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WO2016147268A1 - Système de test de cancer et procédé de test de cancer - Google Patents

Système de test de cancer et procédé de test de cancer Download PDF

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Publication number
WO2016147268A1
WO2016147268A1 PCT/JP2015/057563 JP2015057563W WO2016147268A1 WO 2016147268 A1 WO2016147268 A1 WO 2016147268A1 JP 2015057563 W JP2015057563 W JP 2015057563W WO 2016147268 A1 WO2016147268 A1 WO 2016147268A1
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WO
WIPO (PCT)
Prior art keywords
inspection
nematode
result
unit
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2015/057563
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English (en)
Japanese (ja)
Inventor
坂入　実
範人 久野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Priority to JP2017505883A priority Critical patent/JP6426827B2/ja
Priority to PCT/JP2015/057563 priority patent/WO2016147268A1/fr
Publication of WO2016147268A1 publication Critical patent/WO2016147268A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies

Definitions

  • the present invention relates to a cancer test system and a cancer test method in a cancer test using a nematode.
  • Non-Patent Document 1 A method for detecting cancer utilizing chemotaxis, in which nematodes exhibit repellent behavior in the urine of healthy individuals and induce behavior in the urine of cancer patients, is disclosed (for example, Non-Patent Document 1). ).
  • Non-Patent Document 1 uses a living organism called a nematode, environmental conditions must be severely adjusted. Therefore, even if a cancer test using the technique described in Non-Patent Document 1 is performed systematically, it cannot be realized simply by using the technique described in Non-Patent Document 1.
  • the present invention has been made in view of such a background, and an object of the present invention is to efficiently perform a cancer test using nematodes.
  • the present invention selects a test nematode for analysis based on the test day determination unit that determines the test date based on the number of days of growth of the nematode and the number of days of growth of the nematode.
  • a nematode selection unit a temperature control unit that maintains the environmental temperature of the test at a predetermined temperature, a sample operation unit that dispenses a sample to the test device, and the nematode selected by the nematode selection unit
  • a chemotaxis analysis unit that analyzes the behavior of the nematode after a predetermined time has elapsed from the placement of the nematode and the nematode and outputs a result of the analysis. It is characterized by
  • cancer tests using nematodes can be performed efficiently.
  • FIG. 1 It is a figure showing the schematic structure of the cancer inspection system concerning a 1st embodiment. It is a figure which shows the outline
  • FIG. 3 is a second diagram illustrating an example of a hardware system configuration according to the first embodiment.
  • FIG. 3 is a third diagram illustrating an exemplary hardware system configuration according to the first embodiment. It is a figure (the 1) which shows the example of the test
  • FIG. 1 is a diagram showing a schematic configuration of a cancer test system according to the first embodiment.
  • the cancer testing system 1 includes a management input / output unit 101, a data management unit 102, an examination date determination unit 111, a nematode selection unit 112, a nematode operation unit 113, an examination condition adjustment unit (temperature control unit) 121, and a chemotaxis analysis.
  • the cancer testing system 1 includes a nematode management (nematode management information) DB (Data Base) 201, an examination condition DB 202, an examination result DB 203, an inspected person (inspected person information) DB 204, and a specimen management (specimen management information). It has a DB 205, a medical institution (medical institution information) DB 206, and a request history DB 207. Each DB 201 to 207 will be described later.
  • the cancer testing system 1 includes a testing device (testing apparatus) 301 provided in the nematode storage 302, the sample storage 303, and the testing room 311.
  • the nematode storage 302 is a storage in which nematodes are cultured and stored.
  • the specimen storage 303 is a storage where the specimen is stored frozen.
  • the inspection device 301 is a device in which a nematode and a specimen are dispensed and a cancer test using the nematode is performed. The inspection device 301, nematode storage 302, and specimen storage 303 will be described later.
  • the management input / output unit 101 is operated by an inspector to input information to the nematode management DB 201, the sample management DB 205, the inspected person DB 204, the inspection condition DB 202, and the like. Also, the management input / output unit 101 operates the nematode operation unit 113 or the sample operation unit 141 via the nematode selection unit 112. The management input / output unit 101 also displays the contents of the nematode management DB 201 and the sample management DB 205.
  • the data management unit 102 stores information read from various sensors, a barcode reader, and the like in the examination result DB 203, the inspected person DB 204, and the sample management DB 205. In addition, if the reader who is going to view the test results is a person who is qualified to view the personal information of the subject, and is not qualified to view the personal information of the subject, Limit the information that can be viewed.
  • the inspection date determination unit 111 determines the day to be inspected based on the number of days of growth of the nematode group stored in the nematode management DB 201.
  • the nematode group is a group of nematodes and serves as a nematode culture unit or a dispensing unit.
  • the nematode selection unit 112 selects a group of nematodes used for the cancer test based on information in the nematode management DB 201, information input from the management input / output unit 101, and the like.
  • the nematode operation unit 113 acquires the nematode group selected by the nematode selection unit 112 from the nematode storage 302 and dispenses it to the inspection device 301.
  • the inspection condition adjustment unit 121 adjusts the inspection conditions (temperature, etc.) of the inspection room 311 and the inspection device 301 based on the inspection condition DB 202.
  • the chemotaxis analysis unit 122 performs determination of nematode attracting behavior, avoidance behavior, and calculation of the chemotaxis analysis value based on the result captured by the imaging unit 123. The attracting behavior, repellent behavior, and the runtability analysis value will be described later.
  • the imaging unit 123 is installed in the inspection device 301 and images the nematode chemotaxis behavior result in the inspection device 301.
  • the transmission processing unit 131 outputs (transmits) the result of the cancer test or the like to the input / output unit 161.
  • the inspected person information processing unit 132 inputs application information for cancer testing transmitted from the inspected person into the inspected person DB 204.
  • the sample operation unit 141 acquires a sample from the sample storage 303 according to an instruction from the nematode selection unit 112, information in the sample management DB 204, and the like, and dispenses it to the test device 301.
  • the sample management unit 142 confirms whether or not the sample to be tested is a sample to be tested, and determines whether or not the sample has passed the storage period.
  • the search processing unit 151 searches the medical institution suitable for the subject to be processed based on the inspected person DB 204, the medical institution DB 206, and the like, and updates the request history DB 207.
  • the billing processing unit 152 performs processing related to billing, such as calculating or billing an examination fee charged to the subject, an introduction fee received from a medical institution, and the like.
  • the input / output unit 161 outputs information transmitted from the transmission processing unit 131 or the search processing unit 151.
  • FIG. 2 is a diagram showing an outline of the cancer test according to the first embodiment.
  • FIG. 2 is a view of an inspection device 301 described later as viewed from directly above.
  • the left and right circles indicate the specimen dispensing holes 812
  • the circle in the middle of the sheet indicates the nematode dispensing holes 811.
  • the specimen dispensing hole 812 and the nematode dispensing hole 811 will be described later.
  • about several ⁇ l of the sample (inspected subject's urine, subject-related biological substance) 401 is dispensed from one specimen dispensing hole 812, and about 100 nematodes 411 are transmitted from the nematode dispensing hole 811.
  • the nematode 411 of the nematode group 402 exhibits chemotaxis toward the sample 401.
  • that the nematode 411 exhibits chemotaxis toward the specimen 401 by its olfaction is referred to as an attracting action.
  • the specimen 401 is urine collected from a non-cancer patient
  • the nematode 411 shows chemotaxis away from the specimen 401 due to its olfaction.
  • repelling behavior the fact that the nematode 411 exhibits chemotaxis away from the specimen 401 is referred to as repelling behavior, and is appropriately indicated by a symbol “ ⁇ ”.
  • a chemotaxis analysis value is defined by the following formula
  • the chemotaxis analysis value becomes a positive value, and if there are many nematodes 411 that show repelling behavior, the chemotaxis analysis value has a negative value. That is, the chemotaxis analysis value includes information on the ratio between the number of nematodes that show the attracting behavior and the number of nematodes that show the repelling behavior. If the chemotaxis analysis value is a positive value, the chemotaxis analysis unit 122 determines that the attracting behavior is indicated, and determines that the cancer is “positive”.
  • a chemotaxis analysis value is not restricted to Formula (1).
  • the chemotaxis analysis unit 122 calculates two values: a value obtained by dividing the number of nematodes that showed attraction behavior by the total number of nematodes, and a value obtained by dividing the number of nematodes that showed repellent behavior by the number of all nematodes. May be. Then, “positive” or “negative” may be determined based on the magnitude relationship between these two values.
  • the burden on the subject can be greatly reduced.
  • the result of the cancer test using the nematode 411 can be output numerically, and the examinee can obtain an objective result.
  • FIG. 3 is a diagram illustrating an example of a nematode management DB according to the first embodiment.
  • the nematode management DB 201 has a nematode group ID (Identification), a growing day number, a nematode type, and an address.
  • the nematode group 402 (FIG. 2) in the nematode group ID is a group of nematodes 411 cultured in one petri dish. That is, the nematode group ID is an ID given to a nematode cultured in one petri dish.
  • the nematode group ID may be given by the inspector via the management input / output unit 101 or may be given by the data management unit 102.
  • One nematode group 402 is, for example, a nematode 411 hatched from an egg laid by the same parent nematode.
  • the number of days of growth is the number of days since the nematode 411 hatched from the egg.
  • the number of growing days is stored in the format of “day / time”.
  • the nematode group 402 of “C001” is “10/12: 21”, which indicates that the number of growing days of the nematode group 402 is 10 days and 12 hours and 21 minutes.
  • the growing days of individual nematodes 411 in the nematode group 402 also vary.
  • the average growing days in the nematode group 402 are stored in the growing days column.
  • the number of growing days is information that is input when the inspector inputs the average date and time of hatching in the nematode group 402 and then the data management unit 102 continues to update.
  • the nematode type is the type of nematode 411 in the nematode group 402.
  • the address indicates the location of the nematode storage 302 where the nematode group 402 is stored. For example, the nematode group 402 of “C001” is cultured and stored at address “A7” in the storage of “No. 1”.
  • the nematode type and address are information input by the inspector via the management input / output unit 101.
  • FIG. 4 is a diagram illustrating an example of the inspection condition DB according to the first embodiment.
  • the inspection condition DB 202 includes information on an inspection condition number, an execution place, a specimen storage condition, a nematode condition, a laboratory condition, and inspection suitability.
  • the inspection condition number is a number assigned to the inspection condition, and may be input by the inspector via the management input / output unit 101 or may be assigned by the data management unit 102.
  • the place of implementation is the name of a facility where a cancer test is performed by the nematode 411, and is information input by the inspector via the management input / output unit 101.
  • the sample storage condition stores the storage condition in the sample storage 303 where the sample 401 used for the test condition is stored, and stores information such as the sample collection date, the sample state, and the sample storage temperature.
  • the sample collection date the date and time when the sample was collected is stored.
  • the sample collection date is information stored when the inspector inputs the collection date attached to the sent test kit by the management input / output unit 101.
  • the specimen state is information stored by inputting the result of the examination of the specimen 401 by a periodic inspector by the inspector.
  • the specimen storage temperature is the temperature of the specimen storage 303 obtained from a temperature sensor (not shown) provided in the specimen storage 303.
  • the nematode condition is a condition of the nematode 411 used for the cancer test, and has the nematode type and the number of days of growth.
  • the nematode type is the type of nematode 411 used for the cancer test
  • the number of days of growth is the number of days of growth of the nematode 411 used for the cancer test.
  • the number of days of growth is the number of days since the nematode 411 hatched from the egg.
  • Each information of the nematode type is information input by an inspector or the like with reference to the nematode management DB 201.
  • the information in the nematode management DB 201 may be copied by the data management unit 102.
  • the laboratory conditions are information regarding the laboratory 311 in which the inspection device 301 is installed and a cancer test using the nematode 411 is performed, and includes an implementation temperature and the number of implementations.
  • the implementation temperature is information related to the temperature of the examination room 311 when the cancer examination is carried out, and is information input by the inspector via the management input / output unit 101.
