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WO2016034715A3 - Method for predicting the development of colorectal cancer - Google Patents

Method for predicting the development of colorectal cancer Download PDF

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Publication number
WO2016034715A3
WO2016034715A3 PCT/EP2015/070268 EP2015070268W WO2016034715A3 WO 2016034715 A3 WO2016034715 A3 WO 2016034715A3 EP 2015070268 W EP2015070268 W EP 2015070268W WO 2016034715 A3 WO2016034715 A3 WO 2016034715A3
Authority
WO
WIPO (PCT)
Prior art keywords
patients
stage
colorectal cancer
methods
development
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2015/070268
Other languages
French (fr)
Other versions
WO2016034715A2 (en
Inventor
Laurent TOSOLINI
Gilles VIEIRA
Alexandre Ho-Pun-Cheung
Caroline MOLLEVI
Evelyne Crapez
Eric ASSENAT
Odile PRIGNEAU
Guillaume VETTER-GENOUD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PRESTIZIA
Institut Regional du Cancer de Montpellier
Original Assignee
PRESTIZIA
Institut Regional du Cancer de Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PRESTIZIA, Institut Regional du Cancer de Montpellier filed Critical PRESTIZIA
Publication of WO2016034715A2 publication Critical patent/WO2016034715A2/en
Publication of WO2016034715A3 publication Critical patent/WO2016034715A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present application relates to compositions and methods for analysing and characterizing patients affected by colorectal cancer, and, in particular those affected by locally advanced stage II and stage III cancer of the rectum. The application concerns in particular, the methods and reagents (primers, chips, DNA chips, probes, NGS, real-time PCR, etc.) to determine or evaluate the clinical development of such cancers, and more particularly to assess the manner in which they respond to RCT treatment and/or to determine the risk of metastatic recurrence in said patients. The invention is based in particular on the detection of circulating miRNAs. It can be used on any patient, and in particular on patients having a stage II or stage III cancer.
PCT/EP2015/070268 2014-09-05 2015-09-04 Method for predicting the development of colorectal cancer Ceased WO2016034715A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14183831.8 2014-09-05
EP14183831 2014-09-05

Publications (2)

Publication Number Publication Date
WO2016034715A2 WO2016034715A2 (en) 2016-03-10
WO2016034715A3 true WO2016034715A3 (en) 2016-06-02

Family

ID=51518569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/070268 Ceased WO2016034715A2 (en) 2014-09-05 2015-09-04 Method for predicting the development of colorectal cancer

Country Status (1)

Country Link
WO (1) WO2016034715A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119347A (en) * 2016-06-24 2016-11-16 山东大学齐鲁医院 The primer of colorectal cancer based on serum exosomal microRNAs transfer detection and test kit
CN107130017B (en) * 2017-03-31 2021-01-15 北京大学人民医院 Kit and application of reagent in preparation of kit
CN109385472B (en) * 2018-12-07 2021-10-08 中国科学院近代物理研究所 A serum miRNA marker and method for detecting ionizing radiation damage

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115609A1 (en) * 2015-01-20 2016-07-28 Katholieke Universiteit Leuven Colon cancer
CN106367477A (en) * 2016-08-25 2017-02-01 朱伟 Serum miRNA marker related to auxiliary diagnosis of colorectal cancer, and application thereof
CN107974501A (en) * 2016-10-19 2018-05-01 北京旷博生物技术股份有限公司 Colorectal cancer prognosis microrna molecule marker and application thereof
CN117683885A (en) * 2019-04-30 2024-03-12 觅瑞实验室私人有限公司 A kind of miRNA marker combination and kit for detecting gastric cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
WO2010004562A2 (en) * 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
WO2013093635A2 (en) * 2011-10-21 2013-06-27 Hospital Clinic De Barcelona Plasma micrornas for the detection of early colorectal cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
WO2010004562A2 (en) * 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
WO2013093635A2 (en) * 2011-10-21 2013-06-27 Hospital Clinic De Barcelona Plasma micrornas for the detection of early colorectal cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Arraystar Handbook miRStar(TM) PCR Array Systems", 3 July 2014 (2014-07-03), XP055169727, Retrieved from the Internet <URL:http://web.archive.org/web/20150213151200/http://www.arraystar.com/Manage/UploadFile/Handbook/Arraystar Handbook-miRStar PCR Array Systems.pdf> [retrieved on 20150213] *
ELRASHEID A. H. KHEIRELSEID ET AL: "miRNA expressions in rectal cancer as predictors of response to neoadjuvant chemoradiation therapy", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, vol. 28, no. 2, 18 August 2012 (2012-08-18), DE, pages 247 - 260, XP055230598, ISSN: 0179-1958, DOI: 10.1007/s00384-012-1549-9 *
I-PING YANG ET AL: "The Functional Significance of MicroRNA-29c in Patients with Colorectal Cancer: A Potential Circulating Biomarker for Predicting Early Relapse", PLOS ONE, vol. 8, no. 6, 28 June 2013 (2013-06-28), pages e66842, XP055169156, DOI: 10.1371/journal.pone.0066842 *
QI CHEN ET AL: "Serum miR-19a Predicts Resistance to FOLFOX Chemotherapy in Advanced Colorectal Cancer Cases", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 14, no. 12, 31 December 2013 (2013-12-31), pages 7421 - 7426, XP055169307, ISSN: 1513-7368, DOI: 10.7314/APJCP.2013.14.12.7421 *
TOIYAMA YUJI ET AL: "Serum miR-200c is a novel prognostic and metastasis-predictive biomarkerin patients with colorectal cancer", ANNALS OF SURGERY, vol. 259, no. 4, April 2014 (2014-04-01), United States, pages 735 - 743, XP008174889 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119347A (en) * 2016-06-24 2016-11-16 山东大学齐鲁医院 The primer of colorectal cancer based on serum exosomal microRNAs transfer detection and test kit
CN106119347B (en) * 2016-06-24 2019-12-03 山东大学齐鲁医院 Primers and kits for colorectal cancer metastasis detection based on serum exosomal microRNAs
CN107130017B (en) * 2017-03-31 2021-01-15 北京大学人民医院 Kit and application of reagent in preparation of kit
CN109385472B (en) * 2018-12-07 2021-10-08 中国科学院近代物理研究所 A serum miRNA marker and method for detecting ionizing radiation damage

Also Published As

Publication number Publication date
WO2016034715A2 (en) 2016-03-10

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