022-09-02 贵阳德漫多医疗科技有限公司 一种皮肤热剥脱装置
CN113967067B (zh) * 2021-09-10 2024-04-09 中国医学科学院肿瘤医院 用于消融针的适形消融模拟方法、装置、存储介质及设备

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CN1709212A (zh) * 2005-06-30 2005-12-21 上海交通大学 升降温速率可控的冷热交替肿瘤治疗系统
WO2008008545A2 (fr) * 2006-07-14 2008-01-17 Micrablate Systèmes de distribution d'énergie et utilisations
CN202044338U (zh) * 2011-02-14 2011-11-23 中国科学院理化技术研究所 一种自维持型一体化肿瘤治疗用冷热刀装置
CN203724206U (zh) * 2014-02-20 2014-07-23 中国科学技术大学 一种带药物输送功能的冷热刀及系统
CN104783890A (zh) * 2015-04-14 2015-07-22 上海交通大学 一种黑色素瘤冷热治疗装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643178A (zh) * 2019-05-20 2020-09-11 上海申赞科贸有限公司 肿瘤消融冷热交替治疗设备

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CN104783890B (zh) 2018-05-01

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