  • the test room 311 needs to be at this temperature.
  • the number of executions is the number of executions in one inspection, and is information input by the inspector via the management input / output unit 101.
  • a cancer test using the nematode 411 is performed five times, and the average value and deviation of the chemotaxis analysis are stored as test results in the test result DB 203 Stored.
  • the inspection suitability is a confirmation result of each inspection condition input by the inspector.
  • FIG. 5 is a diagram illustrating an example of the inspection result DB according to the first embodiment.
  • the test result DB 203 stores information related to the result of the cancer test by the nematode 411.
  • the examination number, sex, and age are the same as the examination number, sex, and age in the inspected person DB 204 in FIG.
  • the data management unit 102 refers to the inspected person DB 204 (FIG. 6), and the gender associated with the input inspection number,
  • the age is entered in the sex / age column in the test result DB 203.
  • the examination date is the date on which the cancer examination by the nematode 411 was performed, and may be input by an inspector or may be input by the data management unit 102.
  • the examination condition number is an examination condition for cancer examination and is the same as the examination condition number in the examination condition DB 202 of FIG.
  • the inspection condition number in the inspection result DB 203 is information input by the inspector.
  • the test results are attraction behavior, repellent behavior, and chemotaxis analysis values, and the chemotaxis analysis result of the nematode 411 by the chemotaxis analysis unit 122 is input by the chemotaxis analysis unit 122.
  • the determination information related to determination of a cancer test is stored, and a determination result input via the management input / output unit 101 and a comment are included.
  • the determination result stores “positive” and “negative” results based on the test result column.
  • the determination result may be determined by whether the mobility analysis value 122 exceeds the predetermined threshold value, or may be determined after the inspector confirms the mobility analysis value.
  • the comment column comments input via the management input / output unit 101 by an inspector, a doctor, or the like are stored.
  • FIG. 6 is a diagram illustrating an example of an inspected person DB according to the first embodiment.
  • the inspected person DB 204 stores information on the inspection number, application date, name, sex, date of birth, address, inspection ID, and secondary inspection.
  • the examination number is a number given by the inspected person information processing unit 132 when the inspected person applies for a cancer test by the nematode 411, and is input by the inspected person information processing unit 132.
  • the application date, name, date of birth, and address are information that the inspected person transmits to the inspection organization at the time of application, and are information that is input by the inspected person information processing unit 132.
  • an inspector may be input via the management input / output unit 101.
  • the inspection ID is an ID given by the data management unit 102 when the inspection is started.
  • the secondary inspection is a flag indicating whether or not the current inspection is a secondary inspection.
  • the examinee with the examination number “0002” is the secondary examination, and the examinees with “0001” and “0003” are the primary examination.
  • Information in the secondary examination column is input by the inspector via the management input / output unit 101 or the data management unit 102.
  • the inspected person DB 204 may store information such as the weight and height of the inspected person.
  • FIG. 7 is a diagram illustrating an example of the sample management DB according to the first embodiment.
  • the sample management DB 205 has an examination number, a sample collection date, an address, and the like. Since the inspection number is the same as the inspection number in the inspected person DB 204 in FIG. 6, the description is omitted here. Since the sample collection date is the same as the sample collection date in the examination condition DB 202 of FIG. 4, the description thereof is omitted here.
  • the address indicates the location of the nematode storage 302 where the specimen 401 corresponding to the examination number is stored. For example, the specimen 401 with the examination number “0001” is stored at “A5” in the specimen storage 303 with “No. 1”.
  • Each piece of information in the sample management database 205 is information input via the management input / output unit 101.
  • FIG. 8 is a diagram illustrating an example of a medical institution DB according to the first embodiment.
  • the medical institution DB 206 has a medical institution name, an address, a cancer type that can be examined, and an evaluation, and is information input by an inspector via the management input / output unit 101.
  • the address is the address of a medical institution.
  • the evaluation is an evaluation based on word of mouth or the like, and is represented by “A” (best) to “E” (lowest). This evaluation is used for the degree of recommendation when introducing a medical institution to the subject.
  • FIG. 9 is a diagram illustrating an example of a request history DB according to the first embodiment.
  • the search processor 151 stores the number of times each medical institution has been introduced by the inspection institution for each inspection number (for each subject).
  • the comments in the request history DB 207 are the same as the comments in the inspection result DB 203 in FIG. 5 and are information input by the inspector via the management input / output unit 101.
  • FIG. 10 is a diagram illustrating an example of a hardware system configuration when the inspection center performs a cancer test using a nematode.
  • it has the user terminal 501 which the subject 2 (FIG. 11) has, the inspection organization server 502 which the inspection center 3 (FIG. 11) has, and the inspection apparatus control apparatus 503.
  • the inspection apparatus control apparatus 503 adjusts the temperature of the inspection device 301 installed in the nematode storage 302, the specimen storage 303, the inspection room 311, and the inspection room 311.
  • the user terminal 501 includes a memory 511A, an arithmetic device 512A such as a CPU (Central Processing Unit), a communication device 513A such as a NIC (Network Interface Card), an input device 514A, and a display device 515A.
  • arithmetic device 512A such as a CPU (Central Processing Unit)
  • a communication device 513A such as a NIC (Network Interface Card)
  • an input device 514A and a display device 515A.
  • the input device 515A and the display device 515A correspond to the input / output unit 161 in FIG.
  • the inspection organization server 502 includes a memory 511B, an arithmetic device 512B such as a CPU, a communication device 513B such as a NIC, an input device 514B, and a display device 515B. Further, the inspection organization server 502 has a label printer 516B that prints a label to be attached to the sample container 401A sent from the subject 2 to be inspected.
  • the sample container 401A is a container provided in the test kit, and is a container for storing urine as the sample 401 (FIG. 2). Further, the inspection organization server 502 has DBs 201 to 207.
  • the communication device 513B communicates with the user terminal 501 and the inspection device control device 503.
  • a program stored in a storage device (not shown) is expanded in the memory 511B of the inspection organization server 502. Then, the program developed by the arithmetic device 512B is executed. As described above, by executing the program, the respective units 102, 111 to 113, 121, 122, 131, 132, 141, 142, 151, and 152 in FIG. 1 are realized. Note that the input device 514B and the display device 515B in FIG. 10 correspond to the management input / output unit 101 in FIG.
  • FIG. 11 is a diagram illustrating an example of an inspection procedure according to the first embodiment, and illustrates an example of a procedure when an inspection center performs an inspection. Reference is made to FIG. 10 as appropriate.
  • the cancer test used in this embodiment is possible even if it is not a medical person.
  • the inspection organization server 502 of the inspection center 3 transmits a cancer inspection (primary inspection) guide by the nematode 411 (FIG. 2) by e-mail or the like (S101).
  • the guidance states that the inspection kit will be sent free of charge for the primary inspection.
  • this guide describes that a fee is charged for viewing the primary inspection result, and that a separate fee is charged for the secondary inspection. Further, this guidance may be sent by direct mail or the like.
  • the subject 2 performs a cancer test (first test, first test) using the nematode 411 via a web screen displayed on the input / output unit 161 (display device 515A of the user terminal 501).
  • An application is made (S102).
  • the user terminal 501 of the person to be inspected 2 transmits information on the destination of the test kit, such as the name and address, to the test center 3 together with the application for the cancer test.
  • the inspection center 3 sends the inspection kit to the inspected person 2 free of charge (S103).
  • the inspection kit may be sent at a lower cost (for example, about several hundred yen) than the inspection fee charged at the time of browsing the primary inspection described later or the secondary inspection. In this way, by making the sending of the inspection kit in the primary inspection free or at a low price, the inspected person 2 can easily apply for the primary inspection.
  • the test kit in which urine (sample 401: FIG. 2) is collected together with information such as sex, age, and the name of the prefecture where he / she resides Is sent to the inspection center 3. That is, the subject 2 sends the specimen 401 to the inspection center 3 (S104).
  • the collected urine is referred to as a specimen 401.
  • the primary inspection is free here, the price may be lower (for example, about several hundred yen) than the secondary inspection described later.
  • the examination center 3 freezes and stores the sent specimen 401 in the specimen storage 303 (S105). By storing the specimen 401 in a frozen state in this manner, the specimen 401 can be stored for a long period of time. When a cancer test is performed again using the specimen 401 of the same subject 2, the specimen 401 again receives the specimen from the subject 2. 401 need not be provided. Note that it is desirable to store the specimen 401 with a time limit (for example, 6 months) and to discard it when the time limit has passed. Then, the examination center 3 defrosts the specimen 401 that has been frozen and performs a cancer examination (primary examination) using the specimen 401 and the nematode 411 (S106).
  • a cancer examination primary examination
  • the inspection organization server 502 of the inspection center 3 transmits the result of the primary inspection (inspection result) to the user terminal 501 of the person 2 to be inspected (S107).
  • the inspection center 3 asks the subject 2 whether or not he / she wishes to view the results, and when the subject 2 wishes to view the results of the primary inspection, the inspection center 3 can view the results of the primary inspection.
  • the inspection organization server 502a of the inspection center 3 first transmits only the result of the primary inspection to the user terminal 501 of the person 2 to be inspected, and does not transmit the contents of the primary inspection.
  • the inspection organization server 502a of the inspection center 3 transmits the specific result of the primary inspection to the user terminal 501 of the inspected person 2, so that the inspected person 2 It will be possible to view the specific results of the primary inspection.
  • the inspection center 3 may notify the inspected person 2 that an inspection fee is generated when the inspected person 2 views the result of the primary inspection. In this case, the inspection center 3 charges the inspected person 2 for an inspection fee when the inspected person 2 actually browses the result of the primary inspection. In this way, the inspection center 3 can easily make a profit by setting the inspection kit to be free or at a low price so that the inspection fee is generated when the inspected person 2 views the primary inspection result.
  • the inspected person 2 when the inspected person 2 deposits the requested inspection fee into the inspection center 3, the inspected person 2 can view the screen of the result of the primary inspection (the primary inspection result content screen). . Then, the inspected person 2 browses the result of the primary inspection after depositing (S108). As will be described later, a radio button for selecting a desired process in the future is displayed on the primary inspection result content screen together with the result of the primary inspection.
  • the inspection number, age, gender, etc. of the inspected person 2 are displayed on the primary inspection result content screen.
  • Comments such as the name of the prefecture where the examinee 2 lives, a description of the suspected part about cancer, etc. on the primary test result content screen, a hospital suitable for the examinee 2 to have medical treatment, Information on a medical institution 6 (FIG. 15) such as a clinic may be displayed.
  • comments such as the name of the prefecture where the examinee 2 resides, explanations of suspected parts of cancer, etc., hospitals suitable for the examinee 2 to receive medical treatment, and medical institutions such as clinics 6 (FIG. 15) may be transmitted separately from the primary examination result content screen (the same applies to FIGS. 14 to 16).
  • the inspection process ends (not shown in FIG. 10). If the person to be inspected 2 desires “re-inspection of primary inspection” on the primary inspection result content screen, the process returns to step S102 (not shown in FIG. 10).
  • a medical institution search process described later in FIG. 20 is performed. Further, when the result of the primary test is “negative”, a request for reduction of examination items may be displayed on the primary test result content screen.
  • a request to reduce the number of examination items is a request to the medical institution 6 (FIG. 15) that conducts the health examination to reduce the number of examination items related to cancer when the subject 2 receives a health examination in the future. That is.
  • the efficiency during the health examination can be improved.
  • the subject 2 is also notified that the secondary inspection will be charged from the delivery of the inspection kit.
  • the guidance for the secondary test may be performed only for those who are determined to be positive in the primary test. In this way, it is easy for the inspected person 2 to apply for the delivery of the inspection kit in the primary inspection for free or at a low price, and the inspection center 3 can easily make a profit by paying the secondary inspection.
  • the inspected person 2 When the inspected person 2 selects “I want a secondary inspection” on the content screen of the primary inspection result, the inspected person 2 applies for and pays for the secondary inspection (second inspection) (S109). ).
