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WO2016149697A1 - Chambre de dosage jetable pour pompes à membrane à mouvement alternatif - Google Patents

Chambre de dosage jetable pour pompes à membrane à mouvement alternatif Download PDF

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Publication number
WO2016149697A1
WO2016149697A1 PCT/US2016/023375 US2016023375W WO2016149697A1 WO 2016149697 A1 WO2016149697 A1 WO 2016149697A1 US 2016023375 W US2016023375 W US 2016023375W WO 2016149697 A1 WO2016149697 A1 WO 2016149697A1
Authority
WO
WIPO (PCT)
Prior art keywords
metering chamber
pump body
flexible member
reciprocating pump
pump apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/023375
Other languages
English (en)
Inventor
Forrest PAYNE
Greg Lamps
Anna WASHBURN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SFC Fluidics Inc
Original Assignee
SFC Fluidics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SFC Fluidics Inc filed Critical SFC Fluidics Inc
Publication of WO2016149697A1 publication Critical patent/WO2016149697A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14224—Diaphragm type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
    • A61M5/14593—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit

Definitions

  • the field of the invention is pumps for fluid delivery applications, and in particular to the use of a disposable metering chamber in a pump for cost- effective replacement of fluidic lines.
  • the present invention may be discussed and examples may be given in connection with drug delivery applications, but it is recognized that the present invention is not so limited. Instead, the invention may be useful in any application where it is necessary or advantageous to replace fluidic lines for reasons of disposability, cleanliness, or cross-contamination, while reusing pump electronics in order to reduce costs and waste production.
  • reciprocating pumps can be used to pump fluid from a reservoir to a target.
  • An example of a reciprocating pump is the ePump developed by SFC Fluidics, Inc. (disclosed in U.S. Patent Nos. 7,718,047; 8, 187,441 ; and
  • the present invention relates generally to reciprocating pump systems, and in particular to a disposable metering chamber that allows the user to replace the fluidic line in a reciprocating pump without requiring replacement of the entire pump assembly. It is an object of the present invention to allow a user to replace, particularly in drug delivery applications but in other applications as well, the fluidic line such that the entire fluid path from the reservoir to the target remains clean and sterilized. In existing pump assemblies users are required to replace the entire assembly, including expensive electronics and the pump itself. It is an object of the present invention to allow users to replace only the fluidic line portion of the pump assembly, therefore reducing the cost and waste associated with replacing the entire apparatus.
  • a single flexible diaphragm is in direct contact with the fluid path leading from the reservoir to the target. This prevents replacement of the fluid line without replacing the entire assembly.
  • a disposable metering chamber with a second flexible diaphragm is connected to the flexible diaphragm of the reciprocating pump. This second diaphragm allows the reciprocating pump to indirectly draw in and expel fluid via diaphragm-to-diaphragm contact with the disposable metering chamber. The metering chamber, thus, can be replaced without requiring replacement of the entire pump.
  • FIG. 1 is a schematic diagram of one embodiment of the present invention broken down into its constituent components.
  • FIG. 2 is a schematic diagram showing prior art reciprocating pump
  • FIG. 3 is a schematic diagram of a first embodiment of the present
  • FIG. 4 is a schematic diagram of a second embodiment of the present invention assembled using magnetic connectors.
  • the present invention includes various manners of coupling a flexible
  • the invention comprises a disposable metering chamber body component 2 and a reusable pump body component 4.
  • the present invention employs three flexible members, which may be elastomeric diaphragms, pistons or plungers, immiscible fluid plugs, flexible plastic sheets, or any number of alternate forms.
  • these flexible members will be referred to as diaphragms but it is understood that the present invention is not so limited.
  • the first of the flexible diaphragms 8 is a part of the metering chamber body component 2, as shown.
  • the other two flexible diaphragms 10 are a part of the reusable pump body component 4, as described below.
  • the metering chamber body 2 comprises several components: the metering chamber 6 and metering chamber diaphragm 8.
  • the metering chamber 6 and metering chamber diaphragm 8 are in contact such that, as the diaphragm 8 expands and contracts, the open volume within the metering chamber 6 is contracted or expanded (as the metering chamber diaphragm 8 is in contact with one of the pump body diaphragms 10, described below). This contraction/expansion of the volume within the metering chamber 6 results in the pumping of fluid between the metering chamber 6 and diaphragm 8.
  • the reusable pump body 4 comprises several components: pump body diaphragms 10, ePump half-cells 12, and ionic membrane 14.
  • the ePump uses an ionic fluid in two half-cells 12 that are separated by a selective ionic
  • each of the two half-cells 12 works with one of the flexible members 10 found in the pump body 4 to allow the effective volume of the half-cells 12 to increase or decrease as ions and associated solvent materials travel across the
  • one of the pump body diaphragms 10 is in contact with the metering chamber diaphragm 8 which is then in contact with the metering chamber 6.
  • the two diaphragms 8, 10 move in unison during contraction and expansion of the volume of fluid in the respective ePump half-cell 12.
  • the pump body diaphragm 24 is in direct contact with the metering chamber 22 and the half-cell 26 because the pump body diaphragm 24 is in direct contact with both the fluid in the metering chamber 22 and the ionic pumping solution.
  • removal of the metering chamber 22 and diaphragm 24 for replacement would require opening the pump body 20, which could introduce air bubbles or other contaminants into the ionic solution or could result in the loss of some or all of the ionic solution.
  • the present invention solves these problems, because the disposable metering chamber body 2 allows the metering chamber 6 and diaphragm 8 to be easily removed without opening the pump body 4 and without exposing the ionic solution to contaminants.
  • connection between the disposable metering chamber diaphragm 8 and the pump body diaphragm 10 can be achieved.
  • a key feature of any connection is that it must be reversible without causing damage to the pump body 4 or its diaphragm 10.
  • Figures 3-4 show two embodiments of the present invention, each employing different connective techniques.
  • a variety of adhesives may be used, including pressure sensitive, hot melt, and other adhesives which may allow the diaphragms to be separated from each other at the end of use by means of peelings, application of heat, or use of a solvent to disrupt the adhesive bond.
  • mechanical means may be employed to create the connection.
  • male/female profiles may be mated, as shown in Fig. 3 as a T-shaped connector 30 where a "T" shape is inserted into a slot.
  • a stiff mechanical member is permanently attached to the diaphragm on the pump body side. This member has a T-shaped head that fits into a slot that is permanently attached to the diaphragm of the disposable metering chamber.
  • hook and loop, mushroom-head snap fasteners, or other methods of connection may be employed.
  • magnet attraction may also be used instead of, or in addition to, adhesive and mechanical connection means.
  • a permanent magnet 40 is molded into or attached to the metering body diaphragm and the connecting pump body diaphragm also has a permanent magnet 42 or piece of iron, steel, or other ferromagnetic metal or material molded into or attached to it.
  • the diaphragm on the pump body is formed so that it is brought in close proximity to the diaphragm on the pumping chamber over essentially its entire working surface.
  • the magnets (or magnet and ferromagnetic material) are encapsulated on the opposite sides of the
  • a recess is provided in the metering chamber body for the overmolded magnet or ferromagnetic disk to nest within.
  • the magnetic force will cause the two diaphragms to be connected to each other until such a time when sufficient force is applied to separate them.
  • This connection/separation force can be optimized for the size of the diaphragms and the pumping force required by varying the size/magnetic force of the magnet(s).
  • an electromagnet can be molded into or attached to one of the diaphragms with a piece of iron, steel, or other
  • an electromagnet can be molded into or attached to one diaphragm and a permanent magnet can be molded into or attached to the connecting diaphragm.
  • the permanent magnet can maintain the connection between the diaphragms without flow of electric current through the electromagnet. When appropriate current is applied to the electromagnet, however, it will repel the permanent magnet, which will allow the user to separate the connecting diaphragms.
  • fine magnetic particles may be included in one or both of the connecting diaphragms.
  • iron powder or another similarly ferromagnetic powder may be used in the other diaphragm. This arrangement would allow the diaphragms to be attracted to each other in a similar fashion to the above mentioned permanent magnet solution but without a separate magnet or piece of ferromagnetic material molded into the diaphragms.
  • magnetic flakes, particles, or film may be incorporated directly into the material that makes up the diaphragm.
  • the two diaphragms would contact each other at all points and could be more easily separated than if an adhesive were to be used.
  • a combination of any of these methods of connecting the diaphragms may be used. For example, an embodiment may combine the use of a ferromagnetic powder and permanent magnet to facilitate the connection.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Reciprocating Pumps (AREA)

