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WO2016161333A3 - Compositions comprising bioconjugates - Google Patents

Compositions comprising bioconjugates Download PDF

Info

Publication number
WO2016161333A3
WO2016161333A3 PCT/US2016/025645 US2016025645W WO2016161333A3 WO 2016161333 A3 WO2016161333 A3 WO 2016161333A3 US 2016025645 W US2016025645 W US 2016025645W WO 2016161333 A3 WO2016161333 A3 WO 2016161333A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioconjugates
compositions
glycan
comprised
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/025645
Other languages
French (fr)
Other versions
WO2016161333A2 (en
Inventor
Alyssa Panitch
Ally LAWRENCE
Corey Philip NEU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of WO2016161333A2 publication Critical patent/WO2016161333A2/en
Publication of WO2016161333A3 publication Critical patent/WO2016161333A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This disclosure provides extracellular matrix-binding bioconjugates comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.
PCT/US2016/025645 2015-04-01 2016-04-01 Compositions comprising bioconjugates Ceased WO2016161333A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562141683P 2015-04-01 2015-04-01
US62/141,683 2015-04-01

Publications (2)

Publication Number Publication Date
WO2016161333A2 WO2016161333A2 (en) 2016-10-06
WO2016161333A3 true WO2016161333A3 (en) 2016-11-10

Family

ID=57007698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/025645 Ceased WO2016161333A2 (en) 2015-04-01 2016-04-01 Compositions comprising bioconjugates

Country Status (1)

Country Link
WO (1) WO2016161333A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2280720T (en) 2008-03-27 2019-05-17 Purdue Research Foundation Collagen-binding synthetic peptidoglycans, preparation, and methods of use
JP6603650B2 (en) 2013-03-15 2019-11-06 パーデュー・リサーチ・ファウンデーション Extracellular matrix-bound synthetic peptidoglycan
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
EP3142684A4 (en) 2014-05-12 2018-05-23 Purdue Research Foundation Selectin and icam/vcam peptide ligand conjugates
CN111050778B (en) 2017-07-07 2024-09-10 斯米克Ip有限公司 Bioconjugates with chemically modified backbones
WO2019010484A2 (en) * 2017-07-07 2019-01-10 Symic Ip, Llc Synthetic bioconjugates
US10386338B2 (en) 2017-10-30 2019-08-20 Cynthia Rena Wright DNA/RNA PEMS microcantilever probe for detection of viral infection and detection of genetic variants
CN117384246B (en) * 2023-12-11 2024-05-10 北京大学第三医院（北京大学第三临床医学院） A polypeptide and a hydrogel containing the polypeptide, and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013110056A1 (en) * 2012-01-19 2013-07-25 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications
US20140288002A1 (en) * 2013-03-15 2014-09-25 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
WO2015009787A1 (en) * 2013-07-19 2015-01-22 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013110056A1 (en) * 2012-01-19 2013-07-25 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications
US20140288002A1 (en) * 2013-03-15 2014-09-25 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
WO2015009787A1 (en) * 2013-07-19 2015-01-22 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SINGH ET AL.: "Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid", NATURE MATERIALS, vol. 13, 3 August 2014 (2014-08-03), pages 988 - 995, XP055260788 *
UNTERMAN ET AL.: "Hyaluronic Acid-Binding Scaffold for Articular Cartilage Repair", TISSUE ENGINEERING PART A, vol. 18, 14 August 2012 (2012-08-14), pages 2497 - 2506, XP055328493 *

Also Published As

Publication number Publication date
WO2016161333A2 (en) 2016-10-06

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