  • secondary inspection a sample 401 is separately collected and reexamined, a reexamination before undergoing a close examination at the hospital, an examination to see the progress of the person who has undergone cancer treatment, and the subjective symptoms of cancer are found A re-inspection in the event of a failure is conceivable.
  • the inspection center 3 confirms the application and payment for the secondary inspection, the inspection center 3 defrosts the specimen 401 that has been cryopreserved in step S106 as necessary, and uses the thawed specimen 401 to create a line.
  • a cancer test (secondary test) using the insect 411 is performed (S110). The remaining specimen 401 is stored frozen. Note that, when a notification indicating that a future test is unnecessary is received from the subject 2, the test center 3 discard
  • test center 3 transmits the result of the secondary test (test result) to the subject 2 (S111).
  • the medical institution 6 for receiving a detailed test or treatment.
  • a check box that allows you to select information by cancer type is displayed.
  • the examinee 2 selects a cancer type by selecting and inputting a check box via the input device 514A (S112)
  • the examination institution server 502 of the examination center 3 performs a medical institution search process to be described later and selects it.
  • the medical institution information relating to the entered carcinoma is transmitted (S113).
  • FIG. 12 is a diagram illustrating an example of a hardware configuration of a cancer test system when an intermediary organization exists between an institution performing a cancer test and an examinee.
  • the cancer inspection system in FIG. 12 includes an intermediary organization server 504 in addition to the user terminal 501, the inspection organization server 502a and the inspection device control device 503 installed in the inspection company 5.
  • the agency server 504 is a server provided in the health insurance association 4 in FIG. 14, the medical institution 6 in FIG. 15, the medical care system organization 7 in FIG.
  • the medical care system organization 7 is an organization that manages the quality and cost of medical care at the local or national level. There is a mechanism to form a mother body and provide continuous care.
  • the inspection organization server 502a in FIG. 12 is a server provided in the inspection company 5 in FIGS.
  • the intermediary organization server 504 includes a memory 511C, a calculation device 512C such as a CPU, and a communication device 513C such as a NIC. Note that the mediation institution server 504 may include an input device, a display device, and the like.
  • the communication device 513C communicates with the user terminal 501 and the inspection organization server 502.
  • the intermediary organization server 504 includes a medical institution DB and a request history DB.
  • a program stored in a storage device (not shown) is expanded in the memory 511C of the mediation institution server 504, and the program expanded by the arithmetic unit 512C is executed.
  • the search processing unit 151 and the billing processing unit 152 in FIG. 1 are realized by executing the program in FIG.
  • the intermediary organization server 504 is installed in the medical institution 6 in FIG. 15, the medical institution DB, the request history DB, the search processing unit 151, and the billing processing unit 152 may be omitted.
  • the communication device 513B communicates with the mediation organization server 504.
  • the inspection organization server 502a includes the DBs 201 to 205.
  • a program stored in a storage device (not shown) is expanded in the memory 511B of the inspection organization server 502a, and the program expanded by the arithmetic device 512B is executed.
  • the units 102, 111 to 113, 121, 122, 131, 132, 141, 142 in FIG. 1 are realized by executing the program in FIG.
  • the inspection organization difference 502a may include a medical institution DB, a request history DB, a search processing unit 151, and a billing processing unit 152.
  • the medical institution search process is performed by the inspection company 5.
  • the input device 514B and the display device 515B of the inspection organization server 502 and the input device 514C and the display device 515C of the mediation organization server 504 correspond to the management input / output unit 101 of FIG.
  • FIG. 13 is a diagram showing another example of the hardware configuration of the cancer test system shown in FIGS.
  • the inspection organization server 502b does not have the inspected person DB 204
  • the mediator server 504 includes the inspection result DB 203 and the inspected person DB 204. That is, in the cancer test system of FIG. 13, the health insurance association 4 of FIG. 14, the medical institution 6 of FIG. 15, the medical care system organization 7 of FIG. It will not have information about information. By doing so, the testing company 5 cannot know which subject 401 (FIGS. 14 to 16) the specimen 401 (FIG. 2) currently undergoing a cancer test is, so personal information Can improve confidentiality.
  • FIG. 10 it is desirable that communication between the devices 501 to 504 is encrypted.
  • a plurality of user terminals 501 are installed for each user. Further, by installing a plurality of inspection organization servers 502, 502a, 502b and intermediary organization servers 504 in FIGS. 10, 12, and 13, each unit 102, 111 to 113, 121, 122, 131, 132, 141, The functions of 142, 151, and 152 and the DBs 201 to 207 may be distributed.
  • FIG. 14 is a diagram showing an example of an inspection procedure according to the first embodiment, and shows an example of a procedure through a health insurance association as an intermediary organization. Reference is made to FIG. 12 as appropriate. In FIG. 14, an example through the health insurance association 4 is shown, but a local government may be used instead of the health insurance association 4.
  • the mediation institution server 504 of the health insurance association 4 provides guidance for a cancer test by the nematode 411 (FIG. 2) (S201). This guidance is preferably performed via a portal site or the like. This guide states that the inspection kit will be sent free of charge during the primary inspection.
  • this guide describes that a fee is charged for viewing the primary inspection result, and that a separate fee is charged for the secondary inspection. Further, this guidance may be sent by direct mail or the like.
  • the examinee 2 applies for a cancer test (primary test) with the nematode 411 via a web screen displayed on the input / output unit 161 (the display unit 511A of the user terminal 501). 4 (S202).
  • the user terminal 501 of the person to be inspected 2 transmits information on the destination of the test kit, such as the name and address, to the health insurance association 4 along with the application for the cancer test.
  • the health insurance association 4 requests the inspection company 5 to perform a primary inspection, and transmits information (destination information) on the inspection kit destination to the inspection organization server 502a of the inspection company 5 (S203). .
  • the inspection company 5 sends the inspection kit to the health insurance association 4 (S204).
  • the health insurance association 4 sends the inspection kit sent from the inspection company 5 to the destination sent from the person 2 to be inspected free of charge (S205).
  • the inspection kit may be sent at a lower cost (for example, about several hundred yen) than the inspection fee charged at the time of browsing the primary inspection described later or the secondary inspection. In this way, by making the primary inspection free or at a low price, the inspected person 2 can easily apply for the primary inspection.
  • test subject 2 When the subject 2 collects his urine with the sent test kit, the test subject 2 sends the test kit from which the urine (sample 401: FIG. 2) is collected to the health insurance association 4. That is, the examinee 2 sends the specimen 401 to the health insurance association 4 (S206). Then, the health insurance association 4 sends the sent test kit (specimen 401) to the test company 5 (S207).
  • the inspection company 5 freezes and stores the sent specimen 401 in the specimen storage 303 (S208). By storing the specimen 401 in a frozen state in this manner, the specimen 401 can be stored for a long period of time. When a cancer test is performed again using the specimen 401 of the same subject 2, the specimen 401 again receives the specimen from the subject 2. 401 need not be provided. Note that it is desirable to store the specimen 401 with a time limit (for example, 6 months) and to discard it when the time limit has passed. Then, the examination company 5 defrosts the specimen 401 that has been frozen and performs a cancer examination (primary examination) using the specimen 401 and the nematode 411 (S209).
  • a cancer examination primary examination
  • the inspection organization server 502a of the inspection company 5 transmits the inspection fee of the secondary inspection together with the result of the primary inspection (examination result) to the intermediary organization server 504 of the health insurance association 4 (S210). ).
  • the mediation institution server 504 of the health insurance association 4 transmits the result of the primary inspection to the user terminal device of the person 2 to be inspected (S211). At this time, the health insurance association 4 asks the inspected person 2 whether or not he / she wishes to view the results. . Note that the mediation institution server 504 of the health insurance association 4 first transmits only the fact that the result of the primary inspection is given to the user terminal 501 of the person 2 to be inspected, and does not transmit the contents of the primary inspection. When the payment from the inspected person 2 is confirmed, the intermediary organization server 504 of the health insurance association 4 transmits the specific result of the primary inspection to the user terminal 501 of the inspected person 2 so that the inspected 2 You can view the specific results of the primary inspection.
  • the health insurance association 4 may notify the inspected person 2 that the inspection fee is generated when the inspected person 2 views the result of the primary inspection.
  • the health insurance association 4 may charge the inspected person 2 for an inspection fee when the inspected person 2 actually browses the result of the primary inspection. In this way, the health insurance association 4 can easily make a profit by making the delivery of the inspection kit free or at a low price so that the inspected person 2 inspects the primary inspection result and incurs an inspection fee.
  • the inspected person 2 when the inspected person 2 deposits the inspection fee to the health insurance association 2, the inspected person 2 can view the screen of the result of the primary inspection (the primary inspection result content screen). Then, the inspected person 2 browses the result of the primary inspection after depositing (S212).
  • the primary inspection result content screen displays a radio button and the like for selecting a desired process together with the result of the primary inspection. Furthermore, as will be described later, the inspection number, age, sex, and the like of the inspected person 2 are displayed on the primary inspection result content screen. Comments such as the name of the prefecture where the examinee 2 lives, a description of the suspected part about cancer, etc. on the primary test result content screen, a hospital suitable for the examinee 2 to have medical treatment, Information on a medical institution 6 (FIG. 15) such as a clinic may be displayed.
  • the inspection process ends (not shown in FIG. 14). If the person to be inspected 2 desires “re-inspection of primary inspection” on the primary inspection result content screen, the process returns to step S202 (not shown in FIG. 14).
  • a medical institution search process described later in FIG. 20 is performed.
  • a request for reduction of examination items may be displayed on the primary test result content screen.
  • the request to reduce the number of examination items is to request the medical institution 6 that performs the health examination to reduce the number of examination items related to cancer when the subject 2 receives a health examination in the future.
  • the efficiency during the health examination can be improved.
  • the subject 2 is also notified that the secondary inspection will be charged from the delivery of the inspection kit.
  • the guidance for the secondary test may be performed only for those who are determined to be positive in the primary test.
  • the health insurance association 4 can improve profits by making it easier for the inspected person 2 to apply for the primary inspection free of charge or at a low price, and to charge the secondary inspection.
  • the inspected person 2 who confirmed the result of the cancer test applies for the secondary inspection and payment to the health insurance association 4 (S213).
  • the inspection company 5 The secondary inspection is requested (S214).
  • the examination company 5 defrosts the specimen 401 frozen and stored in step S209 as necessary, and performs a cancer examination (secondary examination) with the nematode 411 using the thawed specimen 401 (S215).
  • the remaining specimen 401 is stored frozen.
  • the testing company 5 discards the sample 401.
  • test result the result of the secondary test
  • mediation organization server 504 of the health insurance association 4 transmits the result of the secondary inspection to the user terminal 501 of the person 2 to be inspected (S217).
  • the medical institution 6 for receiving a detailed test or treatment.
  • a check box that allows you to select information by cancer type is displayed.
  • the intermediary organization server 504 of the health insurance association performs a medical institution search process to be described later and selects it.
  • the medical institution information related to the entered carcinoma is transmitted (S219).
  • FIG. 15 is a diagram illustrating an example of an examination procedure according to the first embodiment, and illustrates an example of a procedure via a medical institution as an intermediary organization.
  • a doctor or the like of the medical institution 6 gives an instruction for a cancer test to the subject 2 according to the result of the examination of the subject 2 (S301).
  • doctors and the like describe that a test kit is sent free of charge in the primary examination.
  • this guide describes that a fee is charged for viewing the primary inspection result, and that a separate fee is charged for the secondary inspection.
  • the examinee 2 applies to the medical institution 6 for a cancer test (primary test) using the nematode 411 (FIG. 2) (S302).
  • the examinee 2 sends to the medical institution 6 information regarding the destination of the test kit, such as name and address, along with an application for a cancer test.
  • the application in step S302 may be performed through a web screen or the like, or may be performed by submitting documents to the window of the medical institution 6.
  • the medical institution 6 requests the inspection company 5 to perform a primary inspection, and transmits information (destination information) on the inspection kit destination to the inspection company server 502a of the inspection company 5 (S303).
  • the inspection company 5 sends the inspection kit to the medical institution 6 (S304).