Abstract

La présente invention concerne un appareil à pompe à mouvement alternatif comprenant une chambre de dosage pouvant être séparée du corps de la pompe pour remplacer la conduite de fluide. Une membrane flexible dans le corps de la chambre de dosage amovible est en contact avec une membrane flexible dans le corps de la pompe réutilisable, de sorte que lorsque la membrane flexible dans le corps de la pompe se dilate et se contracte grâce à une réaction électrochimique, la membrane dans le corps de la chambre de dosage se dilate et se contracte de la même manière. Ladite dilatation et ladite contraction de la membrane de la chambre de dosage permet à un fluide dans la chambre de dosage de s'écouler depuis le réservoir jusqu'à la cible.
PCT/US2016/023375 2015-03-19 2016-03-21 Chambre de dosage jetable pour pompes à membrane à mouvement alternatif Ceased WO2016149697A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562135519P 2015-03-19 2015-03-19
US62/135,519 2015-03-19

Publications (1)

Publication Number Publication Date
WO2016149697A1 true WO2016149697A1 (fr) 2016-09-22

Family

ID=56920211

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/023375 Ceased WO2016149697A1 (fr) 2015-03-19 2016-03-21 Chambre de dosage jetable pour pompes à membrane à mouvement alternatif

Country Status (1)

Country Link
WO (1) WO2016149697A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4121584A (en) * 1976-10-15 1978-10-24 R. Scott Turner Method and apparatus for controlling the dispensing of fluid
US5302093A (en) * 1992-05-01 1994-04-12 Mcgaw, Inc. Disposable cassette with negative head height fluid supply and method
US20020169439A1 (en) * 2001-02-22 2002-11-14 Flaherty J. Christopher Modular infusion device and method
US20120310162A1 (en) * 2009-12-23 2012-12-06 Jean-Denis Rochat Disposable cassette for medical use for a perfusion pump, and method for manufacturing same
WO2014036112A1 (fr) * 2012-08-29 2014-03-06 Sfc Fluidics, Llc Dispositifs microfluidiques actionnés de façon électrochimique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4121584A (en) * 1976-10-15 1978-10-24 R. Scott Turner Method and apparatus for controlling the dispensing of fluid
US5302093A (en) * 1992-05-01 1994-04-12 Mcgaw, Inc. Disposable cassette with negative head height fluid supply and method
US20020169439A1 (en) * 2001-02-22 2002-11-14 Flaherty J. Christopher Modular infusion device and method
US20120310162A1 (en) * 2009-12-23 2012-12-06 Jean-Denis Rochat Disposable cassette for medical use for a perfusion pump, and method for manufacturing same
WO2014036112A1 (fr) * 2012-08-29 2014-03-06 Sfc Fluidics, Llc Dispositifs microfluidiques actionnés de façon électrochimique

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