  • the medical institution 6 sends the inspection kit sent from the inspection company 5 to the destination sent from the person 2 to be inspected free of charge (S305).
  • the inspection kit may be sent at a lower cost (for example, about several hundred yen) than the inspection fee charged at the time of browsing the primary inspection described later or the secondary inspection. In this way, by making the primary inspection free or at a low price, the inspected person 2 can easily apply for the primary inspection.
  • test kit sample 401 from which urine (sample 401: FIG. 2) is collected to medical institution 6. That is, the subject 2 sends the specimen 401 to the medical institution 6 (S306). Then, the medical institution 6 sends the sent test kit (specimen 401) to the test company 5 (S307).
  • the inspection company 5 freezes and stores the sent specimen 401 in the specimen storage 303 (S308). By storing the specimen 401 in a frozen state in this manner, the specimen 401 can be stored for a long period of time. When a cancer test is performed again using the specimen 401 of the same subject 2, the specimen 401 again receives the specimen from the subject 2. 401 need not be provided. Note that it is desirable to store the specimen 401 with a time limit (for example, 6 months) and to discard it when the time limit has passed. Then, the examination company 5 defrosts the specimen 401 that has been frozen and performs a cancer examination (primary examination) using the specimen 401 and the nematode 411 (S309). When the result of the primary inspection is output, the inspection organization server 502a of the inspection company 5 transmits the inspection fee together with the result of the primary inspection (inspection result) to the mediation organization server 504 of the medical institution 6 (S310).
  • the mediation institution server 504 of the medical institution 6 transmits the result of the primary test (test result) to the user terminal 501 of the person 2 to be inspected (S311). At this time, the medical institution 6 asks the examinee 2 whether or not he / she wishes to view the results, and when the examinee 2 wishes to view the results of the primary examination, he / she can view the results of the primary examination. In addition, the mediation institution server 504 of the medical institution 6 first transmits only the fact that the result of the primary inspection is given to the user terminal 501 of the person 2 to be inspected, and does not transmit the contents of the primary inspection.
  • the mediation institution server 504 of the medical institution 6 transmits the specific result of the primary inspection to the user terminal 501 of the inspected person 2 so that the inspected 2 becomes the primary. You can view the specific results of the inspection.
  • the medical institution 6 may notify the inspected person 2 that the inspection fee is generated when the inspected person 2 views the result of the primary inspection.
  • the medical institution 6 may charge the inspecting person 2 for an inspection fee when the inspected person 2 actually browses the result of the primary inspection. In this way, the medical institution 6 can easily make a profit by making the delivery of the test kit free or at a low price and generating a test fee when the inspected person 2 views the primary test result.
  • the inspected person 2 pays the examination fee to the medical institution 6 so that the inspected person 2 can view the screen of the result of the primary inspection (the primary inspection result content screen). . Then, the inspected person 2 browses the result of the primary inspection after depositing (S312). As will be described later, a radio button for selecting a desired process in the future is displayed on the primary inspection result content screen together with the result of the primary inspection. Furthermore, as will be described later, the inspection number, age, sex, and the like of the inspected person 2 are displayed on the primary inspection result content screen. Comments such as the name of the prefecture where the examinee 2 lives, a description of the suspected part about cancer, etc. on the primary test result content screen, a hospital suitable for the examinee 2 to have medical treatment, Information on a medical institution 6 such as a clinic may be displayed.
  • the inspection process ends (not shown in FIG. 15). If the person to be inspected 2 desires “re-inspection of primary inspection” on the primary inspection result content screen, the process returns to step S302 (not shown in FIG. 15).
  • a medical institution search process described later in FIG. 20 is performed.
  • a request for reduction of examination items may be displayed on the primary test result content screen.
  • a request to reduce the number of examination items is a request to the medical institution 6 (FIG. 15) that conducts the health examination to reduce the number of examination items related to cancer when the subject 2 receives a health examination in the future. That is.
  • the medical institution 6 (FIG. 15) that conducts the health examination to reduce the number of examination items related to cancer when the subject 2 receives a health examination in the future. That is.
  • the examinee 2 who confirmed the result of the primary examination applies for the secondary examination and makes payment to the medical institution 6 (S313).
  • the medical institution 6 requests the inspection company 5 for a secondary inspection (S314).
  • the examination company 5 defrosts the specimen 401 frozen and stored in step S309 as necessary, and performs a cancer test (secondary examination) using the nematode 411 using the thawed specimen 401 (S315).
  • the remaining specimen 401 is stored frozen.
  • the testing company 5 discards the sample 401.
  • the test organization server 502a of the test company 5 transmits the result of the cancer test to the mediation organization server 504 of the medical institution 6 (S316). Then, the mediation institution server 504 of the medical institution 6 transmits the test result to the user terminal 501 of the person to be inspected 2 (S317). If the result of the secondary test is “positive”, the medical institution 6 gives a detailed test instruction to the subject 2. The subject 2 receives a medical examination at the medical institution 6 or undergoes a detailed examination according to the result of the secondary examination.
  • FIG. 16 is a diagram illustrating an example of an examination procedure according to the first embodiment, and illustrates an example of a procedure via a medical care system organization as an intermediary organization.
  • the medical care system organization 7 guides a cancer test using the nematode 411 (FIG. 2) (S401). This guidance is preferably performed via a portal site or the like. This guide states that the inspection kit will be sent free of charge for the primary inspection. In addition, this guide describes that a fee is charged for viewing the primary inspection result, and that a separate fee is charged for the secondary inspection. Further, this guidance may be sent by direct mail or the like.
  • the examinee 2 applies for a cancer test (primary test) using the nematode 411 via a web screen displayed on the input / output unit 161 (display device 515A of the user terminal 501). This is performed on the organization 7 (S402). At this time, the subject 2 transmits information about the destination of the test kit, such as the name and address, to the medical care system organization 7 together with the application for the cancer test.
  • a cancer test primary test
  • the subject 2 transmits information about the destination of the test kit, such as the name and address, to the medical care system organization 7 together with the application for the cancer test.
  • the medical care system organization 7 requests the inspection company 5 to perform a primary inspection, and the mediation institution server 504 of the medical care system organization 7 obtains information (destination information) on the inspection kit delivery destination.
  • the data is transmitted to the server 502a (S403).
  • the inspection company 5 sends the inspection kit to the medical care system organization 7 (S404).
  • the medical care system organization 7 sends the test kit sent from the test company 5 to the destination sent from the person 2 to be inspected free of charge (S405).
  • the inspection kit may be sent at a lower cost (for example, about several hundred yen) than the inspection fee charged at the time of browsing the primary inspection described later or the secondary inspection. In this way, by making the primary inspection free or at a low price, the inspected person 2 can easily apply for the primary inspection.
  • test subject 2 When the subject 2 collects his urine with the sent test kit, the test subject 2 sends the test kit from which the urine (sample 401: FIG. 2) is collected to the medical care system organization 7. That is, the examinee 2 sends the specimen 401 to the medical care system organization 7 (S406). Then, the medical care system organization 7 sends the sent test kit (specimen 401) to the test company 5 (S407).
  • the inspection company 5 freezes and stores the sent specimen 401 in the specimen storage 303 (S408). By storing the specimen 401 in a frozen state in this manner, the specimen 401 can be stored for a long period of time. When a cancer test is performed again using the specimen 401 of the same subject 2, the specimen 401 again receives the specimen from the subject 2. 401 need not be provided. Then, the examination company 5 defrosts the specimen 401 that has been frozen and performs a cancer examination (primary examination) using the specimen 401 and the nematode 411 (S409).
  • the inspection organization server 502a of the inspection company 5 transmits the inspection fee together with the result of the primary inspection (inspection result) to the mediation organization server 504 of the medical care system organization 7 (S410). Note that it is desirable to store the specimen 401 with a time limit (for example, 6 months) and to discard it when the time limit has passed.
  • the mediation institution server 504 of the medical care system organization 7 transmits the result of the primary examination to the user terminal device of the examinee 2 (S411). At this time, the medical care system organization 7 asks the subject 2 whether or not he / she wishes to view the results, and when the subject 2 wishes to view the results of the primary examination, the result of the primary examination can be viewed. To do. Note that the mediation institution server 504 of the medical care system organization 7 first transmits only the result of the primary examination to the user terminal 501 of the examinee 2 and does not transmit the contents of the primary examination. When the payment from the inspected person 2 is confirmed, the mediation institution server 504 of the medical care system organization 7 transmits the specific result of the primary inspection to the user terminal 501 of the inspected person 2, so that the inspected 2 Can view the specific results of the primary inspection.
  • the medical care system organization 7 may notify the subject 2 that the examination fee is generated when the subject 2 views the result of the primary examination. In this case, the medical care system organization 7 may charge the inspected person 2 for an inspection fee when the inspected person 2 actually browses the result of the primary inspection. In this way, the medical care system organization 7 can easily make a profit by making the delivery of the test kit free of charge and generating a test fee when the subject 2 views the primary test result.
  • the examinee 2 can view the screen of the primary examination result (primary examination result content screen). Then, the inspected person 2 views the result of the primary inspection after depositing (S412). As will be described later, a radio button for selecting a desired process in the future is displayed on the primary inspection result content screen together with the result of the primary inspection. Furthermore, as will be described later, the inspection number, age, sex, and the like of the inspected person 2 are displayed on the primary inspection result content screen. Comments such as the name of the prefecture where the examinee 2 lives, a description of the suspected part about cancer, etc. on the primary test result content screen, a hospital suitable for the examinee 2 to have medical treatment, Information on a medical institution 6 (FIG. 15) such as a clinic may be displayed.
  • a medical institution 6 FIG. 15
  • the inspection process ends (not shown in FIG. 16). If the person to be inspected 2 desires “re-inspection of primary inspection” on the primary inspection result content screen, the process returns to step S302 (not shown in FIG. 16).
  • a medical institution search process described later in FIG. 20 is performed.
  • a request for reduction of examination items may be displayed on the primary test result content screen.
  • the request to reduce the number of examination items is to request the medical institution 6 that performs the health examination to reduce the number of examination items related to cancer when the subject 2 receives a health examination in the future.
  • the efficiency during the health examination can be improved.
  • the subject 2 is also notified that the secondary inspection will be charged from the delivery of the inspection kit.
  • the guidance for the secondary test may be performed only for those who are determined to be positive in the primary test.
  • the medical care system organization 7 can improve profits by making it easier for the inspected person 2 to apply for the primary inspection free of charge or at a low price, and to charge the secondary inspection.
  • the inspected person 2 who has confirmed the result of the primary examination makes an application and payment for the secondary examination to the medical care system organization 7 (S413), and the medical care system organization 7 confirms the application and payment,
  • a request for a secondary inspection is made to the company 5 (S414).
  • the examination company 5 defrosts the specimen 401 frozen and stored in step S409 as necessary, and performs a cancer test (secondary examination) using the nematode 411 using the thawed specimen 401 (S415).
  • the remaining specimen 401 is stored frozen.
  • the testing company 5 discards the sample 401.
  • the test organization server 502a of the test company 5 transmits the result of the cancer test to the mediation organization server 504 of the medical care system organization 7 (S416). Then, the mediation institution server 504 of the medical care system organization 7 transmits the test result to the user terminal 501 of the person to be inspected 2 (S417). At the same time, the inspection organization server 502a of the inspection company 5 transmits information on the cost reduction effect (cost reduction effect information) to the mediation organization server 504 of the medical care system organization 7 (S418).
  • the cost reduction effect is related to how much the cost can be suppressed by the cancer test by the nematode 411 than the amount presented from the medical care system organization 7.
  • the medical care system organization 7 transfers, for example, what percentage of the reduced cost to the inspection company 5 according to the cost reduction effect.
  • the cost reduction effect is, for example, processing performed by the charging processing unit 152 or the like. Note that the processing in step S418 may be performed after the primary inspection in step S409.
  • the medical institution 6 A check box for selecting the information of FIG. 15 as a cancer type is displayed.
  • the mediation institution server 504 of the medical care system organization 7 performs a medical institution search process described later, The medical institution information related to the selected and input carcinoma is transmitted (S420).
  • FIGS. 17 and 18 are flowcharts showing a cancer test procedure in the test center according to the first embodiment.
  • the inspected person information processing unit 132 registers the inspected person information in the inspected person DB 204 based on the contents of the application (S501 in FIG. 17). Further, the inspected person information processing unit 132 generates an inspection number for the inspected person 2 (FIGS. 11 and 14 to 16) (S502), and stores the generated inspection number in the inspected person DB 204. Then, the inspection number label on which the barcode of the inspection number is printed is attached to the inspection device 301 by the inspector (S503). Next, the inspector sends an inspection kit to the person 2 to be inspected (S504).
  • the sample operation unit 141 stores the sample 401 in the sample storage 303. As a result, the specimen 401 is stored frozen (S512).
  • the examination date determination unit 111 determines the examination date for the specimen 401 with reference to the growth days column of the nematode management DB 201, the examination order of the specimen 401, and the like (S513).
  • the processing in step S513 is because the nematode 411 (FIG. 2) is a living organism, and therefore it is necessary to perform analysis when the nematode 411 is most active based on the number of days of growth of the nematode 411. is there.
  • the number of days of growth of the nematode 411 is 4 to 6 days, preferably about 4 or 5 days.
  • the nematode selection unit 112 selects the analysis nematode group 402 (FIG. 2) from the nematode storage 302 (S521 in FIG. 18). For example, the nematode selection unit 112 selects the nematode group 402 stored at the address of the nematode storage 302 input via the management input / output unit 101. Thereafter, the inspection number of the optimal inspection condition for the nematode 411 of the selected nematode group 402 is stored in the inspection condition column of the inspection result DB 203. This process is performed by the inspector via the management input / output unit 101 (FIG. 1).
  • the nematode selection unit 112 generates a test nematode number for the selected nematode group 402, and assigns the generated test nematode number to the nematode group 402 (S522).
  • the nematode operation unit 113 acquires the nematode group 402 from the nematode storage unit 302 based on the address given from the nematode selection unit 112, the acquired nematode group 402 is dispensed to the inspection device 301. (S535). The procedure for dispensing the nematode group 402 to the inspection device 301 will be described later.
  • the inspection device 301 (FIG. 1) is installed in the inspection room 311 (FIG. 1) by the inspector (S531). Installation of the inspection device 301 may be performed by an inspection device installation apparatus or the like.
  • the inspection condition adjustment unit 121 acquires the inspection condition (here, environmental temperature) from each sensor installed in the inspection room 311 (S532). As an inspection condition, not only the environmental temperature but also humidity may be added.
  • the inspection condition adjustment unit 121 refers to the inspection condition DB 202 to determine whether the inspection conditions of the inspection room 311 and the inspection device 301 are satisfied (S533).
  • the inspection condition adjustment unit 121 determines whether or not the environmental temperature is the optimum temperature for the behavior of the nematode 411. More specifically, the environmental temperature is preferably 22 ° C. or higher and 24 ° C. or lower, but may be 22 ° C. or higher and 24 ° C. or lower as long as the nematode 411 can act. Since the nematode 411 is a living thing, a difference will arise in a test result by environmental conditions, such as the temperature of the test room 311 and the test
  • step S533 when the inspection condition is not satisfied (S533 ⁇ No), the inspection condition adjustment unit 121 returns the process to step S533. If the test condition is satisfied as a result of step S533 (S533 ⁇ Yes), the sample operating unit 141 dispenses the sample 401 to the test device 301 (S534). Subsequently, the nematode operation unit 113 dispenses the nematode 411 into the inspection device 301 (S535). After step S535, the nematode 411 is chemotaxisd within the inspection device 301, so that a cancer test using the nematode 411 is performed (S536).
  • the sample operation unit 141 acquires the sample 401 to be examined from the sample storage 303 (S541). Specifically, the sample operation unit 141 refers to the sample management DB 205 and acquires the sample 401 stored at the address in the sample storage 303 of the sample 401 to be examined.
  • the sample management unit 142 confirms whether or not the examination number attached to the specimen 401 matches the examination number to be processed (S542). For example, the barcode of the examination number attached to the specimen container 401A (FIGS. 10, 12, and 13) is read by a barcode reader, and the specimen management unit 142 makes the read examination number the examination target. It is determined whether or not it matches the inspection number.
  • the specimen management unit 142 has the examination number read by the RFID reader to be examined. It may be determined whether or not it matches the examination number.
  • the specimen operation unit 141 defrosts the specimen 401 that has been frozen and stored (S543), collects an amount necessary for the cancer test from the specimen 401, and collects the collected specimen 401 as necessary. Dilute (S544). The thawing is performed by placing the specimen 401 at room temperature for several minutes. Note that the process of step S544 may be omitted. In addition, it is desirable to dilute the dilution about 10 times, but it may be changed as appropriate depending on the state of the specimen 401 and the examination conditions.
  • a nematode 411 In this cancer test, a nematode 411 is used, and therefore the nematode 411 may not exhibit appropriate chemotaxis even if the specimen 401 is too dark or too thin.
  • the concentration management of the specimen 401 which is a problem specific to this cancer test using the nematode 411, can be solved.
  • the sample operation unit 141 dispenses the sample 401 to the test device 301 (S534).
  • the sample management unit 142 generates a stored sample number for the surplus sample 401 as a result of step S543 (S551). Thereafter, the sample operation unit 141 returns the surplus sample 401 to the sample storage 303, thereby refreezing the sample 401 and storing it in the sample storage 303. Thereafter, the sample management unit 142 determines whether or not the sample 401 frozen and stored in the sample storage 303 is within the storage period (S552). Whether it is within the storage period is determined based on the collection date of the sample management DB 205 or the like. The storage period is, for example, 6 months. When six months have passed, the subject 2 needs to send a new specimen 401.
  • step S553 If the result of step S553 is within the storage period (S552 ⁇ Yes), the sample management unit 142 stores the sample 401 as it is in the sample storage 303 (S553). The specimen 401 returned to the specimen storage 303 is stored frozen. If the result of step S553 is not the retention period (S552 ⁇ No), the sample management unit 142 causes the sample operation unit 141 to discard the sample 401 (S554).
  • FIG. 19 is a flowchart showing a post-cancer test procedure in the test center according to the first embodiment.
  • the nematode 411 (FIG. 2) in the inspection device 301 is stopped (S601).
  • the inspector makes the chemotaxis of the nematode 411 after plotting sodium azide in advance at both ends of the test device 301 (the area near the sample 401 and the opposite side). .
  • This paralyzes the behavior of the nematode 411 that has performed the attracting behavior or the repelling behavior. In this way, the nematode 411 is stopped.
  • the medicine used is not limited to sodium azide as long as it can paralyze the nematode 411.
  • the test condition adjustment unit 121 raises the temperature of the test device 301 to a temperature at which the nematode 411 is killed, and the nematode 411 in the test device 301 is killed so that the nematode 411 is Can be stationary. Specifically, the inspection condition adjustment unit 121 raises the heater 911 (FIG. 24) of the inspection device 301 to a temperature at which the nematode 411 is killed. By doing in this way, the movement of the nematode 411 can be fixed, and the chemotaxis analysis of the nematode 411 is facilitated.
  • the inspection condition adjustment unit 121 determines the temperature rise timing based on information input from the management input / output unit 101. That is, the inspector starts a temperature rise via the management input / output unit 101.
  • the test condition adjustment unit 121 may detect the end of the cancer test and increase the temperature of the test device 301 by using a timer (not shown) provided in the test device 301.
  • the digital microscope 921 (FIG. 24) is installed in the inspection device 301 by the inspector (S602).
  • the installation of the digital microscope 921 on the inspection device 301 will be described later.
  • the microscopic image of the nematode 411 in the inspection device 301 is captured by operating the digital microscope 921 by the inspector (S603).
  • the chemotaxis analysis part 122 performs the chemotaxis analysis of the nematode 411 demonstrated in FIG. 2 by image-processing the acquired microscope image (S604). Then, the chemotaxis analysis unit 122 stores each result of chemotaxis analysis of the nematode 411 (attraction, repelling, chemotaxis) in the test result column of the test result DB 203 (S605).
  • the determination of “positive” or “negative” may be determined by the mobility analyzer 122 if the mobility analysis value is “+”, “positive”, if it is “ ⁇ ”, “negative”. Alternatively, an inspector or doctor may check the output result of the runnability analysis unit 122.
  • the data management unit 102 determines whether or not the current examination is a “primary examination” (S611). This determination is made based on whether or not the data management unit 102 has a flag in the secondary inspection column of the inspected person DB 204. As a result of step S621, in the case of the secondary inspection (S611 ⁇ No), the transmission processing unit 131 outputs the result of the secondary inspection to the input / output unit 161, thereby disclosing the result of the secondary inspection (S612).
  • step S611 when the current examination is a primary examination (S611 ⁇ Yes), the data management unit 102 determines whether the inspected person 2 (FIGS. 11 and 14 to 16) wishes to disclose the examination results. Is determined (S621). In this embodiment, the inspected person 2 is inquired whether or not the inspection result is desired to be disclosed after completion of the primary inspection. However, whether or not the inspection result is desired to be disclosed may be registered when applying for the primary inspection. . As a result of step S621, when the subject 2 does not wish to disclose the test result (S621 ⁇ No), the data management unit 102 in the test result DB 203, the sample management DB 205, and the subject information DB after a certain period of time.
  • step S622 The inspection result data of the inspected person 2 is erased (S622).
  • the billing processing unit 152 performs a billing process for the person 2 to be inspected (S623).
  • the transmission processing unit 131 discloses the contents of the inspection result DB 203 as inspection results to the input / output unit 161, thereby disclosing the primary inspection result (inspection result) to the inspected person 2 (S624).
  • This process corresponds to step S107 in FIG. 11, step S211 in FIG. 14, step S311 in FIG. 15, and step S411 in FIG.
  • guidance for secondary inspection is also performed.
  • step S605 the data management unit 102 determines whether or not linked inspection between the inspection result DB 203 and the inspected person DB 204 is requested via the management input / output unit 101 (S631). As a result of step S631, when linked browsing is not requested (S631 ⁇ No), the data management unit 102 ends the process. As a result of step S631, when linked browsing is requested (S631 ⁇ Yes), the data management unit 102 determines whether the management ID and management password input via the management input / output unit 101 are correct. As a result, it is determined whether or not the requester of linked browsing is a qualified person of linked browsing (S632).
  • step S632 if the person is a qualified person (S632 ⁇ Yes), the data management unit 102 allows the inspection result DB 203 and the inspected person DB 204 to be linked and browsed (S633). That is, the data management unit 102 permits the inspection result and the information on the person 2 to be inspected to be linked and viewed. If the result of step S632 is that the person is not a qualified person (S632 ⁇ No), the data management unit 102 disallows the link browsing between the inspection result DB 203 and the inspected person DB 204 (S634). In this case, for example, the browsing applicant can browse only the inspection result, and cannot know which person 2 to be inspected belongs to. In other words, a viewer who is not qualified for linked browsing can browse the test results in an anonymous state.
  • the data management unit 102 removes important personal information such as name and address from the inspected person DB 204 and replaces the inspection number with the newly generated anonymous inspection ID (not shown). Is generated. Similarly, the data management unit 102 generates an anonymous inspection result DB (not shown) in which the inspection ID of the inspection result DB 203 is replaced with the above-described anonymous inspection ID. Then, the data management unit 102 may make it possible for a non-qualified person who wants to browse to refer to the anonymous examinee DB and the anonymous examination result DB.
  • FIG. 20 is a flowchart illustrating the procedure of the medical institution search process according to the first embodiment.
  • FIG. 20 is a process performed when the inspected person 2 wishes to introduce the medical institution 6 (FIG. 15) after the primary examination or when the inspected person 2 is introduced to the inspected person 2 after the secondary examination. is there.
  • the search processing unit 151 searches the inspected person DB 203 and the medical institution DB 206 to search for the optimal medical institution (S701).
  • step S ⁇ b> 701 the search processing unit 151 is close to the medical institution 6 suitable for the cancer type that the examinee 2 desires to see or examine and the residence of the examinee 2 (for example, the home of the examinee 2.
  • the optimal medical institution is searched by referring to the medical institution DB 206 for the medical institution 6 (FIG. 15) whose radius is within a predetermined range. By such processing, the examinee can easily go and know the medical institution that can cope with the desired cancer type.
  • the search processing unit 151 transmits the searched optimal medical institution to the inspecting person 2 by transmitting it to the input / output unit 161 (S702). Thereafter, the search processing unit 151 registers the request history with respect to the request history DB 207 by incrementing the field corresponding to the optimal medical institution transmitted to the examinee 2 by 1 in the request history DB 207 (S703).
  • the billing processing unit 152 calculates an introduction fee received from the medical institution 6 according to the number of requests stored in the request history DB 207 (S704), and charges the introduction fee to the medical institution 6 (S705). In this way, the medical institution 6 that has received more requests can make a profit by acquiring more patients, and the inspection institution also makes a profit by paying the inspection institution according to the profit. I can give you.
  • FIG. 21 is a schematic diagram of the specimen storage, the nematode storage, and the dispensing system according to the first embodiment.
  • FIG. 21A is a diagram showing a specimen storage.
  • the specimen storage 303 is divided into a plurality of storage rooms 321 as shown in FIG. 21A, and the specimen 401 (FIG. 2) is stored in each storage room 321.
  • the specimen 401 is stored in the storage chamber 321 in a state of being placed in a specimen container 401A (FIGS. 10, 12, and 13).
  • the sample storage 303 is a freezer, and the sample 401 is stored frozen so that it can be stored.
  • Which storage chamber 321 stores the specimen 401 from which person 2 to be examined (FIGS. 11 and 14 to 16) is managed by an address in the specimen management DB 205.
  • Each storage chamber 321 is provided with an inspection object display unit 611. If the specimen 401 stored in the storage room 321 provided therein is the examination target, the examination target display unit 611 is stored in the storage location of the specimen 401 to be examined by the inspector, for example, by lighting in green. To inform.
  • the sample management unit 142 (FIG. 1) refers to the sample management DB 205 (FIG. 7) to instruct the inspection apparatus control device 503, and the inspection apparatus control device 503 turns on the inspection object display unit 611. This can be achieved. By doing in this way, the inspector can easily visually recognize where the specimen 401 to be examined is stored in the specimen storage 303.
  • the sample management unit 142 (FIG. 1) refers to the sample collection date column of the sample management DB 205 to instruct the inspection apparatus control device 503, and the inspection apparatus control device 503 performs the inspection object display unit 611. It can be realized by lighting up. A detailed description of the inspection device 301 will be given later.
  • FIG. 21B is a diagram showing the nematode storage 302.
  • the nematode storage 302 has a plurality of culture tanks 601 as shown in FIG. In the culture tank 601, the nematode 411 (FIG. 2) is cultured. The number of days of growth of the nematode 411 in each culture tank 601 is managed by the nematode management DB 201.
  • Each culture tank 601 may be provided with an applicability display section 602.
  • the nematode selection unit 112 lights the applicability display unit 602 in the culture tank 601 in which the nematodes 411 having a suitable number of days for growth are cultivated, for example, in green.
  • the sample management unit 142 refers to the growing days column of the nematode management DB 201 (FIG. 3) and instructs the inspection device control device 503, and the inspection device control device 503 applies the applicability display portion 602. It can be realized by lighting up. By doing in this way, the inspector can easily confirm which culture tank 601 the nematode 411 is suitable for the inspection.
  • the applicability display part 602 may be displayed in order from the oldest stored nematodes 411 (nematode group 402), that is, in descending order of the number of growing days.
  • the applicability display part 602 corresponding to the culture tank 601 in which the nematode 411 exceeding the growth days suitable for the cancer test is stored may be lit in red, for example.
  • the specimen management unit 142 refers to the growth days column of the nematode management DB 201 to instruct the inspection apparatus control device 503, and the inspection apparatus control device 503 turns on the applicability display unit 602. Can be realized. In this way, the inspector can easily visually recognize the storage location of the nematode 411 to be discarded.
  • FIG. 21C is a diagram showing an outline of the dispensing system according to the first embodiment. This figure corresponds to steps S521, S534, S535, and S541 in FIG.
  • the specimen 401 to be examined is dispensed from the specimen storage 303 to the examination device 301 installed in the examination room 311.
  • the inspector designates the storage chamber 321 in which the inspection target display unit 611 of the storage chamber 321 in which the sample 401 to be inspected is stored is shining through the management input / output unit 101, so that the sample 401 is stored in the sample storage. 303.
  • the inspector may specify a location where the sample 401 to be examined is stored.
  • a nematode 411 suitable for a cancer test is dispensed from the nematode reservoir 302 to the test device 301 installed in the test room 311 by the dispensing system 303.
  • the inspector may specify the culture tank 601 in which the applicability display unit 602 is lit through the management input / output unit 101, or with reference to a nematode management screen M100 (FIG. 31) to be described later.
  • the tank 601 may be specified.
  • the nematode selection unit 112 instructs the dispensing system 621, and the dispensing system 621 dispenses the nematode 411 to the inspection device 301.
  • the dispensing system 303 corresponds to the nematode operation unit 113 and the sample operation unit 141 in FIG.
  • the inspection room 311 is provided with a temperature sensor 622 and an air conditioner (air conditioner) 624 as a temperature control unit, and the inspection condition adjustment unit 121 is an inspection in which the environment of the inspection room 311 is stored in the inspection condition DB 202. Control is performed so as to satisfy conditions (for example, temperature). Further, the inspection room 311 may be provided with a timer 623 so that the inspector is notified of the end of the inspection.
  • a temperature sensor 622 and an air conditioner (air conditioner) 624 as a temperature control unit
  • the inspection condition adjustment unit 121 is an inspection in which the environment of the inspection room 311 is stored in the inspection condition DB 202. Control is performed so as to satisfy conditions (for example, temperature).
  • the inspection room 311 may be provided with a timer 623 so that the inspector is notified of the end of the inspection.
  • FIG. 21 (d) is a diagram showing an outline of an examination system at the time of cancer examination according to the first embodiment.
  • the chemotaxis of the nematode 411 is performed in a state where the plurality of test devices 301 are arranged in the test room 311.
  • imaging with the digital microscope 921 is performed, and the chemotaxis analysis of the nematode 411 is performed based on the captured image.
  • the result of the chemotaxis analysis is stored in the inspection result DB 203.
  • the applicability display unit 602 and the inspection target display unit 611 may be omitted.
  • FIG. 22 is a diagram showing a specific configuration of the dispensing system according to the first embodiment.
  • This dispensing system 621 is a system used in steps S534 and S535 of FIG.
  • the dispensing system 621 includes a first sample acquisition robot 701, a sample rail 702, a dilution table 703, a second sample acquisition robot 704, a dilution robot 705, and a sample dispensing robot 706, which are the sample operation unit 141 in FIG. .
  • the dispensing system 621 includes a nematode acquisition robot 711, a nematode rail 712, and a nematode dispensing robot 713, which are the nematode operation unit 113 of FIG.
  • the first specimen acquisition robot 701 acquires the specimen 401 (specifically, the specimen container 401A: FIGS. 10, 12, and 13) to be examined from the specimen storage 303, Place on the specimen rail 702.
  • the specimen rail 702 is, for example, a belt conveyor, and transports the placed specimen 401 to the front of the dilution table 703.
  • a petri dish 707 and the like are placed on the dilution table 703, and the second sample acquisition robot 704 dispenses a necessary amount of the sample 401 from the transferred sample 401 to the petri dish 707 of the dilution table 703.
  • the dilution robot 705 dilutes the specimen 401 by injecting sterilized water or a buffer solution into the petri dish 707 of the dilution table 703 from a pipette provided in the dilution robot 705.
  • the dilution of the specimen 401 is desirably about 10 times.
  • the sample dispensing robot 706 dispenses the diluted sample 401 in the petri dish 707 of the dilution table 703 to the inspection device 301. With such a system, the sample 401 can be dispensed efficiently.
  • the specimen rail 702 carries the specimen 401 to the position of the first specimen acquisition robot 701 by rotating in the reverse direction, and the first specimen acquisition robot 701 has the specimen 401 that has been transported to the origin of the specimen storage 303.
  • the specimen 401 stored in the specimen storage 303 is stored frozen by the freezing function of the specimen storage 303.
  • a stored sample number may be newly assigned to the sample 401. By doing so, the specimen 401 can be efficiently stored by refreezing.
  • the first sample robot 701 takes out the sample 401 whose storage period has passed from the sample storage 303 and discards it (step S554 in FIG. 18). .
  • the nematode acquisition robot 711 acquires the nematode group 402 (FIG. 2) having the optimal number of days for inspection from the nematode storage 302 and places it on the nematode rail 712. It is determined by referring to the address in the nematode storage 302 where the optimum number of days for growth is stored in the nematode storage 302.
  • the nematode rail 712 is, for example, a belt conveyor, and conveys the placed nematode group 402 to the nematode dispensing robot 713. Then, the nematode dispensing robot 713 dispenses the nematode 411 (FIG. 2) in the nematode group 402 that has been transported to the inspection device 301. With such a system, the nematode 411 can be dispensed efficiently.
  • the nematode rail 712 is rotated in the reverse direction to carry the nematode group 402 to the nematode obtaining robot 711, and the nematode obtaining robot 711 carries the nematode group 402 that has been carried.
  • the nematode 411 which is not used can be efficiently stored again.
  • the remaining nematodes 411 as a result of the cancer test are re-stored in the nematode storage 302, but the remaining nematodes 411 may be discarded.
  • the dispensing system 621 may be installed inside the examination room 311 or installed outside the examination room, and the tips of the sample dispensing robot 706 and the nematode dispensing robot 713 are placed in the examination room 311. You may be allowed to enter the room.
  • FIG. 23 is a diagram illustrating a configuration example of the inspection device according to the first embodiment.
  • the inspection device 301 includes a lid 801, a spacer 802, a mobility part 803 and a base part 804.
  • a mobility part 803 is installed on the base part 804
  • a spacer 802 is installed on the mobility part 803, and a lid 801 is installed on the spacer 802.
  • the base 804, the running portion 803, and the spacer 802 may be bonded to each other or may not be bonded. If the base 804, the running path and the spacer 802 are not bonded to each other, the cleaning of the base 804, the running analysis unit 803, and the spacer 802 is facilitated.
  • the lid 801 has a rectangular parallelepiped shape, and a nematode dispensing hole 811 that is a hole for dispensing the nematode 411 (FIG. 2) is provided in the center. Further, two specimen dispensing holes 812 that are holes for dispensing the specimen 401 (FIG. 2) are provided on both sides of the nematode dispensing hole 811 in the longitudinal direction. By having such a configuration, the nematode 411 and the specimen 401 can be easily placed as will be described later.
  • the spacer 802 has a rectangular and cylindrical shape. Note that the spacer 802 may be omitted.
  • the mobility part 803 has a concave shape. That is, the mobility part 803 has a structure having a bottom rather than a penetrating structure.
  • the sample 401 and the nematode 411 dispensed from the sample dispensing hole 812 and the nematode dispensing hole 811 are placed on the bottom of the chemotaxis part 803. Then, as described with reference to FIG. 2, the nematode 411 performs a repelling action or an inducing action on the specimen 401 on the bottom of the chemotaxis part 803.
  • the bottom of the chemotaxis part 803 is filled with agar as a medium.
  • a buffer solution suction hole 821 penetrating from the side surface to the inside of the mobility portion 803 is provided on the side surface of the mobility portion 803.
  • a cloth-like material such as Kimwipe is inserted into the buffer solution suction hole 821.
  • the nematode 411 is dispensed, the nematode 411 is dispensed together with a buffer solution, and it is desirable that this buffer solution is finally wiped off.
  • the interference liquid suction hole 821 is preferably provided in the vicinity of the place where the nematode 411 is placed.
  • “dispensing” assumes that a certain amount of nematode 411 is dropped together with the buffer solution, but it is sufficient that a certain amount of nematode can be placed in a predetermined place.
  • the base 804 includes a heater 911 and a temperature sensor 912 (see FIG. 24) as a temperature control unit. Thereby, the chemotaxis of the nematode 411 can be performed at a suitable temperature of the nematode 411. Since each inspection device 301 includes the heater 911 and the temperature sensor 912, it is possible to adjust the temperature for each inspection device 301, and it is also possible to kill the nematode 411 by increasing the temperature after the end of mobility. It is.
  • the base 804 is provided with an illumination unit 831.
  • the illumination unit 831 includes an LED (Light Emitting Diode) or the like. The illumination part 831 makes it easy to observe the chemotaxis result of the nematode 411 by illuminating the chemotaxis part 803 from below.
  • the lid 801, the spacer 802, the running portion 803, and the base 804 are made of transparent acrylic or the like.
  • the protrusion part 822 in the mobility part 803 may be abbreviate
  • the bottom part (location where the nematode 411 is chemotaxis) in the chemotaxis part 803 may not be substantially rectangular, for example, substantially C-shaped.
  • FIG. 24 is a diagram showing a procedure for analyzing chemotaxis of nematodes according to the first embodiment.
  • FIG. 24 (a) is a diagram showing a sample and nematode dispensing method. This processing corresponds to the processing in steps S534 and S535 in FIG.
  • a pipette 901 is provided at the tip of the sample dispensing robot 706.
  • the specimen dispensing robot 706 has two specimen dispensing holes 812 provided as shown in FIG. Of these, a pipette 901 is provided on one side. Then, the sample dispensing robot 706 drops the sample 401 from the pipette 901 to place the sample 401 on the bottom of the chemotaxis unit 803.
  • a pipette 902 is provided at the tip of the nematode dispensing robot 713.
  • a predetermined amount (about 100) of nematodes 411 (FIG. 2) is collected by the pipette 902 from the nematode group 402 (FIG. 2) carried by the nematode rail 712 (FIG. 22)
  • the insect dispensing robot 713 pierces the nematode dispensing hole 811 with a pipette 902 as shown in FIG.
  • the nematode dispensing robot 713 places the nematode 411 on the bottom of the chemotaxis unit 803 by dropping the nematode 411 from the pipette.
  • FIG. 24B is a diagram showing the behavior of nematodes. That is, in FIG. 24B, the nematode 411 in the nematode group 402 placed on the inspection device 301 performs chemotaxis with respect to the specimen 401. This process is equivalent to step S536 in FIG.
  • the inspection condition adjustment unit 121 (FIG. 1) acquires the temperature of the chemotaxis part 803 by the temperature sensor 912 of the base 804, and the chemotaxis part 803 has a temperature suitable for the nematode 411 ( For example, the temperature of the heater 911 is adjusted to be 23 ° C.
  • the chemotaxis of the nematode 411 is performed for about one hour.
  • the base 804 is provided with a timer, and an alarm may be sounded after one hour has elapsed since the start of the chemotaxis of the nematode 411. If the temperature of the examination room 311 is adjusted, the heater 911 and the temperature sensor 912 of the base 804 may be omitted.
  • FIG.24 (c) is a figure which shows the observation method of the chemotaxis result of a nematode. This processing corresponds to the processing in steps S602 and S603 in FIG.
  • the digital microscope 921 is installed in the two specimen dispensing holes 812. Installation of the digital microscope 921 may be performed by an inspector or a microscope mounting robot. Thus, the sample dispensing hole 812 also has a role as an imaging unit installation unit.
  • the installation location of the digital microscope 921 is not limited to the specimen dispensing hole 812. It may be installed in a hole provided separately from the specimen dispensing hole 812.
  • the height of the spacer 802 (FIG. 23) is the length of the focal length of the digital microscope 921. By doing so, focusing of the digital microscope 921 is not necessary, or labor can be greatly reduced.
  • the illumination unit 831 of the base 804 is turned on. Then, the chemotaxis result of the nematode 411 can be imaged by the two digital microscopes 921 performing imaging.
  • the digital microscope 921 corresponds to the imaging unit 123 in FIG. Further, as shown in FIG. 21C, when a plurality of inspection devices 301 are installed, the digital microscope 921 moves between the inspection devices 301 so that the plurality of inspection devices 301 are imaged one after another. It may be. Alternatively, the digital microscope 921 may sequentially capture images by moving a plurality of inspection devices 301.
  • Each of the screens P1, P2, and P6 in FIGS. 25 to 29 includes the URL (Uniform Resource Locator) described in the mail transmitted to the user terminal 501 (FIGS. 10, 12, and 13) as the subject 2 (FIG. 11, FIG. 14 to FIG. 16) may be displayed by clicking.
  • the URL may be displayed when the examinee 2 inputs the URL described in the direct mail received by the examinee 2 to the input device 514 ⁇ / b> A of the user terminal 501.
  • an HTML (Hypertext Markup Language) file attached to the mail transmitted to the user terminal 501 may be expanded and displayed.
  • FIG. 25 is a diagram illustrating an example of a primary examination guidance screen according to the first embodiment.
  • FIG. 25 is a screen displayed on the display device 515A of the user terminal 501 that has received the cancer test guidance in step S101 of FIG. 11, step S201 of FIG. 14, and step S401 of FIG. 15 shows a screen displayed on the display device 515A of the user terminal 501 by the subject 2 who has received the cancer test instruction in step S301 in FIG.
  • the primary examination guidance screen P1 displays a column P11 for inputting information related to the delivery destination of the cancer examination collection kit.
  • the primary inspection guidance screen P1 describes that the inspection kit is free of charge as indicated by reference numeral P12.
  • the test kit is displayed as being free of charge, but may be charged at a low price (for example, about several hundred yen).
  • FIG. 26 is a diagram illustrating an example of a primary inspection result notification screen according to the first embodiment.
  • FIG. 26 shows a screen that the examinee 2 views in step S108 in FIG. 11, step S212 in FIG. 14, step S312 in FIG. 15, and step S412 in FIG.
  • the box P21 on the primary inspection result notification screen P2 does not describe specific inspection result contents of the primary inspection, but describes that an inspection fee will be generated when the inspection result contents are confirmed.
  • a primary inspection result content screen P3 shown in FIG. 27 to be described later is displayed and an inspection fee is charged.
  • the inspection fee is generated when the inspection result content is confirmed.
  • the inspection fee may not be generated even when the inspection result content is confirmed.
  • FIG. 27 is a diagram illustrating an example of a primary inspection result content screen according to the first embodiment.
  • the primary inspection result content screen P3 is displayed when the examinee 2 clicks the result browsing button P22 of FIG. 26 via the input device.
  • information inspection number, age, sex, etc.
  • the result of the primary inspection is displayed in the reference P32.
  • “positive” is detected.
  • FIG. 28 is a diagram illustrating an example of an inspection stop confirmation screen according to the first embodiment.
  • the inspection stop confirmation screen P4 is a screen that is displayed when “I do not wish to have any more inspections” in the symbol P33 in FIG. 27 is selected.
  • the specimen 401 (FIG. 2) is frozen and stored for 6 months, or if the secondary examination is performed while the specimen 401 is frozen and stored, the charge is reduced. It is described that the fee for the secondary inspection becomes higher after the cryopreservation period.
  • FIG. 29 is a secondary inspection confirmation screen according to the first embodiment.
  • the secondary inspection confirmation screen P5 is a screen that is displayed when “desired secondary inspection” in P33 in FIG. 27 is selected.
  • the fee is reduced because the sample 401 (FIG. 2) provided last time is frozen and stored for six months, and the sample 401 provided last time is stored frozen. The fee for the secondary inspection is described.
  • the secondary examination confirmation screen P5 describes that it is necessary to resubmit the specimen 401 after the frozen storage period of the specimen 401, and that the test kit is sent free of charge. In this way, the secondary examination fee when the specimen 401 is stored frozen is set to be lower than the secondary examination fee when the specimen 401 is not stored frozen, thereby prompting a quick secondary examination. be able to.
  • FIG. 30 is a diagram illustrating an example of a secondary inspection result confirmation screen according to the first embodiment.
  • FIG. 30 is a screen for browsing the results of the secondary inspection transmitted in step S111 in FIG. 11, step S217 in FIG. 14, step S317 in FIG. 15, and step S418 in FIG.
  • the secondary inspection result is described on the secondary inspection result confirmation screen P6.
  • FIG. 30 describes that the result of the secondary test is “positive”.
  • a check box P61 for selecting which cancer type he / she wants to receive a close examination or treatment is displayed.
  • the examinee 2 checks the check box P61 of the desired cancer type via the input device 514A (FIGS. 10, 12, and 13) of the user terminal 501, and clicks the transmission button P62, FIG.
  • the medical institution search process is started, and the optimal medical institution 6 (FIG. 15) for the selected cancer type is searched.
  • FIG. 31 is a diagram illustrating an example of a nematode management screen according to the first embodiment.
  • the contents of the nematode management DB 201 are displayed on the management input / output unit 101.
  • the rectangle indicated by the symbol M1 indicates the nematode storage 302 (FIG. 1), and in the example of FIG. 31, three nematodes from “No. A storage 302 is displayed.
  • symbol M1 has shown the culture tank 601 (FIG. 21).
  • the culture tank is shown in the rectangle in FIG. 21, in FIG. 31, it is set as the square for description.
  • Each nematode storage 302 is provided with column numbers “A” to “E” and row numbers “1” to “11”, and combinations of column numbers and row numbers (for example, The storage location (address) of the nematode group 402 (FIG. 2) is indicated by “A5”).
  • a storage place M11 indicated by fine oblique lines is a place where a nematode group 402 (4-6 days of growth or 4-5 days of growth) suitable for cancer testing is stored.
  • the inspector can easily confirm the storage location of the nematode group 402 suitable for the cancer test.
  • the nematode group 402 is shown in order from the oldest by the numbers displayed in the storage location M11. That is, the nematode group 402 stored at the address “B4” of “No. 1” in which the number “1” is displayed is the nematode group that is cultured and stored in the storage location M11 indicated by the fine diagonal lines.
  • the nematode group 402 It is the nematode group 402 that is the oldest (the number of growing days is large) among 402. Similarly, the nematode group 402 stored at the address “D6” of “No. 1” in which the number “2” is displayed is the nematode cultured and stored in the storage location M11 indicated by the fine diagonal lines. The nematode group 402 is the second oldest group (the second most growing day) in the group 402.
  • the nematode 411 in the nematode group 402 is a living thing, it is desirable to use the nematode group 402 suitable for the cancer test from the oldest one. As shown in FIG. 31, by displaying numbers in the oldest order of the nematode group 402, the inspector can easily grasp which nematode group 402 should be used.
  • the inspector clicks the storage location M11 of the address “B4” of “No. 1”, the clicked storage location is highlighted as shown in FIG. Thereafter, the inspector operates the management input / output unit 101 to click the selection button M21.
  • the nematode selection unit 112 causes the nematode acquisition robot 711 (FIG. 22) to acquire the nematode group 402 (petri dish) cultured and stored at the address specified in FIG. Place on the insect rail. By doing in this way, the inspector can surely use the nematode group 402 suitable for the cancer test in chronological order.
  • a storage location M12 indicated by a dot in FIG. 31 indicates a location where the nematode group 402 that becomes the nematode group 402 suitable for the cancer test is stored in culture.
  • the nematode group 402 that becomes the nematode group 402 suitable for the cancer test is a nematode group 402 that grows for 4 days within 24 hours. In this way, by indicating the location where the nematode group 402 that becomes the nematode group 402 suitable for the cancer test is stored in culture, the inspector can determine which nematode group 402 can be used next. Can be easily grasped.
  • a storage location M13 indicated by a rough oblique line in FIG. 31 indicates a location where the nematode group 402 that has passed the number of days suitable for cancer testing is cultured and stored.
  • the nematode group 402 that has passed the growth days suitable for the cancer test is, for example, the nematode group 402 having a growth days of 7 days or more.
  • the location where the nematode group 402 that has passed the growth days suitable for the cancer test is cultured and stored is shown, so that the inspector can easily grasp the nematode group 402 to be discarded, and The insect 411 can be efficiently destroyed, and the nematode storage 302 can be used efficiently.
  • information on the nematode group 402 cultured and stored in the storage location may be displayed in a balloon or the like.
  • FIG. 32 is a diagram illustrating an example of a sample management screen according to the first embodiment.
  • the contents of the sample management DB 205 are displayed on the management input / output unit 101.
  • the rectangle indicated by reference numeral N1 indicates the sample storage 303 (FIG. 1), and in the example of FIG. 32, three sample storages 303 from “No. It is displayed.
  • Each specimen storage 303 is assigned a column number “A” to “E” and a row number “1” to “11”, and a combination of the column number and the row number (for example, “ A5 ”) shows the storage location (address) of the specimen 401 (FIG. 2).
  • the management input / output unit 101 When the user operates the management input / output unit 101 and moves the mouse pointer to an arbitrary storage location, information (sample collection date, etc.) of the sample 402 stored in the storage location is displayed in a balloon N21 or the like. Is displayed. By doing so, the inspector can easily grasp the information of the specimen 402. Thereafter, when the user operates the management input / output unit 101 and clicks an arbitrary storage location, the clicked storage location is highlighted as shown by reference numeral N11 in FIG. Thereafter, when the inspector operates the management input / output unit 101 and clicks the selection button N31, the first sample acquisition robot 701 (FIG. 22) selects the sample 401 cultured and stored at the specified address. Obtained from the storage 303 and placed on the specimen rail.
  • the storage location N12 indicated by a dot indicates the storage location of the specimen 401 whose storage period (for example, 6 months from the collection date) has passed.
  • the inspector clicks the storage location N12 and clicks the selection button N31 the sample 401 stored in the clicked storage location N12 may be discarded.
  • the cancer test using the nematode 411 uses a living organism called the nematode 411, the number of days of growth of the nematode 411, the temperature management of the examination room 311 and the examination device 301, and the specimen 401 (FIG. 2) are used. It was necessary to have specialized and advanced knowledge and experience in that it was diluted. Therefore, in the invention according to the first embodiment, the cancer test system 1 manages the growth days of the nematode 411 (nematode group 411: FIG. 2), the temperature management of the test room 311 and the test device 301, and the specimen 401. Therefore, even those who do not have specialized and advanced knowledge or experience can perform a cancer test using the nematode 411.
  • Second Embodiment In the second embodiment, “positive” and “negative” are used for the determination, and further, the test period is determined using the past test results.
  • FIG. 33 is a diagram showing a schematic configuration of a cancer test system according to the second embodiment. 33, the same components as those in FIG. 1 are denoted by the same reference numerals and description thereof is omitted.
  • the cancer test system 1a is different from the cancer test system 1 of FIG. 1 in that it has a test period determining unit 171 that determines a period until the next cancer test based on the test result DB 203, and a transmission processing unit.
  • Reference numeral 131 is a point of transmitting the next cancer test time determined by the test period determination unit 171 to the input / output unit 161.
  • the inspection organization determination unit 171 may be executed by the inspection organization servers 502, 502a, and 502b in FIGS.
  • the encrypted inspection result is obtained from the apparatus including the inspection result DB 203 and the inspected person DB 204. Receive information about.
  • Table 1 shows an example of the relationship between the chemotaxis analysis value t of the nematode 411 (FIG. 2) and “positive” and “negative”.
  • chemotaxis analysis value of Table 1 is a value shown by Formula (1).
  • FIG. 34 is a flowchart illustrating a processing procedure of the examination period determination unit according to the second embodiment.
  • the examination period determining unit 171 acquires the current cancer examination result, the previous cancer examination result, and (examination result) from the examination result DB 203 (S801). Then, the test result is determined based on the current cancer test result and the previous cancer test result (S802). If the result of step S802 is “positive” continuously (for example, twice consecutively) in the predetermined number of times of inspection (S802 ⁇ “continuously +”), the inspection period determination unit 171 2 (FIG. 11, FIG. 14 to FIG. 16), a notification of a close examination required (S811) and introduction of a hospital (S812). Introduction of the medical institution 6 (FIG. 15) is performed by the process of FIG.
  • step S802 when the result of the previous “negative” is changed to “positive” (S802 ⁇ “ ⁇ ⁇ +”), the examination period determining unit 171 determines whether or not the tendency is worsening ( S821). If the result of step S821 shows a tendency of deterioration (S821 ⁇ Yes), the inspection period determination unit 171 shortens the period until the next inspection candidate date from the previous inspection period (shortens the inspection period: S822). In step S821, “being negative” (“negative”) last time is “positive (+)”, and this time is “positive (+)”. This is when there is a problem with the result.
  • step S821 If the result of step S821 shows no tendency to deteriorate (S821 ⁇ No), the examination period determination unit 171 sets the period until the next examination candidate date as the same period as the previous examination period (the same examination period: S823). .
  • “not negative” means that the previous test was “negative ( ⁇ )”, but this time it is “positive (+)”. This is the case when there is no problem.
  • step S802 when the current cancer test result is “negative ( ⁇ )” (S802 ⁇ “ ⁇ ”), the test period determination unit 171 displays the previous cancer test result and the current cancer test result. Compare (S831). Next, the inspection period determination unit 171 determines whether or not the result of the comparison in step S821 is an improvement trend (S832).
  • step S832 If the result of step S832 is that there is no improvement trend (S832 ⁇ No), the inspection period determination unit 171 sets the period until the next inspection candidate date to be the same as the previous inspection period (the same inspection period: S823). .
  • the fact that there is no improvement trend is the case where the previous “negative ( ⁇ )” is also “negative ( ⁇ )” this time, but other tests including subjective symptoms This is when there is a problem with the result.
  • step S832 If the result of step S832 shows an improvement trend (S832-> Yes), the inspection period determination unit 171 makes the period until the next inspection candidate date longer than the previous inspection period (increases the inspection period: S833).
  • the tendency to improve is the case where the previous “negative ( ⁇ )” is also “negative ( ⁇ )” this time, and other tests including subjective symptoms. This is a case where there is no problem in the result.
  • the test period determining unit 171 determines in step S832 that there is an improvement trend. To do.
  • step S802 if “positive (+)” is three times consecutively, the test period determining unit 171 proceeds to steps S811 and S812, and if “positive (+)” is two consecutive times, the test is performed.
  • the period determination unit 171 may make the period until the next inspection candidate date shorter than the previous inspection period.
  • the second embodiment by determining the next inspection time based on the current inspection result or based on the current inspection result and the previous (previous) inspection result, for example, by the nematode 411 Even if negative is detected as a result of the cancer test, the customer who is the subject 2 can be kept connected.
  • the cancer test is performed at one facility, but the cancer test may be performed at a plurality of facilities. That is, one specimen may be divided into a plurality of facilities, and a cancer test may be performed at each facility.
  • each facility be on the same site. This is because a living body such as a nematode may be affected by a slight difference in environmental factors even if it is reared under the same rearing conditions (temperature, humidity, etc.). Therefore, by performing cancer tests at a plurality of facilities, reproducibility can be realized by using a plurality of nematodes reared in the same manner, and the accuracy and reliability of cancer tests can be improved.
  • one sample is separated into two, and IDs are given so that the two separated samples are obtained from the same person 2 to be examined (FIGS. 11, 14 to 16). It is desirable.
  • urine as a sample is subjected to a filter process using a sterilization filter or a filter for removing impurities.
  • urine is used as a specimen, but biologically related substances derived from the subject 2 such as sweat, cells of the subject 2, blood, saliva, exhalation, etc. may be used.
  • a wild-type nematode is used, but a genetically modified nematode such as an indicator gene that can measure the calcium concentration in the nerve is expressed in the olfactory nerve of the nematode. It may be used (transgenic nematodes may be used, or knockout nematodes in which a specific gene is disrupted and deleted) may be used.
  • the advertising fee may be paid to the inspection company 4 from the health insurance association 4 (FIG. 14), the medical institution 6 (FIG. 15), or the medical care system organization 7 (FIG. 16).
  • the present invention is not limited to the above-described embodiment, and includes various modifications.
  • the above-described embodiment has been described in detail for easy understanding of the present invention, and is not necessarily limited to having all the configurations described.
  • a part of the configuration of a certain embodiment can be replaced with the configuration of another embodiment, and the configuration of another embodiment can be added to the configuration of a certain embodiment.
  • each configuration, function, each unit 102, 111 to 113, 121, 122, 131, 132, 141, 142, 151, 152, 161, 171, each of the DBs 201 to 207, etc. are part or all of them.
  • it may be realized by hardware by designing with an integrated circuit.
  • the above-described configurations, functions, and the like are executed by a processor such as a CPU (arithmetic devices 512A, 512B, 512C) interpreting a program that realizes each function. By doing so, it may be realized by software.
  • control lines and information lines are those that are considered necessary for explanation, and not all control lines and information lines are necessarily shown on the product. In practice, it can be considered that almost all configurations are connected to each other.
  • elegans acquisition robot C. elegans operation unit
  • 712 Nematode Rail 713 Nematode Dispensing Robot 801 Lid 802 Spacer 803 Mobility Section 804 Base 811 Nematode Dispensing Hole 812 Specimen Dispensing Hole (Imaging Section Installation Section) 821 Buffer suction hole 831 Illumination unit 911 Heater (temperature control unit) 912 Temperature sensor (temperature controller) M100 Nematode management screen N100 Specimen management screen P1 Primary inspection guidance screen P2 Primary inspection result notification screen P3 Primary inspection result content screen P4 Inspection cancellation confirmation screen P5 Secondary inspection confirmation screen P6 Secondary inspection result confirmation screen

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Abstract

L'invention concerne un système de test de cancer qui est caractérisé en ce qu'il comprend une unité de détermination de jour de test (111) qui détermine le jour de test sur la base de la période de croissance de vers ronds, une unité de sélection de ver rond qui sélectionne des vers ronds pour analyse, sur la base de la période de croissance de vers ronds, une unité de réglage de condition de test (121) qui maintient un dispositif de test (301) à une température prédéfinie, une unité de manipulation d'échantillon (141) qui distribue un échantillon d'urine d'un sujet de test au dispositif de test, une unité de manipulation de ver rond (113) qui place un ver rond sélectionné par l'unité de sélection de ver rond sur le dispositif de test, et une unité d'analyse d'activité (122) qui analyse le ver rond et le comportement du ver rond après passage d'un temps prédéfini depuis la mise en place d'un ver rond et qui délivre en sortie le résultat de l'analyse.
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JPWO2018047959A1 (ja) * 2016-09-12 2019-06-24 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、並びに該評価方法に用いるシャーレおよび行動評価系
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JPWO2018181869A1 (ja) * 2017-03-31 2019-11-21 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫変異体を含むがんの診断薬および該変異体を用いた走性行動評価方法
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JPWO2019013187A1 (ja) * 2017-07-11 2020-05-28 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 組織検体を用いたがんの検出方法
JP7100323B2 (ja) 2017-07-11 2022-07-13 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 組織検体を用いたがんの検出方法
WO2019013187A1 (fr) * 2017-07-11 2019-01-17 株式会社Ｈｉｒｏｔｓｕバイオサイエンス Méthode de dépistage du cancer utilisant un échantillon de tissu
WO2021112162A1 (fr) * 2019-12-06 2021-06-10 株式会社Ｈｉｒｏｔｓｕバイオサイエンス Méthode d'analyse de taxies, méthode d'évaluation de cancers, système d'analyse de taxies et programme
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US12380573B2 (en) 2019-12-06 2025-08-05 Hirotsu Bio Science Inc. Taxis analysis method, cancer evaluation method, taxis analysis system and program
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